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  1. AU=Silvester Nicole
  2. AU="Ahmed H. El-Ghorab"
  3. AU="Kaori Yamamoto"
  4. AU="Cernei C."
  5. AU="Faiz Alfaiz"
  6. AU="Fallon, Anne"
  7. AU="Ramos, Davi L."
  8. AU="Mancini, Valentina"
  9. AU="Lamothe, Valérie"
  10. AU=Powell-Jackson P R AU=Powell-Jackson P R
  11. AU="Neeltje A Kootstra"
  12. AU=Gloria e Silva Filipe AU=Gloria e Silva Filipe
  13. AU="Shuaijia Hao"
  14. AU=Heinrichs Stefan
  15. AU="Khosravan, Shahla"
  16. AU=Garcia-Carracedo Dario
  17. AU="Lannon, Margaret C"
  18. AU=Khan Inam Danish
  19. AU="Choza, Juliana"
  20. AU=Tronin Andrey Y.
  21. AU="Singh, Jyoti"
  22. AU=Charlier Philippe
  23. AU="Thiermann, Horst"
  24. AU="Gullo, Paride"
  25. AU="Lewis, Gayle"
  26. AU=Jain Harshwardhan AU=Jain Harshwardhan
  27. AU="Gaur, Aman"
  28. AU=Huynh Thu P.
  29. AU=Giebel Clarissa
  30. AU=Laskin Daniel M

Suchergebnis

Treffer 1 - 10 von insgesamt 21

Suchoptionen

  1. Buch ; Online: Quicklet on Bill Bryson's Seeing Further

    Silvester, Nicole

    The Story of Science, Discovery, and the Genius of the Royal Society

    2012  

    Abstract: The Royal Society was founded in 1660 from a basis of more informal meetings of physicians, natural philosophers, and other interested parties (there was no such thing as a ""scientist"" yet). It was influenced by Francis Bacon's thinking about science ... ...

    Abstract The Royal Society was founded in 1660 from a basis of more informal meetings of physicians, natural philosophers, and other interested parties (there was no such thing as a ""scientist"" yet). It was influenced by Francis Bacon's thinking about science and knowledge and inspired by the many discoveries that were happening at the time. In a sense, the development of the Royal Society was a mirror of the development of science itself. 2010 was the 350th anniversary of the founding of the Royal Society, and Seeing Further: The Story of Science, Discovery, and the Genius of the Royal Society wa
    Sprache Englisch
    Umfang Online-Ressource (50 p)
    Verlag Hyperink
    Erscheinungsort s.l
    Dokumenttyp Buch ; Online
    Anmerkung Description based upon print version of record
    ISBN 9781614642800 ; 161464280X
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  2. Buch ; Online: Quicklet on The Ice Balloon

    Silvester, Nicole

    S. A. Andree and the Heroic Age of Arctic Exploration by Alec Wilkinson

    2012  

    Abstract: ABOUT THE BOOK "Except for the bottom of the sea or the center of the earth, the North Pole, at the end of the nineteenth century, was the world's last mysterious destination." The Ice Balloon: S.A. Andrée and the Heroic Age of Arctic Exploration ... ...

    Abstract ABOUT THE BOOK "Except for the bottom of the sea or the center of the earth, the North Pole, at the end of the nineteenth century, was the world's last mysterious destination." The Ice Balloon: S.A. Andrée and the Heroic Age of Arctic Exploration retells the attempt by Swedish explorer S.A. Andrée to reach the north pole by hydrogen balloon. Writer Alec Wilkinson recounts the whole story of Andrée's venture from its first conception to the final recovery of its lost artifacts, and intersperses his tale with other events in the history of Arctic exploration. Wilkinson draws on previous acco
    Sprache Englisch
    Umfang Online-Ressource (30 p)
    Verlag Hyperink
    Erscheinungsort s.l
    Dokumenttyp Buch ; Online
    Anmerkung Description based upon print version of record
    ISBN 9781614641087 ; 1614641080
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  3. Buch ; Online: Quicklet on Natural Experiments of History edited by Jared Diamond and James A. Robinson

    Silvester, Nicole

    2012  

    Abstract: Natural Experiments in History grew, in a way, out of co-editor Jared Diamond's book Guns, Germs, and Steel: The Fates of Human Societies. In the earlier book, he spent a chapter looking at the Polynesian expansion as a near-perfect natural experiment in ...

