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Article: Diversity of

Cao, Zi-Jian / Zhao, Juan / Liu, Yu / Wang, Shou-Xian / Zheng, Su-Yue / Qin, Wen-Tao

2024 Volume 14, Page(s) 1288585

Abstract: Introduction: The contamination of : Methods: A comprehensive two-year investigation of the biodiversity of : Results: A total of 90 isolates were obtained and identified as 14 different : Discussion: This study systematically investigated the ... ...

Abstract	Introduction: The contamination of Methods: A comprehensive two-year investigation of the biodiversity of Results: A total of 90 isolates were obtained and identified as 14 different Discussion: This study systematically investigated the diversity of
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1288585
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Article: Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer's Disease, Especially via the Renin-Angiotensin System.

Ma, Ke / Zheng, Zi-Run / Meng, Yu

Journal of clinical medicine

2023 Volume 12, Issue 4

Abstract: Chronic kidney disease (CKD) is a clinical syndrome secondary to the definitive change in function and structure of the kidney, which is characterized by its irreversibility and slow and progressive evolution. Alzheimer's disease (AD) is characterized by ...

Abstract	Chronic kidney disease (CKD) is a clinical syndrome secondary to the definitive change in function and structure of the kidney, which is characterized by its irreversibility and slow and progressive evolution. Alzheimer's disease (AD) is characterized by the extracellular accumulation of misfolded β-amyloid (Aβ) proteins into senile plaques and the formation of neurofibrillary tangles (NFTs) containing hyperphosphorylated tau. In the aging population, CKD and AD are growing problems. CKD patients are prone to cognitive decline and AD. However, the connection between CKD and AD is still unclear. In this review, we take the lead in showing that the development of the pathophysiology of CKD may also cause or exacerbate AD, especially the renin-angiotensin system (RAS). In vivo studies had already shown that the increased expression of angiotensin-converting enzyme (ACE) produces a positive effect in aggravating AD, but ACE inhibitors (ACEIs) have protective effects against AD. Among the possible association of risk factors in CKD and AD, we mainly discuss the RAS in the systemic circulation and the brain.
Language	English
Publishing date	2023-02-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12041459
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Article ; Online: Natural Killer Cells, as the Rising Point in Tissues, Are Forgotten in the Kidney.

Ma, Ke / Zheng, Zi-Run / Meng, Yu

Biomolecules

2023 Volume 13, Issue 5

Abstract: Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells (ILCs). NK cells play roles in the spleen, periphery, and in many tissues, such as the liver, uterine, lung, adipose, and so on. While the immunological ... ...

Abstract	Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells (ILCs). NK cells play roles in the spleen, periphery, and in many tissues, such as the liver, uterine, lung, adipose, and so on. While the immunological functions of NK cells are well established in these organs, comparatively little is known about NK cells in the kidney. Our understanding of NK cells is rapidly rising, with more and more studies highlighting the functional significance of NK cells in different types of kidney diseases. Recent progress has been made in translating these findings to clinical diseases that occur in the kidney, with indications of subset-specific roles of NK cells in the kidney. For the development of targeted therapeutics to delay kidney disease progression, a better understanding of the NK cell with respect to the mechanisms of kidney diseases is necessary. In order to promote the targeted treatment ability of NK cells in clinical diseases, in this paper we demonstrate the roles that NK cells play in different organs, especially the functions of NK cells in the kidney.
MeSH term(s)	Immunity, Innate ; Killer Cells, Natural ; Kidney ; Liver
Language	English
Publishing date	2023-04-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13050748
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Article ; Online: Omicron breakthrough infected individuals show enhanced nasal antibody responses and preserved T cell responses against the EG.5.1 and BA.2.86.

