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Article: One-Year Change in the H

Kim, Min / Yu, Hee Tae / Kim, Tae-Hoon / Uhm, Jae-Sun / Joung, Boyoung / Lee, Moon-Hyoung / Pak, Hui-Nam

2021 Volume 8, Page(s) 699364

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.699364
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Changes in the expression of the B subunit of vacuolar H

Jung, Hyo Young / Kim, Woosuk / Hahn, Kyu Ri / Kang, Min Soo / Kwon, Hyun Jung / Choi, Jung Hoon / Yoon, Yeo Sung / Kim, Dae Won / Yoo, Dae Young / Won, Moo-Ho / Hwang, In Koo

Iranian journal of basic medical sciences

2020 Volume 24, Issue 11, Page(s) 1482–1487

Abstract: Objectives: Vacuolar H: Materials and methods: Transient forebrain ischemia was induced ...

Abstract	Objectives: Vacuolar H Materials and methods: Transient forebrain ischemia was induced by occlusion of both common carotid arteries for 5 min and animals were sacrificed at various time points after ischemia for immunohistochemical staining of ATP6V1B2 and measurements of pH and lactate levels in the hippocampus. Results: ATP6V1B2 immunoreactivity was found to be transiently increased in the hippocampal CA1 region and dentate gyrus 12-24 hr after ischemia when the pH and lactate levels were decreased. In addition, ATP6V1B2 immunoreactivity significantly increased in the hippocampal CA3 and dentate gyrus, regions relatively resistant to ischemic damage, 4 days after ischemia, when the NeuN-positive, mature neuron numbers were significantly decreased in the hippocampal CA1 region. Conclusion: These results suggest that ATP6V1B2 expression is transiently increased in the hippocampus following ischemia, which may be intended to compensate for ischemia-related dysfunction of ATP6V1B2 in the hippocampus.
Language	English
Publishing date	2020-04-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
DOI	10.22038/IJBMS.2021.59275.13155
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Atomic layer etching of Sn by surface modification with H and Cl radicals.

Kim, Doo San / Jang, Yun Jong / Kim, Ye Eun / Gil, Hong Seong / Jeong, Byeong Hwa / Yeom, Geun Young

Nanotechnology

2022 Volume 34, Issue 3

Abstract: Sn is the one of the materials that can be used for next generation extreme ultraviolet (EUV) mask material having a high absorption coefficient and, for the fabrication of the next generation EUV mask, a precise etching of Sn is required. In this study, ...

Abstract	Sn is the one of the materials that can be used for next generation extreme ultraviolet (EUV) mask material having a high absorption coefficient and, for the fabrication of the next generation EUV mask, a precise etching of Sn is required. In this study, the atomic layer etching (ALE) process was performed for the precise etch thickness control and low damage etching of Sn by the formation SnH
Language	English
Publishing date	2022-11-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/ac9981
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Article ; Online: Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells.

Park, Jong-Min / Kim, Do-Hee / Na, Hye-Kyung / Surh, Young-Joon

Oncotarget

2018 Volume 9, Issue 3, Page(s) 3014–3028

Abstract: ... NQO-1) in human Chang liver cells. Expression of NQO-1 and other antioxidant/stress response genes is ... primarily regulated by the transcription factor NF-E2-related factor2 (Nrf2). Exposure of human Chang liver ... methylseleninic acid (MSeA), a monomethylated selenium, induced the expression of NAD(P)H:quinone oxidoreductase-1 ...

