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Article ; Online: Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H

Panagaki, Theodora / Janickova, Lucia / Petrovic, Dunja / Zuhra, Karim / Ditrói, Tamás / Jurányi, Eszter P / Bremer, Olivier / Ascenção, Kelly / Philipp, Thilo M / Nagy, Péter / Filipovic, Milos R / Szabo, Csaba

GeroScience

2024

Abstract: ... we investigated the functional role of the CBS/hydrogen sulfide (H ...

Abstract	Down syndrome (DS) is a genetic condition where the person is born with an extra chromosome 21. DS is associated with accelerated aging; people with DS are prone to age-related neurological conditions including an early-onset Alzheimer's disease. Using the Dp(17)3Yey/ + mice, which overexpresses a portion of mouse chromosome 17, which encodes for the transsulfuration enzyme cystathionine β-synthase (CBS), we investigated the functional role of the CBS/hydrogen sulfide (H
Language	English
Publishing date	2024-04-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2886586-8
ISSN	2509-2723 ; 2509-2715
ISSN (online)	2509-2723
ISSN	2509-2715
DOI	10.1007/s11357-024-01146-8
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Article ; Online: Method to Detect the Cellular Source of Over-Activated NADPH Oxidases Using NAD(P)H Fluorescence Lifetime Imaging.

Bremer, Daniel / Leben, Ruth / Mothes, Ronja / Radbruch, Helena / Niesner, Raluca

Current protocols in cytometry

2017 Volume 80, Page(s) 9.52.1–9.52.14

Abstract: ... emission spectrum. The ubiquitous coenzymes NADH and NADPH, hereafter NAD(P)H, in cells show a short fluorescence ... The fluorescence lifetime of NAD(P)H in this state depends on the binding-site on the specific enzyme. In the case ... measured. Here we present a robust protocol based on NAD(P)H fluorescence lifetime imaging ...

Abstract	Fluorescence-lifetime imaging microscopy (FLIM) is a technique to generate images, in which the contrast is obtained by the excited-state lifetime of fluorescent molecules instead of their intensity and emission spectrum. The ubiquitous coenzymes NADH and NADPH, hereafter NAD(P)H, in cells show a short fluorescence lifetime ≈400 psec in the free-state and a longer fluorescence lifetime when bound to enzymes. The fluorescence lifetime of NAD(P)H in this state depends on the binding-site on the specific enzyme. In the case of NADPH bound to members of the NADPH oxidases family we measured a fluorescence lifetime of 3650 psec as compared to enzymes typically active in cells, in which case fluorescence lifetimes of ∼2000 psec are measured. Here we present a robust protocol based on NAD(P)H fluorescence lifetime imaging in isolated cells to distinguish between normally active enzymes and NADPH oxidases, mainly responsible for oxidative stress. © 2017 by John Wiley & Sons, Inc.
MeSH term(s)	Animals ; Cell Separation ; Cell Survival ; Flow Cytometry ; Fluorescence ; Humans ; Imaging, Three-Dimensional/methods ; Magnetics ; Mice ; NADP/metabolism ; NADPH Oxidases/metabolism ; Time Factors
Chemical Substances	NADP (53-59-8) ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2017-04-03
Publishing country	United States
Document type	Journal Article
ISSN	1934-9300
ISSN (online)	1934-9300
DOI	10.1002/cpcy.20
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Article ; Online: Prof. Dr. Johann H. Karstens zur Emeritierung.

Bremer, M / Meyer, A / Bruns, F

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

2013 Volume 189, Issue 1, Page(s) 89–90

Title translation	To Prof. Dr. Johann H. Karstens on the occasion of his retirement.
MeSH term(s)	Germany ; History, 20th Century ; History, 21st Century ; Radiation Oncology/history ; Radiotherapy/history
Language	German
Publishing date	2013-01
Publishing country	Germany
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	84983-2
ISSN	1439-099X ; 0179-7158 ; 0039-2073
ISSN (online)	1439-099X
ISSN	0179-7158 ; 0039-2073
DOI	10.1007/s00066-012-0267-0
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Article ; Online: Salt-sensitivity of σ(H) and Spo0A prevents sporulation of Bacillus subtilis at high osmolarity avoiding death during cellular differentiation.

