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  1. Article ; Online: Warren D.W. Heston, PhD and Neil H. Bander, MD: Founding Fathers of PSMA Technology.

    Lippowitsch, Connie / Emeka, Adaeze A / Catalona, William J

    Urology

    2022  Volume 164, Page(s) 1–4

    MeSH term(s) Humans ; Technology
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2022.02.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Time Trends and Variation in the Use of Active Surveillance for Management of Low-risk Prostate Cancer in the US.

    Cooperberg, Matthew R / Meeks, William / Fang, Raymond / Gaylis, Franklin D / Catalona, William J / Makarov, Danil V

    JAMA network open

    2023  Volume 6, Issue 3, Page(s) e231439

    Abstract: Importance: Active surveillance (AS) is endorsed by clinical guidelines as the preferred management strategy for low-risk prostate cancer, but its use in contemporary clinical practice remains incompletely defined.: Objective: To characterize trends ... ...

    Abstract Importance: Active surveillance (AS) is endorsed by clinical guidelines as the preferred management strategy for low-risk prostate cancer, but its use in contemporary clinical practice remains incompletely defined.
    Objective: To characterize trends over time and practice- and practitioner-level variation in the use of AS in a large, national disease registry.
    Design, setting, and participants: This retrospective analysis of a prospective cohort study included men with low-risk prostate cancer, defined as prostate-specific antigen (PSA) less than 10 ng/mL, Gleason grade group 1, and clinical stage T1c or T2a, newly diagnosed between January 1, 2014, and June 1, 2021. Patients were identified in the American Urological Association (AUA) Quality (AQUA) Registry, a large quality reporting registry including data from 1945 urology practitioners at 349 practices across 48 US states and territories, comprising more than 8.5 million unique patients. Data are collected automatically from electronic health record systems at participating practices.
    Exposures: Exposures of interest included patient age, race, and PSA level, as well as urology practice and individual urology practitioners.
    Main outcomes and measures: The outcome of interest was the use of AS as primary treatment. Treatment was determined through analysis of electronic health record structured and unstructured clinical data and determination of surveillance based on follow-up testing with at least 1 PSA level remaining greater than 1.0 ng/mL.
    Results: A total of 20 809 patients in AQUA were diagnosed with low-risk prostate cancer and had known primary treatment. The median age was 65 (IQR, 59-70) years; 31 (0.1%) were American Indian or Alaska Native; 148 (0.7%) were Asian or Pacific Islander; 1855 (8.9%) were Black; 8351 (40.1%) were White; 169 (0.8%) were of other race or ethnicity; and 10 255 (49.3%) were missing information on race or ethnicity. Rates of AS increased sharply and consistently from 26.5% in 2014 to 59.6% in 2021. However, use of AS varied from 4.0% to 78.0% at the urology practice level and from 0% to 100% at the practitioner level. On multivariable analysis, year of diagnosis was the variable most strongly associated with AS; age, race, and PSA value at diagnosis were all also associated with odds of surveillance.
    Conclusions and relevance: This cohort study of AS rates in the AQUA Registry found that national, community-based rates of AS have increased but remain suboptimal, and wide variation persists across practices and practitioners. Continued progress on this critical quality indicator is essential to minimize overtreatment of low-risk prostate cancer and by extension to improve the benefit-to-harm ratio of national prostate cancer early detection efforts.
    MeSH term(s) Aged ; Humans ; Male ; Cohort Studies ; Prospective Studies ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/therapy ; Retrospective Studies ; Watchful Waiting ; United States
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.1439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Urology-important advances in clinical medicine: prostatic Acid phosphatase is not a screening test for early prostatic cancer.

    Catalona, W J

    The Western journal of medicine

    2008  Volume 138, Issue 4, Page(s) 554

    Language English
    Publishing date 2008-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189235-6
    ISSN 1476-2978 ; 0093-0415 ; 0008-1264
    ISSN (online) 1476-2978
    ISSN 0093-0415 ; 0008-1264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association Between a 22-feature Genomic Classifier and Biopsy Gleason Upgrade During Active Surveillance for Prostate Cancer.

    Press, Benjamin H / Jones, Tashzna / Olawoyin, Olamide / Lokeshwar, Soum D / Rahman, Syed N / Khajir, Ghazal / Lin, Daniel W / Cooperberg, Matthew R / Loeb, Stacy / Darst, Burcu F / Zheng, Yingye / Chen, Ronald C / Witte, John S / Seibert, Tyler M / Catalona, William J / Leapman, Michael S / Sprenkle, Preston C

    European urology open science

    2022  Volume 37, Page(s) 113–119

    Abstract: Background: Although the Decipher genomic classifier has been validated as a prognostic tool for several prostate cancer endpoints, little is known about its role in assessing the risk of biopsy reclassification for patients on active surveillance, a ... ...

