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Article ; Online: Bioinformatic Study of Possible Acute Regulation of Acid Secretion in the Stomach.

Lee, Yan Hay Grace / Cerf, Nicole T / Shalaby, Nicholas / Montes, Mónica R / Clarke, Ronald J

2024 Volume 257, Issue 1-2, Page(s) 79–89

Abstract: The gastric ... ...

Abstract	The gastric H
MeSH term(s)	Animals ; Sodium-Potassium-Exchanging ATPase/metabolism ; Stomach ; Biological Transport ; H(+)-K(+)-Exchanging ATPase/chemistry ; Ions/metabolism
Chemical Substances	Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10) ; Ions
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	3082-x
ISSN	1432-1424 ; 0022-2631
ISSN (online)	1432-1424
ISSN	0022-2631
DOI	10.1007/s00232-024-00310-7
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Article ; Online: Phantom study investigating the repeatability of radiomic features with alteration of image acquisition parameters in magnetic resonance imaging.

Mitchell-Hay, Rosalind / Ahearn, Trevor / Murray, Alison / Waiter, Gordon

Journal of medical imaging and radiation sciences

2023 Volume 55, Issue 1, Page(s) 19–28

Abstract: Background: Magnetic resonance imaging (MRI) has many different alterable parameters that affect how an image appears. This is relevant in radiomics which produces quantitative features through analysis of medical images. One significant acknowledged ... ...

Abstract	Background: Magnetic resonance imaging (MRI) has many different alterable parameters that affect how an image appears. This is relevant in radiomics which produces quantitative features through analysis of medical images. One significant acknowledged limitation of radiomics is repeatability. This phantom study aims to further investigate the repeatability of radiomic features (RaF), within MRI, across a range of different echo (TE) and repetition times (TR). Methods: A phantom was scanned 10 times under identical conditions on a 3T scanner using head coil over 4 months. The TE ranged from 80 to 110 ms while the TR from 3000 to 5000 ms. Radiomics analysis was performed on the same segmented section of the phantom across all TE and TR combinations. Intraclass Correlation Coefficient (ICC) was calculated across the different TE and TR ranges to investigate the repeatability of RaF. Results: Of 1596 features calculated, 187 features had ICC >0.9 across the range of TE, while 82 features had an ICC >0.9 across a range of TR. 664 had ICC >0.75 across the range of TEs, with 541 across the range of TR values. There was an overlap of 51 features with ICC >0.9. Conclusion: Repeatability of RaF in MRI is dependent on imaging parameters and careful consideration of these, in combination with variable selection, is required when applying radiomics to MRI.
MeSH term(s)	Humans ; Radiomics ; Image Processing, Computer-Assisted/methods ; Reproducibility of Results ; Magnetic Resonance Imaging ; Phantoms, Imaging
Language	English
Publishing date	2023-11-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2426513-5
ISSN	1876-7982 ; 1939-8654
ISSN (online)	1876-7982
ISSN	1939-8654
DOI	10.1016/j.jmir.2023.10.003
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Article ; Online: LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings.

El-Sayed, Kefaya / Youssef, Amany R / Hay, Nehal M Abdel / Osman, Adel M

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

2024 Volume 76, Issue 1, Page(s) 1

Abstract: Background: Coronary artery disease (CAD) is the main cause of death in Egypt. Many LDL-R gene ... Significantly higher proportion of 'T' allele among patient (risk allele). This association is of low strength ... ϕ lies between 0.1 and 0.3). A participant with 'T' allele has 1.95 times higher odds to exhibit CAD ...

Abstract	Background: Coronary artery disease (CAD) is the main cause of death in Egypt. Many LDL-R gene locus single nucleotide polymorphisms (SNP) are found to be associated with the risk of CAD. This research aimed to assess the allelic and genotypic frequencies of rs1122608 SNP and their association with the extent of vessel affection and lipid profile in a population of Egyptians.100 CAD patients and 100 healthy controls of Egyptians were included. PCR-RFLP was used to genotype rs1122608 SNPs. Results: Significantly higher proportion of 'T' allele among patient (risk allele). This association is of low strength (ϕ lies between 0.1 and 0.3). A participant with 'T' allele has 1.95 times higher odds to exhibit CAD versus a participant with 'G' allele. Significantly higher proportion of 'T/T' genotype among cases versus control (risk genotype). This association is of low strength (Cramer's V lies between 0.1 and 0.3). A participant with 'T/T' genotype has 4.5 times higher odds to exhibit CAD versus a participant with 'G/G'. Gensini score showed no significant association with rs1122608 genotypes (p = 0.863). Conclusions: The mutant GT and TT genotypes and minor T allele of rs1122608 were positively correlated with CAD and considered as independent risk factors for CAD.
Language	English
Publishing date	2024-01-02
Publishing country	Germany
Document type	Journal Article
ISSN	2090-911X
ISSN (online)	2090-911X
DOI	10.1186/s43044-023-00430-w
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Article ; Online: Tuning of B

Camacho, Ines S / Wall, Emma / Sazanovich, Igor V / Gozzard, Emma / Towrie, Mike / Hunt, Neil T / Hay, Sam / Jones, Alex R

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 87, Page(s) 13014–13017

Abstract: Time-resolved infrared spectroscopy reveals the flow of electron density through coenzyme ... ...

