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  1. Article ; Online: Innate immunity-With an adaptive twist.

    Josefowicz, Steven Z / Sun, Joseph C

    Immunological reviews

    2024  

    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The potency of hematopoietic stem cell reprogramming for changing immune tone.

    Daman, Andrew W / Cheong, Jin Gyu / Berneking, Laura / Josefowicz, Steven Z

    Immunological reviews

    2024  

    Abstract: Innate immune memory endows innate immune cells with antigen independent heightened responsiveness to subsequent challenges. The durability of this response can be mediated by inflammation induced epigenetic and metabolic reprogramming in hematopoietic ... ...

    Abstract Innate immune memory endows innate immune cells with antigen independent heightened responsiveness to subsequent challenges. The durability of this response can be mediated by inflammation induced epigenetic and metabolic reprogramming in hematopoietic stem and progenitor cells (HSPCs) that are maintained through differentiation to mature immune progeny. Understanding the mechanisms and extent of trained immunity induction by pathogens and vaccines, such as BCG, in HSPC remains a critical area of exploration with important implications for health and disease. Here we review these concepts and present new analysis to highlight how inflammatory reprogramming of HSPC can potently alter immune tone, including to enhance specific anti-tumor responses. New findings in the field pave the way for novel HSPC targeting therapeutic strategies in cancer and other contexts of immune modulation. Future studies are expected to unravel diverse and extensive effects of infections, vaccines, microbiota, and sterile inflammation on hematopoietic progenitor cells and begin to illuminate the broad spectrum of immunologic tuning that can be established through altering HSPC phenotypes. The purpose of this review is to draw attention to emerging and speculative topics in this field where we posit that focused study of HSPC in the framework of trained immunity holds significant promise.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epigenetic and transcriptional control of interferon-β.

    Daman, Andrew W / Josefowicz, Steven Z

    The Journal of experimental medicine

    2021  Volume 218, Issue 9

    Abstract: The three classes of interferons (IFNs) share the ability to inhibit viral replication, activating cell transcriptional programs that regulate both innate and adaptive responses to viral and intracellular bacterial challenge. Due to their unique potency ... ...

    Abstract The three classes of interferons (IFNs) share the ability to inhibit viral replication, activating cell transcriptional programs that regulate both innate and adaptive responses to viral and intracellular bacterial challenge. Due to their unique potency in regulating viral replication, and their association with numerous autoimmune diseases, the tightly orchestrated transcriptional regulation of IFNs has long been a subject of intense investigation. The protective role of early robust IFN responses in the context of infection with SARS-CoV-2 has further underscored the relevance of these pathways. In this viewpoint, rather than focusing on the downstream effects of IFN signaling (which have been extensively reviewed elsewhere), we will summarize the historical and current understanding of the stepwise assembly and function of factors that regulate IFNβ enhancer activity (the "enhanceosome") and highlight opportunities for deeper understanding of the transcriptional control of the ifnb gene.
    MeSH term(s) CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/metabolism ; DNA Methylation ; Enhancer Elements, Genetic ; Epigenesis, Genetic ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/physiology ; Humans ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Promoter Regions, Genetic ; SARS-CoV-2/pathogenicity ; Transcription, Genetic ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances CCAAT-Enhancer-Binding Proteins ; Interferon-beta (77238-31-4) ; UHRF1 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2021-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20210039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Mechanisms of Epigenomic and Functional Convergence Between Glucocorticoid- and IL4-Driven Macrophage Programming.

    Deochand, Dinesh K / Dacic, Marija / Bale, Michael J / Daman, Andrew W / Josefowicz, Steven Z / Oliver, David / Chinenov, Yurii / Rogatsky, Inez

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Macrophages adopt distinct phenotypes in response to environmental cues, with type-2 cytokine interleukin-4 promoting a tissue-repair homeostatic state ( ... ...

    Abstract Macrophages adopt distinct phenotypes in response to environmental cues, with type-2 cytokine interleukin-4 promoting a tissue-repair homeostatic state (M2
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.16.580560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Regulators of chromatin state and transcription in CD4 T-cell polarization.

    Josefowicz, Steven Z

    Immunology

    2013  Volume 139, Issue 3, Page(s) 299–308

    Abstract: Mature naive CD4 T-cells possess the potential for an array of highly specialized functions, from inflammatory to potently suppressive. This potential is encoded in regulatory DNA elements and is fulfilled through modification of chromatin and selective ... ...

    Abstract Mature naive CD4 T-cells possess the potential for an array of highly specialized functions, from inflammatory to potently suppressive. This potential is encoded in regulatory DNA elements and is fulfilled through modification of chromatin and selective activation by the collaborative function of diverse transcription factors in response to environmental cues. The mechanisms and strategies employed by transcription factors for the programming of CD4 T-cell subsets will be discussed. In particular, the focus will be on co-operative activity of environmental response factors in the initial activation of regulatory DNA elements and chromatin alteration, and the subsequent role of 'master regulator' transcription factors in defining the fidelity and environmental responsiveness of different CD4 T-cell subsets.
    MeSH term(s) CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Differentiation ; Chromatin/metabolism ; Gene Expression Regulation ; Humans ; Lymphocyte Activation ; Transcription Factors/genetics ; Transcription Factors/immunology
    Chemical Substances Chromatin ; Transcription Factors
    Language English
    Publishing date 2013-04-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.12115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.181: Show issues Location:
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  6. Article ; Online: Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.

