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  1. Book ; Online: A model-independent Dalitz plot analysis of $B^\pm \to D K^\pm$ with $D \to K^0_{\rm S} h^+h^-$ ($h=\pi, K$) decays and constraints on the CKM angle $\gamma$

    LHCb collaboration / Aaij, R. / Beteta, C. Abellan / Adametz, A. / Adeva, B. / Adinolfi, M. / Adrover, C. / Affolder, A. / Ajaltouni, Z. / Albrecht, J. / Alessio, F. / Alexander, M. / Ali, S. / Alkhazov, G. / Cartelle, P. Alvarez / Alves Jr, A. A. / Amato, S. / Amhis, Y. / Anderlini, L. /
    Anderson, J. / Appleby, R. B. / Gutierrez, O. Aquines / Archilli, F. / Artamonov, A. / Artuso, M. / Aslanides, E. / Auriemma, G. / Bachmann, S. / Back, J. J. / Baesso, C. / Baldini, W. / Barlow, R. J. / Barschel, C. / Barsuk, S. / Barter, W. / Bates, A. / Bauer, Th. / Bay, A. / Beddow, J. / Bediaga, I. / Belogurov, S. / Belous, K. / Belyaev, I. / Ben-Haim, E. / Benayoun, M. / Bencivenni, G. / Benson, S. / Benton, J. / Berezhnoy, A. / Bernet, R. / Bettler, M. -O. / van Beuzekom, M. / Bien, A. / Bifani, S. / Bird, T. / Bizzeti, A. / Bjørnstad, P. M. / Blake, T. / Blanc, F. / Blanks, C. / Blouw, J. / Blusk, S. / Bobrov, A. / Bocci, V. / Bondar, A. / Bondar, N. / Bonivento, W. / Borghi, S. / Borgia, A. / Bowcock, T. J. V. / Bozzi, C. / Brambach, T. / Brand, J. van den / Bressieux, J. / Brett, D. / Britsch, M. / Britton, T. / Brook, N. H. / Brown, H. / Büchler-Germann, A. / Burducea, I. / Bursche, A. / Buytaert, J. / Cadeddu, S. / Callot, O. / Calvi, M. / Gomez, M. Calvo / Camboni, A. / Campana, P. / Carbone, A. / Carboni, G. / Cardinale, R. / Cardini, A. / Carson, L. / Akiba, K. Carvalho / Casse, G. / Cattaneo, M. / Cauet, Ch. / Charles, M. / Charpentier, Ph. / Chen, P. / Chiapolini, N. / Chrzaszcz, M. / Ciba, K. / Vidal, X. Cid / Ciezarek, G. / Clarke, P. E. L. / Clemencic, M. / Cliff, H. V. / Closier, J. / Coca, C. / Coco, V. / Cogan, J. / Cogneras, E. / Collins, P. / Comerma-Montells, A. / Contu, A. / Cook, A. / Coombes, M. / Corti, G. / Couturier, B. / Cowan, G. A. / Craik, D. / Cunliffe, S. / Currie, R. / D'Ambrosio, C. / David, P. / David, P. N. Y. / De Bonis, I. / De Bruyn, K. / De Capua, S. / De Cian, M. / De Miranda, J. M. / De Paula, L. / De Simone, P. / Decamp, D. / Deckenhoff, M. / Degaudenzi, H. / Del Buono, L. / Deplano, C. / Derkach, D. / Deschamps, O. / Dettori, F. / Di Canto, A. / Dickens, J. / Dijkstra, H. / Batista, P. Diniz / Bonal, F. Domingo / Donleavy, S. / Dordei, F. / Suárez, A. Dosil / Dossett, D. / Dovbnya, A. / Dupertuis, F. / Dzhelyadin, R. / Dziurda, A. / Dzyuba, A. / Easo, S. / Egede, U. / Egorychev, V. / Eidelman, S. / van Eijk, D. / Eisenhardt, S. / Ekelhof, R. / Eklund, L. / Rifai, I. El / Elsasser, Ch. / Elsby, D. / Pereira, D. Esperante / Falabella, A. / Färber, C. / Fardell, G. / Farinelli, C. / Farry, S. / Fave, V. / Albor, V. Fernandez / Rodrigues, F. Ferreira / Ferro-Luzzi, M. / Filippov, S. / Fitzpatrick, C. / Fontana, M. / Fontanelli, F. / Forty, R. / Francisco, O. / Frank, M. / Frei, C. / Frosini, M. / Furcas, S. / Torreira, A. Gallas / Galli, D. / Gandelman, M. / Gandini, P. / Gao, Y. / Garnier, J-C. / Garofoli, J. / Garosi, P. / Tico, J. Garra / Garrido, L. / Gaspar, C. / Gauld, R. / Gersabeck, E. / Gersabeck, M. / Gershon, T. / Ghez, Ph. / Gibson, V. / Gligorov, V. V. / Göbel, C. / Golubkov, D. / Golutvin, A. / Gomes, A. / Gordon, H. / Gándara, M. Grabalosa / Diaz, R. Graciani / Cardoso, L. A. Granado / Graugés, E. / Graziani, G. / Grecu, A. / Greening, E. / Gregson, S. / Grünberg, O. / Gui, B. / Gushchin, E. / Guz, Yu. / Gys, T. / Hadjivasiliou, C. / Haefeli, G. / Haen, C. / Haines, S. C. / Hall, S. / Hampson, T. / Hansmann-Menzemer, S. / Harnew, N. / Harnew, S. T. / Harrison, J. / Harrison, P. F. / Hartmann, T. / He, J. / Heijne, V. / Hennessy, K. / Henrard, P. / Morata, J. A. Hernando / van Herwijnen, E. / Hicks, E. / Hill, D. / Hoballah, M. / Hopchev, P. / Hulsbergen, W. / Hunt, P. / Huse, T. / Hussain, N. / Hutchcroft, D. / Hynds, D. / Iakovenko, V. / Ilten, P. / Imong, J. / Jacobsson, R. / Jaeger, A. / Hussein, M. Jahjah / Jans, E. / Jansen, F. / Jaton, P. / Jean-Marie, B. / Jing, F. / John, M. / Johnson, D. / Jones, C. R. / Jost, B. / Kaballo, M. / Kandybei, S. / Karacson, M. / Karbach, T. M. / Keaveney, J. / Kenyon, I. R. / Kerzel, U. / Ketel, T. / Keune, A. / Khanji, B. / Kim, Y. M. / Kochebina, O. / Komarov, V. / Koopman, R. F. / Koppenburg, P. / Korolev, M. / Kozlinskiy, A. / Kravchuk, L. / Kreplin, K. / Kreps, M. / Krocker, G. / Krokovny, P. / Kruse, F. / Kucharczyk, M. / Kudryavtsev, V. / Kvaratskheliya, T. / La Thi, V. N. / Lacarrere, D. / Lafferty, G. / Lai, A. / Lambert, D. / Lambert, R. W. / Lanciotti, E. / Lanfranchi, G. / Langenbruch, C. / Latham, T. / Lazzeroni, C. / Gac, R. Le / van Leerdam, J. / Lees, J. -P. / Lefèvre, R. / Leflat, A. / Lefrançois, J. / Leroy, O. / Lesiak, T. / Li, Y. / Gioi, L. Li / Liles, M. / Lindner, R. / Linn, C. / Liu, B. / Liu, G. / von Loeben, J. / Lopes, J. H. / Asamar, E. Lopez / Lopez-March, N. / Lu, H. / Luisier, J. / Mac Raighne, A. / Machefert, F. / Machikhiliyan, I. V. / Maciuc, F. / Maev, O. / Magnin, J. / Maino, M. / Malde, S. / Manca, G. / Mancinelli, G. / Mangiafave, N. / Marconi, U. / Märki, R. / Marks, J. / Martellotti, G. / Martens, A. / Martin, L. / Sánchez, A. Martín / Martinelli, M. / Santos, D. Martinez / Massafferri, A. / Mathe, Z. / Matteuzzi, C. / Matveev, M. / Maurice, E. / Mazurov, A. / McCarthy, J. / McGregor, G. / McNulty, R. / Meissner, M. / Merk, M. / Merkel, J. / Milanes, D. A. / Minard, M. -N. / Rodriguez, J. Molina / Monteil, S. / Moran, D. / Morawski, P. / Mountain, R. / Mous, I. / Muheim, F. / Müller, K. / Muresan, R. / Muryn, B. / Muster, B. / Mylroie-Smith, J. / Naik, P. / Nakada, T. / Nandakumar, R. / Nasteva, I. / Needham, M. / Neufeld, N. / Nguyen, A. D. / Nguyen-Mau, C. / Nicol, M. / Niess, V. / Nikitin, N. / Nikodem, T. / Nomerotski, A. / Novoselov, A. / Oblakowska-Mucha, A. / Obraztsov, V. / Oggero, S. / Ogilvy, S. / Okhrimenko, O. / Oldeman, R. / Orlandea, M. / Goicochea, J. M. Otalora / Owen, P. / Pal, B. K. / Palano, A. / Palutan, M. / Panman, J. / Papanestis, A. / Pappagallo, M. / Parkes, C. / Parkinson, C. J. / Passaleva, G. / Patel, G. D. / Patel, M. / Patrick, G. N. / Patrignani, C. / Pavel-Nicorescu, C. / Alvarez, A. Pazos / Pellegrino, A. / Penso, G. / Altarelli, M. Pepe / Perazzini, S. / Perego, D. L. / Trigo, E. Perez / Yzquierdo, A. Pérez-Calero / Perret, P. / Perrin-Terrin, M. / Pessina, G. / Petridis, K. / Petrolini, A. / Phan, A. / Olloqui, E. Picatoste / Valls, B. Pie / Pietrzyk, B. / Pilař, T. / Pinci, D. / Playfer, S. / Casasus, M. Plo / Polci, F. / Polok, G. / Poluektov, A. / Polycarpo, E. / Popov, D. / Popovici, B. / Potterat, C. / Powell, A. / Prisciandaro, J. / Pugatch, V. / Navarro, A. Puig / Qian, W. / Rademacker, J. H. / Rakotomiaramanana, B. / Rangel, M. S. / Raniuk, I. / Rauschmayr, N. / Raven, G. / Redford, S. / Reid, M. M. / Reis, A. C. dos / Ricciardi, S. / Richards, A. / Rinnert, K. / Molina, V. Rives / Romero, D. A. Roa / Robbe, P. / Rodrigues, E. / Perez, P. Rodriguez / Rogers, G. J. / Roiser, S. / Romanovsky, V. / Vidal, A. Romero / Rouvinet, J. / Ruf, T. / Ruiz, H. / Sabatino, G. / Silva, J. J. Saborido / Sagidova, N. / Sail, P. / Saitta, B. / Salzmann, C. / Sedes, B. Sanmartin / Sannino, M. / Santacesaria, R. / Rios, C. Santamarina / Santinelli, R. / Santovetti, E. / Sapunov, M. / Sarti, A. / Satriano, C. / Satta, A. / Savrie, M. / Schaack, P. / Schiller, M. / Schindler, H. / Schleich, S. / Schlupp, M. / Schmelling, M. / Schmidt, B. / Schneider, O. / Schopper, A. / Schune, M. -H. / Schwemmer, R. / Sciascia, B. / Sciubba, A. / Seco, M. / Semennikov, A. / Senderowska, K. / Sepp, I. / Serra, N. / Serrano, J. / Seyfert, P. / Shapkin, M. / Shapoval, I. / Shatalov, P. / Shcheglov, Y. / Shears, T. / Shekhtman, L. / Shevchenko, O. / Shevchenko, V. / Shires, A. / Coutinho, R. Silva / Skwarnicki, T. / Smith, N. A. / Smith, E. / Smith, M. / Sobczak, K. / Soler, F. J. P. / Soomro, F. / Souza, D. / De Paula, B. Souza / Spaan, B. / Sparkes, A. / Spradlin, P. / Stagni, F. / Stahl, S. / Steinkamp, O. / Stoica, S. / Stone, S. / Storaci, B. / Straticiuc, M. / Straumann, U. / Subbiah, V. K. / Swientek, S. / Szczekowski, M. / Szczypka, P. / Szumlak, T. / T'Jampens, S. / Teklishyn, M. / Teodorescu, E. / Teubert, F. / Thomas, C. / Thomas, E. / van Tilburg, J. / Tisserand, V. / Tobin, M. / Tolk, S. / Tonelli, D. / Topp-Joergensen, S. / Torr, N. / Tournefier, E. / Tourneur, S. / Tran, M. T. / Tsaregorodtsev, A. / Tsopelas, P. / Tuning, N. / Garcia, M. Ubeda / Ukleja, A. / Urner, D. / Uwer, U. / Vagnoni, V. / Valenti, G. / Gomez, R. Vazquez / Regueiro, P. Vazquez / Vecchi, S. / Velthuis, J. J. / Veltri, M. / Veneziano, G. / Vesterinen, M. / Viaud, B. / Videau, I. / Vieira, D. / Vilasis-Cardona, X. / Visniakov, J. / Vollhardt, A. / Volyanskyy, D. / Voong, D. / Vorobyev, A. / Vorobyev, V. / Voss, H. / Voß, C. / Waldi, R. / Wallace, R. / Wandernoth, S. / Wang, J. / Ward, D. R. / Watson, N. K. / Webber, A. D. / Websdale, D. / Whitehead, M. / Wicht, J. / Wiedner, D. / Wiggers, L. / Wilkinson, G. / Williams, M. P. / Williams, M. / Wilson, F. F. / Wishahi, J. / Witek, M. / Witzeling, W. / Wotton, S. A. / Wright, S. / Wu, S. / Wyllie, K. / Xie, Y. / Xing, F. / Xing, Z. / Yang, Z. / Young, R. / Yuan, X. / Yushchenko, O. / Zangoli, M. / Zavertyaev, M. / Zhang, F. / Zhang, L. / Zhang, W. C. / Zhang, Y. / Zhelezov, A. / Zhong, L. / Zvyagin, A.

