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Article: Reactivation of minimal change disease and IgA nephropathy after COVID-19 vaccination.

Leong, Leanne Ca-Yin / Hong, Wei-Zhen / Khatri, Priyanka

2021 Volume 15, Issue 3, Page(s) 569–570

Language	English
Publishing date	2021-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfab241
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Article ; Online: Spatial-temporal distribution and pedestrian exposure assessment of size-fractionated particles on crosswalk of urban intersection.

He, Hong-di / Wang, Zi-Ye / Zhao, Hong-Mei / Pan, Wei / Lu, Wei-Zhen

Environmental science and pollution research international

2023 Volume 30, Issue 35, Page(s) 83917–83928

Abstract: Vehicles tend to produce more pollutants especially particles at an urban intersection than other segments. Meanwhile, pedestrians at an intersection are inevitably exposed to high particle level and suffered from the health problem. Especially, some ... ...

Abstract	Vehicles tend to produce more pollutants especially particles at an urban intersection than other segments. Meanwhile, pedestrians at an intersection are inevitably exposed to high particle level and suffered from the health problem. Especially, some particles can deposit in different thoracic areas of the respiratory system and cause serious health problems. Hence, in this paper, the particles from 0.3 to 10 μm in 16 channels were measured to compare the spatio-temporal characteristics of them on the crosswalk and the roadside. Based on the roadside of fixed measurements, submicron particles (< 1 μm) are discovered to have a high relation with traffic signal and exhibit a bimodal distribution pattern in the green phase. On the crosswalk of mobile measurements, submicron particles present decreasing trend along the crosswalk while crossing. Additionally, mobile measurements were conducted across six time intervals that correspond to different pedestrian's journey when passing the crosswalk. The results showed that all size particles in the first three journeys present high concentrations than that in other journeys. Furthermore, pedestrian exposure to all 16 channel particles was assessed. The total and regional deposition fractions of these particles in different sizes and age groups are determined. What ought to be paid attention to is that these real-world measurement results contribute to advancing the understanding of pedestrian exposure to size-fractionated particles on crosswalk and assisting the pedestrian to make better informed choice so as to limit particle exposure in these pollution hotspots.
MeSH term(s)	Humans ; Pedestrians ; Air Pollutants/analysis ; Environmental Pollution ; Environmental Pollutants ; Accidents, Traffic
Chemical Substances	Air Pollutants ; Environmental Pollutants
Language	English
Publishing date	2023-06-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-28150-3
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Article: Therapeutic Drug Monitoring in Patients with Systemic Lupus Erythematosus: Utility and Gaps.

Chong, Kar Mun / Jiang, He / Lo, Elaine Ah Gi / Hong, Wei-Zhen / Wong, Emmett Tsz-Yeung / Chan, Gek Cher / Cho, Jiacai

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Despite advances in the treatment of patients with systemic lupus erythematous (SLE), outcomes have remained suboptimal. Persistent disease activity, patient comorbidities and drug toxicities contribute to the accrual of progressive irreversible damage ... ...

Abstract	Despite advances in the treatment of patients with systemic lupus erythematous (SLE), outcomes have remained suboptimal. Persistent disease activity, patient comorbidities and drug toxicities contribute to the accrual of progressive irreversible damage and high rates of morbidity and mortality. Currently, similar drug doses and regimens are promulgated in the treatment guidelines for all SLE patients, despite the vast differences in patient and environmental factors that affect the drugs' metabolism and blood concentrations. This causes a disconnect between drug dosing and drug blood concentrations, which can then result in unpredictability in drug toxicities and therapeutic effects. In this review, we discuss commonly used oral immunosuppressive medications in SLE, their pharmacogenomics, and factors affecting their metabolism and blood concentrations. Further, we highlight the role of therapeutic drug monitoring in SLE, which is the first accessible step to individualising therapy.
Language	English
Publishing date	2024-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020451
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Article ; Online: Continuing Chronic Disease Care During COVID-19 and Beyond.

