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Article ; Online: Fk506 Inhibit Liver Regeneration in HOC Model Rat.

Zhang, Binbin / Han, Bing / Gao, Fei / Fu, Xifeng / Tian, Yanzhang

2023 Volume 55, Issue 3, Page(s) 637–642

Abstract: Background: Studies have shown that lymphocytes support hepatic oval cell (HOC)-dependent liver regeneration and FK506（Tacrolimus） is known as an immunosuppressor. Therefore, we studied the role of FK506 in HOC activation and/or proliferation to guide ... ...

Abstract	Background: Studies have shown that lymphocytes support hepatic oval cell (HOC)-dependent liver regeneration and FK506（Tacrolimus） is known as an immunosuppressor. Therefore, we studied the role of FK506 in HOC activation and/or proliferation to guide the clinical use of FK506. Methods: Thirty male Lewis rats were randomly divided into 4 groups: (A) intervene in activation (n = 8), (B) intervene in proliferation (n = 8), (C) control HOC model (n = 8), and (D) pure partial hepatectomy (PH) (n = 6). The HOC model was established by 2AAF(2-acetylaminofluorene)/PH in groups A to C. FK506 (at a dose of 1 mg/kg/d) was given subcutaneously in group A except on operation day, and not until day 8 post-operation (PO) in group B. Half of the animals were euthanized on days 10 and 14 PO, respectively. The remnant liver was weighed and stained by hematoxylin and eosin and immunohistochemical staining of proliferating cell nuclear antigen and epithelial cell adhesion molecule enabled HOC proliferation analysis. Results: FK506 intervention exacerbated liver damage and hindered the recovery of the HOC model rat. Weight gain was severely retarded or even negative. Liver weight and the liver body weight ratio were lower than control group. HE and immunohistochemistry showed pooer proliferation of hepatocytes and fewer HOC numbers in group A. Conclusion: FK506 inhibited HOC activation by affecting T and NK cells, ultimately blocking liver regeneration. Poor liver regeneration after auxiliary liver transplantation might be associated with the inhibition of HOC activation and proliferation caused by FK506 treatment.
MeSH term(s)	Rats ; Male ; Animals ; Liver Regeneration/physiology ; Tacrolimus/pharmacology ; Rats, Inbred Lew ; Liver/surgery ; Hepatocytes ; Hepatectomy ; Cell Proliferation ; Focal Nodular Hyperplasia/surgery
Chemical Substances	Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2023.02.054
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Article ; Online: [Retracted] Induction of apoptosis by casticin in cervical cancer cells through reactive oxygen species‑mediated mitochondrial signaling pathways.

Chen, Dan / Cao, Jianguo / Tian, Li / Liu, Fei / Sheng, Xifeng

Oncology reports

2022 Volume 49, Issue 1

Abstract: Following the publication of the above paper, it was drawn to the Editors' attention by a concerned reader that certain of the lanes shown in the DNA agarose gel electrophoresis experiment in Figs. 2D bore some striking similarities; furthermore, there ... ...

Abstract	Following the publication of the above paper, it was drawn to the Editors' attention by a concerned reader that certain of the lanes shown in the DNA agarose gel electrophoresis experiment in Figs. 2D bore some striking similarities; furthermore, there were unexpectedly similar‑looking bands included within the gel slices for the western blotting experiments portrayed in Fig. 3B and C. The Editor of
Language	English
Publishing date	2022-11-23
Publishing country	Greece
Document type	Retraction of Publication
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2022.8448
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Zs.A 4213: Show issues

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Article ; Online: Evaluation of Multiple Liver Cancer Scoring Systems.

Sun, Jingchao / Qi, Chao / Liu, Ya / Gao, Fei / Fu, Xifeng / Tian, Yanzhang

Advanced biology

2023 Volume 8, Issue 2, Page(s) e2300301

Abstract: Liver cancer is one of the most common malignant tumors in the world, and its incidence and mortality are increasing year by year. The prognosis of liver cancer depends on the stage of liver cancer, the treatment method, the liver function, and ... ...

