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Book ; Online: Equaliza\c{c}\~ao das escalas NESSCA e SARA utilizando a Teoria da Resposta ao Item na avalia\c{c}\~ao do comprometimento pela doen\c{c}a de Machado-Joseph

Utpott, Nicole Machado / Leotti, Vanessa Bielefeldt / Jardim, Laura Bannach

2020

Abstract: Background: Scale equating is a statistical technique used to establish equivalence relations between different scales. Its use is quite popular in educational evaluation, however, unusual in the health area, where scales of measures are tools that ... ...

Abstract	Background: Scale equating is a statistical technique used to establish equivalence relations between different scales. Its use is quite popular in educational evaluation, however, unusual in the health area, where scales of measures are tools that integrate clinical practice. With the use of different scales, there is a difficulty in comparing scientific results, such as NESSCA and SARA scales, tools for assessing the commitment to Machado-Joseph disease (SCA3/MJD). Objective: Explore the method of scale equating and demonstrate its application through NESSCA and SARA scales, using the Item Response Theory (IRT) approach in assessing SCA3/MJD commitment. Methods: Data came from 227 patients from the Hospital de Cl\'inicas de Porto Alegre with SCA3/MJD who have complete measures for NESSCA and/or SARA scales. The equating design used is that of non-equivalent groups with common items, with separate calibration. The IRT model used in the estimation of the parameters was the generalized partial credit, for NESSCA and SARA. The linear transformation was performed using the Mean/Mean, Mean/Sigma, Haebara and StokingLord methods and the equation of the true score was applied to obtain an estimated relationship between the scores of the scales. Results: Difference between NESSCA score estimated by SARA and observed NESSCA score has shown median of 0.82 points, by Mean/Sigma method. This was the best method of linear transformation among the tested. Conclusions: This study extended the use of scale equating under IRT approach to health outcomes and established an equivalence relationship between NESSCA and SARA scores, making the comparison between patients and scientific results feasible. Comment: in Portuguese
Keywords	Quantitative Biology - Quantitative Methods
Subject code	310
Language	Portuguese
Publishing date	2020-04-24
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Electron-phonon superconductivity in C-doped topological nodal-line semimetal Zr

Bhattacharyya, A / Ferreira, P P / Panda, K / Masunaga, S H / de Faria, L R / Correa, L E / Santos, F B / Adroja, D T / Yokoyama, K / Dorini, T T / Jardim, R F / Eleno, L T F / Machado, A J S

Journal of physics. Condensed matter : an Institute of Physics journal

2021 Volume 34, Issue 3

Abstract: In the present work, we demonstrate that C-doped Zr ...

Abstract	In the present work, we demonstrate that C-doped Zr
Language	English
Publishing date	2021-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/ac2bc7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Diversity and antimicrobial potential of the culturable rhizobacteria from medicinal plant Baccharis trimera Less D.C.

Jardim, Ana Camila Munis / de Oliveira, Jéssica Ellen / Alves, Luana de Moura / Gutuzzo, Giovana Oliveira / de Oliveira, André Luiz Martinez / Rodrigues, Elisete Pains

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2022 Volume 53, Issue 3, Page(s) 1409–1424

Abstract: Plant microbiota is usually enriched with bacteria producers of secondary metabolites and represents a valuable source of novel species and compounds. Here, we analyzed the diversity of culturable root-associated bacteria of the medicinal native plant ... ...