Zhu, Zheng / Li, Shixiong / Fan, Junhao / Shang, Shihao / Zhang, Yao / Zi, Qiong / Zheng, Jihao / Wang, Dongfang / Mou, Xiaoli / Liu, Kepu / Lv, Maoxin / Yuan, Jianlin / Wang, Zhongfang / Yu, Jingyou

Journal of medical virology

2024 Volume 96, Issue 3, Page(s) e29537

MeSH term(s)	Humans ; Antibody Formation ; T-Lymphocytes
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Letter
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29537
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Zs.A 1320: Show issues

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Article ; Online: Using 3D Printing Technology to Design Split-Piece Sleeve Prosthesis in the Revision Surgery of Tumor-Type Total Elbow Prosthetic Fractures: A Case Report.

Zhai, Kai / Zheng, Kai / Xu, Ming / Bao, Zhe-Ming / Hou, Zi-Wei / Yu, Xiu-Chun

Orthopaedic surgery

2024

Abstract: Background: Revision of tumor-type prosthetic fractures is very challenging in clinical work. Traditional repair methods may not be able to meet the needs of complex cases or cause greater bone damage. Therefore, more effective and reliable solutions ... ...

Abstract	Background: Revision of tumor-type prosthetic fractures is very challenging in clinical work. Traditional repair methods may not be able to meet the needs of complex cases or cause greater bone damage. Therefore, more effective and reliable solutions need to be found. Case presentation: This study presents a novel revision technique for managing fractures of tumor-type total elbow prostheses. A 57-year-old female patient was diagnosed with a left distal humeral bone tumor accompanied by pathological fracture and underwent customized tumor-type total elbow prosthesis arthroplasty. After 5 years, she experienced pain and encountered difficulty in flexing the left elbow while lifting heavy objects. The X-ray examination revealed a fracture of the distal humeral prosthesis. As a response, the elbow joint was initially explored, and the damaged component of the prosthesis was extracted. Subsequently, we utilized 3D printing technology to design a split-piece sleeve prosthesis and effectively restored the fractured left distal humerus implant. During the 2-year follow-up, The X-ray demonstrated satisfactory positioning of the prosthesis, which remained securely affixed without any indications of loosening. The Mayo Elbow Performance Score (MEPS) reached 80 points, the Musculoskeletal Tumor Society (MSTS) attained a score of 28 points, and the range of motion of the elbow was measured between 25° and 110°, revealing favorable functional outcomes. Conclusion: The utilization of a 3D printed split-piece sleeve prosthesis presents a viable clinical treatment strategy for addressing fractures in tumor-type elbow prostheses.
Language	English
Publishing date	2024-04-17
Publishing country	Australia
Document type	Case Reports
ZDB-ID	2503162-4
ISSN	1757-7861 ; 1757-7853 ; 1757-7861
ISSN (online)	1757-7861 ; 1757-7853
ISSN	1757-7861
DOI	10.1111/os.14070
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Zs.A 6786: Show issues

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Article ; Online: The Lateral Parabrachial Nucleus Inputs to the Lateral Hypothalamus Trigger Nocifensive Behaviors.

Zheng, Jie-Yan / Wang, Zi-Hao / Zhu, Zi-Yu / Huang, Zi-Han / Song, Ke-Xin / Ye, Bao-Lin / Zhou, Hai-Yun / Gao, Shuang-Qi

Neuroscience

2023 Volume 537, Page(s) 12–20

Abstract: The lateral parabrachial nucleus (LPBN) is known to play a key role in relaying noxious information from the spinal cord to the brain. Different LPBN efferent mediate different aspects of the nocifensive response. However, the function of the LPBN → ... ...

Abstract	The lateral parabrachial nucleus (LPBN) is known to play a key role in relaying noxious information from the spinal cord to the brain. Different LPBN efferent mediate different aspects of the nocifensive response. However, the function of the LPBN → lateral hypothalamus (LH) circuit in response to noxious stimuli has remained unknown. Here, we show that LPBN → LH circuit is activated by noxious stimuli. Interestingly, either activation or inhibition of this circuit induced analgesia. Optogenetic activation of LPBN afferents in the LH elicited spontaneous jumping and induced place aversion. Optogenetic inhibition inhibited jumping behavior to noxious heat. Ablation of LH glutamatergic neurons could abolish light-evoked analgesia and jumping behavior. Our study revealed a role for the LPBN → LH pathway in nocifensive behaviors.
MeSH term(s)	Humans ; Hypothalamic Area, Lateral ; Parabrachial Nucleus/physiology ; Pain/metabolism ; Brain ; Neurons/metabolism
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2023.11.020
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Zs.A 1215: Show issues

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Article ; Online: Quantitative MR imaging biomarkers for distinguishing inflammatory pancreatic mass and pancreatic cancer-a systematic review and meta-analysis.

