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  1. Book: Understanding clinical research

    Lopes, Renato D.

    2013  

    Author's details ed. Renato D. Lopes
    Keywords Biomedical Research ; Clinical Trials as Topic ; Research Design
    Language English
    Size XVI, 245 S.
    Publisher McGraw-Hill Med
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index ; A brief history of clinical trials, drug regulations, and the Food and Drug Administration / Nidhi Tripathy ... [et al.] -- Information technology, access, clinicaltrials.gov / Anjan Chakrabarti and C. Michael Gibson -- The role of academic research organizations in clinical research / Craig J. Reist ... [et al.] -- Ethics of clinical research : an overview and emerging issues / Yee Weng Wong and Kevin A. Schulman -- Introduction to clinical experimentation / Robert Bigelow -- Phase I trials : first in human / Kevin M. Watt, Karen Chiswell, and Michael Cohen-Wolkoweiz -- Phase II clinical trials / Jeffrey T. Guptill and Karen Chiswell -- Phase III and IV clinical trials / Gail E. Hafley, Sergio Leonardi, and Karen S. Pieper -- Challenges of clinical trials in pediatrics / Kevin N. Turner and P. Brian Smith -- Observational research / Michaela Dinan -- Data resources / Ying Xian -- Observational study designs / Bradley G. Hammill -- Challenges of observational designs / David M. Vock -- Specific regression techniques / Phillip J. Schulte -- Analytical methods of addressing confounding / Eric M. Reyes -- Lessons from notable examples in observational research / Zubin Eapen and Lesley H. Curtis
    HBZ-ID HT017955981
    ISBN 978-0-07-174678-6 ; 0-07-174678-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 3801 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Stroke Prevention in Subclinical Atrial Fibrillation. Reply.

    Healey, Jeff S / Lopes, Renato D

    The New England journal of medicine

    2024  Volume 390, Issue 15, Page(s) 1442

    MeSH term(s) Humans ; Atrial Fibrillation/drug therapy ; Pyrazoles/therapeutic use ; Pyridones/therapeutic use ; Stroke/prevention & control
    Chemical Substances apixaban (3Z9Y7UWC1J) ; Pyrazoles ; Pyridones
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2401632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Straining the Limits: Atrial Imaging to Predict Subclinical Atrial Fibrillation.

    Um, Kevin J / Healey, Jeffrey S / Lopes, Renato D

    Circulation. Cardiovascular imaging

    2024  Volume 17, Issue 3, Page(s) e016412

    MeSH term(s) Humans ; Aged ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/physiopathology ; Heart Atria/diagnostic imaging ; Heart Atria/physiopathology
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.123.016412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Standing up for equitable treatment of coronary microvascular dysfunction and myocardial infarction with non-obstructive coronary arteries.

    Fanaroff, Alexander C / Lopes, Renato D

    European journal of internal medicine

    2023  Volume 117, Page(s) 52–54

    MeSH term(s) Humans ; MINOCA ; Myocardial Infarction ; Myocardial Ischemia ; Coronary Vessels ; Coronary Artery Disease ; Coronary Angiography
    Language English
    Publishing date 2023-09-26
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.09.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Innovation in Event Adjudication-Human vs Machine.

    Mahaffey, Kenneth W / Gibson, C Michael / Lopes, Renato D

    JAMA cardiology

    2023  Volume 9, Issue 2, Page(s) 101–102

    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.4900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: When to prescribe oral anticoagulation for patients with device-detected subclinical atrial fibrillation? Insights from the NOAH-AFNET 6 and ARTESiA trials.

    McIntyre, William F / Healey, Jeffrey S / Lopes, Renato D

    European journal of internal medicine

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2024.03.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online ; E-Book: Understanding clinical research

    Lopes, Renato D. / Harrington, Robert A / Lopes, Renato D

    Renato D. Lopes, Robert A. Harrington

    2013  

    Abstract: A complete guide to understanding and applying clinical research results Ideal for both researchers and healthcare providers Understanding Clinical Research addresses both the operational challenges of clinical trials and the needs of clinicians to ... ...

