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Article ; Online: Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms.

de la Hoya, Miguel / Soukarieh, Omar / López-Perolio, Irene / Vega, Ana / Walker, Logan C / van Ierland, Yvette / Baralle, Diana / Santamariña, Marta / Lattimore, Vanessa / Wijnen, Juul / Whiley, Philip / Blanco, Ana / Raponi, Michela / Hauke, Jan / Wappenschmidt, Barbara / Becker, Alexandra / Hansen, Thomas V O / Behar, Raquel / Investigators, KConFaB /

Niederacher, Diether / Arnold, Norbert / Dworniczak, Bernd / Steinemann, Doris / Faust, Ulrike / Rubinstein, Wendy / Hulick, Peter J / Houdayer, Claude / Caputo, Sandrine M / Castera, Laurent / Pesaran, Tina / Chao, Elizabeth / Brewer, Carole / Southey, Melissa C / van Asperen, Christi J / Singer, Christian F / Sullivan, Jan / Poplawski, Nicola / Mai, Phuong / Peto, Julian / Johnson, Nichola / Burwinkel, Barbara / Surowy, Harald / Bojesen, Stig E / Flyger, Henrik / Lindblom, Annika / Margolin, Sara / Chang-Claude, Jenny / Rudolph, Anja / Radice, Paolo / Galastri, Laura / Olson, Janet E / Hallberg, Emily / Giles, Graham G / Milne, Roger L / Andrulis, Irene L / Glendon, Gord / Hall, Per / Czene, Kamila / Blows, Fiona / Shah, Mitul / Wang, Qin / Dennis, Joe / Michailidou, Kyriaki / McGuffog, Lesley / Bolla, Manjeet K / Antoniou, Antonis C / Easton, Douglas F / Couch, Fergus J / Tavtigian, Sean / Vreeswijk, Maaike P / Parsons, Michael / Meeks, Huong D / Martins, Alexandra / Goldgar, David E / Spurdle, Amanda B

Human molecular genetics

2016 Volume 25, Issue 11, Page(s) 2256–2268

Abstract: ... indicated that BRCA1 c.594-2A > C (IVS9-2A > C), previously described to cause exon 10 skipping ... to assess pathogenicity of c.594-2A > C. The combined odds for causality considering case-control ...

Abstract	A recent analysis using family history weighting and co-observation classification modeling indicated that BRCA1 c.594-2A > C (IVS9-2A > C), previously described to cause exon 10 skipping (a truncating alteration), displays characteristics inconsistent with those of a high risk pathogenic BRCA1 variant. We used large-scale genetic and clinical resources from the ENIGMA, CIMBA and BCAC consortia to assess pathogenicity of c.594-2A > C. The combined odds for causality considering case-control, segregation and breast tumor pathology information was 3.23 × 10
MeSH term(s)	Adult ; Aged ; Alternative Splicing/genetics ; BRCA1 Protein/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; DNA Mutational Analysis ; Exons/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Middle Aged ; Mutation/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; RNA Splice Sites/genetics ; RNA Splicing/genetics ; Tumor Suppressor Proteins/genetics
Chemical Substances	BRCA1 Protein ; RNA Splice Sites ; Tumor Suppressor Proteins
Language	English
Publishing date	2016-03-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddw094
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Zs.A 3469: Show issues

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Article: Phase I study of cladribine, cytarabine (Ara-C), granulocyte colony stimulating factor (G-CSF) (CLAG Regimen) and simultaneous escalating doses of imatinib mesylate (Gleevec) in relapsed/refractory AML.

Walker, Alison R / Komrokji, Rami S / Ifthikharuddin, Jainulabdeen / Messina, Patti / Mulford, Deborah / Becker, Michael / Friedberg, Jonathan / Oliva, Jamie / Phillips, Gordon / Liesveld, Jane L / Abboud, Camille

Leukemia research

2008 Volume 32, Issue 12, Page(s) 1830–1836

Abstract: Receptor activated tyrosine kinases such as c-kit, c-fms and PDGFR are known targets of inhibition ... Given the synergy in vitro between Ara-C and imatinib mesylate on AML cell growth inhibition, we initiated a Phase ... myeloid blast crisis were eligible to receive Cladribine 5mg/m(2) days 3-7, Cytarabine 2gm/m(2) days 3-7, G-CSF ...

