LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Core Competency Self-Assessment Enhances Critical Review of Complications and Entrustable Activities.

    Antonacci, Anthony C / Patel, Vihas / Dechario, Samuel P / Antonacci, Caroline / Standring, Oliver J / Husk, Gregg / Coppa, Gene / Jarrett, Mark

    The Journal of surgical research

    2020  Volume 257, Page(s) 221–226

    Abstract: Background: The Accreditation Council for Graduate Medical Education has defined six core competencies (CCs) that every successful physician should possess. However, the assessment of CC achievement among trainees is difficult. This project was designed ...

    Abstract Background: The Accreditation Council for Graduate Medical Education has defined six core competencies (CCs) that every successful physician should possess. However, the assessment of CC achievement among trainees is difficult. This project was designed to prospectively evaluate the impact of resident identification of CC as a component of morbidity review on error identification and standard of care (SOC) assessments. The platform was assessed for its reliability as a measure of resident critical analysis of complication causality across postgraduate year (PGY).
    Materials and methods: A total of 1945 general surgery cases with complications were assessed for error identification and SOC management between January 1, 2016, and December 31, 2018. CC identification was additionally assessed between January 1, 2019, and December 31, 2019, and included 708 general surgery cases. Data were evaluated for error assessments and overall SOC management. PGY4 and 5 residents were compared for number of cases and complications reviewed, severity, error causation, and CC relevance.
    Results: Study groups were equivalent by Clavien-Dindo scores. Error identification significantly increased in all categories: diagnostic (P < 0.001), technical (P < 0.05), judgment (P < 0.001), system (P < 0.001), and communication (P < 0.001). Overall SOC assessments validated by a supervising surgical quality officer were unchanged. An increased exposure to cases with severe complications, error causation, and CC relevance was noted across PGY.
    Conclusions: The addition of CC assessment into morbidity review appears to improve the critical thinking of evaluating residents by increasing the identification of management errors. Used as an element of prospective self-assessment, teaching residents to identify CC principles in cases with complications may assist in learner progression toward clinical competence and critical thinking.
    MeSH term(s) Clinical Competence ; Competency-Based Education/methods ; Follow-Up Studies ; General Surgery/education ; Humans ; Internship and Residency ; Medical Errors/adverse effects ; Medical Errors/prevention & control ; Patient Harm/prevention & control ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Program Evaluation ; Prospective Studies ; Reproducibility of Results ; Self-Assessment ; Severity of Illness Index ; Surgeons/psychology ; Surgical Procedures, Operative/adverse effects ; Surgical Procedures, Operative/education
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2020.07.064
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Ampullary Neuroendocrine Tumors: Insight into a Rare Histology.

    Ruff, Samantha M / Standring, Oliver / Wu, Grace / Levy, Anna / Anantha, Sandeep / Newman, Elliot / Karpeh, Martin S / Nealon, William / Deutsch, Gary B / Weiss, Matthew J / DePeralta, Danielle K

    Annals of surgical oncology

    2021  Volume 28, Issue 13, Page(s) 8318–8328

    Abstract: Background: Ampullary neuroendocrine tumors (NETs) make up < 1% of all gastroenteropancreatic NETs, and information is limited to case series. This study compares patients with ampullary, duodenal, and pancreatic head NETs.: Methods: The National ... ...

    Abstract Background: Ampullary neuroendocrine tumors (NETs) make up < 1% of all gastroenteropancreatic NETs, and information is limited to case series. This study compares patients with ampullary, duodenal, and pancreatic head NETs.
    Methods: The National Cancer Database (2004-2016) was queried for patients with ampullary, duodenal, and pancreatic head NETs. Survival was evaluated using Kaplan-Meier analysis and Cox regression.
    Results: Overall, 872, 9692, and 6561 patients were identified with ampullary, duodenal, and pancreatic head NETs, respectively. Patients with ampullary NETs had more grade 3 tumors (n = 149, 17%) than patients with duodenal (n = 197, 2%) or pancreatic head (n = 740, 11%) NETs. Patients with ampullary NETs had more positive lymph nodes (n = 297, 34%) than patients with duodenal (n = 950, 10%) or pancreatic head (n = 1513, 23%) NETs. On multivariable analysis for patients with ampullary NETs, age (hazard ratio [HR] 1.03, p < 0.0001), Charlson-Deyo score of 2 (HR 2.3, p = 0.001) or ≥3 (HR 2.9, p = 0.013), grade 2 (HR 1.9, p = 0.007) or grade 3 tumors (HR 4.0, p < 0.0001), and metastatic disease (HR 2.0, p = 0.001) were associated with decreased survival. At 5 years, the overall survival (OS) for patients with ampullary, duodenal, and pancreatic head NETs was 59%, 71%, and 50%, respectively (p < 0.0001), whereas the 5-year OS for patients with ampullary, duodenal, and pancreatic head NETs who underwent surgery was 62%, 78%, and 76%, respectively (p < 0.0001).
    Conclusions: Ampullary NETs were more likely to present with high-grade tumors and lymph node metastases. Based on the clinicopathologic and survival data, ampullary NETs have a unique underlying biology compared with duodenal and pancreatic head NETs.
    MeSH term(s) Common Bile Duct Neoplasms/surgery ; Duodenal Neoplasms/surgery ; Humans ; Neuroendocrine Tumors/surgery ; Pancreatic Neoplasms ; Proportional Hazards Models
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10371-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype.

