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  1. Book ; Online ; E-Book: Cardiovascular complications of respiratory disorders

    Martínez-García, Miguel Ángel / Pépin, Jean-Louis / Cazzola, Mario

    (ERS monograph)

    2020  

    Author's details edited by Miguel Ángel Martínez-García, Jean-Louis Pépin and Mario Cazzola
    Series title ERS monograph
    Language English
    Size 1 Online-Ressource (xiii, 317 Seiten), Illustrationen
    Publisher European Respiratory Society
    Publishing place Sheffiled
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020553744
    ISBN 978-1-84984-119-1 ; 9781849841184 ; 1-84984-119-5 ; 1849841187
    DOI 10.1183/2312508X.erm8820
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Pharmacologic Therapy for Obstructive Sleep Apnea: Are We Seeing Some Light at the End of the Tunnel?

    Ayas, Najib / Pépin, Jean-Louis

    American journal of respiratory and critical care medicine

    2023  

    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1778ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Continuous positive airway pressure for prevention of cardiovascular events and mortality: why evidence is evolving.

    Pépin, Jean-Louis / Randerath, Winfried

    The European respiratory journal

    2023  Volume 62, Issue 6

    MeSH term(s) Humans ; Continuous Positive Airway Pressure ; Sleep Apnea, Obstructive/therapy ; Sleep Apnea, Obstructive/physiopathology ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/physiopathology
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01741-2023
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  4. Article ; Online: Reply to: Muscle sympathetic nerve activity and adaptive servo-ventilation: questions remain.

    Tamisier, Renaud / Pépin, Jean-Louis / Lévy, Patrick

    The European respiratory journal

    2023  Volume 61, Issue 4

    MeSH term(s) Humans ; Heart Failure, Systolic ; Sleep Apnea, Central ; Sympathetic Nervous System ; Respiration ; Muscles
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00247-2023
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  5. Article ; Online: Reply to: Central apnoeas, sympathetic activation and mortality in heart failure: look before you leap.

    Tamisier, Renaud / Pépin, Jean-Louis / Lévy, Patrick

    The European respiratory journal

    2023  Volume 61, Issue 3

    MeSH term(s) Humans ; Heart Failure, Systolic ; Sleep Apnea, Central ; Heart Failure ; Respiration ; Muscles
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00042-2023
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  6. Article ; Online: Insights on mandibular jaw movements during polysomnography in obstructive sleep apnea.

    Malhotra, Atul / Martinot, Jean-Benoit / Pépin, Jean-Louis

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 20, Issue 1, Page(s) 151–163

    Abstract: A strong and specific comprehensive physiological association has been documented between mandibular jaw movements and related periods of normal or disturbed breathing across different sleep stages. The mandibular jaw movement biosignal can be ... ...

    Abstract A strong and specific comprehensive physiological association has been documented between mandibular jaw movements and related periods of normal or disturbed breathing across different sleep stages. The mandibular jaw movement biosignal can be incorporated in the polysomnography, displayed on the screen as a function of time like any standard polysomnography signal (eg, airflow, oxygen saturation, respiratory inductance plethysmography bands) and interpreted in the context of the target period of breathing and its associated respiratory effort level. Overall, the mandibular jaw movement biosignal that depicts the muscular trigeminal respiratory drive is a highly effective tool for differentiating between central and obstructive sleep episodes including hypopneas and for providing clinicians with valuable insights into wake/sleep states, arousals, and sleep stages. These fundamental characteristics of the mandibular jaw movement biosignal contrast with photoplethysmography, airflow, or oxygen saturation signals that provide information more about the consequence of the disturbed breathing episode than about the event itself.
    Citation: Malhotra A, Martinot J-B, Pépin J-L. Insights on mandibular jaw movements during polysomnography in obstructive sleep apnea.
    MeSH term(s) Humans ; Polysomnography ; Sleep Apnea, Obstructive/diagnosis ; Sleep/physiology ; Sleep Apnea Syndromes ; Respiration
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10830
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  7. Article ; Online: Letter to the editor of "Sleep Medicine" regarding the publication entitled "Acoustic stimulation time-locked to the beginning of sleep apnea events reduces oxygen desaturations: a pilot-study", by Waeber et al.

    Hernández, Alfredo / Pépin, Jean-Louis

    Sleep medicine

    2021  Volume 93, Page(s) 100

    MeSH term(s) Acoustic Stimulation ; Humans ; Oxygen ; Pilot Projects ; Sleep ; Sleep Apnea Syndromes/therapy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-11-07
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2021.10.036
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  8. Article ; Online: Sleep Telemedicine: A Template for Other Specialties?

    Hwang, Dennis / Pépin, Jean-Louis

    Sleep medicine clinics

    2020  Volume 15, Issue 3, Page(s) xi

    MeSH term(s) Humans ; Sleep ; Telemedicine
    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Editorial
    ISSN 1556-4088
    ISSN (online) 1556-4088
    DOI 10.1016/j.jsmc.2020.07.001
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  9. Article ; Online: Syndrome d’apnées obstructives du sommeil : redéfinir les parcours de soins et accéder à la médecine personnalisée.

    Pépin, Jean-Louis

    Presse medicale (Paris, France : 1983)

    2017  Volume 46, Issue 5, Page(s) 465–467

    Title translation Obstructive sleep apnea: Time to design new clinical pathways and develop personalized medicine.
    Language French
    Publishing date 2017-05
    Publishing country France
    Document type Editorial
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2017.05.012
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  10. Article ; Online: Novel avenues to approach non-CPAP therapy and implement comprehensive obstructive sleep apnoea care.

    Pépin, Jean-Louis / Eastwood, Peter / Eckert, Danny J

    The European respiratory journal

    2022  Volume 59, Issue 6

    Abstract: Recent advances in obstructive sleep apnoea (OSA) pathophysiology and translational research have opened new lines of investigation for OSA treatment and management. Key goals of such investigations are to provide efficacious, alternative treatment and ... ...

    Abstract Recent advances in obstructive sleep apnoea (OSA) pathophysiology and translational research have opened new lines of investigation for OSA treatment and management. Key goals of such investigations are to provide efficacious, alternative treatment and management pathways that are better tailored to individual risk profiles to move beyond the traditional continuous positive airway pressure (CPAP)-focused, "one size fits all" trial-and-error approach, which is too frequently inadequate for many patients. Identification of different clinical manifestations of OSA (clinical phenotypes) and underlying pathophysiological phenotypes (endotypes) that contribute to OSA have provided novel insights into underlying mechanisms and have underpinned these efforts. Indeed, this new knowledge has provided the framework for precision medicine for OSA to improve treatment success rates with existing non-CPAP therapies such as mandibular advancement devices and upper airway surgery, and newly developed therapies such as hypoglossal nerve stimulation and emerging therapies such as pharmacotherapies and combination therapy. Additionally, these concepts have provided insight into potential physiological barriers to CPAP adherence for certain patients. This review summarises the recent advances in OSA pathogenesis, non-CPAP treatment, clinical management approaches and highlights knowledge gaps for future research. OSA endotyping and clinical phenotyping, risk stratification and personalised treatment allocation approaches are rapidly evolving and will further benefit from the support of recent advances in e-health and artificial intelligence.
    MeSH term(s) Artificial Intelligence ; Continuous Positive Airway Pressure ; Humans ; Precision Medicine ; Sleep Apnea, Obstructive/therapy ; Treatment Outcome
    Language English
    Publishing date 2022-06-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01788-2021
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