Hong, Wei-Zhen / Chan, Gek-Cher / Chua, Horng-Ruey

Journal of the American Medical Directors Association

2020 Volume 21, Issue 7, Page(s) 991–992

MeSH term(s)	Adult ; Ambulatory Care/organization & administration ; Betacoronavirus ; COVID-19 ; Chronic Disease/therapy ; Continuity of Patient Care/organization & administration ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Singapore/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-05-16
Publishing country	United States
Document type	Letter
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2020.05.013
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Article: Optimization of return vent height for stratified air distribution system with impinging jet supply satisfying threshold of |PMV| < 0.5

Qin, Chao / Zhou, Wei-Ru / Fang, Hong-Qiang / Lu, Wei-Zhen / Lee, Eric WM.

Journal of cleaner production. 2022 July 20, v. 359

2022

Abstract: The stratified air distribution (STRAD) ventilation system addresses much attention due to the less cooling energy consumption than conventional mixing ventilation systems in maintaining a proper indoor environment. In recent literature, the vent height ... ...

Abstract	The stratified air distribution (STRAD) ventilation system addresses much attention due to the less cooling energy consumption than conventional mixing ventilation systems in maintaining a proper indoor environment. In recent literature, the vent height of STRAD systems has been studied. However, in previous studies, the impacts of over-cooling and/or over-warming on cooling load as well as, consequently, on the optimal return vent height were not systematically considered. In practice, the indoor environment (e.g., predictive mean vote PMV, indoor air quality IAQ) is sensitive to the supply condition (e.g., supply temperature) and the return vent height. This study aims to optimize the return vent height of a STRAD ventilation system with impinging jet supply under a general thermal comfort condition, i.e., threshold of \|PMV\| < 0.5. The evaluated indices include the cooling coil load, the temperature difference between the head and ankles, the average CO₂ concentration, the average mean age of air, and the predicted percentage of dissatisfied. The research outcomes indicate that: a) the increase of supply temperature generally avoids overcooling and reduces cooling coil load; b) the cooling coil load increases and c) the IAQ generally upgrades as the return vent height rises; d) the optimal return vent height with the impinging jet ventilation is recommended as 2.625 m (i.e., near the ceiling), which is different from previously suggested mid-level return vent. Under this optimal return vent height, the supply temperature can be increased to 22 °C with resultant \|PMV\| < 0.5, lower cooling coil load, and better IAQ comparing to the recommended case of mid-level return vent with a supply temperature of 18 °C.
Keywords	air ; air quality ; carbon dioxide ; energy ; temperature ; ventilation systems
Language	English
Dates of publication	2022-0720
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.132033
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of icariin on the transformation efficiency of induced pluripotent stem cells into sperm cells in vitro.

Zhao, Zhen-Li / Hu, Shao-Hua / Wan, Zhi-Sheng / Bu, Wei-Zhen / Chen, Song-Qiang / Han, Tian-Hong / Lu, Yi-Qun

Revista internacional de andrologia

2023 Volume 21, Issue 4, Page(s) 100373

Abstract: Objective: To investigate the effect of icariin on the transformation efficiency of germ cell-like cells from mouse induced pluripotent stem cells into sperm cells in vitro.: Methods: Firstly, mouse induced pluripotent stem cells were induced and ... ...