    Abstract Natural Experiments in History grew, in a way, out of co-editor Jared Diamond's book Guns, Germs, and Steel: The Fates of Human Societies. In the earlier book, he spent a chapter looking at the Polynesian expansion as a near-perfect natural experiment in which a single ancestral Polynesian culture migrated to hundreds of islands in the Pacific Ocean, each with its own different geographic features. Because the culture that settled the islands was the same, any differences that developed between separate island societies could be largely attributed to the geography of the individual islands
    Sprache Englisch
    Umfang Online-Ressource (43 p)
    Verlag Hyperink
    Erscheinungsort s.l
    Dokumenttyp Buch ; Online
    Anmerkung Description based upon print version of record
    ISBN 9781614642855 ; 1614642850
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  4. Buch ; Online: Quicklet on David Roberts and Greg Child's Sandstone Spine

    Silvester, Nicole

    Seeking the Anasazi on the First Traverse of the Comb Ridge (CliffNotes-like Book Summary and Analysis)

    2012  

    Abstract: ABOUT THE BOOK In this book, I have chosen sometimes to be deliberately vague about the name and location of certain prehistoric ruins and rock art. Such an ethic is by now in long use among writers, photographers, and guides who celebrate the ... ...

    Abstract ABOUT THE BOOK In this book, I have chosen sometimes to be deliberately vague about the name and location of certain prehistoric ruins and rock art. Such an ethic is by now in long use among writers, photographers, and guides who celebrate the Southwest. A narrative of personal discovery should not serve as a treasure map." Roberts' and Child's book Sandstone Spine is an account of the expedition of three men along Comb Ridge, a sandstone ridge resembling a miniature mountain range and running for nearly an hundred miles across Arizona and Utah. This area is full of archaeological ruins, p
    Sprache Englisch
    Umfang Online-Ressource (46 p)
    Verlag Hyperink
    Erscheinungsort s.l
    Dokumenttyp Buch ; Online
    Anmerkung Description based upon print version of record
    ISBN 9781614646440 ; 1614646449
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  5. Artikel ; Online: Searching for new cardiovascular drugs: towards improved systems for drug screening?

    Silvester, Nicole C / George, Christopher H

    Expert opinion on drug discovery

    2011  Band 6, Heft 11, Seite(n) 1155–1170

    Abstract: Introduction: The pharmaceutical industry urgently needs new ways of profiling the safety and efficacy of new cardiovascular (CV) drugs and more effectively transitioning these compounds through the stages of CV drug screening. This article reviews new ... ...

    Abstract Introduction: The pharmaceutical industry urgently needs new ways of profiling the safety and efficacy of new cardiovascular (CV) drugs and more effectively transitioning these compounds through the stages of CV drug screening. This article reviews new technologies and methodological innovations and assesses whether these frameworks offer improved solutions to the problems facing the contemporary CV drug development.
    Areas covered: The article comprises literature derived from a systematic search (from 2000 onwards) using the US patent office and ESP@CENET search engines as well as through multiple Boolean terms. The article focuses on patents relating to technologies and resources and categorises the patents according to their niche in the CV drug screening landscape.
    Expert opinion: The CV drug pipeline is stalling due to the inability of many contemporary drug screening frameworks to discriminate between safe, efficacious therapy and hazardous off-target effect. Given the current limitations of drug screening frameworks, there is little scope for expanding the CV drug portfolio with newer, safer drugs with improved mechanisms of action. New screening modalities are urgently needed. Searches reveal that there are few examples of truly new technologies and systems in the patent literature. This apparent failure to revamp facets of the CV drug screening process can only perpetuate the inability of current platforms to improve the CV drug pipeline. Consequently, with few exceptions, there is stagnation in pre-clinical assay design that limits the pharmaceutical industry's ability to search for new drugs in new and more effective ways.
    Sprache Englisch
    Erscheinungsdatum 2011-10-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1517/17460441.2011.625652
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  6. Artikel ; Online: Detecting Phylogenetic Signal and Adaptation in Papionin Cranial Shape by Decomposing Variation at Different Spatial Scales.