    Abstract Background: Although the Decipher genomic classifier has been validated as a prognostic tool for several prostate cancer endpoints, little is known about its role in assessing the risk of biopsy reclassification for patients on active surveillance, a key event that often triggers treatment.
    Objective: To evaluate the association between Decipher genomic classifier scores and biopsy Gleason upgrading among patients on active surveillance.
    Design setting and participants: This was a retrospective cohort study among patients with low- and favorable intermediate-risk prostate cancer on active surveillance who underwent biopsy-based Decipher testing as part of their clinical care.
    Outcome measurements and statistical analysis: We evaluated the association between the Decipher score and any increase in biopsy Gleason grade group (GG) using univariable and multivariable logistic regression. We compared the area under the receiver operating characteristic curve (AUC) for models comprising baseline clinical variables with or without the Decipher score.
    Results and limitations: We identified 133 patients for inclusion with a median age of 67.7 yr and median prostate-specific of 5.6 ng/ml. At enrollment, 75.9% had GG1 and 24.1% had GG2 disease. Forty-three patients experienced biopsy upgrading. On multivariable logistic regression, the Decipher score was significantly associated with biopsy upgrading (odds ratio 1.37 per 0.10 unit increase, 95% confidence interval [CI] 1.05-1.79;
    Conclusions: The Decipher genomic classifier score was associated with short-term biopsy Gleason upgrading among patients on active surveillance.
    Patient summary: The results from this study indicate that among patients with prostate cancer undergoing active surveillance, those with higher Decipher scores were more likely to have higher-grade disease found over time. These findings indicate that the Decipher test might be useful for guiding the intensity of monitoring during active surveillance, such as more frequent biopsy for patients with higher scores.
    Language English
    Publishing date 2022-02-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2022.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Defining Quality Metrics for Active Surveillance: The Michigan Urological Surgery Improvement Collaborative Experience. Letter.

    Gaylis, Franklin D / Cooperberg, Matthew R / Chen, Ronald C / Malin, Jennifer / Loeb, Stacy / Witte, John S / Carroll, Peter R / Cohen, Edward S / Dato, Paul E / Lin, Daniel W / Zheng, Yingye / Seibert, Tyler M / Setzler, Christopher / Wilt, Wanda / Gomez, Scarlett L / Chan, June M L / Catalona, William J

    The Journal of urology

    2021  Volume 206, Issue 1, Page(s) 171–172

    MeSH term(s) Benchmarking ; Humans ; Michigan ; Quality Improvement ; Urology ; Watchful Waiting
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Postal Service and cancer screening.

    Catalona, W J

    The New England journal of medicine

    1999  Volume 341, Issue 7, Page(s) 542; author reply 543

    MeSH term(s) Humans ; Male ; Mass Screening ; Philately ; Postal Service ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/mortality ; United States/epidemiology
    Language English
    Publishing date 1999-08-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJM199908123410720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Refined testing and targeted therapy lead new fight against prostate cancer. Interview by Wayne Kuznar.

    Catalona, W J

    Geriatrics

    1999  Volume 54, Issue 9, Page(s) 49–54; quiz 57

    Abstract: Prostate cancer screening and intervention remain controversial, despite significant strides in the detection and treatment of this common malignancy. False-positive results from the test for prostate specific antigen (PSA) lead to unnecessary workups ... ...

    Abstract Prostate cancer screening and intervention remain controversial, despite significant strides in the detection and treatment of this common malignancy. False-positive results from the test for prostate specific antigen (PSA) lead to unnecessary workups and biopsies, as well as psychological stress for patients. Radial prostatectomy remains the most effective treatment for organ-confined cancer, yet many patients opt for the opt for the organ-sparing advantage of radiation therapy. Others may opt for unproven interventions such as cryoablation. Recently-developed tools designed for use with PSA testing are helping to improve screening accuracy in the lower tier of serum total PSA (2.5 to 10.0 ng/mL).
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor ; Cryosurgery ; Humans ; Male ; Mass Screening/methods ; Middle Aged ; Prostate-Specific Antigen/blood ; Prostatectomy ; Prostatic Neoplasms/therapy ; Radiotherapy/methods
    Chemical Substances Biomarkers, Tumor ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 1999-09
    Publishing country United States
    Document type Interview
    ZDB-ID 2188-x
    ISSN 1936-5764 ; 0016-867X
    ISSN (online) 1936-5764
    ISSN 0016-867X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Screening for prostate cancer. Early screening is important despite lack of data from trials.

    Catalona, W J

    BMJ (Clinical research ed.)

    1997  Volume 315, Issue 7101, Page(s) 187

    MeSH term(s) Humans ; Male ; Mass Screening ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/therapy ; Randomized Controlled Trials as Topic ; Survival Rate ; Time Factors
    Language English
    Publishing date 1997-07-19
    Publishing country England
    Document type Comment ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Prostate-specific antigen in black men.

    Catalona, W J

    The New England journal of medicine

    1997  Volume 336, Issue 2, Page(s) 134–5; author reply 135–6

    MeSH term(s) Age Factors ; Continental Population Groups ; Humans ; Male ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diagnosis ; Reference Values
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 1997-01-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
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  10. Article ; Online: Reply by Authors.

    Cooley, Lauren Folgosa / Emeka, Adaeze A / Meyers, Travis J / Cooper, Phillip R / Lin, Daniel W / Finelli, Antonio / Eastham, James A / Logothetis, Christopher J / Marks, Leonard S / Vesprini, Danny / Goldenberg, S Larry / Higano, Celestia S / Pavlovich, Christian P / Chan, June M / Morgan, Todd M / Klein, Eric A / Barocas, Daniel A / Loeb, Stacy / Helfand, Brian T /
    Scholtens, Denise M / Witte, John S / Catalona, William J

    The Journal of urology

    2021  Volume 206, Issue 5, Page(s) 1156

    Language English
    Publishing date 2021-09-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001937.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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