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  1. Article ; Online: A challenge to the dopamine orthodoxy in schizophrenia?

    Norman, Trevor R / Olver, James S

    The Australian and New Zealand journal of psychiatry

    2023  Volume 57, Issue 9, Page(s) 1198–1199

    MeSH term(s) Humans ; Dopamine ; Schizophrenia/drug therapy
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Editorial
    ZDB-ID 221140-3
    ISSN 1440-1614 ; 0004-8674
    ISSN (online) 1440-1614
    ISSN 0004-8674
    DOI 10.1177/00048674231177958
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  2. Article ; Online: Letters to the Editor: Author reply to Letters to the Editor regarding 'A challenge to the dopamine orthodoxy in schizophrenia?'

    Norman, Trevor R / Olver, James S

    The Australian and New Zealand journal of psychiatry

    2023  Volume 57, Issue 10, Page(s) 1397

    MeSH term(s) Humans ; Schizophrenia/drug therapy ; Dopamine
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-08-26
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 221140-3
    ISSN 1440-1614 ; 0004-8674
    ISSN (online) 1440-1614
    ISSN 0004-8674
    DOI 10.1177/00048674231195563
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  3. Article ; Online: Desvenlafaxine in the treatment of major depression: an updated overview.

    Norman, Trevor R / Olver, James S

    Expert opinion on pharmacotherapy

    2021  Volume 22, Issue 9, Page(s) 1087–1097

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Adolescent ; Adult ; Antidepressive Agents/adverse effects ; Child ; Cyclohexanols/therapeutic use ; Depression ; Depressive Disorder, Major/drug therapy ; Desvenlafaxine Succinate/therapeutic use ; Double-Blind Method ; Drug Interactions ; Female ; Humans
    Chemical Substances Antidepressive Agents ; Cyclohexanols ; Desvenlafaxine Succinate (ZB22ENF0XR)
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2021.1900826
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  4. Article ; Online: Adjunctive Docosahexaenoic Acid in Residual Symptoms of Depression and Anxiety.

    Piperoglou, Michael / Hopwood, Malcolm / Norman, Trevor R

    Journal of clinical psychopharmacology

    2023  Volume 43, Issue 6, Page(s) 493–497

    Abstract: Objective: The aim of the study is to examine the efficacy of omega-3 fatty acid as an adjunct to ongoing pharmacological treatments in patients with residual symptoms of depression and anxiety.: Methods/procedures: This randomized, double-blind, ... ...

    Abstract Objective: The aim of the study is to examine the efficacy of omega-3 fatty acid as an adjunct to ongoing pharmacological treatments in patients with residual symptoms of depression and anxiety.
    Methods/procedures: This randomized, double-blind, placebo-controlled, cross-over trial was conducted at a single private practice site. Participants were drawn from patients attending the practice.Patients meeting criteria had a 4-week run-in period where they continued to receive their prescribed medications and omega-3 supplements. Depression and anxiety ratings were assessed at recruitment and completion of the run-in phase. Patients were randomized to receive an omega-3 supplement (Neurospark) or placebo once daily for 8 weeks then crossed over to the alternative treatment. At the end of the double-blind, cross-over phase, patients received the supplement and were assessed after a 4-week run-out phase.Depression and anxiety symptoms were assessed using the Hamilton scales. Efficacy of treatment was assessed using a linear mixed model analysis with time, order of treatment, diagnosis, and their interaction as factors. Depression and anxiety scales were analyzed as independent measures.
    Results: The study enrolled 47 patients (mean [SD] age, 46.1 [11.2] years; [59.6%] male). Depression scores did not significantly change across assessments ( P > 0.1); there was no effect of order of treatment ( P > 0.1) or an interaction between time, order of treatment, and psychiatric diagnosis ( P > 0.1). Anxiety scores were similarly unchanged across treatment visits and order of treatment, and there was no interaction between time, order of treatment, and psychiatric diagnosis.
    Conclusions: Omega-3 fatty acid supplementation did not significantly alter residual symptoms in this group of patients.
    MeSH term(s) Female ; Humans ; Male ; Middle Aged ; Anxiety/drug therapy ; Depression/drug therapy ; Docosahexaenoic Acids/therapeutic use ; Double-Blind Method ; Fatty Acids, Omega-3/therapeutic use ; Treatment Outcome ; Cross-Over Studies
    Chemical Substances Docosahexaenoic Acids (25167-62-8) ; Fatty Acids, Omega-3
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001767
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  5. Article ; Online: Problematic medical marijuana, but not all cannabinoids?

