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Article: Ventilator-Associated Pneumonia in the Neonatal Intensive Care Unit-Incidence and Strategies for Prevention.

Rangelova, Vanya / Kevorkyan, Ani / Raycheva, Ralitsa / Krasteva, Maya

2024 Volume 14, Issue 3

Abstract: The second most prevalent healthcare-associated infection in neonatal intensive care units (NICUs) is ventilator-associated pneumonia (VAP). This review aims to update the knowledge regarding the incidence of neonatal VAP and to summarize possible ... ...

Abstract	The second most prevalent healthcare-associated infection in neonatal intensive care units (NICUs) is ventilator-associated pneumonia (VAP). This review aims to update the knowledge regarding the incidence of neonatal VAP and to summarize possible strategies for prevention. The VAP incidence ranges from 1.4 to 7 episodes per 1000 ventilator days in developed countries and from 16.1 to 89 episodes per 1000 ventilator days in developing countries. This nosocomial infection is linked to higher rates of illness, death, and longer hospital stays, which imposes a substantial financial burden on both the healthcare system and families. Due to the complex nature of the pathophysiology of VAP, various approaches for its prevention in the neonatal intensive care unit have been suggested. There are two main categories of preventative measures: those that attempt to reduce infections in general (such as decontamination and hand hygiene) and those that target VAP in particular (such as VAP care bundles, head of bed elevation, and early extubation). Some of the interventions, including practicing good hand hygiene and feeding regimens, are easy to implement and have a significant impact. One of the measures that seems very promising and encompasses a lot of the preventive measures for VAP are the bundles. Some preventive measures still need to be studied.
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14030240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials.

Krasteva, Natalia / Georgieva, Milena

Pharmaceutics

2022 Volume 14, Issue 6

Abstract: Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases per annum, whereas the lack of effective therapies highlights the need for novel ... ...

Abstract	Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases per annum, whereas the lack of effective therapies highlights the need for novel therapeutic approaches. Conventional treatment methods, such as surgery, chemotherapy and radiotherapy, are widely applied in oncology practice. Their therapeutic success is little, and therefore, the search for novel technologies is ongoing. Many efforts have focused recently on the development of safe and efficient cancer nanomedicines. Nanoparticles are among them. They are uniquewith their properties on a nanoscale and hold the potential to exploit intrinsic metabolic differences between cancer and healthy cells. This feature allows them to induce high levels of toxicity in cancer cells with little damage to the surrounding healthy tissues. Graphene oxide is a promising 2D material found to play an important role in cancer treatments through several strategies: direct killing and chemosensitization, drug and gene delivery, and phototherapy. Several new treatment approaches based on nanoparticles, particularly graphene oxide, are currently under research in clinical trials, and some have already been approved. Here, we provide an update on the recent advances in nanomaterials-based CRC-targeted therapy, with special attention to graphene oxide nanomaterials. We summarise the epidemiology, carcinogenesis, stages of the CRCs, and current nanomaterials-based therapeutic approaches for its treatment.
Language	English
Publishing date	2022-06-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14061213
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Article ; Online: Old age as a risk factor for liver diseases: Modern therapeutic approaches.

Georgieva, Milena / Xenodochidis, Charilaos / Krasteva, Natalia

Experimental gerontology

2023 Volume 184, Page(s) 112334

Abstract: Recent scientific interest has been directed towards age-related diseases, driven by the significant increase in global life expectancy and the growing population of individuals aged 65 and above. The ageing process encompasses various biological, ... ...

Abstract	Recent scientific interest has been directed towards age-related diseases, driven by the significant increase in global life expectancy and the growing population of individuals aged 65 and above. The ageing process encompasses various biological, physiological, environmental, psychological, behavioural, and social changes, leading to an augmented susceptibility to chronic illnesses. Cardiovascular, neurological, musculoskeletal, liver and oncological diseases are prevalent in the elderly. Moreover, ageing individuals demonstrate reduced regenerative capacity and decreased tolerance towards therapeutic interventions, including organ transplantation. Liver diseases, such as non-alcoholic fatty liver disease, alcoholic liver disease, hepatitis, fibrosis, and cirrhosis, have emerged as significant public health concerns. Paradoxically, these conditions remain underestimated despite their substantial global impact. Age-related factors are closely associated with the severity and unfavorable prognosis of various liver diseases, warranting further investigation to enhance clinical management and develop novel therapeutic strategies. This comprehensive review focuses specifically on age-related liver diseases, their treatment strategies, and contemporary practices. It provides a detailed account of the global burden, types, molecular mechanisms, and epigenetic alterations underlying these liver pathologies.
MeSH term(s)	Aged ; Humans ; Risk Factors ; Liver Cirrhosis/complications ; Liver Cirrhosis/pathology ; Non-alcoholic Fatty Liver Disease/therapy ; Prognosis
Language	English
Publishing date	2023-11-25
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2023.112334
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Article ; Online: Pitfalls of using sequence databases for heterologous expression studies - a technical review.

