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  1. Article ; Online: Complex ultrasound evaluation of non-alcoholic fatty liver disease. "One stop shop" with new ultrasound-based techniques.

    Sparchez, Zeno

    Medical ultrasonography

    2021  Volume 23, Issue 1, Page(s) 5–6

    Abstract: ...

    Abstract .
    MeSH term(s) Humans ; Liver/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2021-03-10
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2529606-1
    ISSN 2066-8643 ; 1844-4172
    ISSN (online) 2066-8643
    ISSN 1844-4172
    DOI 10.11152/mu-3084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6830: Show issues Location:
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  2. Article: Refining Liver Biopsy in Hepatocellular Carcinoma: An In-Depth Exploration of Shifting Diagnostic and Therapeutic Applications.

    Spârchez, Zeno / Crăciun, Rareș / Nenu, Iuliana / Mocan, Lavinia Patricia / Spârchez, Mihaela / Mocan, Tudor

    Biomedicines

    2023  Volume 11, Issue 8

    Abstract: The field of hepatocellular carcinoma (HCC) has faced significant change on multiple levels in the past few years. The increasing emphasis on the various HCC phenotypes and the emergence of novel, specific therapies have slowly paved the way for a ... ...

    Abstract The field of hepatocellular carcinoma (HCC) has faced significant change on multiple levels in the past few years. The increasing emphasis on the various HCC phenotypes and the emergence of novel, specific therapies have slowly paved the way for a personalized approach to primary liver cancer. In this light, the role of percutaneous liver biopsy of focal lesions has shifted from a purely confirmatory method to a technique capable of providing an in-depth characterization of any nodule. Cancer subtype, gene expression, the mutational profile, and tissue biomarkers might soon become widely available through biopsy. However, indications, expectations, and techniques might suffer changes as the aim of the biopsy evolves from providing minimal proof of the disease to high-quality specimens for extensive analysis. Consequently, a revamped position of tissue biopsy is expected in HCC, following the reign of non-invasive imaging-only diagnosis. Moreover, given the advances in techniques that have recently reached the spotlight, such as liquid biopsy, concomitant use of all the available methods might gather just enough data to improve therapy selection and, ultimately, outcomes. The current review aims to discuss the changing role of liver biopsy and provide an evidence-based rationale for its use in the era of precision medicine in HCC.
    Language English
    Publishing date 2023-08-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11082324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Contrast enhanced ultrasound of the prostate. New role in the evaluation of loco-regional therapy of prostate tumors.

    Sparchez, Zeno

    Medical ultrasonography

    2018  Volume 20, Issue 2, Page(s) 125–126

    Abstract: ...

    Abstract .
    MeSH term(s) Brachytherapy ; Catheter Ablation ; Contrast Media ; Electroporation ; High-Intensity Focused Ultrasound Ablation ; Humans ; Image Enhancement ; Male ; Prostate/diagnostic imaging ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/therapy ; Ultrasonography ; Ultrasonography, Interventional
    Chemical Substances Contrast Media
    Language English
    Publishing date 2018-05-04
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2529623-1
    ISSN 2066-8643 ; 1844-4172
    ISSN (online) 2066-8643
    ISSN 1844-4172
    DOI 10.11152/mu-1536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment of hepatitis C virus infection in patients with hepatocellular carcinoma: Truth or dare?

    Mocan, Tudor / Nenu, Iuliana / Crăciun, Rareș / Spârchez, Zeno

    Journal of gastroenterology and hepatology

    2021  Volume 36, Issue 6, Page(s) 1518–1528

    Abstract: The discovery of direct acting antivirals (DAA) with high rates of sustained virusological response is the biggest epoch-making event in the history of hepatitis C virus (HCV) treatment. DAAs improve liver function, prevent hepatic decompensation, and ... ...

