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  1. Article ; Online: What is obesity? : Obesity Musings.

    Dhurandhar, Nikhil V

    International journal of obesity (2005)

    2022  Volume 46, Issue 6, Page(s) 1081–1082

    MeSH term(s) Humans ; Obesity/epidemiology
    Language English
    Publishing date 2022-03-14
    Publishing country England
    Document type Editorial
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-022-01088-1
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  2. Article ; Online: The simplistic view of obesity management: a curse in disguise.

    Dhurandhar, Nikhil V

    International journal of obesity (2005)

    2022  Volume 46, Issue 9, Page(s) 1569–1570

    MeSH term(s) Humans ; Obesity/therapy
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-022-01144-w
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  3. Article ; Online: Potential contributors to variation in weight-loss response to liraglutide.

    Webster, Chelsi M / Mittal, Neha / Dhurandhar, Emily J / Dhurandhar, Nikhil V

    Obesity reviews : an official journal of the International Association for the Study of Obesity

    2023  Volume 24, Issue 7, Page(s) e13568

    Abstract: Obesity treatment requires a chronic state of negative energy balance. Obesity medications can help with this, increasing long-term dietary compliance by promoting satiety or reducing hunger. However, efficacy and safety of obesity medications vary for ... ...

    Abstract Obesity treatment requires a chronic state of negative energy balance. Obesity medications can help with this, increasing long-term dietary compliance by promoting satiety or reducing hunger. However, efficacy and safety of obesity medications vary for individuals. Early identification of non-responders to obesity medications may limit drug exposure while optimizing benefits for responders. This review summarizes factors that impact weight-loss response to liraglutide. Factors linked to greater weight loss on liraglutide include being female, not having diabetes, having relatively high baseline weight, and losing at least 4% of initial weight after 16 weeks of treatment. Other covariates that may predict treatment response but require further confirmation include central effects, nausea, gastric emptying of solids, and genotype. Baseline body mass index, race, and age seem less relevant for predicting weight-loss response to liraglutide. Lesser known and harder-to-measure factors such as cerebral blood flow, food cue reactivity, gut hormone levels, and dietary adherence possibly impact variability of response to liraglutide. This information should assist healthcare providers with establishing realistic weight-loss probability for individual patients. Future research should improve the ability to identify responders to liraglutide. Importantly, this review may provide a framework to identify responders to other obesity medications.
    MeSH term(s) Humans ; Female ; Male ; Liraglutide/pharmacology ; Liraglutide/therapeutic use ; Weight Loss ; Body Weight ; Obesity/drug therapy ; Body Mass Index ; Overweight/drug therapy ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use
    Chemical Substances Liraglutide (839I73S42A) ; Hypoglycemic Agents
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147980-X
    ISSN 1467-789X ; 1467-7881
    ISSN (online) 1467-789X
    ISSN 1467-7881
    DOI 10.1111/obr.13568
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  4. Article ; Online: Confronting the challenge of promoting fruit and vegetable intake for obesity management: An alternative approach.

    Hefner, Marleigh / Kudchadkar, Gaurav / Hia, Raksa Andalib / Sultan, Most Arifa / Booe, Holli / Dhurandhar, Nikhil V

    International journal of obesity (2005)

    2024  

    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-024-01520-8
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  5. Article ; Online: The essential role of primary care providers in obesity management.

    Whigham, Leah D / Messiah, Sarah E / Balasubramanian, Bijal A / Dhurandhar, Nikhil V

    International journal of obesity (2005)

    2023  Volume 47, Issue 4, Page(s) 249–250

    MeSH term(s) Humans ; Obesity Management ; Obesity/therapy ; Primary Health Care
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-023-01268-7
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  6. Article ; Online: E4orf1 Prevents Progression of Fatty Liver Disease in Mice on High Fat Diet.

