LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 48440

Search options

  1. Article ; Online: G

    White, Alex D / Jean-Alphonse, Frederic G / Fang, Fei / Peña, Karina A / Liu, Shi / König, Gabriele M / Inoue, Asuka / Aslanoglou, Despoina / Gellman, Samuel H / Kostenis, Evi / Xiao, Kunhong / Vilardaga, Jean-Pierre

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 13, Page(s) 7455–7460

    Abstract: cAMP production upon activation of G ...

    Abstract cAMP production upon activation of G
    MeSH term(s) Animals ; Arrestins/metabolism ; Cell Membrane/metabolism ; Cyclic AMP/metabolism ; Depsipeptides/pharmacology ; Endosomes/metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; HEK293 Cells ; Humans ; Mice ; Osteoblasts/metabolism ; Parathyroid Hormone/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Primary Cell Culture ; Receptor, Parathyroid Hormone, Type 1/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/physiology ; beta-Arrestins/metabolism
    Chemical Substances Arrestins ; Depsipeptides ; FR900359 ; Parathyroid Hormone ; Receptor, Parathyroid Hormone, Type 1 ; Receptors, G-Protein-Coupled ; beta-Arrestins ; Cyclic AMP (E0399OZS9N) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; GTP-Binding Protein alpha Subunits, Gq-G11 (EC 3.6.5.1)
    Language English
    Publishing date 2020-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1918158117
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: g-C

    Fang, Xiaoya / Feng, Chuanzhe / Li, Tong / Wang, Yanru / Zhu, Shanshan / Ren, Hongqiang / Huang, Hui

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 319, Page(s) 121057

    Abstract: ... carbon nitride (g-C ...

    Abstract Heterocyclic drugs (HCDs) detected at high frequencies in wastewater have raised great concerns and their advanced removal has been the hotspot for safe water reuse in recent years. Two-dimensional graphitic carbon nitride (g-C
    MeSH term(s) Polyvinyl Alcohol ; Alginates ; Wastewater ; Carbon ; Sulfadiazine ; Sulfamethoxazole ; Carbamazepine ; Catalysis
    Chemical Substances Polyvinyl Alcohol (9002-89-5) ; Alginates ; Wastewater ; Carbon (7440-44-0) ; Sulfadiazine (0N7609K889) ; Sulfamethoxazole (JE42381TNV) ; Carbamazepine (33CM23913M)
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.121057
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Smart G-quadruplex hydrogels: From preparations to comprehensive applications.

    Fang, Jun / Zheng, Lijuan / Liu, Yan / Peng, Yuxin / Yang, Qinghui / Huang, Yuewen / Zhang, Jiali / Luo, Lixin / Shen, Dunkai / Tan, Yuyan / Lu, Xuefen / Feng, Guangfu

    International journal of biological macromolecules

    2023  Volume 247, Page(s) 125614

    Abstract: In recent years, the accelerated development of G-quadruplexes and hydrogels has driven ... functions of G-quadruplexes, and the hydrophilicity, high-water retention, high water content, flexibility ... and excellent biodegradability of hydrogels, G-quadruplex hydrogels are widely used in various fields ...

    Abstract In recent years, the accelerated development of G-quadruplexes and hydrogels has driven the development of intelligent biomaterials. Based on the excellent biocompatibility and special biological functions of G-quadruplexes, and the hydrophilicity, high-water retention, high water content, flexibility and excellent biodegradability of hydrogels, G-quadruplex hydrogels are widely used in various fields by combining the dual advantages of G-quadruplexes and hydrogels. Here, we provide a systematic and comprehensive classification of G-quadruplex hydrogels in terms of preparation strategies and applications. This paper reveals how G-quadruplex hydrogels skillfully utilize the special biological functions of G-quadruplexes and the skeleton structure of hydrogels, and expounds its applications in the fields of biomedicine, biocatalysis, biosensing and biomaterials. In addition, we deeply analyze the challenges in preparation, applications, stability and safety of G-quadruplex hydrogels, as well as potential future development directions.
    MeSH term(s) Hydrogels/chemistry ; Hydrogels/therapeutic use ; G-Quadruplexes ; Biocompatible Materials/chemistry ; Biocompatible Materials/therapeutic use ; Humans ; Biosensing Techniques ; Wound Healing ; Infections/drug therapy ; Neoplasms/drug therapy ; Animals
    Chemical Substances Hydrogels ; Biocompatible Materials
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.125614
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Highly dispersed g-C