Abstract	Receptor activated tyrosine kinases such as c-kit, c-fms and PDGFR are known targets of inhibition by imatinib mesylate (Gleevec) and are expressed on AML blasts. Marrow stromal cells and monocytes express KIT ligand, M-CSF and PDGF and are therefore capable of activating survival pathways in these leukemic cells. Given the synergy in vitro between Ara-C and imatinib mesylate on AML cell growth inhibition, we initiated a Phase I study combining CLAG+imatinib mesylate in AML patients. Patients with relapsed, refractory AML or CML myeloid blast crisis were eligible to receive Cladribine 5mg/m(2) days 3-7, Cytarabine 2gm/m(2) days 3-7, G-CSF 300mcg days 2-7, and escalating doses of imatinib mesylate given on days 1-15. The level 1 Gleevec dose was 400mg, while level 2 was 600mg and the level 3 dose 800mg. A total of 16 patients were enrolled, 15 AML and 1 CML myeloid blast crisis. The dose escalation occurred as planned and there was no clear evidence of added toxicity due to imatinib mesylate. One patient with an extensive cardiac history died of cardiac causes on day 1 of therapy however no other deaths occurred within 30 days of starting therapy. One patient had a Grade 3 skin rash at dose level 2. The most common toxicities encountered during induction therapy were nausea, vomiting, rash and diarrhea that were transient and/or reversible. At the 800mg dose 1 patient developed a decline in cardiac ejection fraction on day 20 who later died of sepsis, so this was considered a dose limiting toxicity. Of 16 evaluable patients 11 achieved a hypocellular marrow after initial induction with 1 additional patient achieving a hypocellular marrow following a second course of the same regimen. Four patients (25%) achieved a complete morphologic response with normal cytogenetics, 2 patients (12.5%) achieved a complete morphologic response only and 1 patient had a complete response in the bone marrow but incomplete blood count recovery. The overall response rate was 43.8%. The median overall survival was 175 days (95% CI 16.24-333.76) and the median relapse free survival was 76 days. The addition of imatinib mesylate to CLAG was well tolerated with acceptable toxicities and response rates comparable to other salvage regimens. To assess the efficacy of imatinib mesylate in combination with CLAG, a larger phase II trial is now planned.
MeSH term(s)	Adult ; Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/toxicity ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/toxicity ; Benzamides ; Blast Crisis/chemically induced ; Bone Marrow/drug effects ; Bone Marrow/pathology ; Cladribine/administration & dosage ; Cytarabine/administration & dosage ; Disease-Free Survival ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Humans ; Imatinib Mesylate ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/mortality ; Male ; Middle Aged ; Piperazines/administration & dosage ; Piperazines/therapeutic use ; Pyrimidines/administration & dosage ; Pyrimidines/therapeutic use ; Recurrence ; Time Factors
Chemical Substances	Antineoplastic Agents ; Benzamides ; Piperazines ; Pyrimidines ; Cytarabine (04079A1RDZ) ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Cladribine (47M74X9YT5) ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2008-12
Publishing country	England
Document type	Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2008.04.026
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Zs.A 1321: Show issues

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Article ; Online: Stable carbon isotope fractionation data between H(2)CO(3)(*) and CO(2)(g) extended to 120 °C.

Myrttinen, A / Becker, V / Mayer, B / Barth, J A C

Rapid communications in mass spectrometry : RCM

2014 Volume 28, Issue 15, Page(s) 1691–1696

Abstract: ... fractionation (10(3) lnα(13) C) between H2 CO3 (*) (H2 CO3 + CO2(aq) ) and gaseous CO2 (CO2(g) ) are so far ... lnα(13) CH2CO3 * -CO2(g) values of -1.0 ± 0.1 ‰ were observed with a preference for (12) C in H2 CO3 ... conducted at 20, 60, 80, 100 and 120 °C. H2 CO3 (*) and CO2(g) were sampled separately and ...