Abstract	Selenium has been reported to induce the expression of some cytoprotective enzymes, which may account for its chemoprotective and chemopreventive effects. However, it remains largely unresolved whether these effects are exerted by selenium itself or mediated by its metabolite(s). In the present study, methylseleninic acid (MSeA), a monomethylated selenium, induced the expression of NAD(P)H:quinone oxidoreductase-1 (NQO-1) in human Chang liver cells. Expression of NQO-1 and other antioxidant/stress response genes is primarily regulated by the transcription factor NF-E2-related factor2 (Nrf2). Exposure of human Chang liver cells to MSeA (3 μM) increased nuclear translocation of Nrf2 and binding to antioxidant response elements. Silencing Nrf2 markedly reduced the MSeA-induced NQO-1 expression. In comparison with embryonic fibroblasts from Nrf2 wild-type mice, those from Nrf2 knockout mice failed to induce NQO-1 expression when treated with MSeA. Moreover, MSeA treatment enhanced ubiquitination of Keap1, but repressed Nrf2 ubiquitination. Pretreatment of cells with dithiothreitol abrogated the MSeA-induced NQO-1 expression, suggesting that MSeA causes Keap1 thiol modification. MSeA-induced NQO-1 upregulation was attenuated in cells harbouring the mutant Keap1 in which the cysteine 151 residue was replaced by serine. Oral administration of MSeA (1 mg/kg) by gavage to mice induced hepatic NQO-1 expression. Similar to MSeA, methylselenol generated from selenomethionine by methioninase activity induced NQO-1 expression. In conclusion, MSeA, the immediate precursor of methylselenol, upregulates the expression of NQO-1 via the Keap1-Nrf2 signaling. The above findings suggest that biological activities of selenium are dependent on the nature of the metabolites as well as the type of ingested selenium formulations.
Language	English
Publishing date	2018-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.10289
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Apigenin Isolated from Carduus crispus Protects against H 2 O 2 -Induced Oxidative Damage and Spermatogenic Expression Changes in GC-2spd Sperm Cells

Spandana Rajendra Kopalli / Sung-Kwang Yoo / Bokyung Kim / Si-Kwan Kim / Sushruta Koppula

Molecules, Vol 27, Iss 1777, p

2022 Volume 1777

Abstract: ... against oxidative damage induced by hydrogen peroxide (H 2 O 2 ) and dysregulation in spermatogenesis ... conditions. Apigenin treated alone (2.5, 5, 10 and 20 µM) did not exhibit cytotoxicity, but inhibited the H 2 ... and dose-dependently. Further, H 2 O 2 -induced down-regulation of antioxidant (glutathione S ...

Abstract	Testicular oxidative stress is one of the most common factors underlying male infertility. Welted thistle, Carduus crispus Linn., and its bioactive principles are attracting scientific interest in treating male reproductive dysfunctions. Here, the protective effects of apigenin isolated from C. crispus against oxidative damage induced by hydrogen peroxide (H 2 O 2 ) and dysregulation in spermatogenesis associated parameters in testicular sperm cells was investigated. Cell viabilities, ROS scavenging effects, and spermatogenic associated molecular expressions were measured by MTT, DCF-DA, Western blotting and real-time RT-PCR, respectively. A single peak with 100% purity of apigenin was obtained in HPLC conditions. Apigenin treated alone (2.5, 5, 10 and 20 µM) did not exhibit cytotoxicity, but inhibited the H 2 O 2 -induced cellular damage and elevated ROS levels significantly ( p < 0.05 at 5, 10 and 20 µM) and dose-dependently. Further, H 2 O 2 -induced down-regulation of antioxidant (glutathione S -transferases m5, glutathione peroxidase 4, and peroxiredoxin 3) and spermatogenesis-associated (nectin-2 and phosphorylated-cAMP response element-binding protein) molecular expression in GC-2spd cells were attenuated by apigenin at both protein and mRNA levels ( p < 0.05). In conclusion, our study showed that apigenin isolated from C. crispus might be an effective agent that can protect ROS-induced testicular dysfunctions.
Keywords	welted thistle ; apigenin ; hydrogen peroxide ; reactive oxygen species ; testicular cells ; nectin ; Organic chemistry ; QD241-441
Subject code	616
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Degradation of Organics and Change Concentration in Per-Fluorinated Compounds (PFCs) during Ozonation and UV/H 2 O 2 Advanced Treatment of Tertiary-Treated Sewage

Jesmin Akter / Jai-yeop Lee / Hyun-Ju Ha / In Geol Yi / Da-Hye Hong / Chang-Min Park / Mok-Young Lee / Ilho Kim

Sustainability, Vol 14, Iss 5597, p

2022 Volume 5597

Abstract: This study aimed to investigate the effect of H 2 O 2 addition, ozone feed rate, and UV addition ... effluent from a sewage treatment plant (STP) during the O 3 and UV/H 2 O 2 process. The degradation ... these recalcitrant pollutants. Therefore, the O 3 /UV/H 2 O 2 process was an effective method for treating ...