    2012  

    Abstract: A binned Dalitz plot analysis of $B^\pm \to D K^\pm$ decays, with $D \to K^0_{\rm S} \pi^+\pi^ ... phase of the D decay amplitude over the Dalitz plot, but uses measurements of this quantity from CLEO-c ... and $D \to K^0_{\rm S} K^+ K^-$, is performed to measure the CP-violating observables $x_{\pm}$ and $y ...

    Abstract A binned Dalitz plot analysis of $B^\pm \to D K^\pm$ decays, with $D \to K^0_{\rm S} \pi^+\pi^-$ and $D \to K^0_{\rm S} K^+ K^-$, is performed to measure the CP-violating observables $x_{\pm}$ and $y_{\pm}$ which are sensitive to the CKM angle $\gamma$. The analysis exploits 1.0 $\rm fb^{-1}$ of data collected by the LHCb experiment. The study makes no model-based assumption on the variation of the strong phase of the D decay amplitude over the Dalitz plot, but uses measurements of this quantity from CLEO-c as input. The values of the parameters are found to be $x_- = (0.0 \pm 4.3 \pm 1.5 \pm 0.6) \times 10^{-2}$, $y_- = (2.7 \pm 5.2 \pm 0.8 \pm 2.3) \times 10^{-2}$, $x_+ = (-10.3 \pm 4.5 \pm 1.8 \pm 1.4)\times 10^{-2}$ and $y_+ = (-0.9 \pm 3.7 \pm 0.8 \pm 3.0)\times 10^{-2}$. The first, second, and third uncertainties are the statistical, the experimental systematic, and the error associated with the precision of the strong-phase parameters measured at CLEO-c, respectively. These results correspond to $\gamma = (44^{\,+43}_{\,-38})^\circ$, with a second solution at $\gamma \to \gamma + 180^\circ$, and $r_B = 0.07 \pm 0.04$, where $r_B$ is the ratio between the suppressed and favoured B decay amplitudes.

    Comment: 26 pages,7 figures; this revision with additional author information uploaded
    Keywords High Energy Physics - Experiment
    Subject code 612
    Publishing date 2012-09-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: William H. Oldendorf, M.D. (1925-1992).

    Mazziotta, J C / Collins, R C

    Journal of computer assisted tomography

    1993  Volume 17, Issue 2, Page(s) 169–171

    MeSH term(s) History, 20th Century ; Neurosciences/history ; Radiology/history ; United States
    Language English
    Publishing date 1993-03
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 80392-3
    ISSN 1532-3145 ; 0363-8715
    ISSN (online) 1532-3145
    ISSN 0363-8715
    DOI 10.1097/00004728-199303000-00001
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  3. Article: Interpolated potential energy surfaces and dynamics for atom exchange between H and H3(+), and D and H3(+).

