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  1. Article ; Online: Membrane fusion and fission during eukaryogenesis.

    Romero, Héctor / Aguilar, Pablo S / Graña, Martin / Langleib, Mauricio / Gudiño, Virginia / Podbilewicz, Benjamin

    Current opinion in cell biology

    2024  Volume 86, Page(s) 102321

    Abstract: All eukaryotes can be traced back to a single shared ancestral lineage that emerged from interactions between different prokaryotic cells. Current models of eukaryogenesis describe various selective forces and evolutionary mechanisms that contributed to ... ...

    Abstract All eukaryotes can be traced back to a single shared ancestral lineage that emerged from interactions between different prokaryotic cells. Current models of eukaryogenesis describe various selective forces and evolutionary mechanisms that contributed to the formation of eukaryotic cells. Central to this process were significant changes in cellular structure, resulting in the configuration of a new cell type characterized by internal membrane compartments. Additionally, eukaryogenesis results in a life cycle that relies on cell-cell fusion. We discuss the potential roles of proteins involved in remodeling cellular membranes, highlighting two critical stages in the evolution of eukaryotes: the internalization of symbiotic partners and a scenario wherein the emergence of sexual reproduction is linked to a polyploid ancestor generated by cell-cell fusion.
    MeSH term(s) Phylogeny ; Membrane Fusion ; Prokaryotic Cells/metabolism ; Eukaryotic Cells/metabolism ; Eukaryota ; Biological Evolution
    Language English
    Publishing date 2024-01-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2023.102321
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2963: Show issues Location:
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  2. Article ; Online: Correlation analyses reveal differential diffusion behavior of eisosomal proteins between mother and daughter cells.

    Tedesco, Francisco G Correa / Aguilar, Pablo S / Estrada, Laura C

    Methods and applications in fluorescence

    2022  Volume 10, Issue 4

    Abstract: Eisosomes are nanoscale plasma membrane domains shaped as furrow-like invaginations. ... ...

    Abstract Eisosomes are nanoscale plasma membrane domains shaped as furrow-like invaginations. In
    MeSH term(s) Cell Membrane/metabolism ; Female ; Humans ; Mothers ; Phosphoproteins/chemistry ; Phosphoproteins/metabolism ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Phosphoproteins ; Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article
    ISSN 2050-6120
    ISSN (online) 2050-6120
    DOI 10.1088/2050-6120/ac8fe1
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  3. Article ; Online: High rates of calcium-free diffusion in the cytosol of living cells.

    Villarruel, Cecilia / Aguilar, Pablo S / Ponce Dawson, Silvina

    Biophysical journal

    2021  Volume 120, Issue 18, Page(s) 3960–3972

    Abstract: ... Calcium ( ... ...

    Abstract Calcium (Ca
    MeSH term(s) Calcium/metabolism ; Calcium Channels ; Cytosol/metabolism ; Diffusion ; Oocytes/metabolism
    Chemical Substances Calcium Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2021.08.019
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  4. Article ; Online: Scalable phylogenetic profiling using MinHash uncovers likely eukaryotic sexual reproduction genes.

    Moi, David / Kilchoer, Laurent / Aguilar, Pablo S / Dessimoz, Christophe

    PLoS computational biology

    2020  Volume 16, Issue 7, Page(s) e1007553

    Abstract: Phylogenetic profiling is a computational method to predict genes involved in the same biological process by identifying protein families which tend to be jointly lost or retained across the tree of life. Phylogenetic profiling has customarily been more ... ...

    Abstract Phylogenetic profiling is a computational method to predict genes involved in the same biological process by identifying protein families which tend to be jointly lost or retained across the tree of life. Phylogenetic profiling has customarily been more widely used with prokaryotes than eukaryotes, because the method is thought to require many diverse genomes. There are now many eukaryotic genomes available, but these are considerably larger, and typical phylogenetic profiling methods require at least quadratic time as a function of the number of genes. We introduce a fast, scalable phylogenetic profiling approach entitled HogProf, which leverages hierarchical orthologous groups for the construction of large profiles and locality-sensitive hashing for efficient retrieval of similar profiles. We show that the approach outperforms Enhanced Phylogenetic Tree, a phylogeny-based method, and use the tool to reconstruct networks and query for interactors of the kinetochore complex as well as conserved proteins involved in sexual reproduction: Hap2, Spo11 and Gex1. HogProf enables large-scale phylogenetic profiling across the three domains of life, and will be useful to predict biological pathways among the hundreds of thousands of eukaryotic species that will become available in the coming few years. HogProf is available at https://github.com/DessimozLab/HogProf.
    MeSH term(s) Cluster Analysis ; Computational Biology/methods ; Eukaryota/classification ; Eukaryota/genetics ; Kinetochores/metabolism ; Models, Statistical ; Phylogeny ; Reproduction/genetics
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1007553
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  5. Article ; Online: APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PM

