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  1. Article ; Online: Evolving Stroke Systems of Care: Stroke Diagnosis and Treatment in the Post-Thrombectomy Era.

    Pajor, Michael J / Adeoye, Opeolu M

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2023  Volume 20, Issue 3, Page(s) 655–663

    Abstract: Thrombectomy became the gold-standard treatment of acute ischemic stroke caused by large-vessel occlusions (LVO) in 2015 after five clinical trials published that year demonstrated significantly improved patient outcomes. In subsequent years, advances in ...

    Abstract Thrombectomy became the gold-standard treatment of acute ischemic stroke caused by large-vessel occlusions (LVO) in 2015 after five clinical trials published that year demonstrated significantly improved patient outcomes. In subsequent years, advances in stroke systems of care have centered around improving access to and expanding patient eligibility for thrombectomy. The prehospital and acute stroke treatment settings have had the greatest emphasis. Numerous prehospital stroke scales now provide emergency medical services with focused physical exams to identify LVOs, and many devices to non-invasively detect LVO are undergoing clinical testing. Mobile stroke units deployed throughout Western Europe and the USA also show promising results by bringing elements of acute stroke care directly to the patient. Numerous clinical trials since 2015 have aimed to increase candidates for thrombectomy by expanding indications and the eligibility time window. Further optimizations of thrombectomy treatment have focused on the role of thrombolytics and other adjunctive therapies that may promote neuroprotection and neurorecovery. While many of these approaches require further clinical investigation, the next decade shows significant potential for further advances in stroke care.
    MeSH term(s) Humans ; Brain Ischemia/diagnosis ; Brain Ischemia/surgery ; Ischemic Stroke ; Stroke/diagnosis ; Stroke/surgery ; Thrombectomy/methods ; Emergency Medical Services/methods ; Treatment Outcome
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-023-01371-7
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  2. Article ; Online: Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke.

    Saver, Jeffrey L / Adeoye, Opeolu

    JAMA

    2021  Volume 325, Issue 3, Page(s) 229–231

    MeSH term(s) Brain Ischemia/drug therapy ; Humans ; Ischemic Stroke ; Stroke/drug therapy ; Thrombectomy ; Thrombolytic Therapy
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.22388
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  3. Article ; Online: Endovascular Treatment of Acute Stroke.

    Giles, James A / Vellimana, Ananth K / Adeoye, Opeolu M

    Current neurology and neuroscience reports

    2022  Volume 22, Issue 1, Page(s) 83–91

    Abstract: Purpose of review: In the USA, around 30% of 795,000 strokes per year are due to proximal large-vessel occlusion, and these are a major cause of death and disability. We review the most recent advances regarding treatment of ischemic stroke amenable to ... ...

    Abstract Purpose of review: In the USA, around 30% of 795,000 strokes per year are due to proximal large-vessel occlusion, and these are a major cause of death and disability. We review the most recent advances regarding treatment of ischemic stroke amenable to mechanical thrombectomy.
    Recent findings: In the last four years, clinical trial evidence has expanded the time window for successful endovascular treatment to 24 h. Current research is aimed at expanding patient selection to mild strokes, large ischemic cores and occlusions of smaller, more distal blood vessels. Further, we have developed understanding of how to manage blood pressure after thrombectomy and even had promising results for a neuroprotective agent in these patients. Thrombectomy has transformed the treatment of ischemic stroke due to large-vessel occlusion. Recent research has focused on expanding patient candidacy for endovascular treatment and improving medical management to support better neurologic outcomes.
    MeSH term(s) Endovascular Procedures ; Humans ; Ischemic Stroke/surgery ; Thrombectomy
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-022-01168-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5549: Show issues Location:
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  4. Article ; Online: Alteplase and Adjuvant Therapies for Acute Ischemic Stroke.