    Niu, Luyao / Xin, Jiayu / Liu, Jie / Liu, Yu / Wu, Xi / Zhang, Fang / Li, Xiaowei / Shao, Changlu / Li, Xinghua / Liu, Yichun

    Journal of colloid and interface science

    2023  Volume 638, Page(s) 324–338

    Abstract: A novel polymer-assisted freeze-drying method was adopted for preparing three-dimensional porous nanostructured ... ...

    Abstract A novel polymer-assisted freeze-drying method was adopted for preparing three-dimensional porous nanostructured ZrO
    Language English
    Publishing date 2023-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.01.120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Decade Milestone Advancement of Defect-Engineered g-C

    Hou, Shaoqi / Gao, Xiaochun / Lv, Xingyue / Zhao, Yilin / Yin, Xitao / Liu, Ying / Fang, Juan / Yu, Xingxing / Ma, Xiaoguang / Ma, Tianyi / Su, Dawei

    Nano-micro letters

    2024  Volume 16, Issue 1, Page(s) 70

    Abstract: Over the past decade, graphitic carbon nitride (g-C ...

    Abstract Over the past decade, graphitic carbon nitride (g-C
    Language English
    Publishing date 2024-01-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2642093-4
    ISSN 2150-5551 ; 2150-5551
    ISSN (online) 2150-5551
    ISSN 2150-5551
    DOI 10.1007/s40820-023-01297-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Composite of g-C

    Hu, Jie / Lu, Songhua / Ma, Jianfeng / Zhu, Fang / Komarneni, Sridhar

    Environmental science and pollution research international

    2022  Volume 29, Issue 50, Page(s) 76404–76416

    Abstract: In this paper, the g-C ...

    Abstract In this paper, the g-C
    Language English
    Publishing date 2022-06-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-21224-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Quantitative Evaluation of the Carrier Separation Performance of Heterojunction Photocatalysts: The Case of g-C

    Bian, Fang / Wu, Xinge / Yang, Zhaoying / Shao, Shuai / Meng, Xiangying / Qin, Gaowu

    The journal of physical chemistry letters

    2023  Volume 14, Issue 12, Page(s) 2927–2932

    Abstract: ... Taking the g-C ...

    Abstract Heterojunction photocatalysts are of great interest in the energy and environmental fields, because of their potential to significantly increase the efficiency of harvesting solar energy. Advances in design have been hampered by the continued use of only qualitative analyses. Quantitative evaluation of the carrier separation performance is urgently needed for the design and application of heterojunction photocatalysts. Taking the g-C
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c00427
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Engineering a Red Fluorescent Protein Chromophore for Visualization of RNA G-Quadruplexes.

    He, Chang / Peng, Jiasheng / Li, Zheng / Yang, Qinghui / Zhang, Ying / Luo, Xingyu / Liu, Zekai / Feng, Guangfu / Fang, Jun

    Biochemistry

    2023  Volume 62, Issue 14, Page(s) 2128–2136

    Abstract: ... imaging and therapeutic applications, but their application in the visualization of endogenous RNA G ...

    Abstract Synthetic red fluorescent protein (RFP) chromophores have emerged as valuable tools for biological imaging and therapeutic applications, but their application in the visualization of endogenous RNA G-quadruplexes (G4s) in living cells has been rarely reported so far. Here, by integrating the group of the excellent G4 dye ThT, we modulate RFP chromophores to create a novel fluorescent probe DEBIT with red emission. DEBIT selectively recognizes the G4 structure with the advantage of strong binding affinity, high selectivity, and excellent photostability. Using DEBIT as a fluorescent indicator, the real-time monitoring of RNA G4 in biological systems can be achieved. In summary, our work expands the application of synthetic RFP chromophores and provides an essential dye category to the classical G4 probes.
    MeSH term(s) G-Quadruplexes ; Fluorescent Dyes/chemistry ; Luminescent Proteins/genetics ; RNA/chemistry ; Red Fluorescent Protein
    Chemical Substances Fluorescent Dyes ; Luminescent Proteins ; RNA (63231-63-0)
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00149
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Cryo-EM structure of orphan G protein-coupled receptor GPR21.