    Calderón-Garcidueñas, Lilian / Hernández-Luna, Jacqueline / Aiello-Mora, Mario / Brito-Aguilar, Rafael / Evelson, Pablo A / Villarreal-Ríos, Rodolfo / Torres-Jardón, Ricardo / Ayala, Alberto / Mukherjee, Partha S

    Biomolecules

    2023  Volume 13, Issue 6

    Abstract: This Review emphasizes the impact of APOE4-the most significant genetic risk factor for Alzheimer's disease (AD)-on peripheral and neural effects starting in childhood. We discuss major mechanistic players associated with the APOE alleles' effects in ... ...

    Abstract This Review emphasizes the impact of APOE4-the most significant genetic risk factor for Alzheimer's disease (AD)-on peripheral and neural effects starting in childhood. We discuss major mechanistic players associated with the APOE alleles' effects in humans to understand their impact from conception through all life stages and the importance of detrimental, synergistic environmental exposures. APOE4 influences AD pathogenesis, and exposure to fine particulate matter (PM
    MeSH term(s) Humans ; Air Pollution/adverse effects ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Alzheimer Disease/psychology ; Amyloid beta-Peptides ; Apolipoprotein E4/genetics ; Brain/pathology ; Cities/epidemiology ; Gene-Environment Interaction ; Heterozygote ; Mexico/epidemiology ; Neuroinflammatory Diseases/etiology ; Neuroinflammatory Diseases/genetics ; Particulate Matter/adverse effects ; Suicide/statistics & numerical data
    Chemical Substances Amyloid beta-Peptides ; Apolipoprotein E4 ; Particulate Matter
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13060927
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  6. Article ; Online: Scalable phylogenetic profiling using MinHash uncovers likely eukaryotic sexual reproduction genes.

    David Moi / Laurent Kilchoer / Pablo S Aguilar / Christophe Dessimoz

    PLoS Computational Biology, Vol 16, Iss 7, p e

    2020  Volume 1007553

    Abstract: Phylogenetic profiling is a computational method to predict genes involved in the same biological process by identifying protein families which tend to be jointly lost or retained across the tree of life. Phylogenetic profiling has customarily been more ... ...

    Abstract Phylogenetic profiling is a computational method to predict genes involved in the same biological process by identifying protein families which tend to be jointly lost or retained across the tree of life. Phylogenetic profiling has customarily been more widely used with prokaryotes than eukaryotes, because the method is thought to require many diverse genomes. There are now many eukaryotic genomes available, but these are considerably larger, and typical phylogenetic profiling methods require at least quadratic time as a function of the number of genes. We introduce a fast, scalable phylogenetic profiling approach entitled HogProf, which leverages hierarchical orthologous groups for the construction of large profiles and locality-sensitive hashing for efficient retrieval of similar profiles. We show that the approach outperforms Enhanced Phylogenetic Tree, a phylogeny-based method, and use the tool to reconstruct networks and query for interactors of the kinetochore complex as well as conserved proteins involved in sexual reproduction: Hap2, Spo11 and Gex1. HogProf enables large-scale phylogenetic profiling across the three domains of life, and will be useful to predict biological pathways among the hundreds of thousands of eukaryotic species that will become available in the coming few years. HogProf is available at https://github.com/DessimozLab/HogProf.
    Keywords Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Conference proceedings: Use of artificial intelligence device in colorectal cancer screening colonoscopies. Experience in a second-level hospital

    de Castro, E. González / Aguilar Argeñal, L. F. / de la osa, D. Robles / Claudia, P. U. / Pablo, E. P. / Luis, C. M. / Moretón, Á.M. Montero / Citores, L. Pérez / Román, M. Cimavilla / Luengo, M. Curieses / Fernández, J. Santos / Santamarta, F. Santos / Moreira Da Silva, B. A. / Antolín, S. Maestro / Rancel Medina, F. J. / Laguna, J. Barcenilla / Pérez Millán, A. G.

