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  1. Article ; Online: Smart apps for self-reporting clinical information.

    Houhamdi, Linda / Fournier, Pierre-Edouard

    Lancet (London, England)

    2022  Volume 399, Issue 10335, Page(s) 1575–1576

    MeSH term(s) Humans ; Mobile Applications ; Smartphone
    Language English
    Publishing date 2022-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00453-6
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  2. Article: Coxiella burnetii

    Azouzi, Farah / Olagne, Louis / Edouard, Sophie / Cammilleri, Serge / Magnan, Pierre-Edouard / Fournier, Pierre-Edouard / Million, Matthieu

    Microorganisms

    2023  Volume 11, Issue 9

    Abstract: Cardiovascular infections are the most severe and potentially lethal among the persistent ... ...

    Abstract Cardiovascular infections are the most severe and potentially lethal among the persistent focalized
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11092146
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  3. Article ; Online: Draft Genomes of Two Fusobacterium simiae Strains.

    Zoaiter, Malak / Fournier, Pierre-Edouard / Houhamdi, Linda

    Microbiology resource announcements

    2023  Volume 12, Issue 4, Page(s) e0125522

    Abstract: Here, we reported two draft genomes of Fusobacterium simiae: strain DSM 19848, initially isolated from monkey dental plaque, and its close relative strain Marseille-Q7035, cultivated from a human intra-abdominal abscess puncture fluid. Their genome sizes ...

    Abstract Here, we reported two draft genomes of Fusobacterium simiae: strain DSM 19848, initially isolated from monkey dental plaque, and its close relative strain Marseille-Q7035, cultivated from a human intra-abdominal abscess puncture fluid. Their genome sizes are 2.4 Mb and 2.5Mb, respectively. Their G+C contents were 27.1% and 27.2%, respectively.
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.01255-22
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  4. Article ; Online: Coxiella burnetii Femoro-Popliteal Bypass Infection

    Farah Azouzi / Louis Olagne / Sophie Edouard / Serge Cammilleri / Pierre-Edouard Magnan / Pierre-Edouard Fournier / Matthieu Million

    Microorganisms, Vol 11, Iss 2146, p

    A Case Report

    2023  Volume 2146

    Abstract: Cardiovascular infections are the most severe and potentially lethal among the persistent focalized Coxiella burnetii infections. While aortic infections on aneurysms or prostheses are well-known, with specific complications (risk of fatal rupture), new ... ...

    Abstract Cardiovascular infections are the most severe and potentially lethal among the persistent focalized Coxiella burnetii infections. While aortic infections on aneurysms or prostheses are well-known, with specific complications (risk of fatal rupture), new non-aortic vascular infections are increasingly being described thanks to the emerging use of 18-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET-scan). Here, we describe an infection of a femoro-popliteal bypass that would not have been diagnosed without the use of PET-scan. It is well-known that vascular prosthetic material is a site favorable for bacterial persistence, but the description of unusual anatomical sites, outside the heart or aorta, should raise the clinicians’ awareness and generalize the indications for PET-scan, with careful inclusion of the upper and lower limbs (not included in PET-scan for cancer), particularly in the presence of vascular prostheses. Future studies will be needed to precisely determine their optimal management.
    Keywords Q fever ; Coxiella burnetii ; PET-scan ; vascular graft infection ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  5. Article ; Online: Incidental diagnosis of mpox virus infection in patients undergoing sexually transmitted infection screening-findings from a study in France.

    Edouard, Sophie / Boschi, Céline / Colson, Philippe / Million, Matthieu / Fournier, Pierre-Edouard / La Scola, Bernard / Fenollar, Florence

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 143, Page(s) 107009

    Abstract: Objectives: This study aimed to investigate the prevalence of mpox virus (MPXV) infections in the general population consulting for routine sexually transmitted infections (STIs) in our Marseille public hospital. In fact, the recent worldwide MPXV ... ...