Abstract	Time-resolved infrared spectroscopy reveals the flow of electron density through coenzyme B
MeSH term(s)	Photochemistry ; Cobamides ; Bacteria
Chemical Substances	cobamamide (F0R1QK73KB) ; Cobamides
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc03900e
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Article ; Online: Identification of the rice Rc gene as a main regulator of seed survival under dry storage conditions.

Prasad C T, Manjunath / Kodde, Jan / Angenent, Gerco C / Hay, Fiona R / McNally, Kenneth L / Groot, Steven P C

Plant, cell & environment

2023 Volume 46, Issue 6, Page(s) 1962–1980

Abstract: Seed deterioration during storage results in poor germination, reduced vigour, and non-uniform seedling emergence. The aging rate depends on storage conditions and genetic factors. This study aims to identify these genetic factors determining the ... ...

Abstract	Seed deterioration during storage results in poor germination, reduced vigour, and non-uniform seedling emergence. The aging rate depends on storage conditions and genetic factors. This study aims to identify these genetic factors determining the longevity of rice (Oryza sativa L.) seeds stored under experimental aging conditions mimicking long-term dry storage. Genetic variation for tolerance to aging was studied in 300 Indica rice accessions by storing dry seeds under an elevated partial pressure of oxygen (EPPO) condition. A genome-wide association analysis identified 11 unique genomic regions for all measured germination parameters after aging, differing from those previously identified in rice under humid experimental aging conditions. The significant single nucleotide polymorphism in the most prominent region was located within the Rc gene, encoding a basic helix-loop-helix transcription factor. Storage experiments using near-isogenic rice lines (SD7-1D (Rc) and SD7-1d (rc) with the same allelic variation confirmed the role of the wildtype Rc gene, providing stronger tolerance to dry EPPO aging. In the seed pericarp, a functional Rc gene results in accumulation of proanthocyanidins, an important sub-class of flavonoids having strong antioxidant activity, which may explain the variation in tolerance to dry EPPO aging.
MeSH term(s)	Oryza/genetics ; Genome-Wide Association Study ; Germination/genetics ; Seedlings/genetics ; Seeds/genetics
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391893-2
ISSN	1365-3040 ; 0140-7791
ISSN (online)	1365-3040
ISSN	0140-7791
DOI	10.1111/pce.14581
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Article ; Online: The state and future of pediatric research-an introductory overview : The state and future of pediatric research series.

Speer, Esther M / Lee, Lois K / Bourgeois, Florence T / Gitterman, Daniel / Hay, William W / Davis, Jonathan M / Javier, Joyce R

Pediatric research

2023

Abstract: Impact: This is an introduction to an article series devoted to the current state and future of pediatric research. The role of public-private partnerships, influencing factors, challenges, and recent trends in pediatric research are described, with ... ...

Abstract	Impact: This is an introduction to an article series devoted to the current state and future of pediatric research. The role of public-private partnerships, influencing factors, challenges, and recent trends in pediatric research are described, with emphasis on funding, drug and device development, physician-scientist training, and diversity. Potential solutions and advocacy opportunities are discussed.
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-022-02439-4
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Article ; Online: Consent and Identifiability for Patient Images in Research, Education, and Image-Based Artificial Intelligence.

Salvador, Trina / Gu, Lilly / Hay, Jennifer L / Kurtansky, Nicholas R / Masterson-Creber, Ruth / Halpern, Allan C / Rotemberg, Veronica

JAMA dermatology

2024 Volume 160, Issue 4, Page(s) 470–472

MeSH term(s)	Humans ; Artificial Intelligence ; Educational Status ; Informed Consent
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2024.0084
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Article ; Online: Examining the roles of disability-related body esteem and perceived burdensomeness in suicidal ideation among adults with vision- and mobility-related disabilities.

Khazem, Lauren R / Long, Cameron M / Hay, Jarrod M / Lund, Emily M / Anestis, Michael D / Gratz, Kim L / Tull, Matthew T / Bryan, Craig J

Rehabilitation psychology

2023 Volume 69, Issue 1, Page(s) 24–28

Abstract: Purpose/objective: People with disabilities (PWD) generally exhibit an increased risk of suicidal ideation (SI) and behaviors. Underlying cognitive states, namely perceived burdensomeness, have been identified as a contributor to the increased risk of ... ...

