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  1. Article ; Online: Conversion of a dietary fructose: new clues from the gut microbiome.

    Postic, Catherine

    Nature metabolism

    2020  Volume 2, Issue 3, Page(s) 217–218

    Language English
    Publishing date 2020-03-09
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-020-0185-x
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  2. Article ; Online: La O-GlcNAc transférase - Un « senseur » de nutriments impliqué dans l’homéostasie hépatique.

    Parlati, Lucia / Regnier, Marion / Benhamed, Fadila / Issad, Tarik / Postic, Catherine

    Medecine sciences : M/S

    2024  Volume 40, Issue 2, Page(s) 137–139

    Title translation O-GlcNAc transferase: A nutrient sensor involved in hepatic homeostasis.
    MeSH term(s) Humans ; N-Acetylglucosaminyltransferases ; Animals
    Chemical Substances N-Acetylglucosaminyltransferases (EC 2.4.1.-) ; O-GlcNAc transferase (EC 2.4.1.-)
    Language French
    Publishing date 2024-02-27
    Publishing country France
    Document type Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2023210
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  3. Article: Editorial: The liver as an endocrine organ: Hepatokines and ketone bodies, novel hormones to be acknowledged.

    Risi, Renata / Postic, Catherine / Watanabe, Mikiko

    Frontiers in endocrinology

    2023  Volume 13, Page(s) 1117773

    MeSH term(s) Humans ; Ketone Bodies ; Non-alcoholic Fatty Liver Disease ; Hormones ; Abdomen
    Chemical Substances Ketone Bodies ; Hormones
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.1117773
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  4. Article: New insights into the inter-organ crosstalk mediated by ChREBP.

    Carbinatti, Thais / Régnier, Marion / Parlati, Lucia / Benhamed, Fadila / Postic, Catherine

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1095440

    Abstract: Carbohydrate response element binding protein (ChREBP) is a glucose responsive transcription factor recognized by its critical role in the transcriptional control of glycolysis ... ...

    Abstract Carbohydrate response element binding protein (ChREBP) is a glucose responsive transcription factor recognized by its critical role in the transcriptional control of glycolysis and
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2 ; Gene Expression Regulation ; Non-alcoholic Fatty Liver Disease ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors ; MLXIPL protein, human
    Language English
    Publishing date 2023-02-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1095440
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  5. Article ; Online: The role of ChREBP in carbohydrate sensing and NAFLD development.

    Régnier, Marion / Carbinatti, Thaïs / Parlati, Lucia / Benhamed, Fadila / Postic, Catherine

    Nature reviews. Endocrinology

    2023  Volume 19, Issue 6, Page(s) 336–349

    Abstract: Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). Hepatic metabolism of carbohydrates into ... ...

    Abstract Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). Hepatic metabolism of carbohydrates into lipids is largely dependent on the carbohydrate-responsive element binding protein (ChREBP), a transcription factor that senses intracellular carbohydrates and activates many different target genes, through the activation of de novo lipogenesis (DNL). This process is crucial for the storage of energy as triglycerides in hepatocytes. Furthermore, ChREBP and its downstream targets represent promising targets for the development of therapies for the treatment of NAFLD and T2DM. Although lipogenic inhibitors (for example, inhibitors of fatty acid synthase, acetyl-CoA carboxylase or ATP citrate lyase) are currently under investigation, targeting lipogenesis remains a topic of discussion for NAFLD treatment. In this Review, we discuss mechanisms that regulate ChREBP activity in a tissue-specific manner and their respective roles in controlling DNL and beyond. We also provide in-depth discussion of the roles of ChREBP in the onset and progression of NAFLD and consider emerging targets for NAFLD therapeutics.
    MeSH term(s) Humans ; Carbohydrates ; Diabetes Mellitus, Type 2/metabolism ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Transcription Factors/metabolism
    Chemical Substances Carbohydrates ; Transcription Factors ; MLXIPL protein, human
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-023-00809-4
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    Zs.MG 93: Show issues

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  6. Article: Carbohydrate Sensing Through the Transcription Factor ChREBP.

    Ortega-Prieto, Paula / Postic, Catherine

    Frontiers in genetics

    2019  Volume 10, Page(s) 472

    Abstract: Carbohydrate response element binding protein (ChREBP) is a carbohydrate-signaling transcription factor that in the past years has emerged as a central metabolic regulator. ChREBP expression is mostly abundant in active sites ... ...

    Abstract Carbohydrate response element binding protein (ChREBP) is a carbohydrate-signaling transcription factor that in the past years has emerged as a central metabolic regulator. ChREBP expression is mostly abundant in active sites of
    Language English
    Publishing date 2019-06-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2019.00472
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  7. Article ; Online: New targets for NAFLD.

    Parlati, Lucia / Régnier, Marion / Guillou, Hervé / Postic, Catherine

    JHEP reports : innovation in hepatology

    2021  Volume 3, Issue 6, Page(s) 100346

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models (dietary and genetic animal ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models (dietary and genetic animal models) of NAFLD have deepened our understanding of its aetiology and pathophysiology. Despite the progress made, there are currently no effective treatments for NAFLD. In this review, we will provide an update on the known molecular pathways involved in the pathophysiology of NAFLD and on ongoing studies of new therapeutic targets.
    Language English
    Publishing date 2021-08-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2021.100346
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  8. Article ; Online: Visco-Elastic Parameters at Three-Dimensional MR Elastography for Diagnosing Non-Alcoholic Steatohepatitis and Substantial Fibrosis in Mice.

