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  1. Article: Three's Company: Coexistence of Silicosis, Scleroderma, and Sjogren Syndrome in a Single Patient.

    Ziebelman, Alexis / Raibman-Spector, Shir / Gendelman, Omer

    Case reports in rheumatology

    2022  Volume 2022, Page(s) 4487638

    Abstract: We describe a patient who presented with silicosis, scleroderma, and Sjogren syndrome all at the same time. The diagnoses in this case are all associated with continuous exposure to crystalline silica at the patient's workplace. The following report ... ...

    Abstract We describe a patient who presented with silicosis, scleroderma, and Sjogren syndrome all at the same time. The diagnoses in this case are all associated with continuous exposure to crystalline silica at the patient's workplace. The following report discusses this unique presentation.
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2666708-3
    ISSN 2090-6897 ; 2090-6889
    ISSN (online) 2090-6897
    ISSN 2090-6889
    DOI 10.1155/2022/4487638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Arthroplasty Rates and Risk in Familial Mediterranean Fever Patients: A large Population-Based Study.

    Ben-Shabat, Niv / Fisher, Lior / Maixner, Nitzan / Arow, Mohamad / Ozeri, David J / Patt, Yonatan Shneor / Watad, Abdulla / Amital, Howard / Gendelman, Omer

    Rheumatology (Oxford, England)

    2024  

    Abstract: Background: Familial Mediterranean Fever (FMF) is a genetic disorder characterized by recurrent episodes of fever and inflammation in various organs, including the joints. Traditionally, the arthritis of FMF has been considered relatively harmless. ... ...

    Abstract Background: Familial Mediterranean Fever (FMF) is a genetic disorder characterized by recurrent episodes of fever and inflammation in various organs, including the joints. Traditionally, the arthritis of FMF has been considered relatively harmless. However, anecdotal evidence has suggested that it may contribute to long-term joint damage, which may necessitate surgical joint replacement. This study aimed to investigate the rates of arthroplasty among FMF patients and compare it to the general population.
    Methods: The study used the electronic database of the largest healthcare organization in Israel to identify 9,769 FMF patients diagnosed between 2000 and 2016. A similar number of age-, gender-, and residency-matched controls were also identified. The rates of arthroplasty were compared between the two groups. A logistic regression model predicting the need for arthroplasty within the FMF group was formed to identify potential risk factors.
    Results: Of the 9,769 FMF patients, 114 (1.2%) underwent arthroplasty, compared with 64 (0.7%) of the control group [unadjusted odds ratio (OR)=1.79, 95% confidence interval (CI) 1.32-2.43; partially adjusted OR = 1.97, 95% CI 1.40-2.77; fully adjusted OR = 1.92, 95% CI 1.35-2.72]. Within the FMF cohort, those of North African origin had a significantly higher risk of arthroplasty (OR = 6.89, 95% CI 5.09-9.33; p< 0.001).
    Conclusion: FMF patients can experience long-term joint damage that may require arthroplasty. Although this complication is relatively uncommon in FMF patients, it occurs almost twice as frequently as compared with the general population. FMF patients of North African origin are at an even higher risk.
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae086
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  3. Article: Exploring the Link Between Ankylosing Spondylitis and Inflammatory Bowel Disease: A Retrospective Cohort Study.

    Sharif, Kassem / Lahat, Adi / Shneor Patt, Yonatan / Ben-Shabat, Niv / Omar, Mahmud / Watad, Abdulla / Amital, Howard / Gendelman, Omer

    The Israel Medical Association journal : IMAJ

    2024  Volume 26, Issue 4, Page(s) 226–231

    Abstract: Background: Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are chronic conditions with overlapping pathogenic mechanisms. The genetic predisposition and inflammatory pathways common to both diseases suggest a syndemic relationship. ... ...