Abstract	Rationale: Literature data on experimentally derived equilibrium stable carbon isotope fractionation (10(3) lnα(13) C) between H2 CO3 () (H2 CO3 + CO2(aq) ) and gaseous CO2 (CO2(g) ) are so far only available up to 60 °C and were typically determined at or near atmospheric pressures. Here we experimentally expand this dataset to temperature and pressure conditions close to the supercritical state for CO2 . The objective is to improve the applicability of stable carbon isotopes as a tracer in environments where such conditions prevail. Methods:* Eighteen stable carbon isotope laboratory experiments were conducted in a steel vessel. Deionised water that was acidified with hydrochloric acid (HCl, 1 N) to a pH of 2.4 was equilibrated with CO2(g) at pressures (pCO2 ) of 55 bar for durations between 2 and 188 h. The experiments were conducted at 20, 60, 80, 100 and 120 °C. H2 CO3 () and CO2(g) were sampled separately and their carbon isotope ratios were determined by isotope ratio mass spectrometry. Results:* At 20 °C, average 10(3) lnα(13) CH2CO3 * -CO2(g) values of -1.0 ± 0.1 ‰ were observed with a preference for (12) C in H2 CO3 () consistent with previous research. At elevated temperatures of 120 °C, 10(3) lnα(13) CH2CO3 -CO2(g) values decreased to an average value of -0.7 ± 0.1 ‰. The resulting temperature dependence for carbon isotope fractionation between H2 CO3 () and CO2(g) was 10(3) lnα(13) CH2CO3 -CO2(g) = (0.0025 ± 0.0004) T(°C) - (1.0 ± 0.03) ‰. Carbon isotope equilibrium between H2 CO3 () and CO2(g) was reached within reaction times of 18 h and mostly within 5 h or less. Conclusions:* 10(3) lnα(13) CH2CO3 * -CO2(g) data are now available for temperatures up to 120 °C and for pressures of up to 55 bar. The results suggest that higher pCO2 levels possibly shorten carbon isotope equilibration times. These data are critically important for using δ(13) C values as tracers, for instance at geological CO2 sequestration sites and corresponding natural analogues.
MeSH term(s)	Carbon Dioxide/chemistry ; Carbon Isotopes/analysis ; Carbon Isotopes/chemistry ; Chemical Fractionation/methods ; Mass Spectrometry/methods ; Pressure ; Temperature
Chemical Substances	Carbon Isotopes ; Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2014-08-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	58731-x
ISSN	1097-0231 ; 0951-4198
ISSN (online)	1097-0231
ISSN	0951-4198
DOI	10.1002/rcm.6950
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Zs.A 3461: Show issues

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Article: Effects of N- and C-terminal addition of oligolysines or native loop residues on the biophysical properties of transmembrane domain peptides from a G-protein coupled receptor.

Cano-Sanchez, Patricia / Severino, Beatrice / Sureshbabu, V V / Russo, Joe / Inui, Tatsuya / Ding, Fa-Xiang / Arshava, Boris / Becker, Jeff / Naider, Fred

Journal of peptide science : an official publication of the European Peptide Society

2006 Volume 12, Issue 12, Page(s) 808–822

Abstract: Transmembrane domains (TMDs) of G-protein coupled receptors (GPCRs) have very low water solubility ... many laboratories add oligolysines to the N- and C-termini of peptides that correspond to a TMD. To systematically ...

