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Article ; Online: Subepithelial Lesion-like Carcinoma Occurred in Ulcerative Colitis.

Takabayashi, Kaoru / Shimoda, Masayuki / Iwao, Yasushi / Kanai, Takanori

2023 Volume 62, Issue 20, Page(s) 3085–3086

MeSH term(s)	Humans ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/pathology ; Carcinoma ; Colorectal Neoplasms
Language	English
Publishing date	2023-02-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.1299-22
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Article ; Online: Quantification of the Swallowing Mechanism Through Muscle Synergy Analysis.

Murakami, Chiaki / Sasaki, Makoto / Shimoda, Shingo / Tamada, Yasushi

Dysphagia

2022 Volume 38, Issue 3, Page(s) 973–989

Abstract: Decreased swallowing function increases the risk of choking and aspiration pneumonia. Videofluoroscopy and computed tomography allow for detailed observation of the swallowing movements but have radiation risks. Therefore, we developed a method using ... ...

Abstract	Decreased swallowing function increases the risk of choking and aspiration pneumonia. Videofluoroscopy and computed tomography allow for detailed observation of the swallowing movements but have radiation risks. Therefore, we developed a method using surface electromyography (sEMG) to noninvasively assess swallowing function without radiation exposure. A 44-channel flexible sEMG sensor was used to measure the sEMG signals of the hyoid muscles during swallowing in 14 healthy young adult and 14 elderly subjects. Muscle synergy analysis was performed to extract the muscle synergies from the sEMG signals, and the three synergies were extracted from the hyoid muscle activities during the swallowing experiments. The experimental results showed that the three synergies represent the oral, early pharyngeal, and late pharyngeal swallowing phases and that swallowing strength is tuned by the strength of the muscle activities, whereas swallowing volume is controlled by adjusting muscle activation timing. In addition, the timing of the swallowing reflex is slower in elderly individuals. The results confirm that the proposed approach successfully quantifies swallowing function from sEMG signals, mapping the signals to the swallowing phases.
MeSH term(s)	Young Adult ; Humans ; Aged ; Deglutition/physiology ; Electromyography/methods ; Neck Muscles ; Movement ; Cineradiography ; Deglutition Disorders/diagnostic imaging
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632764-3
ISSN	1432-0460 ; 0179-051X
ISSN (online)	1432-0460
ISSN	0179-051X
DOI	10.1007/s00455-022-10523-4
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Article ; Online: Subjective sleep disturbances across psychiatric illnesses-a transdiagnostic analysis.

Nakamura, Shuntaro / Sugawara, Norio / Kawamata, Yasushi / Yasui-Furukori, Norio / Shimoda, Kazutaka

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

2023 Volume 31, Issue 2, Page(s) 229–230

MeSH term(s)	Humans ; Mental Disorders/complications ; Mental Disorders/diagnosis ; Mental Disorders/psychology ; Sleep Wake Disorders/diagnosis ; Sleep
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Letter
ZDB-ID	2213198-X
ISSN	1440-1665 ; 1039-8562
ISSN (online)	1440-1665
ISSN	1039-8562
DOI	10.1177/10398562231154113
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Zs.A 6220: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Survey of Health Literacy Among Japanese Outpatients with Mental Illness.

Sato, Yoshiteru / Sugawara, Norio / Kawamata, Yasushi / Shimoda, Kazutaka / Yasui-Furukori, Norio

Neuropsychiatric disease and treatment

2023 Volume 19, Page(s) 1369–1378

Abstract: Purpose: Low health literacy has been associated with adverse outcomes in health maintenance and the course of chronic physical illness. In particular, anxiety disorders can also affect one's physical health, causing issues including cardiovascular, ... ...

