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  1. Book ; Online ; Thesis: Esm1 modulates spinal cord vascularization in Vegfaa gain-of-function zebrafish models

    Knapp, Silvana Maria [Verfasser] / Noble, F. le [Akademischer Betreuer]

    2020  

    Author's details Silvana Maria Knapp ; Betreuer: F. le Noble
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher KIT-Bibliothek
    Publishing place Karlsruhe
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Interdependence of Angiogenesis and Arteriogenesis in Development and Disease.

    le Noble, Ferdinand / Kupatt, Christian

    International journal of molecular sciences

    2022  Volume 23, Issue 7

    Abstract: The structure of arterial networks is optimized to allow efficient flow delivery to metabolically active tissues. Optimization of flow delivery is a continuous process involving synchronization of the structure and function of the microcirculation with ... ...

    Abstract The structure of arterial networks is optimized to allow efficient flow delivery to metabolically active tissues. Optimization of flow delivery is a continuous process involving synchronization of the structure and function of the microcirculation with the upstream arterial network. Risk factors for ischemic cardiovascular diseases, such as diabetes mellitus and hyperlipidemia, adversely affect endothelial function, induce capillary regression, and disrupt the micro- to macrocirculation cross-talk. We provide evidence showing that this loss of synchronization reduces arterial collateral network recruitment upon arterial stenosis, and the long-term clinical outcome of current revascularization strategies in these patient cohorts. We describe mechanisms and signals contributing to synchronized growth of micro- and macrocirculation in development and upon ischemic challenges in the adult organism and identify potential therapeutic targets. We conclude that a long-term successful revascularization strategy should aim at both removing obstructions in the proximal part of the arterial tree and restoring "bottom-up" vascular communication.
    MeSH term(s) Adult ; Arteries ; Collateral Circulation ; Humans ; Ischemia ; Neovascularization, Pathologic ; Neovascularization, Physiologic
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23073879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Perspectives on Driving Changes in Project-based Cumulative Effects Assessment for Biodiversity: Lessons from the Canadian Experience.

    Dibo, Ana Paula Alves / Noble, Bram F / Sánchez, Luis Enrique

    Environmental management

    2018  Volume 62, Issue 5, Page(s) 929–941

    Abstract: Cumulative effects assessment (CEA), as a required practice for the environmental assessment (EA) of projects in many countries, faces several practical challenges, especially related to biodiversity. Drawing on the perspectives and experiences of ... ...

    Abstract Cumulative effects assessment (CEA), as a required practice for the environmental assessment (EA) of projects in many countries, faces several practical challenges, especially related to biodiversity. Drawing on the perspectives and experiences of Canadian EA practitioners, this paper explores options or drivers of change for improving project-based assessment to better tackle cumulative effects on biodiversity. An on-line survey was conducted with 40 professionals from the private sector, government departments/agencies, universities, and non-governmental organizations, examining the current challenges and opportunities regarding: CEA process for biodiversity; responsibilities for undertaking CEA tasks; resources to support and promote good CEA practice. In terms of process, there is shared understanding on: (i) the need of EA terms of reference to provide specific directions on CEA; (ii) CEA should capture both human and natural drivers of cumulative change; (iii) spatial boundaries for CEA should be based on ecological boundaries. There are dissenting views about: (i) whether CEA should consider all valued components (VCs) potentially affected by a project or only those for which residual effects are predicted; and (ii) delimitation of future temporal limits. In terms of responsibilities, participants agreed that project proponents should retain a central role in conducting CEA, but government agencies should lead the collection/provision of information about other projects in the study area and baseline VC conditions. Information and knowledge management resources could be also applied in the context of governmental agencies and consultancy firms to support CEA for biodiversity.
    MeSH term(s) Biodiversity ; Canada ; Conservation of Natural Resources/legislation & jurisprudence ; Conservation of Natural Resources/methods ; Environmental Monitoring/legislation & jurisprudence ; Environmental Monitoring/methods ; Government Regulation ; Private Sector ; Surveys and Questionnaires
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1478932-2
    ISSN 1432-1009 ; 0364-152X
    ISSN (online) 1432-1009
    ISSN 0364-152X
    DOI 10.1007/s00267-018-1086-6
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  4. Book ; Online ; Thesis: Flt1 determines the structural design of the arteriolar tree

    Klems, Alina [Verfasser] / Noblé, F. le [Akademischer Betreuer]

    2017  

    Author's details Alina Klems ; Betreuer: F. le Noble
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher KIT-Bibliothek
    Publishing place Karlsruhe
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: A single-cell time-lapse of mouse prenatal development from gastrula to birth.