Widderich, Nils / Rodrigues, Christopher D A / Commichau, Fabian M / Fischer, Kathleen E / Ramirez-Guadiana, Fernando H / Rudner, David Z / Bremer, Erhard

Molecular microbiology

2016 Volume 100, Issue 1, Page(s) 108–124

Abstract: The spore-forming bacterium Bacillus subtilis frequently experiences high osmolarity as a result of desiccation in the soil. The formation of a highly desiccation-resistant endospore might serve as a logical osmostress escape route when vegetative growth ...

Abstract	The spore-forming bacterium Bacillus subtilis frequently experiences high osmolarity as a result of desiccation in the soil. The formation of a highly desiccation-resistant endospore might serve as a logical osmostress escape route when vegetative growth is no longer possible. However, sporulation efficiency drastically decreases concomitant with an increase in the external salinity. Fluorescence microscopy of sporulation-specific promoter fusions to gfp revealed that high salinity blocks entry into the sporulation pathway at a very early stage. Specifically, we show that both Spo0A- and SigH-dependent transcription are impaired. Furthermore, we demonstrate that the association of SigH with core RNA polymerase is reduced under these conditions. Suppressors that modestly increase sporulation efficiency at high salinity map to the coding region of sigH and in the regulatory region of kinA, encoding one the sensor kinases that activates Spo0A. These findings led us to discover that B. subtilis cells that overproduce KinA can bypass the salt-imposed block in sporulation. Importantly, these cells are impaired in the morphological process of engulfment and late forespore gene expression and frequently undergo lysis. Altogether our data indicate that B. subtilis blocks entry into sporulation in high-salinity environments preventing commitment to a developmental program that it cannot complete.
MeSH term(s)	Bacillus subtilis/physiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; DNA-Directed RNA Polymerases/metabolism ; Gene Expression Regulation, Bacterial ; Mutation ; Osmolar Concentration ; Promoter Regions, Genetic ; Protein Binding ; Salinity ; Salt-Tolerance/genetics ; Spores, Bacterial ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Bacterial Proteins ; Transcription Factors ; DNA-Directed RNA Polymerases (EC 2.7.7.6)
Language	English
Publishing date	2016-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	619315-8
ISSN	1365-2958 ; 0950-382X
ISSN (online)	1365-2958
ISSN	0950-382X
DOI	10.1111/mmi.13304
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Article ; Online: Effects of Consuming Sugar-Sweetened Beverages for 2 Weeks on 24-h Circulating Leptin Profiles, Ad Libitum Food Intake and Body Weight in Young Adults.

Sigala, Desiree M / Widaman, Adrianne M / Hieronimus, Bettina / Nunez, Marinelle V / Lee, Vivien / Benyam, Yanet / Bremer, Andrew A / Medici, Valentina / Havel, Peter J / Stanhope, Kimber L / Keim, Nancy L

Nutrients

2020 Volume 12, Issue 12

Abstract: Sugar-sweetened beverage (sugar-SB) consumption is associated with body weight gain. We investigated whether the changes of (Δ) circulating leptin contribute to weight gain and ad libitum food intake in young adults consuming sugar-SB for two weeks. In a ...

Abstract	Sugar-sweetened beverage (sugar-SB) consumption is associated with body weight gain. We investigated whether the changes of (Δ) circulating leptin contribute to weight gain and ad libitum food intake in young adults consuming sugar-SB for two weeks. In a parallel, double-blinded, intervention study, participants (
MeSH term(s)	Adolescent ; Adult ; Area Under Curve ; Aspartame/adverse effects ; Body Weight/drug effects ; Dietary Sugars/adverse effects ; Double-Blind Method ; Eating/drug effects ; Energy Intake/drug effects ; Female ; Humans ; Leptin/blood ; Male ; Postprandial Period/drug effects ; Sugar-Sweetened Beverages/adverse effects ; Sweetening Agents/adverse effects ; Weight Gain/drug effects ; Young Adult
Chemical Substances	Dietary Sugars ; Leptin ; Sweetening Agents ; Aspartame (Z0H242BBR1)
Language	English
Publishing date	2020-12-19
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12123893
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Book: Famillen H***