Abstract	Purpose: Low health literacy has been associated with adverse outcomes in health maintenance and the course of chronic physical illness. In particular, anxiety disorders can also affect one's physical health, causing issues including cardiovascular, respiratory, gastrointestinal and immune system disorders. However, there are no reports on physical health literacy among Japanese patients with mental illness. Patients and methods: A patient background questionnaire, the Japanese version of the Ten-Item Personality Inventory, and the Japanese version of the Health Literacy Scale (HLS-EU-Q47; European Health Literacy Survey Questionnaire) were distributed face to face to 1000 psychiatric outpatients. A total of 785 valid responses including 211 patients with schizophrenia, 261 patients with mood disorders, and 234 patients with anxiety disorders were obtained by mail. Results: Health literacy was "limited" in 52% of patients with schizophrenia, 51% of those with mood disorders, and 38% of those with anxiety disorders. Among patients with mood disorders, there were no differences between those with major depressive disorder and those with bipolar disorder. Anxiety disorders were associated with higher health literacy than schizophrenia and mood disorders (odds ratio (OR) 1.85, 95% confidence interval (95% CI) 1.07, 3.34), and in terms of personality, neuroticism (OR 0.85, 95% CI 0.75, 0.97) and openness (OR 0.85, 95% CI 0.74, 0.98) were associated with limited health literacy, while agreeableness (OR 1.36, 95% CI 1.18, 1.57) and extraversion OR 1.34, 95% CI 1.17, 1.52) were associated with higher health literacy. Conclusion: The results of this study indicate limited health literacy in patients with mental illness, in particular, limited health literacy in outpatients with schizophrenia and mood disorders. In addition, gender and some personality traits were associated with physical health literacy. Based on these results, physical health education should be individualized.
Language	English
Publishing date	2023-06-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S409882
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Article ; Online: HomotopicLI: Rationale, characteristics, and implications of a new threshold-free lateralization index of functional magnetic resonance imaging.

Matsuo, Kayako / Kono, Kenta / Yasui-Furukori, Norio / Shimoda, Kazutaka / Kaji, Yasushi / Akiyama, Kazufumi

Laterality

2022 Volume 27, Issue 5, Page(s) 513–543

Abstract: The reliable preoperative estimation of brain hemispheric asymmetry may be achieved through multiple lateralization indices using functional magnetic resonance imaging. Adding to our previously developed AveLI, we devised a novel threshold-free ... ...

Abstract	The reliable preoperative estimation of brain hemispheric asymmetry may be achieved through multiple lateralization indices using functional magnetic resonance imaging. Adding to our previously developed AveLI, we devised a novel threshold-free lateralization index, HomotopicLI, which computes a basic formula, (Left - Right) / (Left + Right), using voxel values of pairs located symmetrically in relation to the midsagittal line as the terms Left and Right, and averages them within the regions-of-interest. The study aimed to evaluate HomotopicLI before clinical applications. Data were collected from 56 healthy participants who performed four language tasks. We compared seven index types, including HomotopicLI, AveLI, and BaseLI; BaseLI was calculated using the sums of voxel values as the terms. Contrary to our expectations, HomotopicLI performed similarly to AveLI but better than BaseLI in detecting right dominance. A detailed analysis of unilaterally activated voxels of the homotopic pairs revealed that unilateral activation occurred more frequently on the right than on the left when HomotopicLI indicated right dominance. The voxel values during right unilateral activation were smaller than those in the left, causing right dominances in the homotopic pairs by HomotopicLI. These unique features provide an advantage in detecting residual, compensative functions spreading weakly in the non-dominant hemisphere.
MeSH term(s)	Humans ; Functional Laterality/physiology ; Brain Mapping ; Language ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2028955-8
ISSN	1464-0678 ; 1357-650X
ISSN (online)	1464-0678
ISSN	1357-650X
DOI	10.1080/1357650X.2022.2109655
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Article ; Online: Lymphomatoid gastropathy/NK-cell enteropathy involving the stomach and intestine.

Nakajima, Makoto / Shimoda, Masayuki / Takeuchi, Kengo / Dobashi, Akito / Kanai, Takanori / Kanai, Yae / Iwao, Yasushi

Journal of clinical and experimental hematopathology : JCEH

2022 Volume 62, Issue 2, Page(s) 114–118

Abstract: Lymphomatoid gastropathy (LyGa)/natural killer (NK)-cell enteropathy (NKCE) is recognized as a benign NK-cell lymphoproliferative disease. Due to its histological similarity to NK/T cell lymphoma, it is easy to misdiagnose, leading to unnecessary ... ...

Abstract	Lymphomatoid gastropathy (LyGa)/natural killer (NK)-cell enteropathy (NKCE) is recognized as a benign NK-cell lymphoproliferative disease. Due to its histological similarity to NK/T cell lymphoma, it is easy to misdiagnose, leading to unnecessary chemotherapy and poor quality of life. This disease is typically observed in the small and large intestines in North America, whereas almost all cases in Japan occur locally in the stomach. Only 11 LyGa/NKCE cases involving both gastric and intestinal lesions have been reported, and there are few reports providing endoscopic images throughout the gastrointestinal tract. We report a case of LyGa/NKCE involving both the stomach and small and large intestines with detailed upper gastrointestinal endoscopy, colonoscopy, capsule endoscopy and pathology images. Its pathogenesis currently remains elusive, but most patients with LyGa/NKCE in Japan have Helicobacter pylori (H. pylori) infection. Our patient was also positive for H. pylori infection at disease onset, but after receiving eradication therapy, ulcerative lesions in both stomach and intestine regressed and no recurrence was observed. This case suggests a link between the pathogenesis of LyGa/NKCE and H. pylori infection.
MeSH term(s)	Helicobacter Infections/complications ; Humans ; Intestines/pathology ; Lymphoma ; Lymphoproliferative Disorders/pathology ; Quality of Life ; Stomach Diseases/etiology ; Stomach Diseases/pathology ; Stomach Neoplasms/pathology
Language	English
Publishing date	2022-04-27
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2395568-5
ISSN	1880-9952 ; 1880-9952
ISSN (online)	1880-9952
ISSN	1880-9952
DOI	10.3960/jslrt.21032
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Article: Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system.