    Abstract Objectives: This study aimed to investigate the prevalence of mpox virus (MPXV) infections in the general population consulting for routine sexually transmitted infections (STIs) in our Marseille public hospital. In fact, the recent worldwide MPXV outbreak mainly impacted men who have sex with men and the prevalence of MPXV infections in the general population remains poorly defined.
    Methods: All samples addressed routinely to our microbiological laboratory for STIs between July 1 and October 15, 2022 were screened with MPXV-specific quantitative polymerase chain reaction.
    Results: A total of 2688 samples from 1896 patients suspected of having STIs were tested and eight (0.4%) patients were incidentally diagnosed with MPXV infection, including six men and two women. MPXV was detected in rectal swabs (n = 2), urine (n = 2), vaginal swabs (n = 2), a urethral swab (n = 1), and a skin swab (n = 1).
    Conclusions: This study suggests that some MPXV infections are likely to be underdiagnosed because of their non-specific clinical presentation and/or insufficient clinical knowledge of the disease. Our data showed that systematic screening was particularly useful for detecting MPXV in patients without classic lesions or cases of asymptomatic carriage in patients reporting recent high-risk exposure and in patients presenting no obvious risk factor.
    Language English
    Publishing date 2024-03-21
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107009
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Culture-negative endocarditis caused by <i>Stenotrophomonas maltophilia</i>: a report of two cases.

    Balasubramanian, Rayvathy / Fournier, Pierre-Edouard / Menon, Thangam

    Future microbiology

    2022  Volume 17, Page(s) 819–822

    Abstract: ... Stenotrophomonas maltophilia ... , an aerobic, non-fermenting, Gram-negative bacterium, is an emerging nosocomial pathogen. It is considered to be a low-grade pathogen, and infections due to ... S. maltophilia ... are uncommon. However, in the recent ... ...

    Abstract Stenotrophomonas maltophilia, an aerobic, non-fermenting, Gram-negative bacterium, is an emerging nosocomial pathogen. It is considered to be a low-grade pathogen, and infections due to S. maltophilia are uncommon. However, in the recent past, S. maltophilia infections have been on the rise, particularly in patients who are either immunocompromised, aged or on long-term antibiotic therapy. Endocarditis due to S. maltophilia is extremely rare. This is a report of two patients with S. maltophilia endocarditis who were diagnosed by 16S rRNA gene sequencing.
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Endocarditis/complications ; Endocarditis/diagnosis ; Endocarditis/drug therapy ; Gram-Negative Bacterial Infections/diagnosis ; Gram-Negative Bacterial Infections/drug therapy ; Humans ; RNA, Ribosomal, 16S/genetics ; Stenotrophomonas maltophilia/genetics
    Chemical Substances Anti-Bacterial Agents ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2021-0313
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  7. Article ; Online: Carbonyl Cyanide 3-Chloro Phenyl Hydrazone (CCCP) Restores the Colistin Sensitivity in

    Zoaiter, Malak / Zeaiter, Zaher / Mediannikov, Oleg / Sokhna, Cheikh / Fournier, Pierre-Edouard

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: ... Brucella ... ...

    Abstract Brucella intermedia
    MeSH term(s) Humans ; Colistin/pharmacology ; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology ; Hydrazones ; Anti-Bacterial Agents/pharmacology ; Brucella ; Microbial Sensitivity Tests
    Chemical Substances Colistin (Z67X93HJG1) ; mesoxalonitrile (1115-12-4) ; Carbonyl Cyanide m-Chlorophenyl Hydrazone (555-60-2) ; Hydrazones ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032106
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  8. Article ; Online: Past Bartonelloses.

    Fournier, Pierre-Edouard

    Microbiology spectrum

    2016  Volume 4, Issue 3

    Abstract: The origins of human infectious diseases have long fascinated scientists worldwide. Paleomicrobiology offers a unique access to the history of these infections and sheds light on ancient and historical epidemics. In this chapter, we review the ... ...