Abstract	Transmembrane domains (TMDs) of G-protein coupled receptors (GPCRs) have very low water solubility and often aggregate during purification and biophysical investigations. To circumvent this problem many laboratories add oligolysines to the N- and C-termini of peptides that correspond to a TMD. To systematically evaluate the effect of the oligolysines on the biophysical properties of a TMD we synthesized 21 peptides corresponding to either the second (TPIFIINQVSLFLIILHSALYFKY) or sixth (SFHILLIMSSQSLLVPSIIFILAYSLK) TMD of Ste2p, a GPCR from Saccharomyces cerevisiae. Added to the termini of these peptides were either Lys(n) (n = 1,2,3) or the corresponding native loop residues. The biophysical properties of the peptides were investigated by circular dichroism (CD) spectroscopy in trifluoroethanol-water mixtures, sodium dodecyl sulfate (SDS) micelles and dimyristoylphosphocholine (DMPC)-dimyristoylphosphoglycerol (DMPG) vesicles, and by attenuated total reflection Fourier transform infrared (ATR-FTIR) in DMPC/DMPG multilayers. The results show that the conformation assumed depends on the number of lysine residues and the sequence of the TMD. Identical peptides with native or an equal number of lysine residues exhibited different biophysical properties and structural tendencies.
MeSH term(s)	Amino Acid Sequence ; Chromatography, High Pressure Liquid ; Circular Dichroism ; Dimyristoylphosphatidylcholine/chemistry ; Micelles ; Molecular Sequence Data ; Peptide Fragments/chemical synthesis ; Peptide Fragments/chemistry ; Polylysine/chemistry ; Receptors, G-Protein-Coupled/chemistry ; Receptors, Peptide/chemistry ; Saccharomyces cerevisiae/metabolism ; Solvents/chemistry ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Micelles ; Peptide Fragments ; Receptors, G-Protein-Coupled ; Receptors, Peptide ; Solvents ; Polylysine (25104-18-1) ; Dimyristoylphosphatidylcholine (U86ZGC74V5)
Language	English
Publishing date	2006-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1234416-3
ISSN	1099-1387 ; 1075-2617
ISSN (online)	1099-1387
ISSN	1075-2617
DOI	10.1002/psc.816
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Zs.A 6200: Show issues

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Article: Membrane-binding properties of phospholipase C-beta1 and phospholipaseC-beta2: role of the C-terminus and effects of polyphosphoinositides, G-proteins and Ca2+.

Jenco, J M / Becker, K P / Morris, A J

The Biochemical journal

1997 Volume 327 Pt 2, Page(s) 431–437

Abstract: We have studied the binding of two G-protein-regulated phospholipase C (PLC) enzymes, PLCs-beta1 ... removal of the C-terminus of PLC-beta1 and PLC-beta2 produces catalytically active fragments. The affinity ... of the proteins contains residues important for membrane binding. Inclusion of G-protein alpha- and betagamma ...

Abstract	We have studied the binding of two G-protein-regulated phospholipase C (PLC) enzymes, PLCs-beta1 and -beta2, to membrane surfaces using sucrose-loaded bilayer phospholipid vesicles of varying compositions. Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction. As reported by others, removal of the C-terminus of PLC-beta1 and PLC-beta2 produces catalytically active fragments. The affinity of these truncated proteins for phospholipid vesicles is dramatically reduced suggesting that this region of the proteins contains residues important for membrane binding. Inclusion of G-protein alpha- and betagamma-subunit activators in the phospholipid vesicles does not increase the binding of PLC-beta1 or PLC-beta2, and the magnitude of G-protein-mediated PLC activation observed at low phospholipid concentrations (10(-6) M) is comparable to that observed at concentrations at which the enzymes are predominantly membrane-bound (10(-3) M). PLC-beta1 and -beta2 contain C2 domains but Ca2+ does not enhance binding to the vesicles. Our results indicate that binding of these enzymes to membranes involves the C-temini of the proteins and suggest that activation of these enzymes by G-proteins results from a regulated interaction between the membrane-bound proteins rather than G-protein-dependent recruitment of soluble enzymes to a substrate-containing phospholipid surface.
MeSH term(s)	Animals ; Calcium/pharmacology ; Cattle ; GTP-Binding Proteins/metabolism ; Humans ; Isoenzymes/metabolism ; Kinetics ; Liposomes ; Macromolecular Substances ; Phosphatidylinositol Phosphates/pharmacology ; Phospholipase C beta ; Phospholipids/metabolism ; Recombinant Proteins/metabolism ; Structure-Activity Relationship ; Sucrose ; Type C Phospholipases/metabolism
Chemical Substances	Isoenzymes ; Liposomes ; Macromolecular Substances ; Phosphatidylinositol Phosphates ; Phospholipids ; Recombinant Proteins ; Sucrose (57-50-1) ; Type C Phospholipases (EC 3.1.4.-) ; PLCB1 protein, human (EC 3.1.4.11) ; PLCB2 protein, human (EC 3.1.4.11) ; Phospholipase C beta (EC 3.1.4.11) ; GTP-Binding Proteins (EC 3.6.1.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	1997-10-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2969-5
ISSN	1470-8728 ; 0264-6021 ; 0006-2936 ; 0306-3275
ISSN (online)	1470-8728
ISSN	0264-6021 ; 0006-2936 ; 0306-3275
DOI	10.1042/bj3270431
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Book ; Online ; E-Book: Infection in knee replacement