Abstract	Liver cancer is one of the most common malignant tumors in the world, and its incidence and mortality are increasing year by year. The prognosis of liver cancer depends on the stage of liver cancer, the treatment method, the liver function, and individual differences. The prognosis of liver cancer mainly worsens with the progression of the stage. The prediction and staging system of liver cancer prognosis plays a very important role in the outcome of liver cancer prognosis, providing some guidance for clinical practice and bringing benefits for patients. This article reports on the prediction models and staging systems that have been applied in the field of liver cancer in the past 5 years, objectively analyzes the advantages and disadvantages, applicable population of each model and staging system, and searches for other patient and clinical characteristics that need to be considered for successfully establishing a prediction model, aiming to improve the specificity, sensitivity, and accuracy of liver cancer prediction and increase the overall survival rate of liver cancer.
MeSH term(s)	Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/therapy ; Prognosis
Language	English
Publishing date	2023-10-20
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	2701-0198
ISSN (online)	2701-0198
DOI	10.1002/adbi.202300301
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Article ; Online: Hypoxia-Responsive T

Lu, Zhongzhong / Yan, Jincong / Zu, Guangyue / Xu, Mingsheng / Liu, Jihuan / Zhang, Ye / Shi, Lei / Fei, Xifeng / Cao, Yi / Pei, Renjun

Bioconjugate chemistry

2023 Volume 34, Issue 9, Page(s) 1622–1632

Abstract: To realize the accurate diagnosis of tumors by magnetic resonance imaging (MRI), switchable magnetic resonance contrast agents (CAs) between ... ...

Abstract	To realize the accurate diagnosis of tumors by magnetic resonance imaging (MRI), switchable magnetic resonance contrast agents (CAs) between T
MeSH term(s)	Humans ; Contrast Media/chemistry ; Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Polyethylene Glycols/chemistry ; Magnetic Iron Oxide Nanoparticles ; Nanoparticles/chemistry ; Tumor Microenvironment
Chemical Substances	Contrast Media ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/acs.bioconjchem.3c00285
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Article ; Online: Safety, Tolerability, and Pharmacokinetics of Anaprazole, a Novel Proton Pump Inhibitor, in Healthy Chinese Subjects.

Wang, Fangfang / Niu, Xiaoye / Liu, Fei / Ma, Xifeng / Cheng, Fang / Xu, Haiyan / Wang, Li / Xu, Yanjun / Li, Haiyan

Clinical pharmacology in drug development

2024

Abstract: Anaprazole, a newly developed oral proton pump inhibitor, was evaluated for safety, tolerability, and pharmacokinetics in healthy Chinese subjects. This study involved administering either anaprazole sodium enteric-coated tablet or placebo, followed by ... ...

Abstract	Anaprazole, a newly developed oral proton pump inhibitor, was evaluated for safety, tolerability, and pharmacokinetics in healthy Chinese subjects. This study involved administering either anaprazole sodium enteric-coated tablet or placebo, followed by monitoring the incidence and severity of any adverse events (AEs). The pharmacokinetic parameters of anaprazole, its isomer, and main metabolisms were determined. The results showed that both single-dose (2.5-120 mg) and multiple-dose (20 mg once daily, 40 mg once daily, or 20 mg twice daily) oral administration of anaprazole sodium enteric-coated tablet were safe and well tolerated. Following single-dose administration, the median time to reach maximum plasma concentration of anaprazole was between 3.50 and 5.25 hours, with mean elimination half-life of 1.22-3.79 hours. The absorption and elimination of anaprazole in the human body appeared to basically follow linear kinetics. After repeated dosing, steady-state concentrations of anaprazole, its isomer, and primary metabolites were achieved, with a median time to reach maximum plasma concentration of 3-3.75 hours and a mean elimination half-life of 1.61-2.27 hours for anaprazole. There was no significant drug accumulation after multiple-dose oral administration. In conclusion, anaprazole sodium enteric-coated tablets were found to be safe and well tolerated in healthy Chinese individuals. Anaprazole is absorbed and metabolized consistently in the human body without any accumulation.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649010-9
ISSN	2160-7648 ; 2160-763X
ISSN (online)	2160-7648
ISSN	2160-763X
DOI	10.1002/cpdd.1405
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Article ; Online: Combined contributions of cytochrome P450s (CYPs) and non-enzymatic metabolism in the in vitro biotransformation of anaprazole, a novel proton pump inhibitor.

Liu, Fei / Xu, Yanjun / Wang, Li / Ma, Xifeng / Zhang, Zhen / Zhuang, Xiaomei

Naunyn-Schmiedeberg's archives of pharmacology

2023 Volume 396, Issue 8, Page(s) 1759–1771

Abstract: Anaprazole, a new proton pump inhibitor (PPI), is designed for the treatment of acid-related diseases, such as gastric ulcers and gastroesophageal reflux. This study explored the in vitro metabolic transformation of anaprazole. The metabolic stabilities ... ...