    Grunstra, Nicole D S / Bartsch, Silvester J / Le Maître, Anne / Mitteroecker, Philipp

    Systematic biology

    2020  Band 70, Heft 4, Seite(n) 694–706

    Abstract: Phylogenetic reconstruction based on morphometric data is hampered by homoplasies. For example, many similarities in cranial form between primate taxa more strongly reflect ecological similarities rather than phylogenetic relatedness. However, the way in ...

    Abstract Phylogenetic reconstruction based on morphometric data is hampered by homoplasies. For example, many similarities in cranial form between primate taxa more strongly reflect ecological similarities rather than phylogenetic relatedness. However, the way in which the different cranial bones constitute cranial form is, if at all, of less functional relevance and thus largely hidden from selection. We propose that these "constructional details" are better indicators of phylogenetic history than any large-scale shape feature or raw form variable. Within a geometric morphometric context, we show how to analyze the relative extent of bones independently of differences in overall shape. We also show how to decompose total shape variation into small-scale and large-scale shape variation. We apply both methods to the midsagittal cranial morphology of papionin monkeys, which are well known for the discrepancy between morphological similarities and phylogenetic relationships. We study phylogenetic signal and functional adaptation using a molecular phylogeny and contextual data on feeding ecology and locomotor behavior. As expected, total cranial shape, bone outline shape, and large-scale shape features were only weakly associated with phylogenetic distance. But the relative bone contributions and small-scale shape features were both highly correlated with phylogenetic distances. By contrast, the association with ecological and behavioral variables was strongest for the outline shape and large-scale shape features. Studies of morphological adaptation and phylogenetic history thus profit from a decomposition of shape variation into different spatial scales. [Adaptation; canalization; cranial shape; geometric morphometrics; papionini; partial warps; phylogeny.].
    Mesh-Begriff(e) Animals ; Biological Evolution ; Phylogeny ; Skull
    Sprache Englisch
    Erscheinungsdatum 2020-12-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1482572-7
    ISSN 1076-836X ; 1063-5157
    ISSN (online) 1076-836X
    ISSN 1063-5157
    DOI 10.1093/sysbio/syaa093
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: A network-oriented perspective on cardiac calcium signaling.

    George, Christopher H / Parthimos, Dimitris / Silvester, Nicole C

    American journal of physiology. Cell physiology

    2012  Band 303, Heft 9, Seite(n) C897–910

    Abstract: The normal contractile, electrical, and energetic function of the heart depends on the synchronization of biological oscillators and signal integrators that make up cellular signaling networks. In this review we interpret experimental data from molecular, ...