Abstract	This study aimed to investigate the effect of H 2 O 2 addition, ozone feed rate, and UV addition on the change in the concentration of organics such as COD Mn , COD Cr , TOC, and PFCs in tertiary-treated effluent from a sewage treatment plant (STP) during the O 3 and UV/H 2 O 2 process. The degradation of organic pollutants from tertiary effluent is a significant challenge because biological treatment cannot degrade these recalcitrant pollutants. Therefore, the O 3 /UV/H 2 O 2 process was an effective method for treating recalcitrant organics. Several batch tests were conducted to investigate the direct UV photolysis, UV/H 2 O 2 , and ozone-based advanced oxidation process to degrade COD Mn , COD Cr , TOC, and PFCs. The chemical oxygen demand (COD) and total organic carbon (TOC) with UV irradiation showed 95% and 50% removal efficiency percentages under optimal conditions (initial pH = 6.7, H 2 O 2 dosage = 50 mg/L, ozone feed rate = 5.8 mg/L/min. Moreover, UV irradiation, with the addition of H 2 O 2 , and a sufficient dose of ozone, demonstrated the efficient removal of organic compounds by the indication of radical oxidation. (·OH) is the dominant mechanism. However, AOPs are not sufficient to fully treat the PFC compound; thus, additional procedures are required to degrade PFCs. In this study, the removal of organic recalcitrant contaminants and the change in added PFC concentration in tertiary-treated sewage were investigated by applying the ozone-based advanced oxidation process.
Keywords	organic compound ; PFCs ; tertiary wastewater ; O 3 /UV/H 2 O 2 ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	290
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Changes in the expression of the B subunit of vacuolar H+-ATPase, in the hippocampus, following transient forebrain ischemia in gerbils

Hyo Young Jung / Woosuk Kim / Kyu Ri Hahn / Min Soo Kang / Hyun Jung Kwon / Jung Hoon Choi / Yeo Sung Yoon / Dae Won Kim / Dae Young Yoo / Moo-Ho Won / In Koo Hwang

Iranian Journal of Basic Medical Sciences, Vol 24, Iss 11, Pp 1482-

2021 Volume 1487

Abstract: ... in synaptic vesicles. In the present study, we investigated the time-dependent changes in the expression of vacuolar ... Objective(s): Vacuolar H+-ATPase is a highly conserved enzyme that plays an important role ... H+-ATPase V1B2 (ATP6V1B2), a major neuronal subtype of vacuolar H+-ATPase located in the hippocampus, after ...

Abstract	Objective(s): Vacuolar H+-ATPase is a highly conserved enzyme that plays an important role in maintaining an acidic environment for lysosomal function and accumulating neurotransmitters in synaptic vesicles. In the present study, we investigated the time-dependent changes in the expression of vacuolar H+-ATPase V1B2 (ATP6V1B2), a major neuronal subtype of vacuolar H+-ATPase located in the hippocampus, after 5 min of transient forebrain ischemia in gerbils. We also examined the pH and lactate levels in the hippocampus after ischemia to elucidate the correlation between ATP6V1B2 expression and acidosis.Materials and Methods: Transient forebrain ischemia was induced by occlusion of both common carotid arteries for 5 min and animals were sacrificed at various time points after ischemia for immunohistochemical staining of ATP6V1B2 and measurements of pH and lactate levels in the hippocampus.Results: ATP6V1B2 immunoreactivity was found to be transiently increased in the hippocampal CA1 region and dentate gyrus 12–24 hr after ischemia when the pH and lactate levels were decreased. In addition, ATP6V1B2 immunoreactivity significantly increased in the hippocampal CA3 and dentate gyrus, regions relatively resistant to ischemic damage, 4 days after ischemia, when the NeuN-positive, mature neuron numbers were significantly decreased in the hippocampal CA1 region. Conclusion: These results suggest that ATP6V1B2 expression is transiently increased in the hippocampus following ischemia, which may be intended to compensate for ischemia-related dysfunction of ATP6V1B2 in the hippocampus.
Keywords	acidosis ; cell death ; gerbils ; hippocampus ; ischemia ; Medicine ; R
Subject code	630
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Perisomatic changes in h-channels regulate depressive behaviors following chronic unpredictable stress.