    Abstract A complete guide to understanding and applying clinical research results Ideal for both researchers and healthcare providers Understanding Clinical Research addresses both the operational challenges of clinical trials and the needs of clinicians to comprehend the nuances of research methods to accurately analyze study results. This timely resource covers all aspects of clinical trials--from study design and statistics to regulatory oversight--and it delivers a detailed yet streamlined overview of must-know research topics. The text features an accessible three-part organization that traces the evolution of clinical research and explains the bedrock principles and unique challenges of clinical experimentation and observational research. Reinforcing this content are real-life case examples--drawn from the authors' broad experience--that put chapter concepts into action and contribute to a working knowledge of integral research techniques. FEATURES: The most definitive guide to promoting excellence in clinical research, designed to empower healthcare providers to assess a study's strengths and weaknesses with confidence and apply this knowledge to optimize patient outcomesIn-depth coverage of fundamental research methods and protocols from preeminent authorities provides readers with an instructive primer and a springboard for ongoing clinical research educationClear, comprehensive three-part organization: Section One: Evolution of Clinical Research offers a succinct history of clinical trials, drug regulations, and the role of the FDA while covering the impact of information technology and academic research organizationsSection Two: Principles of Clinical Experimentation takes you through the typical phases of clinical trials in the development of medical products, from initial human subject research to postapproval surveillance studiesSection

    Three: Observational Research highlights the underlying principles, pitfalls, and methods for case-control studies, cohort studies, registries, and subgroup analyses within randomized trials.
    MeSH term(s) Epidemiologic Study Characteristics ; Evaluation Studies as Topic ; Research ; Methods ; Science ; Epidemiologic Methods ; Investigative Techniques ; Health Care Evaluation Mechanisms ; Diagnostic Techniques and Procedures ; Public Health ; Quality of Health Care ; Natural Science Disciplines ; Environment and Public Health ; Health Care Quality, Access, and Evaluation ; Health Care ; Research Design ; Clinical Trials as Topic ; Biomedical Research
    Keywords Medicine ; Health & Biological Sciences ; Medical Research
    Subject code 610.72/4
    Language English
    Size 1 online resource (262 pages)
    Edition 1st ed.
    Publisher McGraw Hill
    Publishing place New York
    Document type Book ; Online ; E-Book
    Note English ; Bibliographic Level Mode of Issuance: Monograph
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-07-179265-1 ; 0-07-174678-1 ; 1-299-82591-5 ; 978-0-07-179265-3 ; 978-0-07-174678-6 ; 978-1-299-82591-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Commentary on the 2021 ASH Guidelines on use of anticoagulation in patients with COVID-19 being discharged from the hospital.

    Spyropoulos, Alex C / Lopes, Renato D

    Blood advances

    2022  Volume 6, Issue 17, Page(s) 5045–5048

    MeSH term(s) Anticoagulants/therapeutic use ; Blood Coagulation ; COVID-19 ; Hospitals ; Humans ; Patient Discharge
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2021006871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7153: Show issues Location:
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  9. Article ; Online: COVID-19 Thrombotic Complications and Therapeutic Strategies.

    Fanaroff, Alexander C / Lopes, Renato D

    Annual review of medicine

    2022  Volume 74, Page(s) 15–30

    Abstract: Shortly after the emergence of coronavirus disease 2019 (COVID-19) in late 2019, clinicians rapidly recognized an apparent association between the disease and both arterial and venous thrombotic complications, which was confirmed in epidemiologic studies. ...

    Abstract Shortly after the emergence of coronavirus disease 2019 (COVID-19) in late 2019, clinicians rapidly recognized an apparent association between the disease and both arterial and venous thrombotic complications, which was confirmed in epidemiologic studies. Based on these data, hospitals empirically developed and implemented protocols with different strategies for anticoagulation of hospitalized COVID-19 patients. Subsequent randomized controlled trials (RCTs) clarified the role of anticoagulation in patients hospitalized with COVID-19 and recently discharged from the hospital. In this review, we discuss the epidemiology and pathophysiology of thrombosis in patients with COVID-19, observational comparative effectiveness analyses that provided hints of a benefit from anticoagulation, and finally the RCTs that established which patients with COVID-19 benefit from treatment-dose anticoagulation. These RCTs have demonstrated that hospitalized, noncritically ill patients with COVID-19 benefit from treatment-dose anticoagulation, but patients who are hospitalized and critically ill, discharged from the hospital, or not hospitalized do not benefit.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Anticoagulants/therapeutic use ; Thrombosis/drug therapy ; Thrombosis/epidemiology ; Thrombosis/etiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-042921-110257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Advanced Heart Failure and Transplant Cardiology as a New Subspecialty in Latin America: Challenges and Opportunities Based on a Brazilian Survey Study.

    Bisol, Rafaela Vebber / Clausell, Nadine / Vieira, Jefferson L / Bacal, Fernando / Lopes, Renato D / Goldraich, Livia Adams

    Journal of cardiac failure

    2024  Volume 30, Issue 3, Page(s) 520–522

    MeSH term(s) Humans ; Heart Failure/surgery ; Latin America ; Brazil ; Heart Transplantation ; Cardiology
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Letter
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2023.12.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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