Bremer, Fredrika / Arping, Åsa

(Svenska författare)

2000

Author's details	Fredrika Bremer. Utg. med inledning och kommentarer av Åsa Arping
Series title	Svenska författare
Language	Swedish
Size	XXVI, 242 S
Publisher	Svenska Vitterhetssamfundet
Publishing place	Stockholm
Document type	Book
ISBN	9172300949 ; 9789172300941
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Effects of Consuming Sugar-Sweetened Beverages for 2 Weeks on 24-h Circulating Leptin Profiles, Ad Libitum Food Intake and Body Weight in Young Adults

Sigala, Desiree M. / Widaman, Adrianne M. / Hieronimus, Bettina / Nunez, Marinelle V. / Lee, Vivien / Benyam, Yanet / Bremer, Andrew A. / Medici, Valentina / Havel, Peter J. / Stanhope, Kimber L. / Keim, Nancy L.

2020

Keywords	Text ; ddc:610 ; leptin -- satiety -- energy intake -- energy compensation -- obesity -- aspartame -- fructose -- glucose -- sucrose -- high fructose corn syrup
Language	English
Publishing date	2020-12-19
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T.

Cudalbu, Cristina / Craveiro, Melanie / Mlynárik, Vladimir / Bremer, Juliane / Aguzzi, Adriano / Gruetter, Rolf

Neurochemical research

2015 Volume 40, Issue 12, Page(s) 2639–2646

Abstract: In vivo (1)H MR spectroscopy allows the non invasive characterization of brain metabolites and ... transgenic mouse models of prion disease were created. We performed an in vivo longitudinal (1)H MR spectroscopy ...

Abstract	In vivo (1)H MR spectroscopy allows the non invasive characterization of brain metabolites and it has been used for studying brain metabolic changes in a wide range of neurodegenerative diseases. The prion diseases form a group of fatal neurodegenerative diseases, also described as transmissible spongiform encephalopathies. The mechanism by which prions elicit brain damage remains unclear and therefore different transgenic mouse models of prion disease were created. We performed an in vivo longitudinal (1)H MR spectroscopy study at 14.1 T with the aim to measure the neurochemical profile of Prnp -/- and PrPΔ32-121 mice in the hippocampus and cerebellum. Using high-field MR spectroscopy we were able to analyze in details the in vivo brain metabolites in Prnp -/- and PrPΔ32-121 mice. An increase of myo-inositol, glutamate and lactate concentrations with a decrease of N-acetylaspartate concentrations were observed providing additional information to the previous measurements.
MeSH term(s)	Animals ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Brain Chemistry/genetics ; Cerebellum/pathology ; Glutamic Acid/metabolism ; Hippocampus/pathology ; Inositol/metabolism ; Lactic Acid/metabolism ; Magnetic Resonance Spectroscopy ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Mice, Transgenic ; Prion Diseases/pathology ; Prion Proteins ; Prions/genetics
Chemical Substances	Prion Proteins ; Prions ; Prnp protein, mouse ; Aspartic Acid (30KYC7MIAI) ; Lactic Acid (33X04XA5AT) ; Glutamic Acid (3KX376GY7L) ; Inositol (4L6452S749) ; N-acetylaspartate (997-55-7)
Language	English
Publishing date	2015-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1007/s11064-015-1643-9
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Article ; Online: Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions.