Maxeiner, Stephan / Krasteva-Christ, Gabriela / Althaus, Mike

The Journal of physiology

2023 Volume 601, Issue 9, Page(s) 1611–1623

Abstract: Synthesis of DNA fragments based on gene sequences that are available in public resources has become an efficient and affordable method that has gradually replaced traditional cloning efforts such as PCR cloning from cDNA. However, database entries based ...

Abstract	Synthesis of DNA fragments based on gene sequences that are available in public resources has become an efficient and affordable method that has gradually replaced traditional cloning efforts such as PCR cloning from cDNA. However, database entries based on genome sequencing results are prone to errors which can lead to false sequence information and, ultimately, errors in functional characterisation of proteins such as ion channels and transporters in heterologous expression systems. We have identified five common problems that repeatedly appear in public resources: (1) Not every gene has yet been annotated; (2) not all gene annotations are necessarily correct; (3) transcripts may contain automated corrections; (4) there are mismatches between gene, mRNA and protein sequences; and (5) splicing patterns often lack experimental validation. This technical review highlights and provides a strategy to bypass these issues in order to avoid critical mistakes that could impact future studies of any gene/protein of interest in heterologous expression systems.
MeSH term(s)	Base Sequence ; Amino Acid Sequence ; DNA, Complementary/genetics ; DNA, Complementary/metabolism ; Proteins/genetics
Chemical Substances	DNA, Complementary ; Proteins
Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP284066
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Article ; Online: A Thermostable Lipase Isolated from

Atanasova, Nikolina / Paunova-Krasteva, Tsvetelina / Kambourova, Margarita / Boyadzhieva, Ivanka

Biotech (Basel (Switzerland))

2023 Volume 12, Issue 1

Abstract: The tremendous problem with plastic waste accumulation has determined an interest in biodegradation by effective degraders and their enzymes, such as thermophilic enzymes, which are characterized by high catalytic rates, thermostability, and optimum ... ...

Abstract	The tremendous problem with plastic waste accumulation has determined an interest in biodegradation by effective degraders and their enzymes, such as thermophilic enzymes, which are characterized by high catalytic rates, thermostability, and optimum temperatures close to the melting points of some plastics. In the present work, we report on the ability of a thermophilic lipase, by
Language	English
Publishing date	2023-03-14
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6284
ISSN (online)	2673-6284
DOI	10.3390/biotech12010023
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Article: [Pain in the neonatal period. I -- physiological aspects, causes, response, diagnosis and long-term effects of neonatal pain].

Krasteva, M

Akusherstvo i ginekologiia

2013 Volume 52, Issue 5, Page(s) 47–53

Abstract: Unlabelled: Entering of high-tech methods used in the treatment of premature infants carries the risk of increased invasiveness which causes the pain and stress in them. The aim of this literature review is to present the achievements in the study of ... ...

Abstract	Unlabelled: Entering of high-tech methods used in the treatment of premature infants carries the risk of increased invasiveness which causes the pain and stress in them. The aim of this literature review is to present the achievements in the study of neonatal pain, causes and responses to it, the short-term effects on their status and their later development, as well as the ways of pain's assessment. The newborn after 26-30 weeks of gestation has functionally mature pain receptor apparatus. Numerous invasive procedures cause in the prematurely born baby psycho-physiological abnormalities (changes in heart rate, breathing, blood pressure and oxygen saturation) and behavioral abnormalities (facial expression, motion activity of the body and extremities, sleep disturbances, characteristics of crying). The last mentioned are basis for creating a rating scale for procedural and prolonged pain. Future studies are aimed at creating an universal scales. Conclusion: At the time of intensive treatment, the premature infant is under the adverse effects of acute or repeated pain incentives. They worsen the status, prolong the hospital stay and influence the later neurological development and outcome of the premature infant. In everyday clinical practice, prevention of pain, establishing its severity and its evaluation reduce its negative effects on the newborn.
MeSH term(s)	Humans ; Infant, Newborn ; Infant, Premature/physiology ; Infant, Premature, Diseases/diagnosis ; Infant, Premature, Diseases/therapy ; Intensive Care Units, Neonatal ; Pain/diagnosis ; Pain Management/methods ; Pain Measurement/methods
Language	Bulgarian
Publishing date	2013
Publishing country	Bulgaria
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	137491-6
ISSN	0324-0959 ; 0516-365X ; 0204-6954
ISSN	0324-0959 ; 0516-365X ; 0204-6954
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Article: [Pain in the neonatal period II. non-pharmacological and pharmacological treatment].