    Qiu, Chengxiang / Martin, Beth K / Welsh, Ian C / Daza, Riza M / Le, Truc-Mai / Huang, Xingfan / Nichols, Eva K / Taylor, Megan L / Fulton, Olivia / O'Day, Diana R / Gomes, Anne Roshella / Ilcisin, Saskia / Srivatsan, Sanjay / Deng, Xinxian / Disteche, Christine M / Noble, William Stafford / Hamazaki, Nobuhiko / Moens, Cecilia B / Kimelman, David /
    Cao, Junyue / Schier, Alexander F / Spielmann, Malte / Murray, Stephen A / Trapnell, Cole / Shendure, Jay

    Nature

    2024  Volume 626, Issue 8001, Page(s) 1084–1093

    Abstract: The house mouse (Mus musculus) is an exceptional model system, combining genetic tractability with close evolutionary affinity to ... ...

    Abstract The house mouse (Mus musculus) is an exceptional model system, combining genetic tractability with close evolutionary affinity to humans
    MeSH term(s) Animals ; Female ; Mice ; Pregnancy ; Animals, Newborn/embryology ; Animals, Newborn/genetics ; Cell Differentiation/genetics ; Embryo, Mammalian/cytology ; Embryo, Mammalian/embryology ; Embryonic Development/genetics ; Gastrula/cytology ; Gastrula/embryology ; Gastrulation/genetics ; Kidney/cytology ; Kidney/embryology ; Mesoderm/cytology ; Mesoderm/enzymology ; Neurons/cytology ; Neurons/metabolism ; Retina/cytology ; Retina/embryology ; Single-Cell Analysis ; Somites/cytology ; Somites/embryology ; Time Factors ; Time-Lapse Imaging ; Transcription Factors/genetics ; Transcription, Genetic ; Organ Specificity/genetics
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07069-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  6. Article ; Online: Thymosin ß4 and MRTF-A mitigate vessel regression despite cardiovascular risk factors.

    Kupatt, Christian / Ziegler, Tilman / Bähr, Andrea / Le Noble, Ferdinand

    International immunopharmacology

    2023  Volume 117, Page(s) 109786

    Abstract: Since clinical revascularization techniques of coronary or peripheral artery disease (CAD/PAD) focus on macrovessels of the heart, the microcirculatory compartment largely goes unnoticed. However, cardiovascular risk factors not only drive large vessel ... ...

    Abstract Since clinical revascularization techniques of coronary or peripheral artery disease (CAD/PAD) focus on macrovessels of the heart, the microcirculatory compartment largely goes unnoticed. However, cardiovascular risk factors not only drive large vessel atherosclerosis, but also microcirculatory rarefaction, an instance unmet by current therapeutic schemes. Angiogenic gene therapy has the potential to reverse capillary rarefaction, but only if the disease-causing inflammation and vessel-destabilization are addressed. This review summarizes the current knowledge with regard to capillary rarefaction due to cardiovascular risk factors. Moreover, the potential of Thymosin ß4 (Tß4) and its downstream signal, myocardin-related transcription factor-A (MRTF-A), to counteract capillary rarefaction are discussed.
    MeSH term(s) Humans ; Cardiovascular Diseases/drug therapy ; Thymosin/therapeutic use ; Microvascular Rarefaction ; Microcirculation ; Risk Factors ; Coronary Artery Disease ; Heart Disease Risk Factors
    Chemical Substances myocardin ; Thymosin (61512-21-8)
    Language English
    Publishing date 2023-02-20
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.109786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features.

    Read, David F / Cook, Kate / Lu, Yang Y / Le Roch, Karine G / Noble, William Stafford

    PLoS computational biology

    2019  Volume 15, Issue 9, Page(s) e1007329

    Abstract: Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle. To better understand this regulatory machinery, we assembled a ... ...

    Abstract Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle. To better understand this regulatory machinery, we assembled a rich collection of genomic and epigenomic data sets, including information about transcription factor (TF) binding motifs, patterns of covalent histone modifications, nucleosome occupancy, GC content, and global 3D genome architecture. We used these data to train machine learning models to discriminate between high-expression and low-expression genes, focusing on three distinct stages of the red blood cell phase of the Plasmodium life cycle. Our results highlight the importance of histone modifications and 3D chromatin architecture in Plasmodium transcriptional regulation and suggest that AP2 transcription factors may play a limited regulatory role, perhaps operating in conjunction with epigenetic factors.
    MeSH term(s) Computational Biology/methods ; Erythrocytes/parasitology ; Gene Expression Profiling ; Gene Expression Regulation/genetics ; Genes, Protozoan/genetics ; Histone Code/genetics ; Humans ; Life Cycle Stages/genetics ; Machine Learning ; Malaria, Falciparum ; Models, Biological ; Models, Statistical ; Nucleosomes/genetics ; Plasmodium falciparum/cytology ; Plasmodium falciparum/genetics ; Plasmodium falciparum/pathogenicity
    Chemical Substances Nucleosomes
    Language English
    Publishing date 2019-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1007329
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  8. Article ; Online: Gamma-glutamyl transpeptidase-to-platelet ratio as a biomarker of liver disease and hepatic fibrosis severity in paediatric Cystic Fibrosis.