    Friedberg, Jacob S / Aytan, Nurgul / Cherry, Jonathan D / Xia, Weiming / Standring, Oliver J / Alvarez, Victor E / Nicks, Raymond / Svirsky, Sarah / Meng, Gaoyuan / Jun, Gyungah / Ryu, Hoon / Au, Rhoda / Stein, Thor D

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 2924

    Abstract: Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors, many of which are related to inflammation. The apolipoprotein E (APOE) ε4 allele is the most common genetic risk factor for AD and is related ... ...

    Abstract Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors, many of which are related to inflammation. The apolipoprotein E (APOE) ε4 allele is the most common genetic risk factor for AD and is related to a pro-inflammatory state. To test the hypothesis that microglia and AD-implicated cytokines were differentially associated with AD pathology based on the presence of APOE ε4, we examined the dorsolateral frontal cortex from deceased participants within a community-based aging cohort (n = 154). Cellular density of Iba1, a marker of microglia, was positively associated with tau pathology only in APOE ε4 positive participants (p = 0.001). The cytokines IL-10, IL-13, IL-4, and IL-1α were negatively associated with tau pathology, independent of Aβ
    MeSH term(s) Aged, 80 and over ; Alleles ; Amyloid beta-Peptides/metabolism ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Apolipoprotein E4/genetics ; Biomarkers/metabolism ; Brain/pathology ; Calcium-Binding Proteins/metabolism ; Cell Count ; Cohort Studies ; Cytokines/metabolism ; Dementia/pathology ; Female ; Genotype ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Male ; Microfilament Proteins/metabolism ; Microglia/metabolism ; Microglia/pathology ; Models, Biological ; tau Proteins/metabolism
    Chemical Substances AIF1 protein, human ; Amyloid beta-Peptides ; Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Apolipoprotein E4 ; Biomarkers ; CD68 antigen, human ; Calcium-Binding Proteins ; Cytokines ; Microfilament Proteins ; tau Proteins
    Language English
    Publishing date 2020-02-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-59869-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Pancreatic Cancer Patient-derived Organoids Can Predict Response to Neoadjuvant Chemotherapy.

    Demyan, Lyudmyla / Habowski, Amber N / Plenker, Dennis / King, Daniel A / Standring, Oliver J / Tsang, Caitlin / St Surin, Luce / Rishi, Arvind / Crawford, James M / Boyd, Jeff / Pasha, Shamsher A / Patel, Hardik / Galluzzo, Zachary / Metz, Christine / Gregersen, Peter K / Fox, Sharon / Valente, Cristina / Abadali, Sonya / Matadial-Ragoo, Steffi /
    DePeralta, Danielle K / Deutsch, Gary B / Herman, Joseph M / Talamini, Mark A / Tuveson, David A / Weiss, Matthew J

    Annals of surgery

    2022  Volume 276, Issue 3, Page(s) 450–462

    Abstract: Objective: To evaluate if patient-derived organoids (PDOs) may predict response to neoadjuvant (NAT) chemotherapy in patients with pancreatic adenocarcinoma.: Background: PDOs have been explored as a biomarker of therapy response and for personalized ...