    Afruza, Rownock / Dhurandhar, Nikhil V / Hegde, Vijay

    International journal of molecular sciences

    2022  Volume 23, Issue 16

    Abstract: Non-alcoholic fatty liver disease (NAFLD) covers a broad spectrum of liver diseases ranging from steatosis to cirrhosis. There are limited data on prevention of hepatic steatosis or its progression to liver disease. Here, we tested if either transgenic ( ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) covers a broad spectrum of liver diseases ranging from steatosis to cirrhosis. There are limited data on prevention of hepatic steatosis or its progression to liver disease. Here, we tested if either transgenic (Tg) doxycycline-induced expression in adipose tissue of E4orf1 (E4), an adenoviral protein, or dietary fat restriction attenuated hepatic steatosis or its progression in mice. Twelve to fourteen-week-old TgE4 mice (E4 group) and control mice were exposed to a 60% (Kcal) high fat diet (HFD) for 20 weeks, while another group of mice on HFD for 10 weeks were switched to a chow diet (chow group) for another 10 weeks. Glycemic control was determined at weeks 10 and 20. Tissues were collected for gene and protein analysis at sacrifice. Compared to control, diet reversal significantly reduced body weight in the chow group, whereas E4 expression attenuated weight gain, despite HFD. E4 mice evinced significantly improved glucose clearance, lower endogenous insulin secretion, reduced serum triglycerides, attenuated hepatic steatosis and inflammation. Interestingly, in spite of weight loss and lower liver fat, chow mice showed significant upregulation of hepatic genes involved in lipid metabolism. Despite HFD, E4 prevents hepatic lipid accumulation and progression of hepatic steatosis, while diet reversal maintains hepatic health, but is unable to improve molecular changes.
    MeSH term(s) Adipose Tissue/metabolism ; Animals ; Diet, High-Fat/adverse effects ; Lipid Metabolism/genetics ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/prevention & control
    Language English
    Publishing date 2022-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23169286
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  7. Article ; Online: Current formula for calculating body mass index is applicable to Asian populations.

    Misra, Anoop / Dhurandhar, Nikhil V

    Nutrition & diabetes

    2019  Volume 9, Issue 1, Page(s) 3

    MeSH term(s) Adiposity/ethnology ; Adiposity/physiology ; Asian Continental Ancestry Group ; Body Mass Index ; European Continental Ancestry Group ; Humans ; India ; Republic of Korea
    Language English
    Publishing date 2019-01-28
    Publishing country England
    Document type Editorial
    ZDB-ID 2609314-5
    ISSN 2044-4052 ; 2044-4052
    ISSN (online) 2044-4052
    ISSN 2044-4052
    DOI 10.1038/s41387-018-0070-9
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  8. Article ; Online: E4orf1 Prevents Progression of Fatty Liver Disease in Mice on High Fat Diet

    Rownock Afruza / Nikhil V. Dhurandhar / Vijay Hegde

    International Journal of Molecular Sciences, Vol 23, Iss 16, p

    2022  Volume 9286

    Abstract: Non-alcoholic fatty liver disease (NAFLD) covers a broad spectrum of liver diseases ranging from steatosis to cirrhosis. There are limited data on prevention of hepatic steatosis or its progression to liver disease. Here, we tested if either transgenic ( ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) covers a broad spectrum of liver diseases ranging from steatosis to cirrhosis. There are limited data on prevention of hepatic steatosis or its progression to liver disease. Here, we tested if either transgenic (Tg) doxycycline-induced expression in adipose tissue of E4orf1 (E4), an adenoviral protein, or dietary fat restriction attenuated hepatic steatosis or its progression in mice. Twelve to fourteen-week-old TgE4 mice (E4 group) and control mice were exposed to a 60% (Kcal) high fat diet (HFD) for 20 weeks, while another group of mice on HFD for 10 weeks were switched to a chow diet (chow group) for another 10 weeks. Glycemic control was determined at weeks 10 and 20. Tissues were collected for gene and protein analysis at sacrifice. Compared to control, diet reversal significantly reduced body weight in the chow group, whereas E4 expression attenuated weight gain, despite HFD. E4 mice evinced significantly improved glucose clearance, lower endogenous insulin secretion, reduced serum triglycerides, attenuated hepatic steatosis and inflammation. Interestingly, in spite of weight loss and lower liver fat, chow mice showed significant upregulation of hepatic genes involved in lipid metabolism. Despite HFD, E4 prevents hepatic lipid accumulation and progression of hepatic steatosis, while diet reversal maintains hepatic health, but is unable to improve molecular changes.
    Keywords obesity ; NAFLD ; NASH ; E4orf1 ; diet reversal ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Potential contributors to variation in weight‐loss response to liraglutide

    Webster, Chelsi M. / Mittal, Neha / Dhurandhar, Emily J. / Dhurandhar, Nikhil V.