    Calvopina, Diego A / Lewindon, Peter J / Ramm, Louise E / Noble, Charlton / Hartel, Gunter F / Leung, Daniel H / Ramm, Grant A

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2021  Volume 21, Issue 2, Page(s) 236–242

    Abstract: Background: Cystic fibrosis (CF)-associated liver disease (CFLD) causes significant morbidity and mortality in children with CF. Diagnosis of liver disease prior to development of cirrhosis or portal hypertension (PHT) is challenging. While imaging ... ...

    Abstract Background: Cystic fibrosis (CF)-associated liver disease (CFLD) causes significant morbidity and mortality in children with CF. Diagnosis of liver disease prior to development of cirrhosis or portal hypertension (PHT) is challenging. While imaging modalities using Elastography show great promise they are still not widely available to all clinicians. This study investigated gamma-glutamyl transpeptidase-to-platelet ratio (GPR) as a non-invasive biomarker to detect liver disease and stage fibrosis severity in children with CF.
    Methods: 237 children were enroled including 76 with CFLD and 161 with CF and no detectable liver disease (CFnoLD). CFLD was diagnosed using standard clinical, biochemical and imaging practice guidelines. Hepatic fibrosis was staged on liver biopsies available from 54 children with CFLD. Serum liver biochemistry was used to calculate GPR (median, [IQR]) and receiver operating characteristics (ROC) analysis assessed utility to detect liver disease and stage fibrosis severity.
    Results: GPR was significantly increased in CFLD versus CFnoLD (0.33 [0.19-0.96] vs. 0.15 [0.11-0.21], P<0.0001). GPR demonstrated good diagnostic utility for detecting CFLD with an area under the curve (AUC) of 0.81 (95% confidence Interval [CI] [0.75-0.87]; P<0.0001), with sensitivity of 74% and specificity of 73%, using a cut-off of 0.20. GPR increased with increasing hepatic fibrosis stage. GPR discriminated both moderate-advanced (F2-F4) fibrosis vs. F0-F1 (AUC=0.82; 95%CI [0.71-0.94]; P<0.0001) and advanced (F3-F4) fibrosis vs. F0-F2 (AUC=0.77; 95%CI [0.64-0.90]; P = 0.004), with a cut-off 0.32 and 0.61, respectively. An elevated GPR of >0.84 was predictive of PHT at diagnosis of CFLD (AUC=0.81; 95%CI [0.67-0.95]; P = 0.0003).
    Conclusions: GPR demonstrates good diagnostic utility for assessing the presence of liver disease, PHT and hepatic fibrosis severity in children with CF. These findings will aid in better identification of patients at risk for CF-related liver involvement and the potential for more targeted and timely follow-up and treatment.
    MeSH term(s) Biomarkers ; Child ; Cystic Fibrosis/complications ; Cystic Fibrosis/diagnosis ; Fibrosis ; Humans ; Hypertension, Portal ; Liver/pathology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Platelet Count/methods ; ROC Curve ; Severity of Illness Index ; gamma-Glutamyltransferase
    Chemical Substances Biomarkers ; gamma-Glutamyltransferase (EC 2.3.2.2)
    Language English
    Publishing date 2021-12-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2021.10.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6028: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 459: Show issues

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  9. Book ; Online ; Thesis: Neuronal Flt1 controls spinal cord vascularization involving venous endothelium with high angiogenic potential

    Wild, Raphael [Verfasser] / Noblé, F. le [Akademischer Betreuer]

    2016  

    Author's details Raphael Wild ; Betreuer: F. le Noble
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher KIT-Bibliothek
    Publishing place Karlsruhe
    Document type Book ; Online ; Thesis
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  10. Article: A single-cell transcriptional timelapse of mouse embryonic development, from gastrula to pup.

    Qiu, Chengxiang / Martin, Beth K / Welsh, Ian C / Daza, Riza M / Le, Truc-Mai / Huang, Xingfan / Nichols, Eva K / Taylor, Megan L / Fulton, Olivia / O'Day, Diana R / Gomes, Anne Roshella / Ilcisin, Saskia / Srivatsan, Sanjay / Deng, Xinxian / Disteche, Christine M / Noble, William Stafford / Hamazaki, Nobuhiko / Moens, Cecilia B / Kimelman, David /
    Cao, Junyue / Schier, Alexander F / Spielmann, Malte / Murray, Stephen A / Trapnell, Cole / Shendure, Jay

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The house mouse, ...

    Abstract The house mouse,
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.05.535726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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