    Abstract The origins of human infectious diseases have long fascinated scientists worldwide. Paleomicrobiology offers a unique access to the history of these infections and sheds light on ancient and historical epidemics. In this chapter, we review the paleomicrobiological evidence for Bartonella infections.
    MeSH term(s) Animals ; Bacteriological Techniques/methods ; Bartonella/isolation & purification ; Bartonella Infections/epidemiology ; Bartonella Infections/history ; Fossils/microbiology ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, Ancient ; History, Medieval ; Humans ; Paleopathology/methods
    Language English
    Publishing date 2016-06-20
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ISSN 2165-0497
    ISSN (online) 2165-0497
    DOI 10.1128/microbiolspec.PoH-0007-2015
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  9. Article ; Online: Carbonyl Cyanide 3-Chloro Phenyl Hydrazone (CCCP) Restores the Colistin Sensitivity in Brucella intermedia

    Malak Zoaiter / Zaher Zeaiter / Oleg Mediannikov / Cheikh Sokhna / Pierre-Edouard Fournier

    International Journal of Molecular Sciences, Vol 24, Iss 2106, p

    2023  Volume 2106

    Abstract: Brucella intermedia (formerly Ochrobactrum intermedium ), a non-fermentative bacterium, has been isolated from animals and human clinical specimens. It is naturally resistant to polymyxins, including colistin (CO), and may cause opportunistic infections ... ...

    Abstract Brucella intermedia (formerly Ochrobactrum intermedium ), a non-fermentative bacterium, has been isolated from animals and human clinical specimens. It is naturally resistant to polymyxins, including colistin (CO), and may cause opportunistic infections in humans. We isolated six Brucella intermedia strains from Senegalese monkey stool. In order to determine whether an efflux pump mechanism was involved in CO resistance in B. intermedia, we evaluated the effects of verapamil (VRP), reserpine (RSP), phe-arg β-naphthylamide dihydrochloride (PAβN) and carbonyl cyanide 3-chloro phenyl hydrazone (CCCP), four efflux pump inhibitors, on these colistin-resistant strains. Using the broth microdilution method, a CO and CCCP combination of 2 µg/mL and 10 µg/mL, respectively, significantly reduced the CO minimal inhibitory concentration (MIC) of B. intermedia , supporting an efflux pump mechanism. In contrast, VRP, PAβN and RSP did not restore CO susceptibility. A time kill assay showed a bactericidal effect of the CO–CCCP combination. Genomic analysis revealed a potential implication in the CO resistance mechanism of some conserved efflux pumps, such as YejABEF, NorM and EmrAB, as previously reported in other bacteria. An inhibitory effect of the CO–CCCP combination was observed on biofilm formation using the crystal violet method. These results suggest that the intrinsic CO resistance in Brucella intermedia is linked to an efflux pump mechanism and that the synergistic effect of CO–CCCP may open a new field to identify new treatments to restore antibiotic efficacy in humans.
    Keywords intrinsic colistin resistance ; efflux pump inhibitors ; carbonyl cyanide 3-chloro phenyl hydrazone ; CO-MIC ; synergy ; efflux pump ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Reclassification of eight Akkermansia muciniphila strains and description of Akkermansia massiliensis sp. nov. and Candidatus Akkermansia timonensis, isolated from human feces.

    Ndongo, Sokhna / Armstrong, Nicholas / Raoult, Didier / Fournier, Pierre-Edouard

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21747

    Abstract: Akkermansia muciniphila is a human intestinal tract bacterium that plays an important role in the mucus layer renewal. Several studies have demonstrated that it is a modulator for gut homeostasis and a probiotic for human health. The Akkermansia genus ... ...

    Abstract Akkermansia muciniphila is a human intestinal tract bacterium that plays an important role in the mucus layer renewal. Several studies have demonstrated that it is a modulator for gut homeostasis and a probiotic for human health. The Akkermansia genus contains two species with standing in nomenclature but their genomic diversity remains unclear. In this study, eight new Akkermansia sp. strains were isolated from the human gut. Using the digital DNA-DNA hybridization (dDDH), average nucleotide identity (ANI) and core genome-based phylogenetic analysis applied to 104 A. muciniphila whole genomes sequences, strains were reclassified into three clusters. Cluster I groups A. muciniphila strains (including strain ATCC BAA-835
    Language English
    Publishing date 2022-12-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-25873-0
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