    Abstract Background: Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are chronic conditions with overlapping pathogenic mechanisms. The genetic predisposition and inflammatory pathways common to both diseases suggest a syndemic relationship. While some evidence points to a connection between the two conditions, other reports do not support this link.
    Objectives: To investigate the association between AS and the subsequent incidence of IBD. To identify potential risk factors and effect modifiers that contribute to this relationship.
    Methods: Utilizing the Chronic Disease Registry of Clalit Health Services, we conducted a retrospective cohort study of individuals diagnosed with AS between January 2002 and December 2018. We compared these patients with age- and sex-matched controls, excluding those with a prior diagnosis of IBD. Statistical analyses included chi-square and t-tests for demographic comparisons, and Cox proportional hazards models for evaluating the risk of IBD development, with adjustments for various co-morbidities and demographic factors.
    Results: The study included 5825 AS patients and 28,356 controls. AS patients demonstrated a significantly higher incidence of IBD with hazard ratios of 6.09 for Crohn's disease and 2.31 for ulcerative colitis, after multivariate adjustment. The overall incidence of IBD in the AS cohort was significantly higher compared to controls.
    Conclusions: AS patients exhibit a markedly increased risk of developing IBD. These findings advocate for heightened clinical vigilance for IBD symptoms in AS patients and suggest the need for a multidisciplinary approach to patient care. Further research into the shared pathogenic pathways is needed to develop personalized treatment strategies and improve patient management.
    MeSH term(s) Humans ; Retrospective Studies ; Spondylitis, Ankylosing/epidemiology ; Inflammatory Bowel Diseases/epidemiology ; Colitis, Ulcerative ; Crohn Disease/epidemiology
    Language English
    Publishing date 2024-03-31
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bisphosphonates Related Ocular Side Effects: A Case Series and Review of Literature.

    Gendelman, Omer / Tripto-Shkolnik, Liana / Vered, Iris / Lidar, Merav

    Ocular immunology and inflammation

    2021  Volume 30, Issue 7-8, Page(s) 1995–1999

    Abstract: Objective: To describe the clinical features of patients with bisphosphonate related ocular side effects (BROSE).: Methods: The medical records of all patients with BROSE between January 2009 and December 2019 were reviewed.: Results: Nine cases ... ...

    Abstract Objective: To describe the clinical features of patients with bisphosphonate related ocular side effects (BROSE).
    Methods: The medical records of all patients with BROSE between January 2009 and December 2019 were reviewed.
    Results: Nine cases with BROSE were identified. All subjects were female. Median age at diagnosis was of 69 years. The leading indication for bisphosphonate treatment was osteoporosis (n=7), Paget's disease of bone (n=1) and breast cancer (n=1). Six (66.67%) patients presented with uveitis, one (11%) episcleritis and two (22%) with orbital inflammation. Five events (55.5%) occurred within 10 days of initiating the bisphosphonate and the rest (44.44%) developed within 2 weeks to 3 years later. Four (44.44%) patients had concurrent thyroid disease. An association was found between underlying thyroid disease or autoimmunity.
    Conclusion: BROSE is an uncommon complication of bisphosphonate therapy occurring more frequently in patients with an autoimmune predisposition.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Diphosphonates/adverse effects ; Eye Diseases/chemically induced
    Chemical Substances Diphosphonates
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2021.1922705
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  5. Article ; Online: Increased risk of venous thromboembolism among patients with familial Mediterranean fever.

    Gendelman, Omer / Feifel, Ariel J / Tsur, Avishai M / Comanhester, Doron / Cohen, Arnon D / Amital, Howard

    Journal of thrombosis and thrombolysis

    2022  Volume 54, Issue 4, Page(s) 669–674

    Abstract: Introduction: Familial Mediterranean Fever (FMF) is an auto inflammatory disease characterized by acute febrile attacks, serositis, arthritis and skin rash. Previous studies have identified an association between venous thromboembolism (VTE) and various ...

    Abstract Introduction: Familial Mediterranean Fever (FMF) is an auto inflammatory disease characterized by acute febrile attacks, serositis, arthritis and skin rash. Previous studies have identified an association between venous thromboembolism (VTE) and various inflammatory and autoimmune disorders, driven in large part by inflammatory processes. Despite these established associations, there remains a paucity of data linking FMF to VTE. The purpose of this study is to evaluate the association between VTE in patients with FMF compared to matched controls.
    Method: A population based cross-sectional study was performed utilizing the electronic medical database of Israel's largest healthcare provider, Clalit Health Services. Using this database, we looked at the prevalence of VTE in a cohort of FMF patients compared to matched controls. Univariate logistic regression was used to evaluate the association between FMF and VTE. Multivariate analysis was conducted to adjust for age, sex, socioeconomic status and comorbidities associated with VTE.
    Results: A total of 6534 FMF patients were identified and matched with an equal number of controls. In univariate analysis the cumulative percent of VTE was higher in FMF patient compared to matched controls (FMF 3%, Control 2%). In a multivariate logistic regression analysis FMF was found to be independently associated with VTE (HR 1.96, P < 0.001).
    Conclusion: FMF is associated with increased risk of VTE. This association is likely the result of a chronic and persisting inflammatory state. Physicians should be aware of this sequela and care must be undertaken to control unbalanced disease.
    MeSH term(s) Humans ; Familial Mediterranean Fever/complications ; Familial Mediterranean Fever/epidemiology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/complications ; Cross-Sectional Studies ; Cohort Studies ; Logistic Models
    Language English
    Publishing date 2022-10-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-022-02711-8
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  6. Article ; Online: The frequency of sacroiliitis on MRI in subjects over 55 years of age.