Takanami, Keiko / Kuroiwa, Masaya / Ishikawa, Ren / Imai, Yuji / Oishi, Akane / Hashino, Midori / Shimoda, Yasushi / Sakamoto, Hirotaka / Koide, Tsuyoshi

Frontiers in molecular neuroscience

2023 Volume 16, Page(s) 1280024

Abstract: The prevalence of allergic conjunctivitis in itchy eyes has increased constantly worldwide owing to environmental pollution. Currently, anti-allergic and antihistaminic eye drops are used; however, there are many unknown aspects about the neural circuits ...

Abstract	The prevalence of allergic conjunctivitis in itchy eyes has increased constantly worldwide owing to environmental pollution. Currently, anti-allergic and antihistaminic eye drops are used; however, there are many unknown aspects about the neural circuits that transmit itchy eyes. We focused on the gastrin-releasing peptide (GRP) and GRP receptor (GRPR), which are reportedly involved in itch transmission in the spinal somatosensory system, to determine whether the GRP system is involved in itch neurotransmission of the eyes in the trigeminal sensory system. First, the instillation of itch mediators, such as histamine (His) and non-histaminergic itch mediator chloroquine (CQ), exhibited concentration-dependent high levels of eye scratching behavior, with a significant sex differences observed in the case of His. Histological analysis revealed that His and CQ significantly increased the neural activity of GRPR-expressing neurons in the caudal part of the spinal trigeminal nucleus of the medulla oblongata in GRPR transgenic mice. We administered a GRPR antagonist or bombesin-saporin to ablate GRPR-expressing neurons, followed by His or CQ instillation, and observed a decrease in CQ-induced eye-scratching behavior in the toxin experiments. Intracisternal administration of neuromedin C (NMC), a GRPR agonist, resulted in dose-dependent excessive facial scratching behavior, despite the absence of an itch stimulus on the face. To our knowledge, this is the first study to demonstrate that non-histaminergic itchy eyes were transmitted centrally via GRPR-expressing neurons in the trigeminal sensory system, and that NMC in the medulla oblongata evoked facial itching.
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2023.1280024
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Article ; Online: Inhibition of adult T-cell leukemia cell proliferation by polymerized proanthocyanidin from blueberry leaves through JAK proteolysis.

Ichikawa, Tomonaga / Sugamoto, Kazuhiro / Matsuura, Yasushi / Kunitake, Hisato / Shimoda, Kazuya / Morishita, Kazuhiro

Cancer science

2022 Volume 113, Issue 4, Page(s) 1406–1416

Abstract: We have previously reported that the proanthocyanidin (PAC) fraction of blueberry leaf extract (BB-PAC) inhibits the proliferation of HTLV-1-infected adult T-cell leukemia (ATL) by inducing apoptosis. In the present study, we further analyzed the ... ...

Abstract	We have previously reported that the proanthocyanidin (PAC) fraction of blueberry leaf extract (BB-PAC) inhibits the proliferation of HTLV-1-infected adult T-cell leukemia (ATL) by inducing apoptosis. In the present study, we further analyzed the structure of BB-PAC and elucidated the molecular mechanism underlying the inhibitory function of HTLV-1-infected and ATL cells. After hot water extraction with fractionation with methanol-acetone, BB-PAC was found to be concentrated in fractions 4 to 7 (Fr7). The strongest inhibition of ATL cell growth was observed with Fr7, which contained the highest BB-PAC polymerization degree of 14. The basic structure of BB-PAC is mainly B-type bonds, with A-type bonds (7.1%) and cinchonain I units as the terminal unit (6.1%). The molecular mechanism of cytotoxicity observed around Fr7 against ATL cells was the degradation of JAK1 to 3 and the dephosphorylation of STAT3/5, which occurs by proteasome-dependent proteolysis, confirming that PAC directly binds to heat shock protein 90 (HSP90). JAK degradation was caused by proteasome-dependent proteolysis, and we identified the direct binding of PAC to HSP90. In addition, the binding of cochaperone ATPase homolog 1 (AHA1) to HSP90, which is required for activation of the cofactor HSP90, was inhibited by BB-PAC treatment. Therefore, BB-PAC inhibited the formation of the HSP90/AHA1 complex and promoted the degradation of JAK protein due to HSP90 dysfunction. These results suggest that the highly polymerized PAC component from blueberry leaves has great potential as a preventive and therapeutic agent against HTLV-1-infected and ATL cells.
MeSH term(s)	Adult ; Blueberry Plants/chemistry ; Blueberry Plants/metabolism ; Cell Proliferation ; HSP90 Heat-Shock Proteins/metabolism ; Human T-lymphotropic virus 1 ; Humans ; Leukemia-Lymphoma, Adult T-Cell/drug therapy ; Leukemia-Lymphoma, Adult T-Cell/metabolism ; Polymerization ; Proanthocyanidins ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis
Chemical Substances	HSP90 Heat-Shock Proteins ; Proanthocyanidins ; proanthocyanidin (18206-61-6) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2022-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15277
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Article ; Online: High attenuation mucus in bronchi with allergic bronchopulmonary mycosis.

