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Article ; Online: Targeting innate immune pathways for cancer immunotherapy.

Cao, Longyue L / Kagan, Jonathan C

2023 Volume 56, Issue 10, Page(s) 2206–2217

Abstract: The innate immune system is critical for inducing durable and protective T cell responses to infection and has been increasingly recognized as a target for cancer immunotherapy. In this review, we present a framework wherein distinct innate immune ... ...

Abstract	The innate immune system is critical for inducing durable and protective T cell responses to infection and has been increasingly recognized as a target for cancer immunotherapy. In this review, we present a framework wherein distinct innate immune signaling pathways activate five key dendritic cell activities that are important for T cell-mediated immunity. We discuss molecular pathways that can agonize these activities and highlight that no single pathway can agonize all activities needed for durable immunity. The immunological distinctions between innate immunotherapy administration to the tumor microenvironment versus administration via vaccination are examined, with particular focus on the strategies that enhance dendritic cell migration, interferon expression, and interleukin-1 family cytokine production. In this context, we argue for the importance of appreciating necessity vs. sufficiency when considering the impact of innate immune signaling in inflammation and protective immunity and offer a conceptual guideline for the development of efficacious cancer immunotherapies.
MeSH term(s)	Humans ; Neoplasms ; Cytokines ; Signal Transduction ; Immunity, Innate ; Immunotherapy ; Tumor Microenvironment
Chemical Substances	Cytokines
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2023.07.018
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Hypokalemia-Induced Rhabdomyolysis in a Child with Autism Affected by the COVID-19 Pandemic.

Cao, Longyue L / Gaffney, Lukas K / Marcus, Carolyn

Journal of developmental and behavioral pediatrics : JDBP

2021 Volume 43, Issue 5, Page(s) e356–e360

Abstract: Objective: Pediatric patients with autism spectrum disorder (ASD) often have coexisting feeding disorders. We hope to emphasize the significant implications that these feeding disorders can have on this patient population through a unique case of ... ...

Abstract	Objective: Pediatric patients with autism spectrum disorder (ASD) often have coexisting feeding disorders. We hope to emphasize the significant implications that these feeding disorders can have on this patient population through a unique case of hypokalemia-induced rhabdomyolysis. Method: We present a unique case of a 3-year-old boy with ASD and a longstanding history of food selectivity whose routine was disrupted during the COVID-19 pandemic resulting in avoidant/restrictive food intake disorder and severe undernutrition, who presented with profound hypokalemia and was subsequently found to have elevated muscle enzymes consistent with rhabdomyolysis despite only subtle complaints of difficulty walking. Results: The patient was treated with aggressive hydration, electrolyte therapy, and nasogastric tube feeds, which resulted in clinical and biochemical evidence of improvement. He was also reconnected to ASD-related care services that had lapsed during the COVID-19 pandemic. Conclusion: This case exemplifies the adverse impact that feeding disorders can have on patients with ASD, particularly in the setting of stressors such as a global pandemic, and is also the first documented pediatric case of rhabdomyolysis secondary to hypokalemia from severe undernutrition. It demonstrates that physicians should have a low threshold to assess for clinical and laboratory evidence of rhabdomyolysis in patients with profound hypokalemia because symptoms of hypokalemia-induced rhabdomyolysis can often be subtle, which can delay diagnosis and thereby increase the risk for life-threatening complications from extensive muscle damage.
MeSH term(s)	Autism Spectrum Disorder/complications ; Autistic Disorder ; COVID-19/complications ; Child ; Child, Preschool ; Humans ; Hypokalemia/chemically induced ; Hypokalemia/complications ; Male ; Malnutrition/complications ; Pandemics ; Rhabdomyolysis/chemically induced ; Rhabdomyolysis/therapy
Language	English
Publishing date	2021-11-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	603379-9
ISSN	1536-7312 ; 0196-206X
ISSN (online)	1536-7312
ISSN	0196-206X
DOI	10.1097/DBP.0000000000001035
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Article: Application of Multispectral Camera in Monitoring the Quality Parameters of Fresh Tea Leaves

Chen, Longyue / Xu, Bo / Zhao, Chunjiang / Duan, Dandan / Cao, Qiong / Wang, Fan

Remote Sensing. 2021 Sept. 17, v. 13, no. 18

2021

Abstract: The production of high-quality tea by Camellia sinensis (L.) O. Ktze is the goal pursued ...

