LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 366

Search options

  1. Article ; Online: Balancing accuracy and speed in the development of inhibitory control.

    Schulz, Daniel / Lenhard, Wolfgang / Mangold, Madlen / Schindler, Julia / Richter, Tobias

    Journal of experimental child psychology

    2024  Volume 243, Page(s) 105915

    Abstract: ... assessment of 3- to 6-year-old children in a longitudinal study (N = 431; 212 girls; M ...

    Abstract Inhibitory control develops rapidly and nonlinearly, making its accurate assessment challenging. This research investigated the developmental dynamics of accuracy and response latency in inhibitory control assessment of 3- to 6-year-old children in a longitudinal study (N = 431; 212 girls; M
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218137-x
    ISSN 1096-0457 ; 0022-0965
    ISSN (online) 1096-0457
    ISSN 0022-0965
    DOI 10.1016/j.jecp.2024.105915
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 670: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Of not passing: homelessness, addiction, mental health and care during COVID-19.

    Lenhard, Johannes / Margetts, Megan / Meng, Eana

    Medical humanities

    2022  Volume 49, Issue 1, Page(s) 55–63

    Abstract: People experiencing homelessness in the UK were unconditionally offered housing (and support) from the beginning of the first lockdown in March 2020. For many, that meant '(re)entering' the support system and having a chance to 'move on' to longer-term ... ...

    Abstract People experiencing homelessness in the UK were unconditionally offered housing (and support) from the beginning of the first lockdown in March 2020. For many, that meant '(re)entering' the support system and having a chance to 'move on' to longer-term housing. This beneficial effect of some of the policy reactions to the pandemic on people experiencing homelessness was unexpected. On the flip side, however, particularly for people struggling with drug use and mental health issues, adequate support was not available for long periods of time; support was either suspended temporarily or people were excluded from institutional support for not adhering to, for instance, lockdown rules. Similarly, digital support alternatives-modelled on increasingly widespread telemedicine-did often not work specifically for people struggling with complex needs or women experiencing homelessness. This research paper reports detailed evidence of what we observed as continued and catalysed exclusions based on interviews and ethnographic observations with both people experiencing homelessness and service providers from the beginning of the COVID-19 pandemic. Referring to our insights and learnings from three locally and temporally overlapping research projects between May 2020 and April 2021, we also propose changes to redesign future (health)care provision to prevent such impasses-which extend beyond lockdown situations to general conditional housing and support.
    MeSH term(s) Humans ; Female ; Mental Health ; COVID-19 ; Pandemics ; Communicable Disease Control ; Ill-Housed Persons
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018219-3
    ISSN 1473-4265 ; 1468-215X
    ISSN (online) 1473-4265
    ISSN 1468-215X
    DOI 10.1136/medhum-2021-012367
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Case report: A 33 years-old alcoholic male with diarrhea and progressive muscle weakness mimicking Guillain-Barré syndrome.

    Rudolph, Anja M / Doubrovinskaia, Sofia / Knabbe, Johannes / Seliger, Corinna / Lenhard, Thorsten

    Frontiers in neurology

    2023  Volume 14, Page(s) 1212497

    Abstract: Background: A subacute manifestation of muscle weakness in temporal association with a diarrheal intestinal infection is always suspicious of Guillain-Barré syndrome (GBS). GBS is characterized as an acute inflammatory polyneuroradiculopathy, mediated ... ...

    Abstract Background: A subacute manifestation of muscle weakness in temporal association with a diarrheal intestinal infection is always suspicious of Guillain-Barré syndrome (GBS). GBS is characterized as an acute inflammatory polyneuroradiculopathy, mediated by cross-reacting autoantibodies and typically triggered by various infections, vaccinations or other causes. Hyponatremia can be associated with GBS and is usually seen in more severe cases. However, the presence of relevant hyponatremia in a case suspicious of GBS can lead to a diagnostic dilemma. We here describe an intriguing and initially misleading case of hyponatremia mimicking GBS, where repeated and thorough electrophysiology was the key to the correct diagnosis.
    Case presentation: A 33 years-old man with a history of severe alcohol dependence and schizophrenia developed progressive muscle weakness in the course of a preceding episode of diarrhea. Neurological examination revealed a leg-accentuated tetraplegia with global areflexia. There was also a complex oculomotor dysfunction. Laboratory tests showed hyponatremia of 110 mM. Cerebrospinal-fluid analysis showed a normal cell count and cytological evaluation, protein concentration within the normal range. Electroneurography showed severe proximal nerve conduction block as evidenced by prolonged F-wave latency and distal nerve conduction block as evidenced by prolonged distal motor latencies and reduced motor nerve conduction velocities (NCV) in all peripheral nerves examined. GBS-associated ganglioside autoantibodies were absent. After compensation of hyponatremia alone, muscle weakness improved rapidly and nerve conduction velocity improved similarly. These dynamics are not consistent with GBS and unnecessary immunoglobulin treatment could be avoided.
    Conclusion: Suspicion of GBS in the presence of relevant hyponatremia can be misleading as hyponatremia is able to mimic GBS. We demonstrate that repeated and accurate nerve conduction studies together with F-wave diagnostics is helpful to make the correct diagnosis. We discuss the mechanisms of the causes of hyponatremia in GBS and contrast these with the electropyhsiological changes caused by hyponatremia itself. The correct diagnosis will prevent the uncritical use of intravenous immunoglobulins and save unnecessary costs. Also, a possible aggravation of the hyponatremia by immunoglobulin treatment can be averted.
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1212497
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Phylogeography of a widely distributed plant species reveals cryptic genetic lineages with parallel phenotypic responses to warming and drought conditions.