    Abstract The normal contractile, electrical, and energetic function of the heart depends on the synchronization of biological oscillators and signal integrators that make up cellular signaling networks. In this review we interpret experimental data from molecular, cellular, and transgenic models of cardiac signaling behavior in the context of established concepts in cell network architecture and organization. Focusing on the cellular Ca(2+) handling machinery, we describe how the plasticity and adaptability of normal Ca(2+) signaling is dependent on dynamic network configurations that operate across a wide range of functional states. We consider how (mal)adaptive changes in signaling pathways restrict the dynamic range of the network such that it cannot respond appropriately to physiologic stimuli or perturbation. Based on these concepts, a model is proposed in which pathologic abnormalities in cardiac rhythm and contractility (e.g., arrhythmias and heart failure) arise as a consequence of progressive desynchronization and reduction in the dynamic range of the Ca(2+) signaling network. We discuss how a systems-level understanding of the network organization, cellular noise, and chaotic behavior may inform the design of new therapeutic modalities that prevent or reverse the disease-linked unraveling of the Ca(2+) signaling network.
    Mesh-Begriff(e) Adaptation, Physiological ; Animals ; Calcium Signaling/physiology ; Heart/physiology ; Heart Diseases/physiopathology ; Humans ; Mice ; Models, Cardiovascular ; Rats
    Sprache Englisch
    Erscheinungsdatum 2012-07-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00388.2011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Morphometric Variation at Different Spatial Scales: Coordination and Compensation in the Emergence of Organismal Form.

    Mitteroecker, Philipp / Bartsch, Silvester / Erkinger, Corinna / Grunstra, Nicole D S / Le Maître, Anne / Bookstein, Fred L

    Systematic biology

    2020  Band 69, Heft 5, Seite(n) 913–926

    Abstract: It is a classic aim of quantitative and evolutionary biology to infer genetic architecture and potential evolutionary responses to selection from the variance-covariance structure of measured traits. But a meaningful genetic or developmental ... ...

    Abstract It is a classic aim of quantitative and evolutionary biology to infer genetic architecture and potential evolutionary responses to selection from the variance-covariance structure of measured traits. But a meaningful genetic or developmental interpretation of raw covariances is difficult, and classic concepts of morphological integration do not directly apply to modern morphometric data. Here, we present a new morphometric strategy based on the comparison of morphological variation across different spatial scales. If anatomical elements vary completely independently, then their variance accumulates at larger scales or for structures composed of multiple elements: morphological variance would be a power function of spatial scale. Deviations from this pattern of "variational self-similarity" (serving as a null model of completely uncoordinated growth) indicate genetic or developmental coregulation of anatomical components. We present biometric strategies and R scripts for identifying patterns of coordination and compensation in the size and shape of composite anatomical structures. In an application to human cranial variation, we found that coordinated variation and positive correlations are prevalent for the size of cranial components, whereas their shape was dominated by compensatory variation, leading to strong canalization of cranial shape at larger scales. We propose that mechanically induced bone formation and remodeling are key mechanisms underlying compensatory variation in cranial shape. Such epigenetic coordination and compensation of growth are indispensable for stable, canalized development and may also foster the evolvability of complex anatomical structures by preserving spatial and functional integrity during genetic responses to selection.[Cranial shape; developmental canalization; evolvability; morphological integration; morphometrics; phenotypic variation; self-similarity.].
    Mesh-Begriff(e) Biological Evolution ; Biometry ; Classification/methods ; Humans ; Skull/anatomy & histology ; Skull/growth & development
    Sprache Englisch
    Erscheinungsdatum 2020-04-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1482572-7
    ISSN 1076-836X ; 1063-5157
    ISSN (online) 1076-836X
    ISSN 1063-5157
    DOI 10.1093/sysbio/syaa007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Accelerating surveillance and research of antimicrobial resistance - an online repository for sharing of antimicrobial susceptibility data associated with whole-genome sequences.

    Matamoros, Sébastien / Hendriksen, Rene S / Pataki, Bálint Ármin / Pakseresht, Nima / Rossello, Marc / Silvester, Nicole / Amid, Clara / Aarestrup, Frank M / Koopmans, Marion / Cochrane, Guy / Csabai, Istvan / Lund, Ole / Schultsz, Constance / The Compare Ml-Amr Group

    Microbial genomics

    2020  Band 6, Heft 5

    Abstract: Antimicrobial resistance (AMR) is an emerging threat to modern medicine. Improved diagnostics and surveillance of resistant bacteria require the development of next-generation analysis tools and collaboration between international partners. Here, we ... ...