    Abstract The discovery of direct acting antivirals (DAA) with high rates of sustained virusological response is the biggest epoch-making event in the history of hepatitis C virus (HCV) treatment. DAAs improve liver function, prevent hepatic decompensation, and might even reverse liver fibrosis. Although initial research pointed towards a potential drawback, it is now known beyond doubt that DAA treatment reduces hepatocellular carcinoma (HCC) occurrence or recurrence after curative treatments. Unfortunately, the story has reached another plot twist, as several other issues have emerged: (i) Should we treat patients with early HCC and HCV before or after surgery/ablation? (ii) Should patients with HCC on the waiting list receive DAA before or after liver transplantation? (iii) Should we use interferon-free in patients with intermediate stage HCC or in patients under systemic treatments? In this review, we aim to offer some evidence-based answers to these changing clinical dilemmas where possible, or at least some educated guesses in cases were no or little data exists.
    MeSH term(s) Antiviral Agents/administration & dosage ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/prevention & control ; Carcinoma, Hepatocellular/surgery ; Evidence-Based Medicine ; Female ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Humans ; Liver Neoplasms/etiology ; Liver Neoplasms/prevention & control ; Liver Neoplasms/surgery ; Liver Transplantation ; Male ; Time Factors ; Waiting Lists
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2021-01-14
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.15376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2180: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 299: Show issues

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  5. Article ; Online: Interventional ultrasound beyond the classical abdominal applications. Are guidelines for other applications urgent needed?

    Sparchez, Zeno

    Medical ultrasonography

    2015  Volume 17, Issue 3, Page(s) 271–272

    MeSH term(s) Abdomen/diagnostic imaging ; Humans ; Practice Guidelines as Topic ; Ultrasonography, Interventional
    Language English
    Publishing date 2015-09-02
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2529623-1
    ISSN 2066-8643 ; 1844-4172
    ISSN (online) 2066-8643
    ISSN 1844-4172
    DOI 10.11152/mu.2013.2066.173.zsp
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Contrast-enhanced ultrasonography for evaluating antiangiogenic treatment in hepatocellular carcinoma. A long way from research to clinical practice.

    Spârchez, Zeno

    Medical ultrasonography

    2012  Volume 14, Issue 2, Page(s) 85–86

    MeSH term(s) Benzenesulfonates/therapeutic use ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/drug therapy ; Female ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/drug therapy ; Male ; Neovascularization, Pathologic/diagnostic imaging ; Neovascularization, Pathologic/drug therapy ; Niacinamide/analogs & derivatives ; Phenylurea Compounds ; Pyridines/therapeutic use ; Ultrasonography
    Chemical Substances Benzenesulfonates ; Phenylurea Compounds ; Pyridines ; Niacinamide (25X51I8RD4) ; sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2012-06
    Publishing country Romania
    Document type Editorial ; Comment
    ZDB-ID 2529623-1
    ISSN 2066-8643 ; 1844-4172
    ISSN (online) 2066-8643
    ISSN 1844-4172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Contrast enhancement for ultrasound-guided interventions: when to use it and what to expect?

    Sparchez, Zeno / Mocan, Tudor / Craciun, Rares / Sparchez, Mihaela / Nolsøe, Christian

    Ultrasonography (Seoul, Korea)

    2021  Volume 41, Issue 2, Page(s) 263–278

    Abstract: The use of contrast-enhanced ultrasonography (CEUS) has recently become synonymous with high-standard ultrasonography (US). From expanding the reach of US diagnostics to improving the precision of various invasive procedures, CEUS is rapidly becoming a ... ...

    Abstract The use of contrast-enhanced ultrasonography (CEUS) has recently become synonymous with high-standard ultrasonography (US). From expanding the reach of US diagnostics to improving the precision of various invasive procedures, CEUS is rapidly becoming a standard in numerous niches. However, proficiency in CEUS comes with a cost, both from a learning curve and material standpoint, and as every growing field, lacks firm evidence and standardization. Therefore, in the current paper, we aim to provide an evidence-based review of available methods and to discuss the advantages and pitfalls of CEUS in interventional procedures, trying to provide strong evidence whenever available, or at least an educated expert opinion if data are lacking.
    Language English
    Publishing date 2021-12-09
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2775801-1
    ISSN 2288-5943 ; 2288-5919
    ISSN (online) 2288-5943
    ISSN 2288-5919
    DOI 10.14366/usg.21207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Real-time ultrasound prostate elastography. An increasing role in prostate cancer detection?