    Kahl, Sandra M / Kappel, Christian / Joshi, Jasmin / Lenhard, Michael

    Ecology and evolution

    2021  Volume 11, Issue 20, Page(s) 13986–14002

    Abstract: To predict how widely distributed species will perform under future climate change, it is crucial to understand and reveal their underlying phylogenetics. However, detailed information about plant adaptation and its genetic basis and history remains ... ...

    Abstract To predict how widely distributed species will perform under future climate change, it is crucial to understand and reveal their underlying phylogenetics. However, detailed information about plant adaptation and its genetic basis and history remains scarce and especially widely distributed species receive little attention despite their putatively high adaptability. To examine the adaptation potential of a widely distributed species, we sampled the model plant
    Language English
    Publishing date 2021-09-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.8103
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Standard doses of Triamcinolone do not affect fibroblast cell migration of abdominoplasty patients in-vitro1.

    Anker, Alexandra M / Lenhard, Jasmin / Klein, Silvan M / Felthaus, Oliver / Prantl, Lukas / Ruewe, Marc

    Clinical hemorheology and microcirculation

    2022  Volume 85, Issue 3, Page(s) 307–314

    Abstract: Background: Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing ... ...

    Abstract Background: Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects.
    Objective: The main objective of this study was to gain further information about the impact of the corticosteroid triamcinolone on cell migration in abdominoplasty patients.
    Methods: An in-vitro scratch assay wound healing model was applied to observe cell migration of fibroblasts cultured with nutrient medium containing human seroma aspirate±triamcinolone.
    Results: There were no significant differences regarding cell migration when fibroblasts were incubated with triamcinolone + seroma containing culture medium compared to seroma containing culture medium without triamcinolone.
    Conclusions: The performed in-vitro study suggests that triamcinolone does not decelerate fibroblast cell migration which is considered as a surrogate of wound healing.
    MeSH term(s) Humans ; Triamcinolone/pharmacology ; Seroma ; Cell Movement ; Adrenal Cortex Hormones/pharmacology ; Fibroblasts ; Abdominoplasty
    Chemical Substances Triamcinolone (1ZK20VI6TY) ; Adrenal Cortex Hormones
    Language English
    Publishing date 2022-12-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-229106
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1623: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive

    Bhalla, Manmeet / Herring, Sydney / Lenhard, Alexsandra / Wheeler, Joshua R / Aswad, Fred / Klumpp, Klaus / Rebo, Justin / Wang, Yan / Wilhelmsen, Kevin / Fortney, Kristen / Bou Ghanem, Elsa N

    Infection and immunity

    2024  , Page(s) e0052223

    Abstract: Streptococcus ... ...

    Abstract Streptococcus pneumoniae
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00522-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Rolling the evolutionary dice:

    Frost, Kelly M / Charron-Smith, Sierra L / Cotsonas, Terence C / Dimartino, Daniel C / Eisenhart, Rachel C / Everingham, Eric T / Holland, Elle C / Imtiaz, Kainat / Kornowicz, Cory J / Lenhard, Lydia E / Lynch, Liz H / Moore, Nadia P / Phadke, Kavya / Reed, Makayla L / Smith, Samantha R / Ward, Liza L / Wadsworth, Crista B

    Microbiology spectrum

    2024  Volume 12, Issue 2, Page(s) e0350723

    Abstract: Species within the ... ...

    Abstract Species within the genus
    MeSH term(s) Humans ; Neisseria ; Azithromycin/pharmacology ; Drug Resistance, Bacterial/genetics ; Anti-Bacterial Agents/pharmacology ; Neisseria gonorrhoeae/genetics ; Gonorrhea/drug therapy ; Anti-Infective Agents/pharmacology ; beta-Lactams/pharmacology ; Microbial Sensitivity Tests ; Penicillins
    Chemical Substances Azithromycin (83905-01-5) ; Anti-Bacterial Agents ; Anti-Infective Agents ; beta-Lactams ; Penicillins
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03507-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.