    Eshed, Iris / Druyan, Amit / Stern, Myriam / Giat, Eitan / Gendelman, Omer / Lidar, Merav

    Skeletal radiology

    2022  Volume 51, Issue 8, Page(s) 1595–1601

    Abstract: Objective: To evaluate the frequency of sacroiliitis in older subjects.: Materials and methods: Consecutive MRI examinations of the sacroiliac joints (SIJs) performed for suspected sacroiliitis (2005-2019) in patients ≥ 18 years were retrospectively ... ...

    Abstract Objective: To evaluate the frequency of sacroiliitis in older subjects.
    Materials and methods: Consecutive MRI examinations of the sacroiliac joints (SIJs) performed for suspected sacroiliitis (2005-2019) in patients ≥ 18 years were retrospectively evaluated for the presence of active/structural lesions and were categorized for the presence/absence of sacroiliitis. Clinical and imaging parameters were compared between subjects with sacroiliitis according to age groups < 40 years, 40-55, and > 55 years. Clinical parameters including inflammatory back pain (IBP) and other spondyloarthritis (SpA) features were retrieved from the medical records.
    Results: A total of 431 patients with SIJs MRI were evaluated: median age, 44 [IQR 35-54]; female:male 267(62%):164(38%). Sacroiliitis was diagnosed in 89 (20.6%) subjects-median age, 41 years [IQR 32-54], 52% females- and was equally prevalent among the different age groups: > 40 years old, 23.6%; 40-55, 20%; and > 55 years old, 17%, p = 0.43, with active/structural lesions equally dispersed. Older patients (> 55) started suffering from back pain at an older age and had a longer delay in diagnosis. Gender distribution, the presence of IBP, and other SpA features were no different in patients < 45 and > 55 years of age.
    Conclusions: The frequency of sacroiliitis on SIJs-MRI in subjects > 55 years is similar to its frequency in younger subjects and is associated with the same type and magnitude of active and structural MRI lesions. Clinical parameters such as IBP and additional SpA features are similarly prevalent in older and younger subjects suggesting they suffer from the same disease and differing only in age of presentation.
    MeSH term(s) Adult ; Aged ; Back Pain/diagnostic imaging ; Back Pain/epidemiology ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Retrospective Studies ; Sacroiliac Joint/diagnostic imaging ; Sacroiliitis/diagnostic imaging ; Spondylarthritis/diagnostic imaging
    Language English
    Publishing date 2022-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-022-04001-z
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  7. Article: Association of fibromyalgia with cancerous and non-cancerous gastrointestinal comorbidities: a cross-sectional study.

    Savin, Einat / Tsur, Avishai M / Watad, Abdulla / Gendelman, Omer / Kopylov, Uri / Cohen, Arnon D / Amital, Howard

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 6, Page(s) 1248–1253

    Abstract: Objectives: Several studies have shown a higher prevalence of irritable bowel syndrome (IBS) among patients with fibromyalgia yet, data regarding association between fibromyalgia and other gastrointestinal disorders have been relatively overlooked. Our ... ...