Abstract	Anaprazole, a new proton pump inhibitor (PPI), is designed for the treatment of acid-related diseases, such as gastric ulcers and gastroesophageal reflux. This study explored the in vitro metabolic transformation of anaprazole. The metabolic stabilities of anaprazole in human plasma and human liver microsomes (HLM) were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Then, the contribution (%) of non-enzymatic and cytochrome P450s (CYPs) enzyme-mediated anaprazole metabolism was assessed. To obtain the metabolic pathways of anaprazole, the metabolites generated in HLM, thermal deactivated HLM, and cDNA-expressed recombinant CYPs incubation systems were identified by ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS). Results showed that anaprazole was very stable in human plasma and unstable in HLM. The contribution (%) of non-enzymatic vs. CYPs enzyme-mediated metabolism was 49% vs. 51%. CYP3A4 was the major enzyme (48.3%), followed by CYP2C9 (17.7%) and CYP2C8 (12.3%), in responsible for the metabolism of anaprazole. Specific chemical inhibitors targeting CYP enzymes notably blocked the metabolic transformation of anaprazole. Six metabolites of anaprazole were identified in the non-enzymatic system, whereas 17 metabolites were generated in HLM. The biotransformation reactions mainly included sulfoxide reduction to thioether, sulfoxide oxidation to sulfone, deoxidation, dehydrogenation, O-dealkylation or O-demethylation of thioether, O-demethylation and dehydrogenation of thioether, O-dealkylation and dehydrogenation of thioether, thioether O-dealkylation and dehydrogenation of thioether, and O-dealkylation of sulfone. Both enzymatic and non-enzymatic metabolisms contribute to the clearance of anaprazole in human. Anaprazole is less likely to develop drug-drug interactions in clinical use compared to other PPIs.
MeSH term(s)	Humans ; Proton Pump Inhibitors/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry/methods ; Cytochrome P-450 Enzyme System/metabolism ; Biotransformation ; Sulfoxides/metabolism ; Sulfoxides/pharmacology ; Sulfones ; Sulfides
Chemical Substances	Proton Pump Inhibitors ; Cytochrome P-450 Enzyme System (9035-51-2) ; Sulfoxides ; Sulfones ; Sulfides
Language	English
Publishing date	2023-02-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02415-7
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Article ; Online: Diverse Sesquiterpenoids from the Roots of Croton crassifolius and Their Inhibitory Effects on Ferroptosis.

Yang, Fei / Jiang, Xiufen / Cao, Liudan / Gu, Qiong / Teng, Xifeng / He, Lin

Chemistry & biodiversity

2022 Volume 19, Issue 4, Page(s) e202101028

Abstract: One new sesquiterpenoid, 10-epi-lochmolin F (1), together with 13 known sesquiterpenoids, was isolated from the roots of Croton crassifolius. The structures of these compounds were confirmed by UV, IR, MS, and NMR spectroscopic analysis. The absolute ... ...

Abstract	One new sesquiterpenoid, 10-epi-lochmolin F (1), together with 13 known sesquiterpenoids, was isolated from the roots of Croton crassifolius. The structures of these compounds were confirmed by UV, IR, MS, and NMR spectroscopic analysis. The absolute configuration of compound 1 was elucidated by analysis of X-ray crystallography. All the 14 isolated sesquiterpenoids were screened for their inhibitory effects on ferroptosis in HT-22 cells. Two compounds 4 and 7 showed certain inhibitory effects against RSL3-induced ferroptosis with EC
MeSH term(s)	Croton/chemistry ; Crystallography, X-Ray ; Ferroptosis ; Molecular Structure ; Plant Roots/chemistry ; Sesquiterpenes/chemistry
Chemical Substances	Sesquiterpenes
Language	English
Publishing date	2022-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202101028
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Article ; Online: Inhibition of TGF-β1-induced epithelial-mesenchymal transition in gliomas by DMC-HA.

Shi, Lei / Wang, Zhimin / Rong, Jun / Fei, Xifeng / Li, Xuetao / He, Bao / Gong, Weiyi / Qian, Jin

Aging

2023 Volume 15, Issue 24, Page(s) 15183–15195

Abstract: DMC-HA, a novel HDAC inhibitor, has previously demonstrated antiproliferative activity against various cancers, including gliomas. However, the role of DMC-HA in the regulation of EMT and its underlying mechanisms remain unknown. This study aimed to ... ...