    Lenhard, Svenja / Gerlich, Sarah / Khan, Azkia / Rödl, Saskia / Bökenkamp, Jan-Eric / Peker, Esra / Zarges, Christine / Faust, Janina / Storchova, Zuzana / Räschle, Markus / Riemer, Jan / Herrmann, Johannes M

    The Journal of cell biology

    2023  Volume 222, Issue 10

    Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses high amounts of the protein Orf9b to target the mitochondrial outer membrane protein Tom70. Tom70 serves as an import receptor for mitochondrial precursors and, independently of ... ...

    Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) expresses high amounts of the protein Orf9b to target the mitochondrial outer membrane protein Tom70. Tom70 serves as an import receptor for mitochondrial precursors and, independently of this function, is critical for the cellular antiviral response. Previous studies suggested that Orf9b interferes with Tom70-mediated antiviral signaling, but its implication for mitochondrial biogenesis is unknown. In this study, we expressed Orf9b in human HEK293 cells and observed an Orf9b-mediated depletion of mitochondrial proteins, particularly in respiring cells. To exclude that the observed depletion was caused by the antiviral response, we generated a yeast system in which the function of human Tom70 could be recapitulated. Upon expression of Orf9b in these cells, we again observed a specific decline of a subset of mitochondrial proteins and a general reduction of mitochondrial volume. Thus, the SARS-CoV-2 virus is able to modulate the mitochondrial proteome by a direct effect of Orf9b on mitochondrial Tom70-dependent protein import.
    MeSH term(s) Humans ; Coronavirus Nucleocapsid Proteins/genetics ; COVID-19/genetics ; HEK293 Cells ; Membrane Proteins ; Mitochondrial Membrane Transport Proteins/genetics ; Saccharomyces cerevisiae ; SARS-CoV-2
    Chemical Substances Coronavirus Nucleocapsid Proteins ; Membrane Proteins ; Mitochondrial Membrane Transport Proteins ; nucleocapsid phosphoprotein, SARS-CoV-2
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202303002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.190: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Implementation of different relationship estimate methodologies in breeding value prediction in kiwiberry (

    Mertten, Daniel / Baldwin, Samantha / Cheng, Canhong H / McCallum, John / Thomson, Susan / Ashton, David T / McKenzie, Catherine M / Lenhard, Michael / Datson, Paul M

    Molecular breeding : new strategies in plant improvement

    2023  Volume 43, Issue 10, Page(s) 75

    Abstract: In dioecious crops such as : Supplementary information: The online version contains supplementary material available at 10.1007/s11032-023-01419-8. ...

    Abstract In dioecious crops such as
    Supplementary information: The online version contains supplementary material available at 10.1007/s11032-023-01419-8.
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230924-2
    ISSN 1572-9788 ; 1380-3743
    ISSN (online) 1572-9788
    ISSN 1380-3743
    DOI 10.1007/s11032-023-01419-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 6088: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Impact of the Injection Site on Growth Characteristics, Phenotype and Sensitivity towards Cytarabine of Twenty Acute Leukaemia Patient-Derived Xenograft Models.

    Schueler, Julia / Greve, Gabriele / Lenhard, Dorothée / Pantic, Milena / Edinger, Anna / Oswald, Eva / Lübbert, Michael

    Cancers

    2020  Volume 12, Issue 5

    Abstract: Rodent models have contributed significantly to the understanding of haematological malignancies. One important model system in this context are patient-derived xenografts (PDX). In the current study, we examined 20 acute leukaemia PDX models for growth ... ...

    Abstract Rodent models have contributed significantly to the understanding of haematological malignancies. One important model system in this context are patient-derived xenografts (PDX). In the current study, we examined 20 acute leukaemia PDX models for growth behaviour, infiltration in haemopoietic organs and sensitivity towards cytarabine. PDX were injected intratibially (i.t.), intrasplenicaly (i.s.) or subcutaneously (s.c.) into immune compromised mice. For 18/20 models the engraftment capacity was independent of the implantation site. Two models could exclusively be propagated in one or two specific settings. The implantation site did influence tumour growth kinetics as median overall survival differed within one model depending on the injection route. The infiltration pattern was similar in i.t. and i.s. models. In contrast to the s.c. implantation, only one model displayed circulating leukaemic cells outside of the locally growing tumour mass. Cytarabine was active in all four tested models. Nevertheless, the degree of sensitivity was specific for an individual model and implantation site. In summary, all three application routes turned out to be feasible for the propagation of PDX. Nevertheless, the distinct differences between the settings highlight the need for well characterized platforms to ensure the meaningful interpretation of data generated using those powerful tools.
    Language English
    Publishing date 2020-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12051349
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top