Krasteva, M

Akusherstvo i ginekologiia

2013 Volume 52, Issue 6, Page(s) 29–37

Abstract: Unlabelled: In their postnatal development the newborns are often exposed to the influence of procedural and repetitive painful stimuli that worsen their status. This requires the implementation of non-pharmacological and pharmacological treatment. Aim - ...

Abstract	Unlabelled: In their postnatal development the newborns are often exposed to the influence of procedural and repetitive painful stimuli that worsen their status. This requires the implementation of non-pharmacological and pharmacological treatment. Aim - to explore the literature data on the possibilities of non-pharmacological and pharmacological treatment methods which are implemented to reduce and control pain in neonatal period. Some of the non-pharmacological strategies are the priority of the personnel who gives care of newborns (swaddling, nonnutritive sucking, usage of sweet solution, etc.) Ever more is discussed the participation of mother(parents)in the care of her child's comfort and pain reduction. The breastfeeding and "kangaroo" care additionally reduce negative effects of pain. The importance of the music continues to be explored. The principles of pharmacological therapy include: control of procedure pain, its treatment during mechanical ventilation and at the time and after surgical intervention which is based on analgesia. Specificities of the pharmacotherapy of newborns and premature infants require careful application of the medications and additional studies on these children. Conclusion: The elimination of neonatal pain and its negative effects on the newborn is achieved by applying different strategies. Non-pharmacological methods reduce pain stimuli and ensure the child's comfort and the pharmacological methods block and eliminate the pain. Most often a combination of them is used in practice.
MeSH term(s)	Analgesia/methods ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/diagnosis ; Infant, Newborn, Diseases/therapy ; Pain/diagnosis ; Pain Management/methods
Language	Bulgarian
Publishing date	2013
Publishing country	Bulgaria
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	137491-6
ISSN	0324-0959 ; 0516-365X ; 0204-6954
ISSN	0324-0959 ; 0516-365X ; 0204-6954
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Article ; Online: Length-weight relationship of European catfish (Silurus glanis L.) fry reared at different stocking densities under controlled conditions

V. Krasteva / M. Yankova

Agricultural Science and Technology, Vol 13, Iss 1, Pp 47-

2021 Volume 51

Abstract: Abstract. The present paper investigates the body length and weight, and the size-weight variations of one-month-old European catfish reared at 4 variants of stocking density: Variant 1 – 5 spec/l; Variant 2 – 10 spec/l; Variant 3 – 15 spec/l and Variant ...

Abstract	Abstract. The present paper investigates the body length and weight, and the size-weight variations of one-month-old European catfish reared at 4 variants of stocking density: Variant 1 – 5 spec/l; Variant 2 – 10 spec/l; Variant 3 – 15 spec/l and Variant 4 – 28 spec/l. The experiment is carried out at the Institute of Fisheries and Aquaculture, Plovdiv for a period of 16 days, using a production system consisting of tubs with continuous water flow (0.7 l/min). At the end of the experiment, the fish from each variant are sorted in three size-weight groups: A – large, B – medium and C – small. The number of fish in each group is established. From the group of the medium- and small-sized fish, 150 speciments are measured, while from the group of the large specimens, which are the smallest in number, all specimens are measured for the biometric parameters body weight (BW, g) and total body length (TL, cm). The results from the study show small variations in the length and weight of the fish reared at the lowest stocking density (Variant 1). As the density increase, the size-weight differences between the specimens from Group A also increased, while of those from Group B they decrease. The number of the medium-sized fish decrease (p≤0.001) while the number of large specimens (p≤0.01) and small fish increase (p≤0.001).
Keywords	body length ; body weight ; density ; size ; specimens ; variations ; Agriculture ; S
Subject code	590
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Trakia University. Faculty of Agriculture, Stara Zagora
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New insights in the renal distribution profile of TRPC3 - Of mice and men.

