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  1. Article ; Online: Peri-implant Soft Tissue Management: Cairo Opinion Consensus Conference.

    Del Amo, Fernando Suárez López / Yu, Shan-Huey / Sammartino, Gilberto / Sculean, Anton / Zucchelli, Giovanni / Rasperini, Giulio / Felice, Pietro / Pagni, Giorgio / Iorio-Siciliano, Vincenzo / Grusovin, Maria Gabriella / Salvi, Giovanni E / Rebaudi, Alberto / Luongo, Giuseppe / Krauser, Jack T / Stefanini, Martina / Blasi, Andrea / Mouhyi, Jaafar / Ben Amor, Faten / Hamasni, Fatme M /
    Valavanis, Konstantinos / Simonpieri, Alain / Osman, Ahmed M / Qorri, Erda / Rullo, Rosario / Naipoglu, Arzu / Bruno, Vincenzo / Marenzi, Gaetano / Riccitiello, Francesco / Gasparro, Roberta / Mardas, Nikos / Spagnuolo, Gianrico / Fortunato, Leonzio / Wang, Hom-Lay

    International journal of environmental research and public health

    2020  Volume 17, Issue 7

    Abstract: ... Modern Dentistry Association (SENAME) (4-6 November 2016, Cairo, Egypt). The conference focused ...

    Abstract Peri-implant soft tissues play a role of paramount importance, not only on the esthetic appearance, but also on the maintenance and long-term stability of implants. The present report presents the conclusions from the Consensus Conference of the South European North African Middle Eastern Implantology & Modern Dentistry Association (SENAME) (4-6 November 2016, Cairo, Egypt). The conference focused on the topic of the soft tissue around dental implants, and in particular, on the influence of implant configurations on the marginal soft tissues, soft tissue alterations after immediate, early or delayed implant placement and immediate loading, the long-term outcomes of soft tissue stability around dental implants, and soft tissue augmentation around dental implants. Thirty world experts in this field were invited to take part in this two-day event; however, only 29 experts were in the final consensus voting process.
    MeSH term(s) Consensus ; Dental Implants ; Egypt ; Humans ; Mouth Mucosa
    Chemical Substances Dental Implants
    Language English
    Publishing date 2020-03-28
    Publishing country Switzerland
    Document type Congress
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17072281
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  2. Article: Iron Absorption: Molecular and Pathophysiological Aspects.

    Correnti, Margherita / Gammella, Elena / Cairo, Gaetano / Recalcati, Stefania

    Metabolites

    2024  Volume 14, Issue 4

    Abstract: Iron is an essential nutrient for growth among all branches of life, but while iron is among the most common elements, bioavailable iron is a relatively scarce nutrient. Since iron is fundamental for several biological processes, iron deficiency can be ... ...

    Abstract Iron is an essential nutrient for growth among all branches of life, but while iron is among the most common elements, bioavailable iron is a relatively scarce nutrient. Since iron is fundamental for several biological processes, iron deficiency can be deleterious. On the other hand, excess iron may lead to cell and tissue damage. Consequently, iron balance is strictly regulated. As iron excretion is not physiologically controlled, systemic iron homeostasis is maintained at the level of absorption, which is mainly influenced by the amount of iron stores and the level of erythropoietic activity, the major iron consumer. Here, we outline recent advances that increased our understanding of the molecular aspects of iron absorption. Moreover, we examine the impact of these recent insights on dietary strategies for maintaining iron balance.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo14040228
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  3. Article: Macrophages and Iron: A Special Relationship.

    Recalcati, Stefania / Cairo, Gaetano

    Biomedicines

    2021  Volume 9, Issue 11

    Abstract: Macrophages perform a variety of different biological functions and are known for their essential role in the immune response. In this context, a principal function is phagocytic clearance of pathogens, apoptotic and senescent cells. However, the major ... ...

    Abstract Macrophages perform a variety of different biological functions and are known for their essential role in the immune response. In this context, a principal function is phagocytic clearance of pathogens, apoptotic and senescent cells. However, the major targets of homeostatic phagocytosis by macrophages are old/damaged red blood cells. As such, macrophages play a crucial role in iron trafficking, as they recycle the large quantity of iron obtained by hemoglobin degradation. They also seem particularly adapted to handle and store amounts of iron that would be toxic to other cell types. Here, we examine the specific and peculiar iron metabolism of macrophages.
    Language English
    Publishing date 2021-10-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9111585
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  4. Article ; Online: Iron Mining for Erythropoiesis.

    Correnti, Margherita / Gammella, Elena / Cairo, Gaetano / Recalcati, Stefania

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: Iron is necessary for essential processes in every cell of the body, but the erythropoietic compartment is a privileged iron consumer. In fact, as a necessary component of hemoglobin and myoglobin, iron assures oxygen distribution; therefore, a ... ...