    Obesity Reviews. 2023 July, v. 24, no. 7 p.e13568-

    2023  

    Abstract: Obesity treatment requires a chronic state of negative energy balance. Obesity medications can help with this, increasing long‐term dietary compliance by promoting satiety or reducing hunger. However, efficacy and safety of obesity medications vary for ... ...

    Abstract Obesity treatment requires a chronic state of negative energy balance. Obesity medications can help with this, increasing long‐term dietary compliance by promoting satiety or reducing hunger. However, efficacy and safety of obesity medications vary for individuals. Early identification of non‐responders to obesity medications may limit drug exposure while optimizing benefits for responders. This review summarizes factors that impact weight‐loss response to liraglutide. Factors linked to greater weight loss on liraglutide include being female, not having diabetes, having relatively high baseline weight, and losing at least 4% of initial weight after 16 weeks of treatment. Other covariates that may predict treatment response but require further confirmation include central effects, nausea, gastric emptying of solids, and genotype. Baseline body mass index, race, and age seem less relevant for predicting weight‐loss response to liraglutide. Lesser known and harder‐to‐measure factors such as cerebral blood flow, food cue reactivity, gut hormone levels, and dietary adherence possibly impact variability of response to liraglutide. This information should assist healthcare providers with establishing realistic weight‐loss probability for individual patients. Future research should improve the ability to identify responders to liraglutide. Importantly, this review may provide a framework to identify responders to other obesity medications.
    Keywords blood flow ; body mass index ; compliance ; diabetes ; digestive system ; drugs ; energy balance ; females ; genotype ; health services ; hunger ; nausea ; obesity ; probability ; satiety ; weight loss
    Language English
    Dates of publication 2023-07
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 2147980-X
    ISSN 1467-789X ; 1467-7881
    ISSN (online) 1467-789X
    ISSN 1467-7881
    DOI 10.1111/obr.13568
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: E4orf1 improves adipose tissue-specific metabolic risk factors and indicators of cognition function in a mouse model of Alzheimer's disease.

    Khan, Md Shahjalal Hossain / Hefner, Marleigh / Reddy, Arubala / Dhurandhar, Nikhil V / Hegde, Vijay

    Nutrition & diabetes

    2023  Volume 13, Issue 1, Page(s) 13

    Abstract: Objective: Obesity, impaired glycemic control, and hepatic steatosis often coexist and are risk factors for developing dementia, and Alzheimer's disease (AD). We hypothesized that a therapeutic agent that improves glycemic control and steatosis may ... ...

    Abstract Objective: Obesity, impaired glycemic control, and hepatic steatosis often coexist and are risk factors for developing dementia, and Alzheimer's disease (AD). We hypothesized that a therapeutic agent that improves glycemic control and steatosis may attenuate obesity-associated progression of dementia. We previously identified that adenoviral protein E4orf1 improves glycemic control and reduces hepatic steatosis despite obesity in mice. Here, we determined if this metabolic improvement by E4orf1 will ameliorate cognitive decline in a transgenic mouse model of AD.
    Methods: Fourteen- to twenty-month-old APP/PS1/E4orf1 and APP/PS1 (control) mice were fed a high-fat diet. Cognition was determined by Morris Water Maze (MWM). Systemic glycemic control and metabolic signaling changes in adipose tissue, liver, and brain were determined.
    Results: Compared to control, E4orf1 expression significantly improved glucose clearance, reduced endogenous insulin requirement and lowered body-fat, enhanced glucose and lipid metabolism in adipose tissue, and reduced de novo lipogenesis in the liver. In the brain, E4orf1 mice displayed significantly greater expression of genes involved in neurogenesis and amyloid-beta degradation and performed better in MWM testing.
    Conclusion: This study opens-up the possibility of addressing glycemic control and steatosis for attenuating obesity-related cognitive decline. It also underscores the potential of E4orf1 for the purpose, which needs further investigations.
    MeSH term(s) Mice ; Animals ; Alzheimer Disease/metabolism ; Glucose/metabolism ; Adipose Tissue/metabolism ; Mice, Transgenic ; Cognition ; Disease Models, Animal ; Obesity/complications ; Obesity/metabolism ; Risk Factors ; Fatty Liver/metabolism ; Mice, Inbred C57BL
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-08-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2609314-5
    ISSN 2044-4052 ; 2044-4052
    ISSN (online) 2044-4052
    ISSN 2044-4052
    DOI 10.1038/s41387-023-00242-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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