    Spârchez, Zeno

    Medical ultrasonography

    2011  Volume 13, Issue 1, Page(s) 3–4

    MeSH term(s) Computer Systems ; Elasticity Imaging Techniques/methods ; Humans ; Image Enhancement/methods ; Male ; Prostate/diagnostic imaging ; Prostatic Neoplasms/diagnostic imaging
    Language English
    Publishing date 2011-03
    Publishing country Romania
    Document type Editorial ; Comment
    ZDB-ID 2529623-1
    ISSN 2066-8643 ; 1844-4172
    ISSN (online) 2066-8643
    ISSN 1844-4172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The added value of CEUS and ultrasound-guided biopsy in diagnosing an aggressive desmoplastic small round cell tumour of peritoneum in a young male. A case report.

    Sparchez, Mihaela / Mocan, Tudor / Caraiani, Cosmin / Rusu, Ioana / Sparchez, Zeno Adrian

    Medical ultrasonography

    2022  

    Abstract: Desmoplastic small round cell tumour (DSRCT) is a rare and highly aggressive mesenchymal neoplasm with poor prognosis that develops in male adolescents and young adults. We report the case of a 32-year-old male admitted with abdominal distension and ... ...

    Abstract Desmoplastic small round cell tumour (DSRCT) is a rare and highly aggressive mesenchymal neoplasm with poor prognosis that develops in male adolescents and young adults. We report the case of a 32-year-old male admitted with abdominal distension and ascites. An ultrasonography (US) scan showed multiple peritoneal masses with large ascites. The dominant mass had a hypervascular homogenous aspect at contrast-enhanced ultrasound with wash-out in the venous phase. Thoracoabdominal CT, performed for staging the disease, confirmed the US aspect. The US-guided percutaneous biopsy revealed DSRCT of the peritoneum. Chemotherapy was then started with minimal clinical improvement, increase in tumoral burden and death after three months. US and US-guided biopsy played an essential role in diagnosing this case. The aggressive course of the disease and seeding at paracentesis sites are the particularities of the presented case.
    Language English
    Publishing date 2022-03-06
    Publishing country Romania
    Document type Case Reports
    ZDB-ID 2529606-1
    ISSN 2066-8643 ; 1844-4172
    ISSN (online) 2066-8643
    ISSN 1844-4172
    DOI 10.11152/mu-3502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: The Role of Immunohistochemistry in the Differential Diagnosis between Intrahepatic Cholangiocarcinoma, Hepatocellular Carcinoma and Liver Metastasis, as Well as Its Prognostic Value.

    Mocan, Lavinia Patricia / Rusu, Ioana / Melincovici, Carmen Stanca / Boșca, Bianca Adina / Mocan, Tudor / Crăciun, Rareș / Spârchez, Zeno / Iacobescu, Maria / Mihu, Carmen Mihaela

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 9

    Abstract: Intrahepatic cholangiocarcinoma (iCCA) is the second most frequent primary hepatic malignant tumor, after hepatocellular carcinoma (HCC). Its incidence has risen worldwide, yet the only potentially curative treatment, surgical resection, is seldom ... ...

    Abstract Intrahepatic cholangiocarcinoma (iCCA) is the second most frequent primary hepatic malignant tumor, after hepatocellular carcinoma (HCC). Its incidence has risen worldwide, yet the only potentially curative treatment, surgical resection, is seldom applicable, and the median overall survival remains extremely low. So far, there are no personalized therapy regimens. This study investigated whether routine immunohistochemical stains have diagnostic and/or prognostic value in iCCA. Clinical, imaging, and pathology data were retrospectively gathered for patients diagnosed with iCCA, HCC, or liver metastases assessed using liver needle biopsies. Three study groups with an equal number of cases (
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13091542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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