    Abstract Iron is necessary for essential processes in every cell of the body, but the erythropoietic compartment is a privileged iron consumer. In fact, as a necessary component of hemoglobin and myoglobin, iron assures oxygen distribution; therefore, a considerable amount of iron is required daily for hemoglobin synthesis and erythroid cell proliferation. Therefore, a tight link exists between iron metabolism and erythropoiesis. The liver-derived hormone hepcidin, which controls iron homeostasis via its interaction with the iron exporter ferroportin, coordinates erythropoietic activity and iron homeostasis. When erythropoiesis is enhanced, iron availability to the erythron is mainly ensured by inhibiting hepcidin expression, thereby increasing ferroportin-mediated iron export from both duodenal absorptive cells and reticuloendothelial cells that process old and/or damaged red blood cells. Erythroferrone, a factor produced and secreted by erythroid precursors in response to erythropoietin, has been identified and characterized as a suppressor of hepcidin synthesis to allow iron mobilization and facilitate erythropoiesis.
    MeSH term(s) Erythropoiesis/physiology ; Hemoglobins ; Hepcidins/genetics ; Hepcidins/metabolism ; Iron/metabolism ; Mining
    Chemical Substances Hemoglobins ; Hepcidins ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-05-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105341
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  5. Article ; Online: Macrophages and Iron

    Stefania Recalcati / Gaetano Cairo

    Biomedicines, Vol 9, Iss 1585, p

    A Special Relationship

    2021  Volume 1585

    Abstract: Macrophages perform a variety of different biological functions and are known for their essential role in the immune response. In this context, a principal function is phagocytic clearance of pathogens, apoptotic and senescent cells. However, the major ... ...

    Abstract Macrophages perform a variety of different biological functions and are known for their essential role in the immune response. In this context, a principal function is phagocytic clearance of pathogens, apoptotic and senescent cells. However, the major targets of homeostatic phagocytosis by macrophages are old/damaged red blood cells. As such, macrophages play a crucial role in iron trafficking, as they recycle the large quantity of iron obtained by hemoglobin degradation. They also seem particularly adapted to handle and store amounts of iron that would be toxic to other cell types. Here, we examine the specific and peculiar iron metabolism of macrophages.
    Keywords macrophage ; iron ; ferroptosis ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Iron Availability in Tissue Microenvironment: The Key Role of Ferroportin.

    Gammella, Elena / Correnti, Margherita / Cairo, Gaetano / Recalcati, Stefania

    International journal of molecular sciences

    2021  Volume 22, Issue 6

    Abstract: Body iron levels are regulated by hepcidin, a liver-derived peptide that exerts its function by controlling the presence of ferroportin (FPN), the sole cellular iron exporter, on the cell surface. Hepcidin binding leads to FPN internalization and ... ...

    Abstract Body iron levels are regulated by hepcidin, a liver-derived peptide that exerts its function by controlling the presence of ferroportin (FPN), the sole cellular iron exporter, on the cell surface. Hepcidin binding leads to FPN internalization and degradation, thereby inhibiting iron release, in particular from iron-absorbing duodenal cells and macrophages involved in iron recycling. Disruption in this regulatory mechanism results in a variety of disorders associated with iron-deficiency or overload. In recent years, increasing evidence has emerged to indicate that, in addition to its role in systemic iron metabolism, FPN may play an important function in local iron control, such that its dysregulation may lead to tissue damage despite unaltered systemic iron homeostasis. In this review, we focus on recent discoveries to discuss the role of FPN-mediated iron export in the microenvironment under both physiological and pathological conditions.
    MeSH term(s) Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Cellular Microenvironment/genetics ; Hepcidins/genetics ; Hepcidins/metabolism ; Homeostasis/genetics ; Humans ; Iron/metabolism ; Liver/metabolism ; Macrophages/metabolism ; Protein Binding
    Chemical Substances Cation Transport Proteins ; Hepcidins ; metal transporting protein 1 ; Iron (E1UOL152H7)
    Language English
    Publishing date 2021-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22062986
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  7. Article ; Online: Iron Mining for Erythropoiesis

    Margherita Correnti / Elena Gammella / Gaetano Cairo / Stefania Recalcati

    International Journal of Molecular Sciences, Vol 23, Iss 5341, p

    2022  Volume 5341

    Abstract: Iron is necessary for essential processes in every cell of the body, but the erythropoietic compartment is a privileged iron consumer. In fact, as a necessary component of hemoglobin and myoglobin, iron assures oxygen distribution; therefore, a ... ...