    Moyano, Gloria E / Pearson, David / Collins, Michael A

    The Journal of chemical physics

    2004  Volume 121, Issue 24, Page(s) 12396–12401

    Abstract: ... of atomic hydrogen/deuterium exchange in collisions of H(3)(+) with H (D). One of the surfaces is based ...

    Abstract Two ab initio interpolated potential energy surfaces have been constructed to study the dynamics of atomic hydrogen/deuterium exchange in collisions of H(3)(+) with H (D). One of the surfaces is based on energy calculations using quadratic configuration interaction with single and double excitations. The second includes a perturbative treatment of the triple excitations and an additive correction for basis set deficiency. Results from classical dynamics simulation of the exchange reaction on these surfaces are presented and discussed.
    Language English
    Publishing date 2004-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/1.1810479
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  4. Article: Mapping and characterization of the primary and anamnestic H-2(d)-restricted cytotoxic T-lymphocyte response in mice against human metapneumovirus.

    Melendi, Guillermina A / Zavala, Fidel / Buchholz, Ursula J / Boivin, Guy / Collins, Peter L / Kleeberger, Steven R / Polack, Fernando P

    Journal of virology

    2007  Volume 81, Issue 20, Page(s) 11461–11467

    Abstract: ... respiratory infections. For human metapneumovirus (hMPV), an H-2(d)-restricted CTL epitope in the M2-2 protein has been ... algorithms to predict H-2(d) CTL epitopes in BALB/c mice. A dominant epitope (GYIDDNQSI) in positions 81 ...

    Abstract Cytotoxic T lymphocytes (CTLs) are important for the control of virus replication during respiratory infections. For human metapneumovirus (hMPV), an H-2(d)-restricted CTL epitope in the M2-2 protein has been described. In this study, we screened the hMPV F, G, N, M, M2-1, and M2-2 proteins using three independent algorithms to predict H-2(d) CTL epitopes in BALB/c mice. A dominant epitope (GYIDDNQSI) in positions 81 to 89 of the antitermination factor M2-1 and a subdominant epitope (SPKAGLLSL) in N(307-315) were detected during the anti-hMPV CTL response. Passive transfer of CD8(+) T-cell lines against M2-1(81-89) and N(307-315) protected Rag1(-/-) mice against hMPV challenge. Interestingly, diversification of CTL targets to include multiple epitopes was observed after repetitive infections. A subdominant response against the previously described M2-2 epitope was detected after the third infection. An understanding of the CTL response against hMPV is important for developing preventive and therapeutic strategies against the virus.
    MeSH term(s) Adoptive Transfer ; Amino Acid Sequence ; Animals ; Epitope Mapping ; Epitopes ; H-2 Antigens/immunology ; Humans ; Metapneumovirus/immunology ; Mice ; Mice, Inbred BALB C ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/virology
    Chemical Substances Epitopes ; H-2 Antigens
    Language English
    Publishing date 2007-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.02423-06
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  5. Article ; Online: Is predictive coding falsifiable?

    Bowman, H / Collins, D J / Nayak, A K / Cruse, D

    Neuroscience and biobehavioral reviews

    2023  Volume 154, Page(s) 105404

    Abstract: Predictive-coding has justifiably become a highly influential theory in Neuroscience. However, the possibility of its unfalsifiability has been raised. We argue that if predictive-coding were unfalsifiable, it would be a problem, but there are patterns ... ...

    Abstract Predictive-coding has justifiably become a highly influential theory in Neuroscience. However, the possibility of its unfalsifiability has been raised. We argue that if predictive-coding were unfalsifiable, it would be a problem, but there are patterns of behavioural and neuroimaging data that would stand against predictive-coding. Contra (vanilla) predictive patterns are those in which the more expected stimulus generates the largest evoked-response. However, basic formulations of predictive-coding mandate that an expected stimulus should generate little, if any, prediction error and thus little, if any, evoked-response. It has, though, been argued that contra (vanilla) predictive patterns can be obtained if precision is higher for expected stimuli. Certainly, using precision, one can increase the amplitude of an evoked-response, turning a predictive into a contra (vanilla) predictive pattern. We demonstrate that, while this is true, it does not present an absolute barrier to falsification. This is because increasing precision also reduces latency and increases the frequency of the response. These properties can be used to determine whether precision-weighting in predictive-coding justifiably explains a contra (vanilla) predictive pattern, ensuring that predictive-coding is falsifiable.
    MeSH term(s) Humans ; Neuroimaging
    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105404
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  6. Article ; Online: Theory of Mind and Social Informant Discrepancy in Autism.