    Wong, Thian-Sze / Gao, Wei / Chen, Geng / Qiu, Chen / He, Guodong / Ye, Fang / Wu, Zhangsong / Zeng, Zicheng / Du, Yang

    MedComm

    2023  Volume 4, Issue 1, Page(s) e205

    Abstract: GPR21 belongs to class A orphan G protein-coupled receptor (GPCR). The endogenous ligands for human ...

    Abstract GPR21 belongs to class A orphan G protein-coupled receptor (GPCR). The endogenous ligands for human GPR21 remain unidentified. GPR21 expression is associated with developing type 2 diabetes (T2DM), a multifactorial metabolic disease caused by pancreatic β-cell dysfunction, decreasing insulin production, insulin resistance, and obesity. Animal studies suggested that GPR21 is a potential therapeutic target for T2DM treatment. The underlying mechanisms leading to GPR21 self-activation remain unknown. In our co-expression analysis, we noted that GPR21 could also form a stable complex with an unreported Gα protein subtype, Gαs. To gain further insights into the structural mechanisms of GPR21 activation, we employed cryo-electron microscopy (cryo-EM) and single-particle analysis to resolve the high-resolution structure of GPR21-Gαs complexes. The clear electron density map of the GPR21-Gαs provided direct evidence that GPR21 could couple to Gαs protein at physiological conditions. Thus, GPR21 might mediate previously unexplored pathways in normal or pathological conditions, which warrants further investigation. Structure-guided mutagenesis and biochemical analysis revealed that extracellular loop 2 (ECL2) of GPR21 is essential for the receptor transducing intracellular signal via cAMP. Together, the new structure data reveal a novel signaling cascade of human GPR21 mediated by ECL2 and provide fundamental information for future structure-based drug development.
    Language English
    Publishing date 2023-01-25
    Publishing country China
    Document type Journal Article
    ISSN 2688-2663
    ISSN (online) 2688-2663
    DOI 10.1002/mco2.205
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.

    Guo, Lulu / Zhang, Yumu / Fang, Guoxing / Tie, Lu / Zhuang, Yuming / Xue, Chenyang / Liu, Qi / Zhang, Minghui / Zhu, Kongkai / You, Chongzhao / Xu, Peiyu / Yuan, Qingning / Zhang, Chao / Liu, Lei / Rong, Naikang / Peng, Shengxuan / Liu, Yuan / Wang, Chuanzheng / Luo, Xin /
    Lv, Zongyao / Kang, Dongwei / Yu, Xiao / Zhang, Cheng / Jiang, Yi / Dong, Xinzhong / Zhou, Jiuyao / Liu, Zhongmin / Yang, Fan / Eric Xu, H / Sun, Jin-Peng

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 5004

    Abstract: ... mechanisms for peptidic allergen recognition. Below the ligand binding pocket, the G ...

    Abstract MRGPRX1, a Mas-related GPCR (MRGPR), is a key receptor for itch perception and targeting MRGPRX1 may have potential to treat both chronic itch and pain. Here we report cryo-EM structures of the MRGPRX1-Gi1 and MRGPRX1-Gq trimers in complex with two peptide ligands, BAM8-22 and CNF-Tx2. These structures reveal a shallow orthosteric pocket and its conformational plasticity for sensing multiple different peptidic itch allergens. Distinct from MRGPRX2, MRGPRX1 contains a unique pocket feature at the extracellular ends of TM3 and TM4 to accommodate the peptide C-terminal "RF/RY" motif, which could serve as key mechanisms for peptidic allergen recognition. Below the ligand binding pocket, the G
    MeSH term(s) Humans ; Cytoplasm ; Cytosol ; Ligands ; Pruritus ; Receptors, G-Protein-Coupled ; Signal Transduction
    Chemical Substances Ligands ; Receptors, G-Protein-Coupled ; mas-related gene-X1 receptor, human
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-40705-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top