Abstract	DMC-HA, a novel HDAC inhibitor, has previously demonstrated antiproliferative activity against various cancers, including gliomas. However, the role of DMC-HA in the regulation of EMT and its underlying mechanisms remain unknown. This study aimed to explore the effects of DMC-HA on TGF-β1-induced EMT in human gliomas and the underlying mechanisms involved. Our results showed that TGF-β1 induced EMT of U87 and U251 cells, leading to a decrease in epithelial marker ZO-1 and an increase in mesenchymal markers N-cadherin and Vimentin. Moreover, TGF-β1 treatment resulted in a significant increase in the migratory and invasive abilities of the cells. However, treatment with DMC-HA effectively inhibited the augmented migration and invasion of glioma cells induced by TGF-β1. Additionally, DMC-HA inhibits TGF-β1-induced EMT by suppressing canonical Smad pathway and non-canonical TGF-β/Akt and Erk signalling pathways. These findings suggest that DMC-HA has potential therapeutic implications for gliomas by inhibiting EMT progression.
MeSH term(s)	Humans ; Cell Line, Tumor ; Cell Movement ; Epithelial-Mesenchymal Transition/drug effects ; Glioma/drug therapy ; Transforming Growth Factor beta1/antagonists & inhibitors ; Transforming Growth Factor beta1/metabolism ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use
Chemical Substances	Transforming Growth Factor beta1 ; Histone Deacetylase Inhibitors
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205340
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Article ; Online: Quantitative proteomic dataset of whole protein in three melanoma samples of 92.1, 92.1-A and 92.1-B.

Fei, Xifeng / Xie, Xiangtong / Ji, Xiaoyan / Tian, Haiyan / Sun, Fei / Jiang, Dongyi / Wang, Zhimin / Huang, Qiang

Data in brief

2022 Volume 45, Page(s) 108592

Abstract: Distant metastasis is common in ocular uveal melanoma (uveal melanoma, UM) [1], with possible identification of relevant protein markers in peripheral blood [2], [3]. Proteomics analyses serve as a basis for the screening of new target proteins. However, ...

Abstract	Distant metastasis is common in ocular uveal melanoma (uveal melanoma, UM) [1], with possible identification of relevant protein markers in peripheral blood [2], [3]. Proteomics analyses serve as a basis for the screening of new target proteins. However, it is difficult to determine whether the relevant proteins in peripheral blood are the same kinesins as those in primary lesions and metastases. Specially in this study, human UM cells (92.1) [4] were inoculated into the back of the eyeball and the brain of inbred line nude mice transplanted with enhanced green fluorescent protein (EGFP) [5], respectively, to simulate the growth of UM
Language	English
Publishing date	2022-09-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.108592
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Article ; Online: Tumor-Microenvironment-Activatable Nanoparticle Mediating Immunogene Therapy and M2 Macrophage-Targeted Inhibitor for Synergistic Cancer Immunotherapy.

Hu, Yuzhu / Nie, Wen / Lyu, Liang / Zhang, Xifeng / Wang, Wanyu / Zhang, Yunchu / He, Shi / Guo, Anjie / Liu, Fei / Wang, Bilan / Qian, Zhiyong / Gao, Xiang

ACS nano

2024 Volume 18, Issue 4, Page(s) 3295–3312

Abstract: Immunotherapy has achieved prominent clinical efficacy in combating cancer and has recently become a mainstream treatment strategy. However, achieving broad efficacy with a single modality is challenging, and the heterogeneity of the tumor ... ...

Abstract	Immunotherapy has achieved prominent clinical efficacy in combating cancer and has recently become a mainstream treatment strategy. However, achieving broad efficacy with a single modality is challenging, and the heterogeneity of the tumor microenvironment (TME) restricts the accuracy and effectiveness of immunotherapy strategies for tumors. Herein, a TME-responsive targeted nanoparticle to enhance antitumor immunity and reverse immune escape by codelivering interleukin-12 (IL-12) expressing gene and colony-stimulating factor-1 receptor (CSF-1R) inhibitor PLX3397 (PLX) is presented. The introduction of disulfide bonds and cyclo(Arg-Gly-Asp-d-Phe-Lys) (cRGD) peptides conferred reduction reactivity and tumor targeting to the nanoparticles, respectively. It is hypothesized that activating host immunity by the local expression of IL-12, while modulating the tumor-associated macrophages (TAM) function through blocking CSF-1/CSF-1R signaling, could constitute a feasible approach for cancer immunotherapy. The fabricated functional nanoparticle successfully ameliorated the TME by stimulating the proliferation and activation of T lymphocytes, promoting the repolarization of TAMs, reducing myeloid-derived suppressor cells (MDSCs), and promoting the maturation of dendritic cells (DC) as well as the secretion of antitumor cytokines, which efficiently suppressed tumor growth and metastasis. Finally, substantial changes in the TME were deciphered by single-cell analysis including infiltration of different cells, transcriptional states, secretory signaling and cell-cell communications. These findings provide a promising combinatorial immunotherapy strategy through immunomodulatory nanoparticles.
MeSH term(s)	Humans ; Tumor Microenvironment ; Immunotherapy ; Macrophages/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Interleukin-12/metabolism ; Nanoparticles/chemistry ; Cell Line, Tumor
Chemical Substances	Interleukin-12 (187348-17-0)
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c10037
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