    Collins, Alister S / Carroll, Kevin J / Gerber, Alan H / Keenan, Elliot Gavin / Lerner, Matthew D

    Child psychiatry and human development

    2024  

    Abstract: When autistic youth are asked to assess their own social skills, they frequently rate themselves more favorably than their parents rate them. The magnitude of this informant discrepancy has been shown to relate to key clinical outcomes such as treatment ... ...

    Abstract When autistic youth are asked to assess their own social skills, they frequently rate themselves more favorably than their parents rate them. The magnitude of this informant discrepancy has been shown to relate to key clinical outcomes such as treatment response. It has been proposed that this discrepancy arises from difficulties with Theory of Mind. Participants were 167 youth 11 to 17 years old; 72% male, and their parents. Youth completed self-report measures of social skills and social cognitive tasks, while their parents completed questionnaires regarding social skills. A repeated-measures ANOVA indicated both non-autistic and autistic youth rated themselves more favorably than their parents rated them across all measures. Zero-order correlations revealed that raw differences between parent- and participant-report were negatively correlated with scores on parent-reported Theory of Mind measures. However, polynomial analysis did not indicate interaction effects between parent- and participant-report on any of the measures used. Polynomial regression revealed that increases in parent-reported social skill predicted larger increases in parent-report Theory of Mind at low levels of parent-reported social skill compared to high levels of parent-reported social skill. Participant-report social skills predicted performance on a behavioral Theory of Mind test in a curvilinear fashion, such that the relationship was positive at low levels of participant-reported social skills, but negative at high levels. This study replicates the finding that raw difference score analyses may result in illusory effects that are not supported when using more contemporary analysis methods, and that more complex and subtle relationships between social insight and perspective-taking exist within autistic youth.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 223895-0
    ISSN 1573-3327 ; 0009-398X
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    ISSN 0009-398X
    DOI 10.1007/s10578-024-01676-4
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  7. Article ; Online: The Delphi of ORACLE: An Expert Consensus Survey for the Development of the Observational Risk Assessment of Contractures (Longitudinal Evaluation).

    Tariq, Hina / Collins, Kathryn / Dunn, Joel / Tait, Desiree / Porter, Sam

    Clinical rehabilitation

    2024  Volume 38, Issue 5, Page(s) 664–677

    Abstract: Objective: Despite rising prevalence rates, no standard tool is available to identify individuals at risk of developing contractures. This study aimed to gain expert consensus on items for the development of the Observational Risk Assessment Tool for ... ...

    Abstract Objective: Despite rising prevalence rates, no standard tool is available to identify individuals at risk of developing contractures. This study aimed to gain expert consensus on items for the development of the Observational Risk Assessment Tool for Contractures: Longitudinal Evaluation (ORACLE) for care home residents.
    Design: A two-round, online modified Delphi study.
    Participants: Panellists were qualified healthcare professionals with a background in physiotherapy, occupational therapy, nursing, and rehabilitation medicine.
    Main outcome measures: In the first round, the experts were asked to rate the predesigned list of items on a Likert scale while in the second round, consensus was sought in the areas of disagreement identified in the previous round.
    Results: The two rounds of the Delphi survey included 30 and 25 panellists, respectively. The average clinical and academic experience of the panellists was 22.2 years and 10.5 years, respectively. The panel demonstrated a high level of consensus regarding the clinical factors (10 out of 15 items); preventive care approaches (9 out of 10 items), and contextual factors (12 out of 13 items) ranging from 70% to 100%.
    Conclusion: This Delphi study determined expert consensus on items to be included in a contracture risk assessment tool (ORACLE). The items were related to factors associated with joint contractures, appropriate preventive care interventions, and potentially relevant contextual factors associated with care home settings. The promise of a risk assessment tool that includes these items has the capacity to reduce the risk of contracture development or progression and to trigger timely and appropriate referrals to help prevent further loss of function and independence.
    MeSH term(s) Humans ; Consensus ; Contracture/diagnosis ; Contracture/etiology ; Delphi Technique ; Health Personnel ; Surveys and Questionnaires
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 639276-3
    ISSN 1477-0873 ; 0269-2155
    ISSN (online) 1477-0873
    ISSN 0269-2155
    DOI 10.1177/02692155241229285
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  8. Article ; Online: Complexities of protecting children from violence during the COVID-19 pandemic: Providers' and policymakers' best practices, innovations and challenges in 12 countries.