Abstract	Plant microbiota is usually enriched with bacteria producers of secondary metabolites and represents a valuable source of novel species and compounds. Here, we analyzed the diversity of culturable root-associated bacteria of the medicinal native plant Baccharis trimera (Carqueja) and screened promising isolates for their antimicrobial properties. The rhizobacteria were isolated from the endosphere and rhizosphere of B. trimera from Ponta Grossa and Ortigueira localities and identified by sequencing and restriction analysis of the 16S rDNA. The most promising isolates were screened for antifungal activities and the production of siderophores and biosurfactants. B. trimera presented a diverse community of rhizobacteria, constituted of 26 families and 41 genera, with a predominance of Streptomyces and Bacillus genera, followed by Paenibacillus, Staphylococcus, Methylobacterium, Rhizobium, Tardiphaga, Paraburkholderia, Burkholderia, and Pseudomonas. The more abundant genera were represented by different species, showing a high diversity of the microbiota associated to B. trimera. Some of these isolates potentially represent novel species and deserve further examination. The communities were influenced by both the edaphic properties of the sampling locations and the plant niches. Approximately one-third of the rhizobacteria exhibited antifungal activity against Sclerotinia sclerotiorum and Colletotrichum gloeosporioides, and a high proportion of isolates produced siderophores (25%) and biosurfactants (42%). The most promising isolates were members of the Streptomyces genus. The survey of B. trimera returned a diverse community of culturable rhizobacteria and identified potential candidates for the development of plant growth-promoting and protection products, reinforcing the need for more comprehensive investigations of the microbiota of Brazilian native plants and habitats.
MeSH term(s)	Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Antifungal Agents/metabolism ; Antifungal Agents/pharmacology ; Baccharis/metabolism ; Bacteria ; Humans ; Plant Roots/microbiology ; Plants, Medicinal ; Rhizosphere ; Siderophores/metabolism
Chemical Substances	Anti-Bacterial Agents ; Antifungal Agents ; Siderophores
Language	English
Publishing date	2022-04-29
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-022-00759-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Looking deep into C-H functionalization: the synthesis and application of cyclopentadienyl and related metal catalysts.

Jardim, Guilherme A M / de Carvalho, Renato L / Nunes, Mateus P / Machado, Luana A / Almeida, Leandro D / Bahou, Karim A / Bower, John F / da Silva Júnior, Eufrânio N

Chemical communications (Cambridge, England)

2022 Volume 58, Issue 19, Page(s) 3101–3121

Abstract: Metal catalyzed C-H functionalization offers a versatile platform for methodology development and ...

Abstract	Metal catalyzed C-H functionalization offers a versatile platform for methodology development and a wide variety of reactions now exist for the chemo- and site-selective functionalization of organic molecules. Cyclopentadienyl-metal (CpM) complexes of transition metals and their correlative analogues have found widespread application in this area, and herein we highlight several key applications of commonly used transition-metal Cp-type catalysts. In addition, an understanding of transition metal Cp-type catalyst synthesis is important, particularly where modifications to the catalyst structure are required for different applications, and a summary of this aspect is given.
Language	English
Publishing date	2022-03-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d1cc07040a
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Article ; Online: Hepatitis C virus in vitro replication is efficiently inhibited by acridone Fac4.

Campos, Guilherme Rodrigues Fernandes / Bittar, Cíntia / Jardim, Ana Carolina Gomes / Shimizu, Jacqueline Farinha / Batista, Mariana Nogueira / Paganini, Eder Ramos / Assis, Letícia Ribeiro de / Bartlett, Christopher / Harris, Mark / Bolzani, Vanderlan da Silva / Regasini, Luis Octavio / Rahal, Paula

The Journal of general virology

2017 Volume 98, Issue 7, Page(s) 1693–1701

Abstract: Hepatitis C virus (HCV) affects about 170 million people worldwide. The current treatment has ...