Abstract	The production of high-quality tea by Camellia sinensis (L.) O. Ktze is the goal pursued by both producers and consumers. Rapid, nondestructive, and low-cost monitoring methods for monitoring tea quality could improve the tea quality and the economic benefits associated with tea. This research explored the possibility of monitoring tea leaf quality from multi-spectral images. Threshold segmentation and manual sampling methods were used to eliminate the image background, after which the spectral features were constructed. Based on this, the texture features of the multi-spectral images of the tea canopy were extracted. Three machine learning methods, partial least squares regression, support vector machine regression, and random forest regression (RFR), were used to construct and train multiple monitoring models. Further, the four key quality parameters of tea polyphenols, total sugars, free amino acids, and caffeine content were estimated using these models. Finally, the effects of automatic and manual image background removal methods, different regression methods, and texture features on the model accuracies were compared. The results showed that the spectral characteristics of the canopy of fresh tea leaves were significantly correlated with the tea quality parameters (r ≥ 0.462). Among the sampling methods, the EXG_Ostu sampling method was best for prediction, whereas, among the models, RFR was the best fitted modeling algorithm for three of four quality parameters. The R² and root-mean-square error values of the built model were 0.85 and 0.16, respectively. In addition, the texture features extracted from the canopy image improved the prediction accuracy of most models. This research confirms the modeling application of a combination of multi-spectral images and chemometrics, as a low-cost, fast, reliable, and nondestructive quality control method, which can effectively monitor the quality of fresh tea leaves. This provides a scientific reference for the research and development of portable tea quality monitoring equipment that has general applicability in the future.
Keywords	Camellia sinensis ; caffeine ; cameras ; canopy ; chemometrics ; leaves ; models ; polyphenols ; prediction ; quality control ; research and development ; support vector machines ; tea ; texture
Language	English
Dates of publication	2021-0917
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs13183719
Database	NAL-Catalogue (AGRICOLA)

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Article: Fidgetin-Like 2 siRNA Enhances the Wound Healing Capability of a Surfactant Polymer Dressing.

O'Rourke, Brian P / Kramer, Adam H / Cao, Longyue L / Inayathullah, Mohammed / Guzik, Hillary / Rajadas, Jayakumar / Nosanchuk, Joshua D / Sharp, David J

Advances in wound care

2019 Volume 8, Issue 3, Page(s) 91–100

Abstract: Microtubules (MTs) are intracellular polymers that provide structure to the cell, serve as railways for intracellular transport, and regulate many cellular activities, including cell migration. The dynamicity and function of the MT cytoskeleton are ... ...

Abstract	Microtubules (MTs) are intracellular polymers that provide structure to the cell, serve as railways for intracellular transport, and regulate many cellular activities, including cell migration. The dynamicity and function of the MT cytoskeleton are determined in large part by its regulatory proteins, including the recently discovered MT severing enzyme Fidgetin-like 2 (FL2). Downregulation of FL2 expression with small interfering RNA (siRNA) results in a more than twofold increase in cell migration rate
Language	English
Publishing date	2019-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2650541-1
ISSN	2162-1934 ; 2162-1918
ISSN (online)	2162-1934
ISSN	2162-1918
DOI	10.1089/wound.2018.0827
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Article ; Online: Comprehensive evaluation of molecule property prediction with ChatGPT.

Cai, Xibao / Lai, Houtim / Wang, Xing / Wang, Longyue / Liu, Wei / Wang, Yijun / Wang, Zixu / Cao, Dongsheng / Zeng, Xiangxiang

Methods (San Diego, Calif.)

2024 Volume 222, Page(s) 133–141

Abstract: The versatility of ChatGPT in performing a diverse range of tasks has elicited considerable interest on its potential applications within professional fields. Taking drug discovery as a testbed, this paper provides a comprehensive evaluation of ChatGPT's ...