    Abstract Objective: To evaluate if patient-derived organoids (PDOs) may predict response to neoadjuvant (NAT) chemotherapy in patients with pancreatic adenocarcinoma.
    Background: PDOs have been explored as a biomarker of therapy response and for personalized therapeutics in patients with pancreatic cancer.
    Methods: During 2017-2021, patients were enrolled into an IRB-approved protocol and PDO cultures were established. PDOs of interest were analyzed through a translational pipeline incorporating molecular profiling and drug sensitivity testing.
    Results: One hundred thirty-six samples, including both surgical resections and fine needle aspiration/biopsy from 117 patients with pancreatic cancer were collected. This biobank included diversity in stage, sex, age, and race, with minority populations representing 1/3 of collected cases (16% Black, 9% Asian, 7% Hispanic/Latino). Among surgical specimens, PDO generation was successful in 71% (15 of 21) of patients who had received NAT prior to sample collection and in 76% (39 of 51) of patients who were untreated with chemotherapy or radiation at the time of collection. Pathological response to NAT correlated with PDO chemotherapy response, particularly oxaliplatin. We demonstrated the feasibility of a rapid PDO drug screen and generated data within 7 days of tissue resection.
    Conclusion: Herein we report a large single-institution organoid biobank, including ethnic minority samples. The ability to establish PDOs from chemotherapy-naive and post-NAT tissue enables longitudinal PDO generation to assess dynamic chemotherapy sensitivity profiling. PDOs can be rapidly screened and further development of rapid screening may aid in the initial stratification of patients to the most active NAT regimen.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/surgery ; Antineoplastic Agents/therapeutic use ; Ethnicity ; Humans ; Minority Groups ; Neoadjuvant Therapy ; Organoids ; Pancreatic Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000005558
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy.

    Standring, Oliver J / Friedberg, Jacob / Tripodis, Yorghos / Chua, Alicia S / Cherry, Jonathan D / Alvarez, Victor E / Huber, Bertrand R / Xia, Weiming / Mez, Jesse / Alosco, Michael L / Nicks, Raymond / Mahar, Ian / Pothast, Morgan J / Gardner, Hannah M / Meng, Gaoyuan / Palmisano, Joseph N / Martin, Brett M / Dwyer, Brigid / Kowall, Neil W /
    Cantu, Robert C / Goldstein, Lee E / Katz, Douglas I / Stern, Robert A / McKee, Ann C / Stein, Thor D

    Acta neuropathologica

    2019  Volume 138, Issue 3, Page(s) 401–413

    Abstract: Cerebral amyloid angiopathy (CAA) consists of beta-amyloid deposition in the walls of the cerebrovasculature and is commonly associated with Alzheimer's disease (AD). However, the association of CAA with repetitive head impacts (RHI) and with chronic ... ...

    Abstract Cerebral amyloid angiopathy (CAA) consists of beta-amyloid deposition in the walls of the cerebrovasculature and is commonly associated with Alzheimer's disease (AD). However, the association of CAA with repetitive head impacts (RHI) and with chronic traumatic encephalopathy (CTE) is unknown. We evaluated the relationship between RHI from contact sport participation, CTE, and CAA within a group of deceased contact sport athletes (n = 357), a community-based cohort (n = 209), and an AD cohort from Boston University AD Center (n = 241). Unsupervised hierarchal cluster analysis demonstrated a unique cluster (n = 11) with increased CAA in the leptomeningeal vessels compared to the intracortical vessels (p < 0.001) comprised of participants with significantly greater frequencies of CTE (7/11) and history of RHI. Overall, participants with CTE (n = 251) had more prevalent (p < 0.001) and severe (p = 0.010) CAA within the frontal leptomeningeal vessels compared to intracortical vessels. Compared to those with AD, participants with CTE had more severe CAA in frontal than parietal lobes (p < 0.001) and more severe CAA in leptomeningeal than intracortical vessels (p = 0.002). The overall frequency of CAA in participants with CTE was low, and there was no significant association between contact sport participation and the presence of CAA. However, in those with CAA, a history of contact sports was associated with increased CAA severity in the frontal leptomeningeal vessels (OR = 4.01, 95% CI 2.52-6.38, p < 0.001) adjusting for AD, APOE ε4 status, and age. Participants with CAA had increased levels of sulcal tau pathology and decreased levels of the synaptic marker PSD-95 (p's < 0.05), and CAA was a predictor of dementia (OR = 1.75, 95% CI 1.02-2.99, p = 0.043) adjusting for age, sex, and comorbid pathology. Overall, contact sport participation and CTE were associated with more severe frontal and leptomeningeal CAA, and CAA was independently associated with worse pathological and clinical outcomes.
    MeSH term(s) Aged ; Aged, 80 and over ; Athletes ; Athletic Injuries/complications ; Athletic Injuries/pathology ; Brain/pathology ; Cerebral Amyloid Angiopathy/complications ; Cerebral Amyloid Angiopathy/pathology ; Chronic Traumatic Encephalopathy/complications ; Chronic Traumatic Encephalopathy/pathology ; Female ; Humans ; Male ; Sports
    Language English
    Publishing date 2019-06-10
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-019-02031-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top