    Gottula, Adam L / Barreto, Andrew D / Adeoye, Opeolu

    Seminars in neurology

    2021  Volume 41, Issue 1, Page(s) 16–27

    Abstract: Acute ischemic stroke (AIS) is a time sensitive medical emergency and a leading cause of morbidity and mortality worldwide. Intravenous (IV) recombinant tissue plasminogen activator (IV alteplase) is currently the only proven effective medication for the ...

    Abstract Acute ischemic stroke (AIS) is a time sensitive medical emergency and a leading cause of morbidity and mortality worldwide. Intravenous (IV) recombinant tissue plasminogen activator (IV alteplase) is currently the only proven effective medication for the treatment of AIS with promising adjuvant medications currently under investigation. Recent advances in endovascular thrombectomy have broadened therapeutic options in specific patient populations, with modern treatment strategies utilizing advanced imaging modalities to extend the window for treatment. In all cases, rapid treatment remains a priority. The future of IV alteplase and the changing standard for treatment of AIS remain unwritten with the increasing evidence for imaging selection for both endovascular thrombectomy and IV alteplase, while novel adjuncts are under investigation. In this article, we review the history of IV alteplase investigations for stroke, evidence for thrombectomy as an adjunct to IV alteplase, and the potential of novel adjuvant therapeutics currently under investigation.
    MeSH term(s) Brain Ischemia/diagnostic imaging ; Brain Ischemia/drug therapy ; Fibrinolytic Agents/therapeutic use ; Humans ; Ischemic Stroke ; Stroke/diagnostic imaging ; Stroke/drug therapy ; Thrombectomy ; Tissue Plasminogen Activator ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0040-1722720
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  5. Article ; Online: Management of patients with transient ischemic attack in the emergency department.

    Silver, Brian / Adeoye, Opeolu

    Neurology

    2016  Volume 86, Issue 17, Page(s) 1568–1569

    Language English
    Publishing date 2016-04-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000002621
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    Zs.MO 374: Show issues

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  6. Article ; Online: Estimated Population Access to Acute Stroke and Telestroke Centers in the US, 2019.

    Zachrison, Kori S / Cash, Rebecca E / Adeoye, Opeolu / Boggs, Krislyn M / Schwamm, Lee H / Mehrotra, Ateev / Camargo, Carlos A

    JAMA network open

    2022  Volume 5, Issue 2, Page(s) e2145824

    MeSH term(s) Critical Care/statistics & numerical data ; Cross-Sectional Studies ; Emergency Medical Services/statistics & numerical data ; Health Services Accessibility/statistics & numerical data ; Humans ; Stroke/therapy ; Telemedicine/statistics & numerical data ; United States
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.45824
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  7. Article ; Online: Iterative Development of the Caregiver Wellness After Traumatic Brain Injury Program (CG-Well).

    Kreitzer, Natalie / Adeoye, Opeolu / Wade, Shari L / Kurowki, Brad G / Thomas, Stephanie / Gillespie, Lauren / Bakas, Tamilyn

    The Journal of head trauma rehabilitation

    2023  Volume 38, Issue 6, Page(s) E424–E436

    Abstract: Objectives: (1) To iteratively design a web/phone-based intervention to support caregivers of adults acutely following traumatic brain injury (TBI), Caregiver Wellness (CG-Well), and (2) to obtain qualitative and quantitative feedback on CG-Well from ... ...