    Abstract Objectives: Several studies have shown a higher prevalence of irritable bowel syndrome (IBS) among patients with fibromyalgia yet, data regarding association between fibromyalgia and other gastrointestinal disorders have been relatively overlooked. Our aim was to investigate the association between fibromyalgia and gastrointestinal disorders including both benign and malignant conditions.
    Methods: We conducted a retrospective cross-sectional study based on the comprehensive electronic database of the largest health maintenance organisation in Israel. All subjects with a diagnosis of fibromyalgia in their medical records and age- and sex-matched controls were included in the study. We investigated the association of fibromyalgia with benign gastrointestinal disorders including IBS, gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), celiac disease, Crohn's disease, ulcerative colitis, and with gastrointestinal malignancies including colorectal, pancreatic, stomach, liver, and bile duct cancers.
    Results: The study enrolled 18,598 patients with fibromyalgia and 36,985 controls. The mean age was 56.5 years (standard deviation=14) with a female predominance (91%). Fibromyalgia was significantly associated with IBS (OR 4.61, 95% CI 4.09-5.2, p<0.001), GERD (OR 2.62, 95% CI 2.5-2.75, p<0.001), PUD (OR 2.13, 95% CI 1.98-2.3, p<0.001), celiac disease (OR 2.08, 95% CI 1.63-2.65, p<0.001), Crohn's disease (OR 1.85, 95% CI 1.408-2.32, p<0.001) and ulcerative colitis (OR 1.81, 95%CI 1.4-2.33, p<0.001). Nonetheless, no significant differences were found regarding the prevalence of gastrointestinal malignancies between the fibromyalgia patients and controls.
    Conclusions: Our findings suggest that FM is positively associated with various benign but not malignant GI disorders.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Fibromyalgia/diagnosis ; Fibromyalgia/epidemiology ; Fibromyalgia/complications ; Crohn Disease/complications ; Crohn Disease/epidemiology ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/epidemiology ; Colitis, Ulcerative/complications ; Cross-Sectional Studies ; Irritable Bowel Syndrome/epidemiology ; Irritable Bowel Syndrome/complications ; Celiac Disease/complications ; Retrospective Studies ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/epidemiology ; Gastroesophageal Reflux/complications ; Neoplasms/epidemiology ; Neoplasms/complications ; Prevalence
    Language English
    Publishing date 2023-04-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/rp5lkn
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  8. Article ; Online: Familial Mediterranean fever and asthma.

    Tsur, Avishai M / Watad, Abdulla / Gendelman, Omer / Nissan, Daniel / Cohen, Arnon D / Amital, Howard

    Rheumatology (Oxford, England)

    2021  Volume 60, Issue 12, Page(s) 5642–5646

    Abstract: Objective: To assess the association between FMF and asthma.: Methods: This study was designed as a cross-sectional study. All patients diagnosed with FMF between 1 January 2000 and 31 December 2016 who were prescribed colchicine were included in the ...

    Abstract Objective: To assess the association between FMF and asthma.
    Methods: This study was designed as a cross-sectional study. All patients diagnosed with FMF between 1 January 2000 and 31 December 2016 who were prescribed colchicine were included in the study. Controls were matched by sex, date of birth, residential socioeconomic status and country of birth. Logistic regression models were used to determine the odds ratio for asthma in FMF patients and controls.
    Results: A total of 7098 FMF patients who were prescribed colchicine were identified. Of them, 3547 (50%) were females, 3632 (51%) were of low residential socioeconomic status and 6160 (87%) were born in Israel. Their median age at the end of follow-up was 37 years (23-54). In an unadjusted logistic regression, FMF was associated with asthma [odds ratio (OR)=1.33, 95% CI: 1.17, 1.51; P <0.001]. The association persisted after adjusting for sex, socioeconomic status and country of birth (OR=1.33, 95% CI: 1.18, 1.52; P <0.001).
    Conclusion: FMF is positively associated with asthma. Further research is required to validate our results and explore possible explanations of this association. These findings cast doubt on previous studies implying FMF to be a protective factor from asthma.
    MeSH term(s) Adolescent ; Adult ; Asthma/epidemiology ; Asthma/etiology ; Child ; Cross-Sectional Studies ; Familial Mediterranean Fever/complications ; Familial Mediterranean Fever/epidemiology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Israel/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Socioeconomic Factors ; Young Adult
    Language English
    Publishing date 2021-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keab159
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  9. Article: Association Between Behçet's Disease and Depression.