Abstract	Hepatitis C virus (HCV) affects about 170 million people worldwide. The current treatment has a high cost and variable response rates according to the virus genotype. Acridones, a group of compounds extracted from natural sources, showed potential antiviral actions against HCV. Thus, this study aimed to evaluate the effect of a panel of 14 synthetic acridones on the HCV life cycle. The compounds were screened using an Huh7.5 cell line stably harbouring the HCV genotype 2a subgenomic replicon SGR-Feo-JFH-1. Cells were incubated in the presence or absence of compounds for 72 h and cell viability and replication levels were assessed by MTT and luciferase assays, respectively. At a concentration of 5 µM the acridone Fac4 exhibited a >90 % inhibition of HCV replication with no effect on cell viability. The effects of Fac4 on virus replication, entry and release steps were evaluated in Huh7.5 cells infected with the JFH-1 isolate of HCV (HCVcc). Fac4 inhibited JFH-1 replication to approximately 70 %, while no effect was observed on virus entry. The antiviral activity of Fac4 was also observed on viral release, with almost 80 % of inhibition. No inhibitory effect was observed against genotype 3 replication. Fac4 was able to intercalate into dsRNA, however did not inhibit NS5B polymerase activity or translation driven by the HCV IRES. Although its mode of action is partly understood, Fac4 presents significant inhibition of HCV replication and can therefore be considered as a candidate for the development of a future anti-HCV treatment.
MeSH term(s)	Acridones/chemical synthesis ; Acridones/pharmacology ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; Genome, Viral/drug effects ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepacivirus/physiology ; Hepatitis C/virology ; Humans ; Replicon/drug effects ; Virus Internalization/drug effects ; Virus Replication/drug effects
Chemical Substances	Acridones ; Antiviral Agents
Language	English
Publishing date	2017-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	219316-4
ISSN	1465-2099 ; 0022-1317
ISSN (online)	1465-2099
ISSN	0022-1317
DOI	10.1099/jgv.0.000808
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Article ; Online: Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry.

Shimizu, Jacqueline Farinha / Lima, Caroline Sprengel / Pereira, Carina Machado / Bittar, Cintia / Batista, Mariana Nogueira / Nazaré, Ana Carolina / Polaquini, Carlos Roberto / Zothner, Carsten / Harris, Mark / Rahal, Paula / Regasini, Luis Octávio / Jardim, Ana Carolina Gomes

Scientific reports

2017 Volume 7, Issue 1, Page(s) 16127

Abstract: Hepatitis C virus (HCV) is one of the leading causes of liver diseases and transplantation ...

Abstract	Hepatitis C virus (HCV) is one of the leading causes of liver diseases and transplantation worldwide. The current available therapy for HCV infection is based on interferon-α, ribavirin and the new direct-acting antivirals (DAAs), such as NS3 protease and NS5B polymerase inhibitors. However, the high costs of drug design, severe side effects and HCV resistance presented by the existing treatments demonstrate the need for developing more efficient anti-HCV agents. This study aimed to evaluate the antiviral effects of sorbifolin (1) and pedalitin (2), two flavonoids from Pterogyne nitens on the HCV replication cycle. These compounds were investigated for their anti-HCV activities using genotype 2a JFH-1 subgenomic replicons and infectious virus systems. Flavonoids 1 and 2 inhibited virus entry up to 45.0% and 78.7% respectively at non-cytotoxic concentrations. The mechanism of the flavonoid 2 block to virus entry was demonstrated to be by both the direct action on virus particles and the interference on the host cells. Alternatively, the flavonoid 1 activity was restricted to its virucidal effect. Additionally, no inhibitory effects on HCV replication and release were observed by treating cells with these flavonoids. These data are the first description of 1 and 2 possessing in vitro anti-HCV activity.
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Fabaceae/chemistry ; Flavones/chemistry ; Flavones/pharmacology ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Hepacivirus/drug effects ; Interferon-alpha/pharmacology ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; Flavones ; Flavonoids ; Interferon-alpha ; pedalitin
Language	English
Publishing date	2017-11-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-16336-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: On the application of 3d metals for C-H activation toward bioactive compounds: The key step for the synthesis of silver bullets.

Carvalho, Renato L / de Miranda, Amanda S / Nunes, Mateus P / Gomes, Roberto S / Jardim, Guilherme A M / Júnior, Eufrânio N da Silva

Beilstein journal of organic chemistry

2021 Volume 17, Page(s) 1849–1938

Abstract: Several valuable biologically active molecules can be obtained through C-H activation processes ... catalysts in this matter. This review summarizes the use of 3d metal catalysts in C-H activation processes ...