Wang, Zi-He / Zhu, Liang / Xue, Hua-Dan / Jin, Zheng-Yu

European radiology

2024

Abstract: Objectives: To evaluate the diagnostic performance of quantitative magnetic resonance (MR) imaging biomarkers in distinguishing between inflammatory pancreatic masses (IPM) and pancreatic cancer (PC).: Methods: A literature search was conducted using ...

Abstract	Objectives: To evaluate the diagnostic performance of quantitative magnetic resonance (MR) imaging biomarkers in distinguishing between inflammatory pancreatic masses (IPM) and pancreatic cancer (PC). Methods: A literature search was conducted using PubMed, Embase, the Cochrane Library, and Web of Science through August 2023. Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) was used to evaluate the risk of bias and applicability of the studies. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were calculated using the DerSimonian-Laird method. Univariate meta-regression analysis was used to identify the potential factors of heterogeneity. Results: Twenty-four studies were included in this meta-analysis. The two main types of IPM, mass-forming pancreatitis (MFP) and autoimmune pancreatitis (AIP), differ in their apparent diffusion coefficient (ADC) values. Compared with PC, the ADC value was higher in MFP but lower in AIP. The pooled sensitivity/specificity of ADC were 0.80/0.85 for distinguishing MFP from PC and 0.82/0.84 for distinguishing AIP from PC. The pooled sensitivity/specificity for the maximal diameter of the upstream main pancreatic duct (dMPD) was 0.86/0.74, with a cutoff of dMPD ≤ 4 mm, and 0.97/0.52, with a cutoff of dMPD ≤ 5 mm. The pooled sensitivity/specificity for perfusion fraction (f) was 0.82/0.68, and 0.82/0.77 for mass stiffness values. Conclusions: Quantitative MR imaging biomarkers are useful in distinguishing between IPM and PC. ADC values differ between MFP and AIP, and they should be separated for consideration in future studies. Clinical relevance statement: Quantitative MR parameters could serve as non-invasive imaging biomarkers for differentiating malignant pancreatic neoplasms from inflammatory masses of the pancreas, and hence help to avoid unnecessary surgery. Key points: • Several quantitative MR imaging biomarkers performed well in differential diagnosis between inflammatory pancreatic mass and pancreatic cancer. • The ADC value could discern pancreatic cancer from mass-forming pancreatitis or autoimmune pancreatitis, if the two inflammatory mass types are not combined. • The diameter of main pancreatic duct had the highest specificity for differentiating autoimmune pancreatitis from pancreatic cancer.
Language	English
Publishing date	2024-04-19
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-024-10720-9
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Zs.A 3300: Show issues

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Article ; Online: Small RNAs: Efficient and miraculous effectors that play key roles in plant-microbe interactions.

Jiang, Chun-Hao / Li, Zi-Jie / Zheng, Li-Yu / Yu, Yi-Yang / Niu, Dong-Dong

Molecular plant pathology

2023 Volume 24, Issue 8, Page(s) 999–1013

Abstract: Plants' response to pathogens is highly complex and involves changes at different levels, such as activation or repression of a vast array of genes. Recently, many studies have demonstrated that many RNAs, especially small RNAs (sRNAs), are involved in ... ...