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1783713
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 162: Show issues

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  8. Article: Ultrasound Strain Elastography Reliability in the Assessment of the Plantar Fascia and Its Relationship with the Plantar Thickness in Healthy Adults: An Intra and Interobserver Reliability Study in Novice Evaluators.

    Aguilar-Nuñez, Daniel / Cervera-Garvi, Pablo / Aguilar-Garcia, Maria / Cuevas-Cervera, Maria / Gonzalez-Muñoz, Ana / Navarro-Ledesma, Santiago

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: Purpose: This study was aimed at verifying both the intraobserver and interobserver reliability of measuring plantar fascia stiffness for a given image in healthy active adults.: Methodology: This study is reported following the Guidelines of ... ...

    Abstract Purpose: This study was aimed at verifying both the intraobserver and interobserver reliability of measuring plantar fascia stiffness for a given image in healthy active adults.
    Methodology: This study is reported following the Guidelines of Reporting Reliability and Agreement Studies. A total of 20 plantar fascia from healthy volunteers were analyzed. The thickness of the plantar fascia was measured vertically from the anterior edge of the inferior calcaneal border to the inferior border of the plantar fascia and the ultrasound elastography measurement was taken at the calcaneal insertion of the plantar fascia with the region of interest one centimeter away from the insertion.
    Results: The ultrasound strain elastography measurements: the right intraobserver 1 showed an ICC value of 0.9 and the left intraobserver 1 showed an ICC value of 0.78, while the right intraobserver 2 showed an ICC value of 0.91 and the left intraobserver 2 showed an ICC value of 0.83. Interobserver measurements showed excellent reliability with a right ICC value of 0.8 and a left ICC value of 0.9 for the plantar fascia thickness measurements.
    Discussion: The results of this study showed a strong correlation between left and right plantar fascia thickness. The intraobserver reliability was excellent for both plantar fascia ultrasound strain elastography and thickness measurements, with interobserver measurements showing excellent reliability.
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11072040
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  9. Article ; Online: Microanalytical Characterization of an Innovative Modern Mural Painting Technique by SEM-EDS, NMR and Micro-ATR-FTIR among Others.

    Aguilar-Rodríguez, Pablo / Zetina, Sandra / Mejía-González, Adrián / Esturau-Escofet, Nuria

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 2

    Abstract: During the 20th century, modern painters experimented with different mediums and painting techniques, one of them was Rafael Coronel in his mural painting, ...

    Abstract During the 20th century, modern painters experimented with different mediums and painting techniques, one of them was Rafael Coronel in his mural painting,
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28020564
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    Zs.MO 81: Show issues

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  10. Article ; Online: Relationship between perceptual and mechanical markers of fatigue during bench press and bench pull exercises: impact of inter-set rest period length.

    Janicijevic, Danica / Miras-Moreno, Sergio / Morenas-Aguilar, Maria Dolores / Jiménez-Martínez, Pablo / Alix-Fages, Carlos / García-Ramos, Amador

    PeerJ

    2024  Volume 12, Page(s) e16754

    Abstract: This study aimed to explore whether the relationship between perceptual (rating of perceived exertion; RPE) and mechanical (maximal number of repetitions completed [MNR], fastest set velocity, and mean velocity decline) variables is affected by the ... ...

    Abstract This study aimed to explore whether the relationship between perceptual (rating of perceived exertion; RPE) and mechanical (maximal number of repetitions completed [MNR], fastest set velocity, and mean velocity decline) variables is affected by the length of inter-set rest periods during resistance training sets not leading to failure. Twenty-three physically active individuals (15 men and eight women) randomly completed 12 testing sessions resulting from the combination of two exercises (bench press and bench pull), three inter-set rest protocols (1, 3, and 5 min), and two minimal velocity thresholds (farther from muscular failure [MVT
    MeSH term(s) Male ; Female ; Humans ; Exercise Therapy ; Exercise ; Resistance Training ; Fatigue ; Rest
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.16754
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