Abstract	Several valuable biologically active molecules can be obtained through C-H activation processes. However, the use of expensive and not readily accessible catalysts complicates the process of pharmacological application of these compounds. A plausible way to overcome this issue is developing and using cheaper, more accessible, and equally effective catalysts. First-row transition (3d) metals have shown to be important catalysts in this matter. This review summarizes the use of 3d metal catalysts in C-H activation processes to obtain potentially (or proved) biologically active compounds.
Language	English
Publishing date	2021-07-30
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2192461-2
ISSN	1860-5397
ISSN	1860-5397
DOI	10.3762/bjoc.17.126
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: On the application of 3d metals for C–H activation toward bioactive compounds

Renato L. Carvalho / Amanda S. de Miranda / Mateus P. Nunes / Roberto S. Gomes / Guilherme A. M. Jardim / Eufrânio N. da Silva Júnior

Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1849-

The key step for the synthesis of silver bullets

2021 Volume 1938

Abstract: Several valuable biologically active molecules can be obtained through C–H activation processes ... catalysts in this matter. This review summarizes the use of 3d metal catalysts in C–H activation processes ...

Abstract	Several valuable biologically active molecules can be obtained through C–H activation processes. However, the use of expensive and not readily accessible catalysts complicates the process of pharmacological application of these compounds. A plausible way to overcome this issue is developing and using cheaper, more accessible, and equally effective catalysts. First-row transition (3d) metals have shown to be important catalysts in this matter. This review summarizes the use of 3d metal catalysts in C–H activation processes to obtain potentially (or proved) biologically active compounds.
Keywords	bioactive compounds ; c–h activation ; 3d metals ; drugs ; medicinal chemistry ; Science ; Q ; Organic chemistry ; QD241-441
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Beilstein-Institut
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Plant-derived antivirals against hepatitis c virus infection.

Jardim, Ana Carolina Gomes / Shimizu, Jacqueline Farinha / Rahal, Paula / Harris, Mark

Virology journal

2018 Volume 15, Issue 1, Page(s) 34

Abstract: Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 ...

Abstract	Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; however, a number of drugs are available for the treatment of infection. The availability of direct-acting antivirals (DAAs) has dramatically improved therapeutic options for HCV genotype 1. However, the high costs and potential for development of resistance presented by existing treatment demonstrate the need for the development of more efficient new antivirals, or combination of therapies that target different stages of the viral lifecycle. Over the past decades, there has been substantial study of compounds extracted from plants that have activity against a range of microorganisms that cause human diseases. An extensive variety of natural compounds has demonstrated antiviral action worldwide, including anti-HCV activity. In this context, plant-derived compounds can provide an alternative approach to new antivirals. In this review, we aim to summarize the most promising plant-derived compounds described to have antiviral activity against HCV.
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Biological Products/chemistry ; Biological Products/pharmacology ; Cell Line ; Cells, Cultured ; Hepacivirus/drug effects ; Hepatitis C/virology ; Humans ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Structure-Activity Relationship ; Virus Assembly/drug effects ; Virus Internalization/drug effects ; Virus Release/drug effects ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; Biological Products ; Plant Extracts
Language	English
Publishing date	2018-02-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-018-0945-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Looking deep into C–H functionalization: the synthesis and application of cyclopentadienyl and related metal catalysts

Jardim, Guilherme A. M. / de Carvalho, Renato L. / Nunes, Mateus P. / Machado, Luana A. / Almeida, Leandro D. / Bahou, Karim A. / Bower, John F. / da Silva Júnior, Eufrânio N.

Chemical communications. 2022 Mar. 3, v. 58, no. 19

2022

Abstract: Metal catalyzed C–H functionalization offers a versatile platform for methodology development and ...

Abstract	Metal catalyzed C–H functionalization offers a versatile platform for methodology development and a wide variety of reactions now exist for the chemo- and site-selective functionalization of organic molecules. Cyclopentadienyl-metal (CpM) complexes of transition metals and their correlative analogues have found widespread application in this area, and herein we highlight several key applications of commonly used transition-metal Cp-type catalysts. In addition, an understanding of transition metal Cp-type catalyst synthesis is important, particularly where modifications to the catalyst structure are required for different applications, and a summary of this aspect is given.
Keywords	carbon-hydrogen bond activation ; catalysts ; catalytic activity ; chemical communication ; organic compounds ; transition elements
Language	English
Dates of publication	2022-0303
Size	p. 3101-3121.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d1cc07040a
Database	NAL-Catalogue (AGRICOLA)

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