    Norman, Trevor R

    The Australian and New Zealand journal of psychiatry

    2017  Volume 52, Issue 1, Page(s) 95

    MeSH term(s) Cannabinoids ; Cannabis ; Health Promotion ; Medical Marijuana
    Chemical Substances Cannabinoids ; Medical Marijuana
    Language English
    Publishing date 2017-08-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 221140-3
    ISSN 1440-1614 ; 0004-8674
    ISSN (online) 1440-1614
    ISSN 0004-8674
    DOI 10.1177/0004867417722643
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  6. Article ; Online: Diagnostic agreement and concordance between consultation-liaison psychiatry and non-psychiatric (medical and surgical) doctors: changes within junior doctor's terms.

    Kim, Hannah / Khanna, Rahul / Olver, James / Norman, Trevor R

    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

    2022  Volume 30, Issue 1, Page(s) 60–63

    Abstract: Objective: To investigate whether diagnostic agreement and concordance between non-psychiatric (medical and surgical) doctors and consultation-liaison psychiatry changes within junior doctors' terms.: Method: This was a retrospective cohort analysis ... ...

    Abstract Objective: To investigate whether diagnostic agreement and concordance between non-psychiatric (medical and surgical) doctors and consultation-liaison psychiatry changes within junior doctors' terms.
    Method: This was a retrospective cohort analysis of referrals from medical and surgical units to a consultation-liaison psychiatry service. Diagnostic agreement was calculated across all diagnoses and expressed as a percentage. Diagnostic concordance (expressed using Cohen's Kappa) was calculated for the two most common diagnoses of depression and delirium. Diagnostic agreement and concordance in the first two weeks (Timepoint A) were compared to those in the last two weeks (Timepoint B) of junior doctors' terms.
    Results: Around half the referrals (Timepoint A = 48.1%, Timepoint B = 54.0%) were excluded as no diagnosis was listed.Diagnostic agreement over all diagnoses was 31.7% (Timepoint A) and 29.9% (Timepoint B) and was not statistically different. Diagnostic concordance for depression increased from fair to moderate but was not statistically significant. Diagnostic concordance for delirium was substantial for both timepoints and were not statistically different.
    Conclusions: No statistically significant change in diagnostic accuracy over a junior doctors' term was found in this study.
    MeSH term(s) Humans ; Mental Disorders/diagnosis ; Physicians/psychology ; Psychiatry ; Referral and Consultation ; Retrospective Studies
    Language English
    Publishing date 2022-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2213198-X
    ISSN 1440-1665 ; 1039-8562
    ISSN (online) 1440-1665
    ISSN 1039-8562
    DOI 10.1177/10398562211037338
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  7. Article ; Online: Agomelatine for depression: expanding the horizons?

    Norman, Trevor R / Olver, James S

    Expert opinion on pharmacotherapy

    2019  Volume 20, Issue 6, Page(s) 647–656

    Abstract: Introduction: Agomelatine is an antidepressant with unique pharmacological actions; it is both a melatonin agonist and selective serotonin antagonist. Both actions combined are necessary for antidepressant efficacy. Effects on melatonin receptors enable ...

    Abstract Introduction: Agomelatine is an antidepressant with unique pharmacological actions; it is both a melatonin agonist and selective serotonin antagonist. Both actions combined are necessary for antidepressant efficacy. Effects on melatonin receptors enable resynchronisation of disrupted circadian rhythms with beneficial effects on sleep patterns. Areas covered: The issue of use of an antidepressant for depression co-morbid with somatic disorders is covered by the authors. A review of the literature from 2000 to August 2018 was undertaken using Scopus and Web of Science with the key words: agomelatine, depression, medical illness. Depression in Parkinson's disease, cardiovascular illness and type II diabetes is reviewed with evidence of efficacy. Bipolar depression and seasonal affective disorder may also react favourably. Agomelatine may have specific efficacy on symptoms of anhedonia. Expert opinion: Despite approval in some major jurisdictions, the drug has failed to gain registration in the United States. A defining issue may be questions about longer term efficacy: unequivocal effectiveness in placebo-controlled relapse prevention studies has not always been demonstrated. Continuation studies suggest maintenance of clinical responsiveness. A major disadvantage of the drug is its' potential hepatotoxicity and the need for repeated clinical laboratory tests.
    MeSH term(s) Acetamides/therapeutic use ; Antidepressive Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Circadian Rhythm ; Depression/drug therapy ; Diabetes Mellitus, Type 2/psychology ; Humans ; Hypnotics and Sedatives/therapeutic use ; Seasonal Affective Disorder/drug therapy ; Serotonin Antagonists/therapeutic use
    Chemical Substances Acetamides ; Antidepressive Agents ; Hypnotics and Sedatives ; Serotonin Antagonists ; agomelatine (137R1N49AD)
    Language English
    Publishing date 2019-02-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2019.1574747
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  8. Article: Psilocybin in neuropsychiatry: a review of its pharmacology, safety, and efficacy.