    Davidson, Jennifer / Karadzhov, Dimitar / Collins, Hilllary / Brown, Aaron

    Child abuse & neglect

    2023  Volume 146, Page(s) 106480

    Abstract: Background: Globally, the COVID-19 pandemic has put children at an increased risk of neglect, violence and other human rights violations. Despite growing evidence of its impact on child protective services, there has been a dearth of research from low- ... ...

    Abstract Background: Globally, the COVID-19 pandemic has put children at an increased risk of neglect, violence and other human rights violations. Despite growing evidence of its impact on child protective services, there has been a dearth of research from low- and middle-income countries.
    Objective: This cross-sectional qualitative study explored service providers' and policymakers' views and experiences of children's protection, in real-time, in the last quarter of 2020.
    Methods: A smartphone app-based survey containing both open- and closed-ended questions was used. The data were analyzed using descriptive statistics and qualitative content analysis.
    Participants and setting: Eighty-four respondents participated, including service providers, service managers and policymakers, mostly representing non-governmental organizations (NGOs), civil society organizations (CSOs) and governments across 12 countries (predominantly Kenya, South Africa and the Philippines).
    Results: Most respondents reported their sectors had experienced challenges in protecting children from violence - particularly delays in reporting abuse and pursuing justice, and reaching those living in poor and/or rural areas. Good practices and innovations in children's protection during the pandemic were reported in several domains: advocacy and signposting; justice; health care; education and awareness-raising; children's visibility; and virtual service delivery. Community resources and involvement were also highlighted as vital. The ineffectiveness of child protection laws, policies and organizational responses, however, hindered the implementation of effective practices.
    Conclusions: The COVID-19 pandemic has accentuated the complexities and interconnectivity of systems, processes and actors and their joint impact on children's protection and rights. Collectively, the findings reinforce the criticality of collaborative, urgent and child-centered responses.
    MeSH term(s) Humans ; Pandemics/prevention & control ; COVID-19/epidemiology ; Cross-Sectional Studies ; Violence/prevention & control ; Delivery of Health Care
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 799143-5
    ISSN 1873-7757 ; 0145-2134
    ISSN (online) 1873-7757
    ISSN 0145-2134
    DOI 10.1016/j.chiabu.2023.106480
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  9. Article ; Online: Modeling the likely economic cost of non-adherence to TB medicines in the Philippines.

    Collins, D / Lam, H / Firdaus, H / Antipolo, J / Mangao, P

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2020  Volume 24, Issue 9, Page(s) 902–909

    Abstract: SETTING: ...

    Abstract SETTING:
    MeSH term(s) Cost-Benefit Analysis ; Humans ; Philippines/epidemiology ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology
    Language English
    Publishing date 2020-11-06
    Publishing country France
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.19.0652
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  10. Article ; Online: Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1.

    Carvalho, Luís A R / Sousa, Bárbara B / Zaidman, Daniel / Kiely-Collins, Hannah / Bernardes, Gonçalo J L

    Chembiochem : a European journal of chemical biology

    2024  Volume 25, Issue 4, Page(s) e202300736

    Abstract: PROTAC linker design remains mostly an empirical task. We employed the PRosettaC computational software in the design of sulfonyl-fluoride-based PROTACs targeting acyl protein thioesterase 1 (APT1). The software efficiently generated ternary complex ... ...

    Abstract PROTAC linker design remains mostly an empirical task. We employed the PRosettaC computational software in the design of sulfonyl-fluoride-based PROTACs targeting acyl protein thioesterase 1 (APT1). The software efficiently generated ternary complex models from empirically-designed PROTACs and suggested alkyl linkers to be the preferred type of linker to target APT1. Western blotting analysis revealed efficient degradation of APT1 and activity-based protein profiling showed remarkable selectivity of an alkyl linker-based PROTAC amongst serine hydrolases. Collectively, our data suggests that combining PRosettaC and chemoproteomics can effectively assist in triaging PROTACs for synthesis and providing early data on their potency and selectivity.
    Language English
    Publishing date 2024-01-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202300736
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