    Soshnev, Alexey A / Josefowicz, Steven Z / Allis, C David

    Molecular cell

    2018  Volume 69, Issue 3, Page(s) 533

    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2018.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5055: Show issues Location:
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  7. Article: Microbial cancer immunotherapy reprograms hematopoietic stem cells to enhance anti-tumor immunity.

    Daman, Andrew W / Antonelli, Anthony C / Redelman-Sidi, Gil / Paddock, Lucinda / Cheong, Jin Gyu / Jurado, Leonardo F / Benjamin, Anna / Jiang, Song / Ahimovic, Dughan / Khayat, Shireen / Bale, Michael J / Loutochin, Oleg / McPherson, Victor A / Pe'er, Dana / Divangahi, Maziar / Pietzak, Eugene / Josefowicz, Steven Z / Glickman, Michael S

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Mycobacterium bovis: One sentence summary: BCG administered in the bladder reprograms bone marrow HSPCs and contributes to tumor ... ...

    Abstract Mycobacterium bovis
    One sentence summary: BCG administered in the bladder reprograms bone marrow HSPCs and contributes to tumor control
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.21.586166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection.

    Lercher, Alexander / Cheong, Jin-Gyu / Jiang, Chenyang / Hoffmann, Hans-Heinrich / Ashbrook, Alison W / Yin, Yue S / Quirk, Corrine / DeGrace, Emma J / Chiriboga, Luis / Rosenberg, Brad R / Josefowicz, Steven Z / Rice, Charles M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Pathogen encounter results in long-lasting epigenetic imprinting that shapes diseases caused by heterologous pathogens. The breadth of this innate immune memory is of particular interest in the context of respiratory pathogens with increased pandemic ... ...

    Abstract Pathogen encounter results in long-lasting epigenetic imprinting that shapes diseases caused by heterologous pathogens. The breadth of this innate immune memory is of particular interest in the context of respiratory pathogens with increased pandemic potential and wide-ranging impact on global health. Here, we investigated epigenetic imprinting across cell lineages in a disease relevant murine model of SARS-CoV-2 recovery. Past SARS-CoV-2 infection resulted in increased chromatin accessibility of type I interferon (IFN-I) related transcription factors in airway-resident macrophages. Mechanistically, establishment of this innate immune memory required viral pattern recognition and canonical IFN-I signaling and augmented secondary antiviral responses. Past SARS-CoV-2 infection ameliorated disease caused by the heterologous respiratory pathogen influenza A virus. Insights into innate immune memory and how it affects subsequent infections with heterologous pathogens to influence disease pathology could facilitate the development of broadly effective therapeutic strategies.
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.24.568354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.

    Soshnev, Alexey A / Josefowicz, Steven Z / Allis, C David

    Molecular cell

    2016  Volume 62, Issue 5, Page(s) 681–694

    Abstract: Information encoded in DNA is interpreted, modified, and propagated as chromatin. The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for transcriptional outcomes provided by the combinatorial and dynamic nature of ... ...

    Abstract Information encoded in DNA is interpreted, modified, and propagated as chromatin. The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for transcriptional outcomes provided by the combinatorial and dynamic nature of epigenetic processes. Advances in genome editing, visualization technology, and genome-wide analyses have revealed unprecedented complexity of chromatin pathways, offering explanations to long-standing questions and presenting new challenges. Here, we review recent findings, exemplified by the emerging understanding of crossregulatory interactions within chromatin, and emphasize the pathologic outcomes of epigenetic misregulation in cancer.
    MeSH term(s) Animals ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Chromatin Assembly and Disassembly ; DNA Methylation ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Histones/metabolism ; Humans ; Methylation ; Models, Molecular ; Mutation ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Nucleic Acid Conformation ; Oncogenes ; Phosphorylation ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship ; Transcription, Genetic
    Chemical Substances Histones
    Language English
    Publishing date 2016-06-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2016.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5055: Show issues Location:
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  10. Article ; Online: Publisher Correction: Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability.

    Guo, Peipei / Liu, Ying / Geng, Fuqiang / Daman, Andrew W / Liu, Xiaoyu / Zhong, Liangwen / Ravishankar, Arjun / Lis, Raphael / Barcia Durán, José Gabriel / Itkin, Tomer / Tang, Fanying / Zhang, Tuo / Xiang, Jenny / Shido, Koji / Ding, Bi-Sen / Wen, Duancheng / Josefowicz, Steven Z / Rafii, Shahin

    Nature cell biology

    2022  Volume 24, Issue 2, Page(s) 279

    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-022-00851-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 12: Show issues

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