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  1. Article ; Online: Complex vascular bundles, thick ascending limbs, and aquaporins: wringing out the outer medulla.

    Pallone, Thomas L

    American journal of physiology. Renal physiology

    2013  Volume 306, Issue 5, Page(s) F505–6

    MeSH term(s) Animals ; Kidney Medulla/blood supply ; Male
    Language English
    Publishing date 2013-12-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00663.2013
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  2. Article ; Online: Adaptive responses of rat descending vasa recta to ischemia.

    Zhang, Zhong / Payne, Kristie / Pallone, Thomas L

    American journal of physiology. Renal physiology

    2017  Volume 314, Issue 3, Page(s) F373–F380

    Abstract: tested whether rat descending vasa recta (DVR) undergo regulatory adaptations after the kidney is exposed to ischemia. Left kidneys (LK) were subjected to 30-min renal artery cross clamp. After 48 h, the postischemic LK and contralateral right kidney (RK) ...

    Abstract tested whether rat descending vasa recta (DVR) undergo regulatory adaptations after the kidney is exposed to ischemia. Left kidneys (LK) were subjected to 30-min renal artery cross clamp. After 48 h, the postischemic LK and contralateral right kidney (RK) were harvested for study. When compared with DVR isolated from either sham-operated LK or the contralateral RK, postischemic LK DVR markedly increased their NO generation. The selective inducible NOS (iNOS) inhibitor 1400W blocked the NO response. Immunoblots from outer medullary homogenates showed a parallel 2.6-fold increase in iNOS expression ( P = 0.01). Microperfused postischemic LK DVR exposed to angiotensin II (ANG II, 10 nM), constricted less than those from the contralateral RK, and constricted more when exposed to 1400W (10 µM). Resting membrane potentials of pericytes from postischemic LK DVR pericytes were hyperpolarized relative to contralateral RK pericytes (62.0 ± 1.6 vs. 51.8 ± 2.2 mV, respectively, P < 0.05) or those from sham-operated LK (54.9 ± 2.1 mV, P < 0.05). Blockade of NO generation with 1400W did not repolarize postischemic pericytes (62.5 ± 1.4 vs. 61.1 ± 3.4 mV); however, control pericytes were hyperpolarized by exposure to NO donation from S-nitroso- N-acetyl- dl-penicillamine (51.5 ± 2.9 to 62.1 ± 1.4 mV, P < 0.05). We conclude that postischemic adaptations intrinsic to the DVR wall occur after ischemia. A rise in 1400W sensitive NO generation and iNOS expression occurs that is associated with diminished contractile responses to ANG II. Pericyte hyperpolarization occurs that is not explained by the rise in ambient NO generation within the DVR wall.
    MeSH term(s) Adaptation, Physiological ; Amidines/pharmacology ; Angiotensin II/pharmacology ; Animals ; Arterioles/drug effects ; Arterioles/metabolism ; Arterioles/physiopathology ; Benzylamines/pharmacology ; Constriction ; Disease Models, Animal ; Endothelial Cells/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Ischemia/metabolism ; Ischemia/pathology ; Ischemia/physiopathology ; Kidney/blood supply ; Kidney/pathology ; Membrane Potentials ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/antagonists & inhibitors ; Nitric Oxide Synthase Type II/metabolism ; Pericytes/metabolism ; Rats, Sprague-Dawley ; Renal Artery/physiopathology ; Renal Artery/surgery ; Renal Circulation/drug effects ; Vasoconstriction/drug effects ; Vasoconstrictor Agents/pharmacology
    Chemical Substances Amidines ; Benzylamines ; Enzyme Inhibitors ; N-(3-(aminomethyl)benzyl)acetamidine ; Vasoconstrictor Agents ; Angiotensin II (11128-99-7) ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, rat (EC 1.14.13.39)
    Language English
    Publishing date 2017-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00062.2017
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  3. Article ; Online: Control of renal Na+ excretion by heme oxygenase.