    Pitaro Alter, Bar / Tiosano, Shmuel / Kuntzman, Yuval / Gendelman, Omer / Shalom, Guy / Watad, Abdulla / Amital, Howard / Cohen, Arnon D / Amital, Daniela

    The Israel Medical Association journal : IMAJ

    2022  Volume 24, Issue 11, Page(s) 727–731

    Abstract: Background: Behçet's disease (BD) is a chronic vasculitic multi-systemic disease of unknown etiology. BD is characterized by recurrent attacks of oral aphthae, genital ulcers, and uveitis. BD is a multisystemic disorder and as such it may provoke ... ...

    Abstract Background: Behçet's disease (BD) is a chronic vasculitic multi-systemic disease of unknown etiology. BD is characterized by recurrent attacks of oral aphthae, genital ulcers, and uveitis. BD is a multisystemic disorder and as such it may provoke various psychiatric manifestations, including depression.
    Objectives: To evaluate the association between BD and depression, adjusting for established risk factors for depression.
    Methods: We executed a cross-sectional study based on the Clalit Health Services database, the largest healthcare organization in Israel, serving over 4.4 million members. For this study 873 BD patients were detected and matched with 4369 controls by age and sex.
    Results: The rate of depression was higher among the BD patients compared with the control group (9.39% vs 5.49%, respectively, odds ratio [OR] 1.79, 95% confidence interval [95%CI] 1.37-2.31, P < 0.001). An association between BD and depression was also observed on multivariable analysis (OR 1.83, 95%CI 1.39-2.39, P < 0.001). When stratifying the data, according to established risk factors, the association between BD and depression was prominent in the youngest age group (18-39 years of age), low and high socioeconomical status, and non-smokers.
    Conclusions: Establishing the association between BD and depression should influence the attitude and the treatment of BD patients, as this relationship requires a more holistic approach and a multidisciplinary treatment regimen for all patient needs.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Adult ; Behcet Syndrome/complications ; Behcet Syndrome/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/etiology ; Stomatitis, Aphthous ; Uveitis
    Language English
    Publishing date 2022-11-27
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The possible onset of fibromyalgia following acute COVID-19 infection.

    Savin, Einat / Rosenn, Gali / Tsur, Avishai M / Hen, Or / Ehrenberg, Scott / Gendelman, Omer / Buskila, Dan / Halpert, Gilad / Amital, Daniela / Amital, Howard

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0281593

    Abstract: Introduction: The exact pathogenesis of fibromyalgia (FM) syndrome is unclear. However, various infectious have been implicated with the development of FM after their acute phase. We aimed to investigate the incidence of FM syndrome among convalesced ... ...

    Abstract Introduction: The exact pathogenesis of fibromyalgia (FM) syndrome is unclear. However, various infectious have been implicated with the development of FM after their acute phase. We aimed to investigate the incidence of FM syndrome among convalesced individuals following hospitalization for Acute Coronavirus Disease-2019 (COVID-19).
    Methods: We performed a cross-sectional study on patients who were discharged after COVID-19 hospitalization from the Sheba Medical Center, Israel, between July 2020 to November 2020. A phone interview was performed consisting of the following questionnaires: the Fibromyalgia Survey Diagnostic Criteria Questionnaire, Sense of Coherence Questionnaire to evaluate resilience, and the Subjective Traumatic Outlook Questionnaire to assess the associated psychological aspects of the trauma. The incidence of post-COVID FM was calculated and regression models were performed to identify predictors.
    Results: The study population consisted of 198 eligible patients who completed the phone interview. The median age was 64 (52-72) and 37% were women. The median follow-up was 5.2 months (IQR 4.4-5.8). The incidence of FM was 15% (30 patients) and 87% (172 patients) had at least one FM-related symptom. Female gender was significantly associated with post-COVID FM (OR 3.65, p = 0.002). In addition, high median Subjective Traumatic Outlook scores and low median Sense of Coherence scores were both significantly associated with post-COVID FM (OR 1.19, p<0.001 and OR 0.92, p<0.001, respectively).
    Conclusions: FM is highly prevalent among COVID-19 convalescent patients. Our finding suggests that a significant subjective traumatic experience and a low resilience are highly associated with post-COVID FM.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Fibromyalgia/complications ; Fibromyalgia/epidemiology ; Fibromyalgia/diagnosis ; Cross-Sectional Studies ; COVID-19/complications ; COVID-19/epidemiology ; Surveys and Questionnaires ; Israel/epidemiology
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0281593
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