Abstract	Objective: To investigate the effect of icariin on the transformation efficiency of germ cell-like cells from mouse induced pluripotent stem cells into sperm cells in vitro. Methods: Firstly, mouse induced pluripotent stem cells were induced and cultured to transform into germ cell-like cells, and the primordial germ cell-like cells were identified by Western blot and RT-PCR. Then, different concentrations of icariin (0.1μg/mL, 1μg/mL, 10μg/mL and 100μg/mL) were added into the culture medium, and the obtained primitive germ cell-like cells were cultured, Western blot and RT-PCR were used to identify the obtained sperm cells, the transformation efficiency was compared. Results: The primordium germ cell-like cells obtained from mouse induced pluripotent stem cells in vitro specially expressed Oct-4 protein, C-kit protein, Mvh mRNA, Fragilis mRNA and Stella mRNA. The sperm cells were specially expressed VASA, SCP3 and γH2AX proteins. RT-PCR showed that the sperm cells were specially expressed Ddx4, Tp2 and Prm1 mRNA. Compared with the control group, the expression level of VASA protein (1.744±0.283, 2.882±0.373, 6.489±0.460), SCP3 protein (2.250±0.306, 7.058±0.521, 8.654±0.804), γH2AX protein (4.304±0.433, 5.713±0.339, 9.268±0.545), Ddx4 mRNA (1.374±0.145, 2.846±0.194, 4.021±0.154), Tp2 mRNA (1.358±0.130, 3.623±0.326, 5.811±0.390) and Prm1 mRNA (1.326±0.162, 3.487±0.237, 4.666±0.307) in 0.1μg/mL, 1μg/mL, 10μg/mL icariin experimental groups were all lower than that of VASA protein (10.560±0.413), SCP3 protein (13.804±0.642), γH2AX protein (11.874±0.464), Ddx4 mRNA (6.4005±0.361), Tp2 mRNA (7.314±0.256) and Prm1 mRNA (7.334±0.390) in 100μg/mL icariin experimental group. Conclusions: Icariin can promote the transformation of mouse induced pluripotent stem cells into sperm cells in vitro, and it is concentration-dependent manner in a certain concentration range.
MeSH term(s)	Male ; Animals ; Mice ; Induced Pluripotent Stem Cells/metabolism ; Cell Differentiation ; Semen ; Spermatozoa ; RNA, Messenger/metabolism
Chemical Substances	icariin (VNM47R2QSQ) ; RNA, Messenger
Language	English
Publishing date	2023-07-01
Publishing country	Spain
Document type	Journal Article
ISSN	1698-0409
ISSN (online)	1698-0409
DOI	10.1016/j.androl.2023.100373
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Article: [Influence of Different Types of Dewatering Agents on the Solidification Effect and Physical and Chemical Properties of Sediment].

Ren, Jun / Yin, Peng / Wang, Wei-Zhen / Tang, Wan-Ying / Yin, Hong-Bin / Zhu, Li-Juan

Huan jing ke xue= Huanjing kexue

2022 Volume 43, Issue 7, Page(s) 3672–3681

Abstract: In order to study the comprehensive effects of different types of dehydrating agents on the dewatering and solidification of dredged sediments, this study took the dredged sediments of Taihu Lake as the research object and selected microorganisms, ... ...

Abstract	In order to study the comprehensive effects of different types of dehydrating agents on the dewatering and solidification of dredged sediments, this study took the dredged sediments of Taihu Lake as the research object and selected microorganisms, polymeric iron aluminum salts, organic polymers, organic-inorganic composites, and aluminum salt microorganisms. These five types of composite dehydrating agents were used to conduct a three-month solidification test on the dredged sediment by means of geotechnical pipe bag solidification. The results of the study showed that the dehydration efficiency of organic polymers and organic-inorganic composite chemicals was better. After one month, the water content of sediment dropped to 61.78% and 63.26%, respectively, which then dropped to 40.56% and 32.16% after three months. Compared with that of the unsolidified sludge, the total nitrogen of the bottom sludge after solidification by the organic-inorganic composite agent was reduced by 74.82%, reaching 591 mg·kg
MeSH term(s)	Aluminum ; Dehydration ; Environmental Monitoring ; Geologic Sediments/chemistry ; Humans ; Iron ; Metals, Heavy/analysis ; Nitrogen/analysis ; Organic Chemicals ; Phosphorus/analysis ; Polymers ; Sewage ; Water Pollutants, Chemical/analysis
Chemical Substances	Metals, Heavy ; Organic Chemicals ; Polymers ; Sewage ; Water Pollutants, Chemical ; Phosphorus (27YLU75U4W) ; Aluminum (CPD4NFA903) ; Iron (E1UOL152H7) ; Nitrogen (N762921K75)
Language	Chinese
Publishing date	2022-06-01
Publishing country	China
Document type	Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202109133
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Article ; Online: Single-nucleus transcriptome sequencing reveals hepatic cell atlas in pigs.

Zhu, Jun-Hong / Guan, Xuan-Cheng / Yi, Lan-Lan / Xu, Hong / Li, Qiu-Yan / Cheng, Wen-Jie / Xie, Yu-Xiao / Li, Wei-Zhen / Zhao, Hong-Ye / Wei, Hong-Jiang / Zhao, Su-Mei

BMC genomics

2023 Volume 24, Issue 1, Page(s) 770

Abstract: Background: As the largest substantive organ of animals, the liver plays an essential role in the physiological processes of digestive metabolism and immune defense. However, the cellular composition of the pig liver remains poorly understood. This ... ...