Kim, C S / Brager, D H / Johnston, D

Molecular psychiatry

2017 Volume 23, Issue 4, Page(s) 892–903

Abstract: Chronic stress can be a precipitating factor in the onset of depression. Lentiviral-mediated knockdown of HCN1 protein expression and reduction of functional ... ...

Abstract	Chronic stress can be a precipitating factor in the onset of depression. Lentiviral-mediated knockdown of HCN1 protein expression and reduction of functional I
MeSH term(s)	Action Potentials ; Animals ; Antidepressive Agents/metabolism ; CA1 Region, Hippocampal/metabolism ; Cyclic Nucleotide-Gated Cation Channels ; Depression/metabolism ; Depressive Disorder, Major/metabolism ; Disease Models, Animal ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/physiology ; Male ; Neurons/metabolism ; Patch-Clamp Techniques/methods ; Potassium Channels/genetics ; Potassium Channels/metabolism ; Potassium Channels/physiology ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological/metabolism ; Stress, Psychological/physiopathology ; Thapsigargin/pharmacology
Chemical Substances	Antidepressive Agents ; Cyclic Nucleotide-Gated Cation Channels ; Hcn1 protein, rat ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; Potassium Channels ; Thapsigargin (67526-95-8)
Language	English
Publishing date	2017-04-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/mp.2017.28
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Article ; Online: The Impact of Natural Variation of OH Radical Demand of Drinking Water Sources on the Optimum Operation of the UV/H

Kwon, Minhwan / Kim, Seonbaek / Jung, Youmi / Hwang, Tae-Mun / Stefan, Mihaela I / Kang, Joon-Wun

Environmental science & technology

2019 Volume 53, Issue 6, Page(s) 3177–3186

Abstract: ... H ...

Abstract	Hydroxyl radical (•OH) water demand is a key parameter which impacts the design and operation of UV/H
MeSH term(s)	Drinking Water ; Hydrogen Peroxide ; Oxidation-Reduction ; Ultraviolet Rays ; Water Pollutants, Chemical ; Water Purification
Chemical Substances	Drinking Water ; Water Pollutants, Chemical ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2019-02-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.8b05686
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Article ; Online: Overexpression of OsF 3 H modulates WBPH stress by alteration of phenylpropanoid pathway at a transcriptomic and metabolomic level in Oryza sativa

Rahmatullah Jan / Muhammad Aqil Khan / Sajjad Asaf / In-Jung Lee / Kyung-Min Kim

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 16

Abstract: Abstract The whitebacked planthopper (WBPH), has become a devastating pest for rice crops, causes serious yield losses each year, and urgently needs biological control. Here, we developed a WBPH-resistant rice cultivar by overexpressing the OsF3H gene. A ...

Abstract	Abstract The whitebacked planthopper (WBPH), has become a devastating pest for rice crops, causes serious yield losses each year, and urgently needs biological control. Here, we developed a WBPH-resistant rice cultivar by overexpressing the OsF3H gene. A genetic functional analysis of the OsF3H gene confirmed its role in facilitating flavonoid contents and have indicated that the expression of the OsF3H gene is involved in regulation of the downstream genes (OsDFR and OsFLS) of the flavonoid pathway and genes (OsSLR1 and OsWRKY13) involved in other physiological pathways. OxF3H (OsF3H transgenic) plants accumulated significant amounts of the flavonols kaempferol (Kr) and quercetin (Qu) and the anthocyanins delphinidin and cyanidin, compared to the wild type, in response to the stress induced by WBPH. Similarly, OsF3H-related proteins were significantly expressed in OxF3H lines after WBPH infestation. The present study, indicated that the regulation of JA in OxF3H plants was suppressed due the overexpression of the OsF3H gene, which induced the expression of downstream genes related to anthocyanin. Similarly, the OsWRKY13 transcriptional factor was significantly suppressed in OxF3H plants during WBPH infestation. Exogenous application of Kr and Qu increased the survival rates of susceptible TN1 lines in response to WBPH, while decreased the survival rate of first instar WBPHs, indicating that both flavonols exhibit pesticide activity. Phenotypic demonstration also affirms that OxF3H plants show strong resistance to WBPH compared with wild type. Collectively, our result suggested that OsF3H overexpression led to the up-regulation of defense related genes and enhanced rice resistance to WBPH infestation.
Keywords	Medicine ; R ; Science ; Q
Subject code	580
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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