    Dodd, Seetal / Norman, Trevor R / Eyre, Harris A / Stahl, Stephen M / Phillips, Arnie / Carvalho, André F / Berk, Michael

    CNS spectrums

    2022  , Page(s) 1–11

    Abstract: Psilocybin is a tryptamine alkaloid found in some mushrooms, especially those of the ... ...

    Abstract Psilocybin is a tryptamine alkaloid found in some mushrooms, especially those of the genus
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/S1092852922000888
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  9. Article ; Online: The effect of agomelatine on 5HT(2C) receptors in humans: a clinically relevant mechanism?

    Norman, Trevor R

    Psychopharmacology

    2012  Volume 221, Issue 1, Page(s) 177–8; author reply 179

    MeSH term(s) Acetamides/pharmacology ; Female ; Humans ; Hypnotics and Sedatives/pharmacology ; Male ; Receptor, Serotonin, 5-HT2C/drug effects
    Chemical Substances Acetamides ; Hypnotics and Sedatives ; Receptor, Serotonin, 5-HT2C
    Language English
    Publishing date 2012-02-15
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-012-2656-6
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  10. Article ; Online: Agomelatine, melatonin and depressive disorder.

    Norman, Trevor R

    Expert opinion on investigational drugs

    2013  Volume 22, Issue 4, Page(s) 407–410

    Abstract: Alteration of nocturnal melatonin production, along with circadian rhythm disturbance, has been demonstrated in several psychiatric disorders. It has been postulated that such disturbances might be causal reflecting a more fundamental abnormality of the ... ...

    Abstract Alteration of nocturnal melatonin production, along with circadian rhythm disturbance, has been demonstrated in several psychiatric disorders. It has been postulated that such disturbances might be causal reflecting a more fundamental abnormality of the function of the suprachiasmatic nucleus (SCN). The SCN contains the body's master 'clock' while the pineal-SCN nexus is intricate to the nighttime production of melatonin. The more compelling case for causality is made for major depressive disorder (MDD). Lending weight to this proposition is the introduction of agomelatine as an antidepressant agent. Through its actions on melatonin receptors agomelatine can resynchronise circadian rhythms. The circadian hypothesis would posit that normalisation of disturbance would be sufficient of itself to alleviate the symptoms of MDD. Thus, strategies designed to bring about resynchronisation of circadian rhythms should be therapeutically effective in depression. Critical examination of the efficacy of such interventions in MDD suggests that the circadian alteration may be necessary but is not sufficient for an antidepressant effect. Exogenous melatonin administration and bright light therapy have mixed results in limited controlled clinical evaluations. Furthermore, agomelatine has other actions which pre-clinical studies suggest are as important to its therapeutic effects as are its actions on melatonin receptors ipso facto its resynchronising properties. Whether circadian effects are antidepressant remains a moot point and awaits the clinical evaluation of highly selective resynchronising agents.
    MeSH term(s) Acetamides/pharmacology ; Animals ; Antidepressive Agents/pharmacology ; Circadian Rhythm/drug effects ; Depression/physiopathology ; Depressive Disorder/physiopathology ; Humans ; Melatonin/pharmacology ; Melatonin/physiology
    Chemical Substances Acetamides ; Antidepressive Agents ; agomelatine (137R1N49AD) ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2013-03-11
    Publishing country England
    Document type Editorial
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1517/13543784.2013.779668
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