Longo, Umile Giuseppe / Budhiparama, Nicolaas C. / Lustig, Sébastien / Becker, Roland / Espregueira-Mendes, João Duarte

2022

Abstract: Epidemiology and socioeconomic impact of infections in knee replacement -- Aetiology and pathogenesis of knee replacement infections.Biomaterials in artificial joint replacement. The role of the surface on bacteria-implant interactions -- In-vitro and in- ...

Author's details	Umile Giuseppe Longo, Nicolaas C. Budhiparama, Sébastien Lustig, Roland Becker, João Espregueira-Mendes editors
Abstract	Epidemiology and socioeconomic impact of infections in knee replacement -- Aetiology and pathogenesis of knee replacement infections.Biomaterials in artificial joint replacement. The role of the surface on bacteria-implant interactions -- In-vitro and in-vivo models for the study of prosthetic joint infections. Clinical manifestation. General and local symptoms. Diagnosis. Laboratory diagnosis -- Microbiological diagnosis -- Molecular analysis and histological evaluation -- Imaging -- Definitional criteria and algorithms of diagnosis. Treatment of knee replacement infections. Systemic antibiotic therapy -- Innovative pharmacological strategies -- Surgical approaches -- DAIR -- One stage -- Two stage -- Static spacers -- Dynamic spacers -- Arthrodesis -- Outcomes -- Complications -- Resistant germs. Current evidence on prevention of knee replacement infections. Medical optimization of patient prior to surgery -- Antibiotic prophylaxis during primary and revision joint replacement -- Preoperative management -- Intraoperative management -- Dental Procedures after joint replacement -- Thromboprophylaxis and haematomas -- Antibiotic impregnated cement -- Arthroplasty following Prior septic arthritis -- Antibiotic-loaded cement in primary and revision joint replacement -- Operative Room -- Tourniquet -- Intraarticular injection prior Joint replacement. This book provides an in-depth overview of the aetiology, treatment and prevention of infections following knee arthroplasty. It presents up-to-date information on available techniques and salvage procedures for complex patients with infected, total knee arthroplasty. Divided into 5 sections, this book explores biomaterials, clinical manifestations, diagnosis, treatment and prevention, including preoperative optimisation, in order to reduce knee infections. This book is a valuable reference resource for practicing orthopaedic surgeons, residents, and medical students wishing to understand the fundamental concepts in infectious disease medicine needed in current orthopaedic practice.
Keywords	Orthopedics ; Sports medicine
Language	English
Size	1 Online-Ressource (xvi,365 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021150216
ISBN	978-3-030-81553-0 ; 9783030815523 ; 3-030-81553-6 ; 3030815528
DOI	10.1007/978-3-030-81553-0
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Symbolik in der psychodynamischen Therapie von Kindern und Jugendlichen

Becker, Evelyn-Christina / Maltzahn, Gabriele von / Lutz, Christiane

(Psychodynamische Psychotherapie mit Kindern, Jugendlichen und jungen Erwachsenen)

2019

Abstract: Symbole können in ihrer bildhaften Bedeutung mehr aussagen als viele Worte. Im therapeutischen Prozess erlauben sie, wenn sich ihre Bedeutung entschlüsselt, ein vertieftes Verständnis der kindlichen Psyche. Das vorliegende Buch möchte über die ... ...