    Abstract Iron is necessary for essential processes in every cell of the body, but the erythropoietic compartment is a privileged iron consumer. In fact, as a necessary component of hemoglobin and myoglobin, iron assures oxygen distribution; therefore, a considerable amount of iron is required daily for hemoglobin synthesis and erythroid cell proliferation. Therefore, a tight link exists between iron metabolism and erythropoiesis. The liver-derived hormone hepcidin, which controls iron homeostasis via its interaction with the iron exporter ferroportin, coordinates erythropoietic activity and iron homeostasis. When erythropoiesis is enhanced, iron availability to the erythron is mainly ensured by inhibiting hepcidin expression, thereby increasing ferroportin-mediated iron export from both duodenal absorptive cells and reticuloendothelial cells that process old and/or damaged red blood cells. Erythroferrone, a factor produced and secreted by erythroid precursors in response to erythropoietin, has been identified and characterized as a suppressor of hepcidin synthesis to allow iron mobilization and facilitate erythropoiesis.
    Keywords iron metabolism ; erythropoiesis ; erythroferrone ; hepcidin ; hypoxia ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Iron Availability in Tissue Microenvironment

    Elena Gammella / Margherita Correnti / Gaetano Cairo / Stefania Recalcati

    International Journal of Molecular Sciences, Vol 22, Iss 2986, p

    The Key Role of Ferroportin

    2021  Volume 2986

    Abstract: Body iron levels are regulated by hepcidin, a liver-derived peptide that exerts its function by controlling the presence of ferroportin (FPN), the sole cellular iron exporter, on the cell surface. Hepcidin binding leads to FPN internalization and ... ...

    Abstract Body iron levels are regulated by hepcidin, a liver-derived peptide that exerts its function by controlling the presence of ferroportin (FPN), the sole cellular iron exporter, on the cell surface. Hepcidin binding leads to FPN internalization and degradation, thereby inhibiting iron release, in particular from iron-absorbing duodenal cells and macrophages involved in iron recycling. Disruption in this regulatory mechanism results in a variety of disorders associated with iron-deficiency or overload. In recent years, increasing evidence has emerged to indicate that, in addition to its role in systemic iron metabolism, FPN may play an important function in local iron control, such that its dysregulation may lead to tissue damage despite unaltered systemic iron homeostasis. In this review, we focus on recent discoveries to discuss the role of FPN-mediated iron export in the microenvironment under both physiological and pathological conditions.
    Keywords ferroportin ; iron ; macrophages ; microenvironment ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Mutual Cross Talk Between Iron Homeostasis and Erythropoiesis.

    Rybinska, Ilona / Cairo, Gaetano

    Vitamins and hormones

    2017  Volume 105, Page(s) 143–160

    Abstract: Iron is necessary for physiological processes essential for the activity of all cells, but the erythropoietic compartment is a privileged iron consumer. In fact, a considerable amount of iron is daily required for hemoglobin synthesis and erythroid cell ... ...

    Abstract Iron is necessary for physiological processes essential for the activity of all cells, but the erythropoietic compartment is a privileged iron consumer. In fact, a considerable amount of iron is daily required for hemoglobin synthesis and erythroid cell proliferation. Therefore, a tight link exists between iron metabolism and erythropoiesis. The iron needed for hemoglobin synthesis is mainly ensured by inhibiting hepcidin expression, thereby increasing both ferroportin-mediated iron export from the duodenal absorptive cells and iron release from the reticuloendothelial cells that process old and/or damaged red blood cells. This mechanism makes certain that sufficient iron availability to the erythropoietic compartment occurs. Recent studies established that hypoxia and/or hypoxia-induced erythropoietin are not direct regulators of hepcidin, which is indirectly inhibited by erythropoietic drive, in particular under pathological conditions characterized by expanded but ineffective erythropoiesis, such as β-thalassemia. Among the number of factors proposed as mediators linking erythropoiesis with liver hepcidin suppression, erythroferrone, a hormone produced and secreted by erythroid precursors, appears the best candidate.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/bs.vh.2017.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Ironing out Macrophage Immunometabolism.

    Recalcati, Stefania / Gammella, Elena / Cairo, Gaetano

    Pharmaceuticals (Basel, Switzerland)

    2019  Volume 12, Issue 2

    Abstract: Over the last decade, increasing evidence has reinforced the key role of metabolic reprogramming in macrophage activation. In addition to supporting the specific immune response of different subsets of macrophages, intracellular metabolic pathways also ... ...

    Abstract Over the last decade, increasing evidence has reinforced the key role of metabolic reprogramming in macrophage activation. In addition to supporting the specific immune response of different subsets of macrophages, intracellular metabolic pathways also directly control the specialized effector functions of immune cells. In this context, iron metabolism has been recognized as an important component of macrophage plasticity. Since macrophages control the availability of this essential metal, changes in the expression of genes coding for the major proteins of iron metabolism may result in different iron availability for the macrophage itself and for other cells in the microenvironment. In this review, we discuss how macrophage iron can also play a role in immunometabolism.
    Language English
    Publishing date 2019-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph12020094
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