Abstract	The versatility of ChatGPT in performing a diverse range of tasks has elicited considerable interest on its potential applications within professional fields. Taking drug discovery as a testbed, this paper provides a comprehensive evaluation of ChatGPT's ability on molecule property prediction. The study focuses on three aspects: 1) Effects of different prompt settings, where we investigate the impact of varying prompts on the prediction outcomes of ChatGPT; 2) Comprehensive evaluation on molecule property prediction, where we conduct a comprehensive evaluation on 53 ADMET-related endpoints; 3) Analysis of ChatGPT's potential and limitations, where we make comparisons with models tailored for molecule property prediction, thus gaining a more accurate understanding of ChatGPT's capabilities and limitations in this area. Through comprehensive evaluation, we find that 1) With appropriate prompt settings, ChatGPT can attain satisfactory prediction outcomes that are competitive with specialized models designed for those tasks. 2) Prompt settings significantly affect ChatGPT's performance. Among all prompt settings, the strategy of selecting examples in few-shot has the greatest impact on results. Scaffold sampling greatly outperforms random sampling. 3) The capacity of ChatGPT to accomplish high-precision predictions is significantly influenced by the quality of examples provided, which may constrain its practical applicability in real-world scenarios. This work highlights ChatGPT's potential and limitations on molecule property prediction, which we hope can inspire future design and evaluation of Large Language Models within scientific domains.
MeSH term(s)	Drug Discovery ; Research Design
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1066584-5
ISSN	1095-9130 ; 1046-2023
ISSN (online)	1095-9130
ISSN	1046-2023
DOI	10.1016/j.ymeth.2024.01.004
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Zs.A 3239: Show issues

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Article ; Online: Atg7 inhibits Warburg effect by suppressing PKM2 phosphorylation resulting reduced epithelial-mesenchymal transition.

Feng, Yanling / Liu, Jingwei / Guo, Wendong / Guan, Yi / Xu, Hongde / Guo, Qiqiang / Song, Xiaoyu / Yi, Fei / Liu, Ting / Zhang, Wenyu / Dong, Xiang / Cao, Longyue L / O'Rourke, Brian P / Cao, Liu

International journal of biological sciences

2018 Volume 14, Issue 7, Page(s) 775–783

Abstract: Metabolic reprogramming is a distinct hallmark in tumorigenesis. Autophagy can rewire cell metabolism by regulating intracellular homeostasis. Warburg effect is a specific energy metabolic process that allows tumor cells to metabolize glucose via ... ...

Abstract	Metabolic reprogramming is a distinct hallmark in tumorigenesis. Autophagy can rewire cell metabolism by regulating intracellular homeostasis. Warburg effect is a specific energy metabolic process that allows tumor cells to metabolize glucose via glycolysis into lactate even in the presence of oxygen. Although both autophagy and Warburg effect are involved in the stress response to energy crisis in tumor cells, their molecular relationship has remained largely elusive. We found that Atg7, a key molecule involved in autophagy, inhibits the Warburg effect. Mechanistically, Atg7 binds PKM2 and prevents its Tyr-105 phosphorylation by FGFR1. Furthermore, the hyperphosphorylation of PKM2 and its induced Warburg effect due to Atg7 deficiency promote epithelial-mesenchymal transition (EMT). Conversely, overexpression of Atg7 inhibits PKM2 phosphorylation and the Warburg effect, thereby inhibiting EMT of tumor cells. Our work reveals a molecular link between Atg7 and the Warburg effect, which may provide insight into novel strategies for cancer treatment.
MeSH term(s)	Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Proliferation/genetics ; Cell Proliferation/physiology ; Epithelial-Mesenchymal Transition/genetics ; Epithelial-Mesenchymal Transition/physiology ; HeLa Cells ; Humans ; Immunoprecipitation ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Phosphorylation ; Protein Binding ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Signal Transduction/genetics ; Signal Transduction/physiology ; Thyroid Hormones/genetics ; Thyroid Hormones/metabolism ; Thyroid Hormone-Binding Proteins
Chemical Substances	Carrier Proteins ; Membrane Proteins ; Thyroid Hormones ; FGFR1 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1) ; Autophagy-Related Protein 7 (EC 6.2.1.45)
Language	English
Publishing date	2018-05-12
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.26077
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Article ; Online: Control of mitochondrial function and cell growth by the atypical cadherin Fat1.