    Abstract Antimicrobial resistance (AMR) is an emerging threat to modern medicine. Improved diagnostics and surveillance of resistant bacteria require the development of next-generation analysis tools and collaboration between international partners. Here, we present the 'AMR Data Hub', an online infrastructure for storage and sharing of structured phenotypic AMR data linked to bacterial whole-genome sequences. Leveraging infrastructure built by the European COMPARE Consortium and structured around the European Nucleotide Archive (ENA), the AMR Data Hub already provides an extensive data collection of more than 2500 isolates with linked genome and AMR data. Representing these data in standardized formats, we provide tools for the validation and submission of new data and services supporting search, browse and retrieval. The current collection was created through a collaboration by several partners from the European COMPARE Consortium, demonstrating the capacities and utility of the AMR Data Hub and its associated tools. We anticipate growth of content and offer the hub as a basis for future research into methods to explore and predict AMR.
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/genetics ; Databases, Genetic ; Drug Resistance, Bacterial ; High-Throughput Nucleotide Sequencing ; Internet ; Phenotype ; Whole Genome Sequencing/methods
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2020-03-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000342
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: A new system for profiling drug-induced calcium signal perturbation in human embryonic stem cell-derived cardiomyocytes.

    Lewis, Kimberley J / Silvester, Nicole C / Barberini-Jammaers, Steven / Mason, Sammy A / Marsh, Sarah A / Lipka, Magdalena / George, Christopher H

    Journal of biomolecular screening

    2014  Band 20, Heft 3, Seite(n) 330–340

    Abstract: The emergence of human stem cell-derived cardiomyocyte (hSCCM)-based assays in the cardiovascular (CV) drug discovery sphere requires the development of improved systems for interrogating the rich information that these cell models have the potential to ... ...

    Abstract The emergence of human stem cell-derived cardiomyocyte (hSCCM)-based assays in the cardiovascular (CV) drug discovery sphere requires the development of improved systems for interrogating the rich information that these cell models have the potential to yield. We developed a new analytical framework termed SALVO (synchronization, amplitude, length, and variability of oscillation) to profile the amplitude and temporal patterning of intra- and intercellular calcium signals in hSCCM. SALVO quantified drug-induced perturbations in the calcium signaling "fingerprint" in spontaneously contractile hSCCM. Multiparametric SALVO outputs were integrated into a single index of in vitro cytotoxicity that confirmed the rank order of perturbation as astemizole > thioridazine > cisapride > flecainide > valdecoxib > sotalol > nadolol ≈ control. This rank order of drug-induced Ca(2+) signal disruption is in close agreement with the known arrhythmogenic liabilities of these compounds in humans. Validation of the system using a second set of compounds and hierarchical cluster analysis demonstrated the utility of SALVO to discriminate drugs based on their mechanisms of action. We discuss the utility of this new mechanistically agnostic system for the evaluation of in vitro drug cytotoxicity in hSCCM syncytia and the potential placement of SALVO in the early stage drug screening framework.
    Mesh-Begriff(e) Anti-Arrhythmia Agents/pharmacology ; Calcium Signaling/drug effects ; Cell Line ; Cells, Cultured ; Cluster Analysis ; Drug Discovery/methods ; Drug Evaluation, Preclinical ; Embryonic Stem Cells/cytology ; Humans ; Membrane Potentials/drug effects ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Troponin T/metabolism
    Chemische Substanzen Anti-Arrhythmia Agents ; Troponin T
    Sprache Englisch
    Erscheinungsdatum 2014-11-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1433680-7
    ISSN 1552-454X ; 1087-0571
    ISSN (online) 1552-454X
    ISSN 1087-0571
    DOI 10.1177/1087057114557232
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4911: Hefte anzeigen Standort:
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