Abstract	Background: As the largest substantive organ of animals, the liver plays an essential role in the physiological processes of digestive metabolism and immune defense. However, the cellular composition of the pig liver remains poorly understood. This investigation used single-nucleus RNA sequencing technology to identify cell types from liver tissues of pigs, providing a theoretical basis for further investigating liver cell types in pigs. Results: The analysis revealed 13 cells clusters which were further identified 7 cell types including endothelial cells, T cells, hepatocytes, Kupffer cells, stellate cells, B cells, and cholangiocytes. The dominant cell types were endothelial cells, T cells and hepatocytes in the liver tissue of Dahe pigs and Dahe black pigs, which accounts for about 85.76% and 82.74%, respectively. The number of endothelial cells was higher in the liver tissue of Dahe pigs compared to Dahe black pigs, while the opposite tendency was observed for T cells. Moreover, functional enrichment analysis demonstrated that the differentially expressed genes in pig hepatic endothelial cells were significantly enriched in the protein processing in endoplasmic reticulum, MAPK signaling pathway, and FoxO signaling pathway. Functional enrichment analysis demonstrated that the differentially expressed genes in pig hepatic T cells were significantly enriched in the thyroid hormone signaling pathway, B cell receptor signaling pathway, and focal adhesion. Functional enrichment analysis demonstrated that the differentially expressed genes in pig hepatic hepatocytes were significantly enriched in the metabolic pathways. Conclusions: In summary, this study provides a comprehensive cell atlas of porcine hepatic tissue. The number, gene expression level and functional characteristics of each cell type in pig liver tissue varied between breeds.
MeSH term(s)	Animals ; Swine ; Transcriptome ; Endothelial Cells ; Plant Breeding ; Hepatocytes/metabolism ; Liver/metabolism
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09765-9
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Article: Continuing Chronic Disease Care During COVID-19 and Beyond

Hong, Wei-Zhen / Chan, Gek-Cher / Chua, Horng-Ruey

J Am Med Dir Assoc

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #276640
Database	COVID19

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Article ; Online: Characterizing the variation of particles in varied sizes from a container truck in a port area.

Zhao, Hong-Mei / He, Hong-di / Lu, Wei-Zhen / Hao, Yang-Yang

Environmental monitoring and assessment

2020 Volume 192, Issue 12, Page(s) 787

Abstract: The transportation of container trucks in urban areas not only frequently causes traffic jams but also produces severe air pollution. With regard to this consideration, measurements of particle concentrations and traffic volume on different polluted days ...

Abstract	The transportation of container trucks in urban areas not only frequently causes traffic jams but also produces severe air pollution. With regard to this consideration, measurements of particle concentrations and traffic volume on different polluted days were carried out to discover the varied characteristics of particles from container truck transportation in the port area. Based on the original data, descriptive statistics were performed firstly to reveal the statistical characteristics of particle number concentrations (PNC). The Kolmogorov-Smirnov test as well as the Anderson-Darling test was adopted to identify the "best-fit" distributions on PNC data while the corresponding maximum likelihood estimation was conducted to estimate the parameters of the identified distribution. Additionally, the Pearson correlation analysis and principal component analysis were performed respectively to reveal the relationships between traffic volume and PNC. The results showed that on a hazy day, PNC levels in the morning were generally higher than those in the afternoon, while on a non-hazy day, the results were opposite. Particles in all sizes on a non-hazy day and larger than 0.5 μm on a hazy day were verified to fit the lognormal distribution. In contrast to the particles below 2 μm, the particles above 2 μm exhibited higher correlations with the traffic flow of a container truck in the morning on a hazy day. These results indicate the importance of reducing air pollution from a container truck and provide policymakers with a foundation for possible measures in a port city.
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/analysis ; Cities ; Environmental Monitoring ; Motor Vehicles ; Particulate Matter/analysis ; Vehicle Emissions/analysis
Chemical Substances	Air Pollutants ; Particulate Matter ; Vehicle Emissions
Language	English
Publishing date	2020-11-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-020-08752-x
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