Cao, Longyue L / Riascos-Bernal, Dario F / Chinnasamy, Prameladevi / Dunaway, Charlene M / Hou, Rong / Pujato, Mario A / O'Rourke, Brian P / Miskolci, Veronika / Guo, Liang / Hodgson, Louis / Fiser, Andras / Sibinga, Nicholas E S

Nature

2016 Volume 539, Issue 7630, Page(s) 575–578

Abstract: Mitochondrial products such as ATP, reactive oxygen species, and aspartate are key regulators of cellular metabolism and growth. Abnormal mitochondrial function compromises integrated growth-related processes such as development and tissue repair, as ... ...

Abstract	Mitochondrial products such as ATP, reactive oxygen species, and aspartate are key regulators of cellular metabolism and growth. Abnormal mitochondrial function compromises integrated growth-related processes such as development and tissue repair, as well as homeostatic mechanisms that counteract ageing and neurodegeneration, cardiovascular disease, and cancer. Physiologic mechanisms that control mitochondrial activity in such settings remain incompletely understood. Here we show that the atypical Fat1 cadherin acts as a molecular 'brake' on mitochondrial respiration that regulates vascular smooth muscle cell (SMC) proliferation after arterial injury. Fragments of Fat1 accumulate in SMC mitochondria, and the Fat1 intracellular domain interacts with multiple mitochondrial proteins, including critical factors associated with the inner mitochondrial membrane. SMCs lacking Fat1 (Fat1
MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Aorta/cytology ; Aorta/injuries ; Aorta/metabolism ; Arteries/cytology ; Arteries/injuries ; Arteries/metabolism ; Aspartic Acid/metabolism ; Cadherins/chemistry ; Cadherins/deficiency ; Cadherins/metabolism ; Cell Proliferation ; Cell Respiration ; Gene Knockout Techniques ; Humans ; Male ; Mice ; Mitochondria/chemistry ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/metabolism ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/injuries ; Muscle, Smooth, Vascular/metabolism ; Neointima/metabolism ; Oxygen/metabolism ; Oxygen Consumption
Chemical Substances	Cadherins ; Mitochondrial Proteins ; fat1 protein, mouse ; Aspartic Acid (30KYC7MIAI) ; Adenosine Triphosphate (8L70Q75FXE) ; Oxygen (S88TT14065)
Language	English
Publishing date	2016-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature20170
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
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Article: Oolong tea cultivars categorization and germination period classification based on multispectral information.

Cao, Qiong / Zhao, Chunjiang / Bai, Bingnan / Cai, Jie / Chen, Longyue / Wang, Fan / Xu, Bo / Duan, Dandan / Jiang, Ping / Meng, Xiangyu / Yang, Guijun

Frontiers in plant science

2023 Volume 14, Page(s) 1251418

Abstract: Recognizing and identifying tea plant ( ...

Abstract	Recognizing and identifying tea plant (
Language	English
Publishing date	2023-08-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1251418
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Article: Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach.

Cao, Liu / Xu, Xiaoling / Cao, Longyue L / Wang, Rui-Hong / Coumoul, Xavier / Kim, Sang S / Deng, Chu-Xia

Carcinogenesis

2007 Volume 28, Issue 7, Page(s) 1401–1407

Abstract: Environmental and genetic factors are important both in affecting life span and neoplastic transformation. We have shown previously that mice, which are homozygous for full-length breast cancer-associated gene-1 (Brca1) deletion and heterozygous for a ... ...