Stanhope, Kimber L / Griffen, Steven C / Bremer, Andrew A / Vink, Roel G / Schaefer, Ernst J / Nakajima, Katsuyuki / Schwarz, Jean-Marc / Beysen, Carine / Berglund, Lars / Keim, Nancy L / Havel, Peter J

The American journal of clinical nutrition

2011 Volume 94, Issue 1, Page(s) 112–119

Abstract: ... facility (fructose GI = 38, glucose GI = 83). The 24-h glucose and insulin profiles and fasting plasma ... peaks and the 23-h area under the curve compared with the baseline diet and with the consumption ...

Abstract	Background: Consumption of sugar-sweetened beverages has been shown to be associated with dyslipidemia, insulin resistance, fatty liver, diabetes, and cardiovascular disease. It has been proposed that adverse metabolic effects of chronic consumption of sugar-sweetened beverages are a consequence of increased circulating glucose and insulin excursions, ie, dietary glycemic index (GI). Objective: We determined whether the greater adverse effects of fructose than of glucose consumption were associated with glucose and insulin exposures. Design: The subjects were studied in a metabolic facility and consumed energy-balanced diets containing 55% of energy as complex carbohydrate for 2 wk (GI = 64). The subjects then consumed 25% of energy requirements as fructose- or glucose-sweetened beverages along with their usual ad libitum diets for 8 wk at home and then as part of energy-balanced diets for 2 wk at the metabolic facility (fructose GI = 38, glucose GI = 83). The 24-h glucose and insulin profiles and fasting plasma glycated albumin and fructosamine concentrations were measured 0, 2, 8, and 10 wk after beverage consumption. Results: Consumption of fructose-sweetened beverages lowered glucose and insulin postmeal peaks and the 23-h area under the curve compared with the baseline diet and with the consumption of glucose-sweetened beverages (all P < 0.001, effect of sugar). Plasma glycated albumin concentrations were lower 10 wk after fructose than after glucose consumption (P < 0.01, effect of sugar), whereas fructosamine concentrations did not differ between groups. Conclusion: The results suggest that the specific effects of fructose, but not of glucose and insulin excursions, contribute to the adverse effects of consuming sugar-sweetened beverages on lipids and insulin sensitivity. This study is registered at clinicaltrials.gov as NCT01165853.
MeSH term(s)	Adult ; Aged ; Beverages ; Blood Glucose/analysis ; Female ; Fructose/administration & dosage ; Glucose/administration & dosage ; Humans ; Insulin/blood ; Lipoprotein Lipase/metabolism ; Male ; Metabolic Syndrome/etiology ; Middle Aged ; Postprandial Period/physiology
Chemical Substances	Blood Glucose ; Insulin ; Fructose (30237-26-4) ; Lipoprotein Lipase (EC 3.1.1.34) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2011-05-25
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.3945/ajcn.110.002246
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Article ; Online: SUMMARY OF GREEN PLANT PHYLOGENY AND CLASSIFICATION.

Bremer, Kåre

Cladistics : the international journal of the Willi Hennig Society

2021 Volume 1, Issue 4, Page(s) 369–385

Abstract: ... H. Wagner, and P. Crane. The relationships of green plants to other green organisms (Prochloron ...

Abstract	Abstract- A cladogram of green plants involving all major extant groups of green algae, bryophytes, pteridophytes, and seed plants is presented. It is partly based on contributions by B. Mishler and S. Churchill, H. Wagner, and P. Crane. The relationships of green plants to other green organisms (Prochloron, euglenophytes) are discussed. The characters and subclades of the cladogram are briefly discussed, with an attempt to indicate weak points. The possibility of including some major extinct groups is considered. A cladistic classification consistent with the cladogram is presented. Grades are abandoned as taxa and major clades like the division Chlorophyta (green algae excluding micro-monadophytes and charophytes sensu Mattox and Stewart), the division Streptophyta (charophytes + embryophytes), the subdivision Embryophytina (land plants or embryophytes), the superclass Tracheidatae (tracheophytes), and the class Spermatopsida (seed plants) are recognized.
Language	English
Publishing date	2021-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1462608-1
ISSN	1096-0031 ; 0748-3007
ISSN (online)	1096-0031
ISSN	0748-3007
DOI	10.1111/j.1096-0031.1985.tb00434.x
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