Author's details	Evelyn-Christina Becker, Gabriele von Maltzahn, Christiane Lutz
Series title	Psychodynamische Psychotherapie mit Kindern, Jugendlichen und jungen Erwachsenen
Abstract	Symbole können in ihrer bildhaften Bedeutung mehr aussagen als viele Worte. Im therapeutischen Prozess erlauben sie, wenn sich ihre Bedeutung entschlüsselt, ein vertieftes Verständnis der kindlichen Psyche. Das vorliegende Buch möchte über die Interpretation von Symbolen des täglichen Lebens, der Natur, aber auch des kindlichen Spiels, die heilenden Kräfte der Psyche betonen, die sich über ein Verstehen des Symbols aktivieren lassen. Anhand zahlreicher Fallvignetten wird der entwicklungsfördernde Gehalt der Symbole aufgezeigt und ihre archetypische Gültigkeit unterstrichen.
Keywords	Behandlungstechnik ; C. G. Jung ; Kinder- und Jugendlichenpsychotherapie ; Kinderpsychoanalyse ; Kinderpsychotherapie ; Symbolarbeit ; Symbole ; Psychodynamische Psychotherapie ; Kind ; Jugend ; Symbolik
Subject	Psychodynamische Therapie ; Jugend ; Jugendalter ; Jugendlicher ; Teenager ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
Subject code	150
Language	German
Size	190 Seiten, Illustrationen, 20.3 cm x 14 cm, 260 g
Edition	1. Auflage
Publisher	Verlag W. Kohlhammer
Publishing place	Stuttgart
Publishing country	Germany
Document type	Book
HBZ-ID	HT020024365
ISBN	978-3-17-030639-4 ; 3-17-030639-1 ; 9783170306400 ; 9783170306417 ; 9783170306424 ; 3170306405 ; 3170306413 ; 3170306421
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Article ; Online: Development of the internal family systems model: Honoring contributions from family systems therapies.

Brenner, Elizabeth G / Schwartz, Richard C / Becker, Carol

Family process

2023 Volume 62, Issue 4, Page(s) 1290–1306

Abstract: We describe Richard Schwartz's development of the Internal Family Systems model (IFS) from his position as a Structural/Strategic family therapist. Four decades ago, Schwartz struggled to help clients who exhibited serious risk of harm to self and others. ...

Abstract	We describe Richard Schwartz's development of the Internal Family Systems model (IFS) from his position as a Structural/Strategic family therapist. Four decades ago, Schwartz struggled to help clients who exhibited serious risk of harm to self and others. Through a process of inquiry, he began to work with the positive intentions behind his most challenging clients' harmful thoughts and behaviors. He applied foundational ideas from family systems thinking to patterns of internal experiences. As he experimented with ways of applying these ideas, he created an approach to healing. We summarize the IFS model delineating ways a range of family systems theory and practice inform its development and contribute to its best practice. Our purposes are to inform IFS practitioners who are not trained in foundational family systems models as well as to acknowledge the significant contributions family therapy theories made in the development and best practice of the IFS model.
MeSH term(s)	Humans ; Family/psychology ; Psychoanalytic Theory
Language	English
Publishing date	2023-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	212740-4
ISSN	1545-5300 ; 0014-7370
ISSN (online)	1545-5300
ISSN	0014-7370
DOI	10.1111/famp.12943
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Zs.A 560: Show issues

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Article ; Online: Seven-year prospective study on yearly incidence of Orbivirus infection of captive white-tailed deer and potential Culicoides vectors.

Becker, Michael / Gentry, Glen / Husseneder, Claudia / Foil, Lane

Journal of medical entomology

2024 Volume 61, Issue 2, Page(s) 465–472

Abstract: ... from specimens of C. debilipalpis and C. stellifer, and most of the EHDV-positive pools were from specimens of C ... venustus and C. stellifer. During the 7-yr period, 112 white-tailed deer that died at the study location ...