Abstract	Environmental and genetic factors are important both in affecting life span and neoplastic transformation. We have shown previously that mice, which are homozygous for full-length breast cancer-associated gene-1 (Brca1) deletion and heterozygous for a p53-null mutation (Brca1(Delta11/Delta11)p53(+/-)), display premature aging and high frequency of spontaneous lymphoma and mammary tumor formation. To investigate the role of Brca1 in regulation of organ homeostasis and susceptibility of Brca1 deficiency to environmental carcinogens, we examined biological function of Brca1 in maintaining organ homeostasis and carcinogen-induced tumorigenesis. Brca1(Delta11/Delta11)p53(+/-) mice showed altered gastrointestinal tract homeostasis, including hyperkeratosis in the esophagus and forestomach. At 6 months of age, most mutant mice displayed hyperplasia in their forestomach and esophagus, leading to dysplasia and carcinoma formation in older animals. Brca1 mutant mice exhibited increased expression of Redd1, elevated reactive oxygen species and are more sensitive to oxidative stress induced lethality. Upon methyl-N-amylnitrosamine (MNAN) treatment, 70% Brca1 mutant mice developed tumors within 4 months whereas only 14% control animals developed tumor at the same period of the time. Our further analysis revealed that the tumorigenesis is accompanied by the loss of p53 and increased expression of a number of oncogenes, including Cyclin D1, phosphorylated form of Akt, beta-catenin, Runx-2 and c-Myc. These results suggest that Brca1 is involved in renewable organ homeostasis, linking the environmental and genetic factors in carcinogenesis and aging, and providing new insights into genomic instability in organism maintenance and tumorigenesis.
MeSH term(s)	Aging/metabolism ; Aging/pathology ; Animals ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; Carcinogens, Environmental/toxicity ; Cell Transformation, Neoplastic/chemically induced ; Cell Transformation, Neoplastic/metabolism ; Cells, Cultured ; Esophageal Neoplasms/chemically induced ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Mice ; Mice, Mutant Strains ; Mutation ; Nitrosamines/toxicity ; Oxidative Stress ; Stomach Neoplasms/chemically induced ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Tumor Suppressor Protein p53/genetics
Chemical Substances	BRCA1 Protein ; Carcinogens, Environmental ; Nitrosamines ; Tumor Suppressor Protein p53 ; N-amyl-N-methylnitrosamine (13256-07-0)
Language	English
Publishing date	2007-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgm060
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Zs.A 1558: Show issues

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Article ; Online: A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.

Cao, Liu / Xu, Xioaling / Bunting, Samuel F / Liu, Jie / Wang, Rui-Hong / Cao, Longyue L / Wu, J Julie / Peng, Tie-Nan / Chen, Junjie / Nussenzweig, Andre / Deng, Chu-Xia / Finkel, Toren

Molecular cell

2009 Volume 35, Issue 4, Page(s) 534–541

Abstract: The molecular pathways leading from genomic instability to cellular senescence and/or cell death remain incompletely characterized. Using mouse embryonic fibroblasts with constitutively increased DNA damage due to the absence of the full-length form of ... ...

Abstract	The molecular pathways leading from genomic instability to cellular senescence and/or cell death remain incompletely characterized. Using mouse embryonic fibroblasts with constitutively increased DNA damage due to the absence of the full-length form of the tumor suppressor Brca1 (Brca1(Delta 11/Delta 11)), we show that deletion of p53 binding protein 1 (53BP1) selectivity abrogates senescence and cell death stimulated by reduced Brca1 activity. Furthermore, the embryonic lethality induced by Brca1 mutation can be alleviated by 53BP1 deletion. Adult Brca1(Delta 11/Delta 11)53BP1(-/-) manifest constitutively high levels of genomic instability, yet age relatively normally, with a surprisingly low incidence of overall tumor formation. Together, these in vitro and in vivo data suggest that 53BP1 is specifically required for the development of premature senescence and apoptosis induced by Brca1 deficiency. These observations may have important implications for Brca1-mediated tumor formation as well as for the molecular pathway leading from genomic instability to organismal aging.
MeSH term(s)	Aging/genetics ; Aging/metabolism ; Animals ; Apoptosis/genetics ; Ataxia Telangiectasia Mutated Proteins ; BRCA1 Protein/deficiency ; BRCA1 Protein/genetics ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cells, Cultured ; Cellular Senescence/drug effects ; Cellular Senescence/genetics ; Cellular Senescence/radiation effects ; Checkpoint Kinase 2 ; Chromosomal Proteins, Non-Histone ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Doxorubicin/toxicity ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Gamma Rays ; Genomic Instability/drug effects ; Genomic Instability/radiation effects ; Histones/genetics ; Histones/metabolism ; Hydrogen Peroxide/toxicity ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Mice, Knockout ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Tumor Suppressor p53-Binding Protein 1
Chemical Substances	BRCA1 Protein ; Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone ; DNA-Binding Proteins ; H2AX protein, mouse ; Histones ; Intracellular Signaling Peptides and Proteins ; Trp53bp1 protein, mouse ; Tumor Suppressor Proteins ; Tumor Suppressor p53-Binding Protein 1 ; Doxorubicin (80168379AG) ; Hydrogen Peroxide (BBX060AN9V) ; Checkpoint Kinase 2 (EC 2.7.1.11) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; Atm protein, mouse (EC 2.7.11.1) ; Chek2 protein, mouse (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2009-08-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2009.06.037
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