Diebolt, Coline M / Schaudien, Dirk / Junker, Kerstin / Krasteva-Christ, Gabriela / Tschernig, Thomas / Englisch, Colya N

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

2023 Volume 252, Page(s) 152192

Abstract: Several reports previously investigated the Transient Receptor Potential Canonical subfamily channel 3 (TRPC3) in the kidney. However, most of the conclusions are based on animal samples or cell cultures leaving the door open for human tissue ... ...

Abstract	Several reports previously investigated the Transient Receptor Potential Canonical subfamily channel 3 (TRPC3) in the kidney. However, most of the conclusions are based on animal samples or cell cultures leaving the door open for human tissue investigations. Moreover, results often disagreed among investigators. Histological description is lacking since most of these studies focused on functional aspects. Nevertheless, the same reports highlighted the potential key-role of TRPC3 in renal disorders. Hence, our interest to investigate the localization of TRPC3 in human kidneys. For this purpose, both healthy mouse and human kidney samples that were originated from tumor nephrectomies have been prepared for immunohistochemical staining using a knockout-validated antibody. A blocking peptide was used to confirm antibody specificity. A normalized weighted diaminobenzidine (DAB) area score between 0 and 3 comparable to a pixelwise H-score was established and employed for semiquantitative analysis. Altogether, our results suggest that glomeruli only express little TRPC3 compared to several segments of the tubular system. Cortical and medullary proximal tubules are stained, although intracortical differences in staining exist in mice. Intermediate tubules, however, are only weakly stained. The distal tubule was studied in three localizations and staining was marked although slightly varying throughout the different subsegments. Finally, the collecting duct was also immunolabeled in both human and mouse tissue. We therefore provide evidence that TRPC3 is expressed in various localizations of both human and mouse samples. We verify results of previous studies and propose until now undescribed localizations of TRPC3 in the mouse but especially and of greater interest in the human kidney. We thereby not only support the translational concept of the TRPC3 channel as key-player in physiology and pathophysiology of the human kidney but also present new potential targets to functional analysis.
MeSH term(s)	Animals ; Humans ; Cell Culture Techniques ; Kidney
Chemical Substances	TRPC3 cation channel
Language	English
Publishing date	2023-11-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1106738-x
ISSN	1618-0402 ; 0940-9602
ISSN (online)	1618-0402
ISSN	0940-9602
DOI	10.1016/j.aanat.2023.152192
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Article: Comprehensive Assessment of Graphene Oxide Nanoparticles: Effects on Liver Enzymes and Cardiovascular System in Animal Models and Skeletal Muscle Cells.

Keremidarska-Markova, Milena / Sazdova, Iliyana / Ilieva, Bilyana / Mishonova, Milena / Shkodrova, Milena / Hristova-Panusheva, Kamelia / Krasteva, Natalia / Chichova, Mariela

Nanomaterials (Basel, Switzerland)

2024 Volume 14, Issue 2

Abstract: The growing interest in graphene oxide (GO) for different biomedical applications requires thoroughly examining its safety. Therefore, there is an urgent need for reliable data on how GO nanoparticles affect healthy cells and organs. In the current work, ...

Abstract	The growing interest in graphene oxide (GO) for different biomedical applications requires thoroughly examining its safety. Therefore, there is an urgent need for reliable data on how GO nanoparticles affect healthy cells and organs. In the current work, we adopted a comprehensive approach to assess the influence of GO and its polyethylene glycol-modified form (GO-PEG) under near-infrared (NIR) exposure on several biological aspects. We evaluated the contractility of isolated frog hearts, the activity of two rat liver enzymes-mitochondrial ATPase and diamine oxidase (DAO), and the production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells following direct exposure to GO nanoparticles. The aim was to study the influence of GO nanoparticles at multiple levels-organ; cellular; and subcellular-to provide a broader understanding of their effects. Our data demonstrated that GO and GO-PEG negatively affect heart contractility in frogs, inducing stronger arrhythmic contractions. They increased ROS production in C2C12 myoblasts, whose effects diminished after NIR irradiation. Both nanoparticles in the rat liver significantly stimulated DAO activity, with amplification of this effect after NIR irradiation. GO did not uncouple intact rat liver mitochondria but caused a concentration-dependent decline in ATPase activity in freeze/thaw mitochondria. This multifaceted investigation provides crucial insights into GOs potential for diverse implications in biological systems.
Language	English
Publishing date	2024-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14020188
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