    Abstract Objectives: (1) To iteratively design a web/phone-based intervention to support caregivers of adults acutely following traumatic brain injury (TBI), Caregiver Wellness (CG-Well), and (2) to obtain qualitative and quantitative feedback on CG-Well from experts and caregivers to refine the intervention.
    Setting: A level I trauma and tertiary medical center.
    Participants: Convenience sample of a total of 19 caregivers and 25 experts.
    Design: Multistep prospective study with iterative changes to CG-Well: (1) developed intervention content based on qualitative feedback from a prior study and literature review; (2) obtained qualitative feedback from 10 experts; (3) refined content using a modified Delphi approach involving 4 caregivers and 6 experts followed by qualitative interviews with 9 caregivers; (4) designed CG-Well website and videos; and (5) obtained feedback on program acceptability, appropriateness, and feasibility from 6 caregivers and 9 experts.
    Interventions: CG-Well included content on TBI, self-care and support, and skill-building strategies delivered through a website and telephone calls.
    Main outcome measures: Qualitative data were analyzed using content analysis. Caregivers and experts completed Likert-type scales to rate module relevance, clarity, accuracy, utility and website acceptability, appropriateness, and feasibility (1 = strongly disagree to 5 = strongly agree). Means and standard deviations (SD) characterized ratings.
    Results: Qualitative findings were instrumental in designing and refining CG-Well. Ratings were positive for modules (means and SD for relevant [4.9, 0.33], clear [4.6, 0.53], accurate [4.9, 0.33], and useful [5, 0]) and the website (means and SD for acceptable [4.8, 0.36], appropriate [4.8, 0.35], and feasible [4.8, 0.36]).
    Conclusions: The iterative design process for CG-Well resulted in a highly acceptable program. An early-stage randomized controlled trial is underway to estimate treatment effects for a future well-powered clinical trial.
    MeSH term(s) Adult ; Humans ; Caregivers ; Prospective Studies ; Brain Injuries, Traumatic ; Telephone
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639221-0
    ISSN 1550-509X ; 0885-9701
    ISSN (online) 1550-509X
    ISSN 0885-9701
    DOI 10.1097/HTR.0000000000000869
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    Zs.A 2278: Show issues Location:
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  8. Article ; Online: ACEP-SAEM response to the National Institutes of Health (NIH) proposal to simplify the review framework for research project grant applications.

    Knack, Sarah K / Kim, Howard / Paxton, James / Garg, Nidhi / Lumba-Brown, Angela / Levy, Phil / Puskarich, Mike / Silbergleit, Rob / D'Onofrio, Gail / Adeoye, Opeolu / Kang, Chris / Diercks, Deb / Neumar, Robert / Sharp, Willard W

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2023  Volume 30, Issue 9, Page(s) 963–964

    MeSH term(s) United States ; Humans ; National Institutes of Health (U.S.) ; Emergency Medicine ; Biomedical Research
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14730
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    Zs.A 4479: Show issues Location:
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  9. Article ; Online: Control of elevated blood pressure in acute intracerebral hemorrhage.

    Adeoye, Opeolu

    F1000 medicine reports

    2010  Volume 2, Page(s) 75

    Abstract: Intracerebral hemorrhage remains a challenging worldwide clinical problem with no proven treatments. In the acute phase of the illness, there has been some controversy regarding the appropriate management of elevated blood pressure. Recently published ... ...

    Abstract Intracerebral hemorrhage remains a challenging worldwide clinical problem with no proven treatments. In the acute phase of the illness, there has been some controversy regarding the appropriate management of elevated blood pressure. Recently published and ongoing clinical trials are beginning to shed some light on appropriate blood pressure management in acute intracerebral hemorrhage. This brief review focuses on these trials. In the next few years, it is hoped that clinical uncertainty regarding this issue will be obviated after completion of these trials.
    Language English
    Publishing date 2010-10-21
    Publishing country England
    Document type Journal Article
    ISSN 1757-5931
    ISSN (online) 1757-5931
    DOI 10.3410/M2-75
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  10. Article ; Online: Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials.

    Broderick, Joseph P / Adeoye, Opeolu / Elm, Jordan

    Stroke

    2017  Volume 48, Issue 7, Page(s) 2007–2012

    MeSH term(s) Clinical Trials as Topic ; Humans ; Stroke/therapy ; Treatment Outcome
    Language English
    Publishing date 2017-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.117.017866
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    Zs.A 448: Show issues Location:
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