    Khalfallah, Meryem / Doblas, Sabrina / Hammoutene, Adel / Julea, Felicia / Postic, Catherine / Valla, Dominique / Paradis, Valérie / Garteiser, Philippe / Van Beers, Bernard E

    Journal of magnetic resonance imaging : JMRI

    2023  Volume 59, Issue 1, Page(s) 97–107

    Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is increasing worldwide and is a growing cause of liver cirrhosis and cancer. The performance of the magnetic resonance elastography (MRE) visco-elastic parameters in diagnosing progressive forms of ... ...

    Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is increasing worldwide and is a growing cause of liver cirrhosis and cancer. The performance of the magnetic resonance elastography (MRE) visco-elastic parameters in diagnosing progressive forms of NAFLD, including nonalcoholic steatohepatitis (NASH) and substantial fibrosis (F ≥ 2), needs to be clarified.
    Purpose: To assess the value of three-dimensional MRE visco-elastic parameters as markers of NASH and substantial fibrosis in mice with NAFLD.
    Study type: Prospective.
    Animal model: Two mouse models of NAFLD were induced by feeding with high fat diet or high fat, choline-deficient, amino acid-defined diet.
    Field strength/sequence: 7T/multi-slice multi-echo spin-echo MRE at 400 Hz with motion encoding in the three spatial directions.
    Assessment: Hepatic storage and loss moduli were calculated. Histological analysis was based on the NASH Clinical Research Network criteria.
    Statistical tests: Mann-Whitney, Kruskal-Wallis tests, Spearman rank correlations and multiple regressions were used. Diagnostic performance was assessed with areas under the receiver operating characteristic curves (AUCs). P value <0.05 was considered significant.
    Results: Among the 59 mice with NAFLD, 21 had NASH and 20 had substantial fibrosis (including 8 mice without and 12 mice with NASH). The storage and loss moduli had similar moderate accuracy for diagnosing NASH with AUCs of 0.67 and 0.66, respectively. For diagnosing substantial fibrosis, the AUC of the storage modulus was 0.73 and the AUC of the loss modulus was 0.81, indicating good diagnostic performance. Using Spearman correlations, histological fibrosis, inflammation and steatosis, but not ballooning, were significantly correlated with the visco-elastic parameters. Using multiple regression, fibrosis was the only histological feature independently associated with the visco-elastic parameters.
    Conclusion: MRE in mice with NAFLD suggests that the storage and loss moduli have good diagnostic performance for detecting progressive NAFLD defined as substantial fibrosis rather than NASH.
    Evidence level: 1 TECHNICAL EFFICACY STAGE: 2.
    MeSH term(s) Animals ; Mice ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Elasticity Imaging Techniques/methods ; Prospective Studies ; Biopsy ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/etiology ; Fibrosis
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.28765
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    Zs.A 3648: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 236: Show issues

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  9. Article ; Online: Emerging role of miR-21 in non-alcoholic fatty liver disease.

    Benhamouche-Trouillet, Samira / Postic, Catherine

    Gut

    2016  Volume 65, Issue 11, Page(s) 1781–1783

    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2015-310044
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  10. Article ; Online: The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism.

    Benichou, Emmanuel / Seffou, Bolaji / Topçu, Selin / Renoult, Ophélie / Lenoir, Véronique / Planchais, Julien / Bonner, Caroline / Postic, Catherine / Prip-Buus, Carina / Pecqueur, Claire / Guilmeau, Sandra / Alves-Guerra, Marie-Clotilde / Dentin, Renaud

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1879

    Abstract: Cancer cells integrate multiple biosynthetic demands to drive unrestricted proliferation. How these cellular processes crosstalk to fuel cancer cell growth is still not fully understood. Here, we uncover the mechanisms by which the transcription factor ... ...

    Abstract Cancer cells integrate multiple biosynthetic demands to drive unrestricted proliferation. How these cellular processes crosstalk to fuel cancer cell growth is still not fully understood. Here, we uncover the mechanisms by which the transcription factor Carbohydrate responsive element binding protein (ChREBP) functions as an oncogene during hepatocellular carcinoma (HCC) development. Mechanistically, ChREBP triggers the expression of the PI3K regulatory subunit p85α, to sustain the activity of the pro-oncogenic PI3K/AKT signaling pathway in HCC. In parallel, increased ChREBP activity reroutes glucose and glutamine metabolic fluxes into fatty acid and nucleic acid synthesis to support PI3K/AKT-mediated HCC growth. Thus, HCC cells have a ChREBP-driven circuitry that ensures balanced coordination between PI3K/AKT signaling and appropriate cell anabolism to support HCC development. Finally, pharmacological inhibition of ChREBP by SBI-993 significantly suppresses in vivo HCC tumor growth. Overall, we show that targeting ChREBP with specific inhibitors provides an attractive therapeutic window for HCC treatment.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Liver Neoplasms/metabolism ; Signal Transduction ; Carcinogenesis ; Cell Proliferation ; Cell Line, Tumor
    Chemical Substances Transcription Factors ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45548-w
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