Abstract	Purpose/objective: People with disabilities (PWD) generally exhibit an increased risk of suicidal ideation (SI) and behaviors. Underlying cognitive states, namely perceived burdensomeness, have been identified as a contributor to the increased risk of suicidal thoughts and behaviors in PWD. However, the role of body esteem in the development of SI in this population remains unexamined, despite its salience in other populations. In this study, we examined whether the interaction of perceived burdensomeness and body esteem contributed to the perceived likelihood of future SI among PWD, and whether this relationship was further moderated by disability type. Method: Participants included 119 adults with self-reported vision- and mobility-related disabilities who participated in a larger study focused on disability and suicide involving interviews and self-report measures. We examined the interaction between perceived burdensomeness and disability-related body esteem on self-reported likelihood of future SI and whether this interaction was further moderated by disability type (i.e., vision- or mobility-related disability). Results: Greater perceived burdensomeness was associated with a greater perceived likelihood of future SI only for participants with vision impairments and at low levels of body esteem. Conclusions/implications: The combination of experiences of perceived burdensomeness and low body esteem may be particularly relevant to SI among people with vision-related versus mobility-related disabilities. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Adult ; Humans ; Suicidal Ideation ; Interpersonal Relations ; Suicide/psychology ; Risk Factors ; Disabled Persons ; Psychological Theory
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	224747-1
ISSN	1939-1544 ; 0090-5550
ISSN (online)	1939-1544
ISSN	0090-5550
DOI	10.1037/rep0000514
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Article ; Online: Two decades of climate change alters seed longevity in an alpine herb: implications for ex situ seed conservation

White, F. J. / Hay, F. R. / Abeli, T. / Mondoni, A.

Alp Botany. 2023 Apr., v. 133, no. 1 p.11-20

2023

Abstract: Climate warming in mountain areas is increasing faster than the global average, threatening alpine plants. Climate affects many traits including seeds, the longevity of which is important for conservation, facilitating genebank storage. Seeds of alpine ... ...

Abstract	Climate warming in mountain areas is increasing faster than the global average, threatening alpine plants. Climate affects many traits including seeds, the longevity of which is important for conservation, facilitating genebank storage. Seeds of alpine species are considered short-lived in storage, but their longevity increases when produced under a warmer parental environment. Consequently, with climate warming, seeds of alpine species may have increased fitness and be longer-lived in genebank storage. We assessed seed longevity under artificial ageing in 10 accessions of the arctic-alpine species Viscaria alpina stored under genebank conditions for different time periods over the last 20 years. The seed collection site was in the northern Apennines, where above average warming and variable precipitation has been recorded. The time taken for viability to fall to 50% (p₅₀) was estimated using probit analysis; correlation and general linear regression were used to investigate the effects of length of time in storage, seed mass and climate under which seeds were produced on seed longevity. p₅₀ varied between 7.77 and 18.49 days. There was no relationship between length of time in storage or seed mass on seed longevity. p₅₀ was higher in years with increased temperature and lower precipitation during the growing season, with precipitation having more impact than temperature. The results suggest that seeds of alpine species are suitable for genebank storage, and inter-annual variation in precipitation induces a plastic response in seed longevity. Using genebank stored seeds provides insights into how alpine species may respond to future climate changes and could have implications for genebank storage.
Keywords	botany ; climate ; climate change ; gene banks ; longevity ; probit analysis ; regression analysis ; seed collecting ; seed longevity ; seed weight ; temperature ; viability
Language	English
Dates of publication	2023-04
Size	p. 11-20.
Publishing place	Springer International Publishing
Document type	Article ; Online
ZDB-ID	2600962-6
ISSN	1664-221X ; 1664-2201
ISSN (online)	1664-221X
ISSN	1664-2201
DOI	10.1007/s00035-022-00289-8
Database	NAL-Catalogue (AGRICOLA)

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Book: The physiology of crop yield

Hay, Robert K. M. / Porter, John R.

2006

Author's details	Robert K. M. Hay ; John R. Porter
Keywords	Crop yields ; Crops/Physiology
Subject code	631.558
Language	English
Size	XIII, 314 S. : graph. Darst., 25cm
Edition	2. ed.
Publisher	Blackwell Publ
Publishing place	Oxford u.a.
Publishing country	Great Britain
Document type	Book
Old title	Frühere Ausg. u.d.T. An introduction to the physiology of crop yield
HBZ-ID	HT014400282
ISBN	1-4051-0859-2 ; 978-1-4051-0859-1
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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068/1768	available for loan (reading room)	Freihandmagazin (U1)

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