Abstract	Bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) are arthropod-borne viruses that are transmitted by biting midges in the genus Culicoides (Diptera: Ceratopogonidae) and can cause hemorrhagic disease in certain ruminants. The objectives of this study were to measure the incidence of BTV and EHDV infections in captive white-tailed deer herd as well as tissues and corresponding presence of Culicoides midges at a location near Clinton, LA. During a 7-yr study with yearly outbreaks of hemorrhagic disease in the deer herd, 15 species of Culicoides were captured using Centers for Disease Control (CDC) black light traps. Reverse transcriptase quantitative polymerase chain reaction (PCR) was performed to screen for BTV and EHDV in pools of midges and tissues of deer. From 2012 to 2018, 1,711 pools of midges representing 24,859 specimens were tested, and specimens from 5 of the 15 collected species (Culicoides debilipalpis, Culicoides stellifer, Culicoides venustus, Culicoides haematopotus, and Culicoides crepuscularis) were found to be PCR positive for BTV and EHDV. Most of the BTV-positive pools of biting midges were from specimens of C. debilipalpis and C. stellifer, and most of the EHDV-positive pools were from specimens of C. venustus and C. stellifer. During the 7-yr period, 112 white-tailed deer that died at the study location were PCR positive for BTV or EHDV: detected BTV serotypes were 10 and 12 and EHDV serotypes were 1, 2, and 6. There was a significant increase in BTV/EHDV antibody prevalence in white-tailed deer during the study; antibody-positive rates increased from 15% to 78% in the deer herd of approximately 100 animals.
MeSH term(s)	Animals ; Sheep ; Ceratopogonidae ; Reoviridae Infections ; Deer ; Prospective Studies ; Incidence ; Insect Vectors ; Ruminants ; Bluetongue ; Virus Diseases ; Hemorrhagic Disease Virus, Epizootic ; Bluetongue virus ; Sheep Diseases
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	410635-0
ISSN	1938-2928 ; 0022-2585
ISSN (online)	1938-2928
ISSN	0022-2585
DOI	10.1093/jme/tjae006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: TONI - One for all? Participatory development of a transtheoretic and transdiagnostic online intervention for blended care.

Behr, S / Fenski, F / Boettcher, J / Knaevelsrud, C / Hammelrath, L / Kovacs, G / Schirmer, W / Petrick, H / Becker, P / Schaeuffele, C

Internet interventions

2024 Volume 35, Page(s) 100723

Abstract: Background: Internet-based interventions offer a way to meet the high demand for psychological support. However, this setting also has disadvantages, such as the lack of personal contact and the limited ability to respond to crises. Blended care ... ...

Abstract	Background: Internet-based interventions offer a way to meet the high demand for psychological support. However, this setting also has disadvantages, such as the lack of personal contact and the limited ability to respond to crises. Blended care combines Internet-based interventions with face-to-face psychotherapy and merges the benefits of both settings. To ensure the uptake of blended care in routine care, Internet-based interventions need to be suitable for different therapeutic approaches and mental disorders. Objective: This paper describes the participatory development process of the Internet-based intervention "TONI" using a common therapeutic language and content on various transdiagnostic topics to be integrated into routine outpatient psychotherapy. Methods: To develop this intervention in a participatory manner, we followed the Integrate, Design, Assess, and Share (IDEAS) framework. In a multilevel development process, we used a combination of interviews, focus groups, and proofreading to optimally tailor online modules to routine outpatient psychotherapy. Building on well-established cognitive-behavioral online content, we included expert interviews with psychodynamic ( Results: We describe the development process of TONI step-by-step, outlining the specific requirements that therapists from different therapeutic approaches as well as PWLE have and how we implemented them in our intervention. This includes the content and specific exercises in the online modules, aspects of data protection, language, design, and usability. Conclusion: Internet-based interventions that use a common therapeutic language and address therapeutic principles across different approaches have the potential to advance digitalization in psychotherapy. Involving psychotherapists and PWLE in intervention development may positively impact acceptance and usage in practice. This study shows how participatory intervention development involving both psychotherapists and PWLE can be carried out.
Language	English
Publishing date	2024-02-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2764252-5
ISSN	2214-7829 ; 2214-7829
ISSN (online)	2214-7829
ISSN	2214-7829
DOI	10.1016/j.invent.2024.100723
Database	MEDical Literature Analysis and Retrieval System OnLINE

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