Abstract	Plants' response to pathogens is highly complex and involves changes at different levels, such as activation or repression of a vast array of genes. Recently, many studies have demonstrated that many RNAs, especially small RNAs (sRNAs), are involved in genetic expression and reprogramming affecting plant-pathogen interactions. The sRNAs, including short interfering RNAs and microRNAs, are noncoding RNA with 18-30 nucleotides, and are recognized as key genetic and epigenetic regulators. In this review, we summarize the new findings about defence-related sRNAs in the response to pathogens and our current understanding of their effects on plant-pathogen interactions. The main content of this review article includes the roles of sRNAs in plant-pathogen interactions, cross-kingdom sRNA trafficking between host and pathogen, and the application of RNA-based fungicides for plant disease control.
MeSH term(s)	Host-Pathogen Interactions/genetics ; RNA, Small Interfering/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA Interference ; Plants/genetics ; Plants/metabolism
Chemical Substances	RNA, Small Interfering ; MicroRNAs
Language	English
Publishing date	2023-04-07
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2020755-4
ISSN	1364-3703 ; 1364-3703
ISSN (online)	1364-3703
ISSN	1364-3703
DOI	10.1111/mpp.13329
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Article ; Online: Nanopolystyrene size effect and its combined acute toxicity with halogenated PAHs on Daphnia magna.

Sun, Qing / Yang, Yu-Ting / Zheng, Zi-Yi / Ni, Hong-Gang

The Science of the total environment

2023 Volume 912, Page(s) 169435

Abstract: Nanoplastics (NPs, diameter <1 μm) not only have toxicity but also change the toxicity of other pollutants in water. To date, the nanopolystyrene (nano-PS) size effect and its combined toxicity with halogenated polycyclic aromatic hydrocarbons (HPAHs) ... ...

Abstract	Nanoplastics (NPs, diameter <1 μm) not only have toxicity but also change the toxicity of other pollutants in water. To date, the nanopolystyrene (nano-PS) size effect and its combined toxicity with halogenated polycyclic aromatic hydrocarbons (HPAHs) remain unclear. In this study, the single toxicity, combined toxicity, and mode of action of the binary mixture of polystyrene (PS) and HPAH were examined. At the same time, the nano-PS size effect on combined toxicity was also discussed. According to our results, the 48 h acute toxicity test results showed that 30 nm PS was highly toxic (EC
MeSH term(s)	Animals ; Daphnia magna ; Water Pollutants, Chemical/analysis ; Polycyclic Aromatic Hydrocarbons/toxicity ; Polycyclic Aromatic Hydrocarbons/analysis ; Polystyrenes/toxicity ; Water ; Daphnia
Chemical Substances	Water Pollutants, Chemical ; Polycyclic Aromatic Hydrocarbons ; Polystyrenes ; Water (059QF0KO0R)
Language	English
Publishing date	2023-12-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.169435
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Zs.A 949: Show issues

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Article ; Online: High-fat diet alters immune cells in spleen, kidney and tumor and impacts the volume growth of renal cell carcinoma.

Run Zheng, Zi / Ma, Ke / Yue Li, Hong / Meng, Yu

International immunopharmacology

2023 Volume 124, Issue Pt B, Page(s) 110982

Abstract: Renal cell carcinoma (RCC) is strongly associated with abnormal or excessive fat deposition in the body, whose processes include persistent adipose inflammation and other disturbances with the development and function of immune cells. Researchers have ... ...

Abstract	Renal cell carcinoma (RCC) is strongly associated with abnormal or excessive fat deposition in the body, whose processes include persistent adipose inflammation and other disturbances with the development and function of immune cells. Researchers have recently become more and more interested in understanding how high-fat diet (HFD) affects the development and course of RCC by causing immunological dysfunction. Consequently, we explore the effect of HFD on the changes of immune cell groups in spleens, normal kidneys and tumors, mainly revealing the changes of T cells, B cells and NK cells, and further preliminarily exploring the changes of NK cell phenotype. Our findings demonstrate that: (1) HFD impacts the volume growth of ACHN tumor; (2) HFD increases the frequency of CD3
MeSH term(s)	Humans ; Animals ; Mice ; Carcinoma, Renal Cell ; Spleen/pathology ; Diet, High-Fat/adverse effects ; Kidney/pathology ; Obesity ; Kidney Neoplasms ; Mice, Inbred C57BL
Language	English
Publishing date	2023-10-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110982
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