Hattori, Shigeaki / Oguma, Tsuyoshi / Ishiguro, Takashi / Suzuki, Junko / Fukunaga, Koichi / Shimoda, Terufumi / Kimura, Hirokazu / Obase, Yasushi / Okada, Naoki / Tanaka, Jun / Kitahara, Asako / Tomomatsu, Katsuyoshi / Shiraishi, Yoshiki / Asano, Koichiro

Mycoses

2024 Volume 67, Issue 2, Page(s) e13705

Abstract: Background: High-attenuation mucus (HAM) is a specific manifestation of allergic bronchopulmonary mycosis (ABPM) on chest computed tomography (CT).: Objectives: To compare the diagnostic accuracy of the two definitions of HAM and to clarify the ... ...

Abstract	Background: High-attenuation mucus (HAM) is a specific manifestation of allergic bronchopulmonary mycosis (ABPM) on chest computed tomography (CT). Objectives: To compare the diagnostic accuracy of the two definitions of HAM and to clarify the clinical and radiographic characteristics of HAM-positive and HAM-negative ABPM. Methods: CT images at the diagnosis of ABPM using Asano's criteria were retrospectively analysed. In Study #1, radiographic data obtained using the same CT apparatus in a single institute were analysed to determine the agreement between the two definitions of HAM: a mucus plug that is visually denser than the paraspinal muscles or that with a radiodensity ≥70 Hounsfield units. In Study #2, HAM was diagnosed by comparison with the paraspinal muscles in patients with ABPM reporting to 14 medical institutes in Japan. Results: In Study #1, 93 mucus plugs from 26 patients were analysed. A substantial agreement for HAM diagnosis was observed between the two methods, with a κ coefficient of 0.72. In Study #2, 60 cases of ABPM were analysed; mucus plugs were present in all cases and HAM was diagnosed in 45 (75%) cases. The median A. fumigatus-specific IgE titre was significantly lower in HAM-positive patients than in HAM-negative patients (2.5 vs. 24.3 U Conclusion: In conclusion, agreement between the two methods to diagnose HAM was substantial. HAM was associated with some immunological and radiographic characteristics, including lower levels of sensitization to A. fumigatus and the presence of distal airway lesions.
MeSH term(s)	Humans ; Invasive Pulmonary Aspergillosis ; Aspergillosis, Allergic Bronchopulmonary/diagnostic imaging ; Retrospective Studies ; Bronchi ; Mucus
Language	English
Publishing date	2024-02-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.13705
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Article ; Online: Chiral Phosphoric Acid-Catalyzed Kinetic Resolution via Amide Bond Formation.

Shimoda, Yasushi / Yamamoto, Hisashi

Journal of the American Chemical Society

2017 Volume 139, Issue 20, Page(s) 6855–6858

Abstract: We describe the kinetic resolution of a readily available 2-pyridyl ester via an amide bond formation catalyzed by a chiral Brønsted acid. A chiral phosphoric acid bearing a 2,4,6-trimethyl-3,5-dinitrophenyl group at the 3,3'-position enabled this ... ...

Abstract	We describe the kinetic resolution of a readily available 2-pyridyl ester via an amide bond formation catalyzed by a chiral Brønsted acid. A chiral phosphoric acid bearing a 2,4,6-trimethyl-3,5-dinitrophenyl group at the 3,3'-position enabled this transformation with high selectivities. We also found that the addition of Lewis acid increased both the reactivity and selectivity in the substrate with a methoxy group.
Language	English
Publishing date	2017-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.7b03592
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