    Pallone, Thomas L

    Hypertension (Dallas, Tex. : 1979)

    2007  Volume 49, Issue 1, Page(s) 23–24

    MeSH term(s) Animals ; Heme Oxygenase (Decyclizing)/physiology ; Humans ; Kidney Medulla/enzymology ; Kidney Medulla/physiology ; Natriuresis/physiology
    Chemical Substances Heme Oxygenase (Decyclizing) (EC 1.14.14.18)
    Language English
    Publishing date 2007-01
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/01.HYP.0000250089.99513.f6
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  4. Article ; Online: Aquaporin 1, urea transporters, and renal vascular bundles.

    Pallone, Thomas L

    Journal of the American Society of Nephrology : JASN

    2007  Volume 18, Issue 11, Page(s) 2798–2800

    MeSH term(s) Aquaporin 1/metabolism ; Humans ; Kidney Medulla/blood supply ; Kidney Medulla/metabolism ; Kidney Tubules, Collecting/metabolism ; Loop of Henle/metabolism ; Membrane Transport Proteins/metabolism ; Osmosis ; Urea Transporters
    Chemical Substances Membrane Transport Proteins ; Aquaporin 1 (146410-94-8)
    Language English
    Publishing date 2007-10-17
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2007080936
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  5. Article ; Online: Descending Vasa Recta Endothelial Membrane Potential Response Requires Pericyte Communication.

    Zhang, Zhong / Payne, Kristie / Pallone, Thomas L

    PloS one

    2016  Volume 11, Issue 5, Page(s) e0154948

    Abstract: Using dual-cell electrophysiological recording, we examined the routes for equilibration of membrane potential between the pericytes and endothelia that comprise the descending vasa recta (DVR) wall. We measured equilibration between pericytes in intact ... ...

    Abstract Using dual-cell electrophysiological recording, we examined the routes for equilibration of membrane potential between the pericytes and endothelia that comprise the descending vasa recta (DVR) wall. We measured equilibration between pericytes in intact vessels, between pericytes and endothelium in intact vessels and between pericytes physically separated from the endothelium. Dual pericyte recording on the abluminal surface of DVR showed that both resting potential and subsequent time-dependent voltage fluctuations after vasoconstrictor stimulation remained closely equilibrated, regardless of the agonist employed (angiotensin II, vasopressin or endothelin 1). When pericytes where removed from the vessel wall but retained physical contact with one another, membrane potential responses were also highly coordinated. In contrast, responses of pericytes varied independently when they were isolated from both the endothelium and from contact with one another. When pericytes and endothelium were in contact, their resting potentials were similar and their temporal responses to stimulation were highly coordinated. After completely isolating pericytes from the endothelium, their mean resting potentials became discordant. Finally, complete endothelial isolation eliminated all membrane potential responses to angiotensin II. We conclude that cell-to-cell transmission through the endothelium is not needed for pericytes to equilibrate their membrane potentials. AngII dependent responses of DVR endothelia may originate from gap junction coupling to pericytes rather than via receptor dependent signaling in the endothelium, per se.
    MeSH term(s) Angiotensin II/pharmacology ; Animals ; Cell Communication/drug effects ; Cell Separation ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiology ; Gap Junctions/drug effects ; Gap Junctions/metabolism ; Linear Models ; Membrane Potentials/drug effects ; Patch-Clamp Techniques ; Pericytes/cytology ; Pericytes/drug effects ; Pericytes/metabolism ; Rats, Sprague-Dawley ; Vasoconstriction/drug effects
    Chemical Substances Angiotensin II (11128-99-7)
    Language English
    Publishing date 2016-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0154948
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  6. Article: Is oxidative stress differentially regulated in the renal cortex and medulla?

    Pallone, Thomas L

    Nature clinical practice. Nephrology

    2006  Volume 2, Issue 3, Page(s) 118–119

    MeSH term(s) Animals ; Humans ; Hydrogen Peroxide/metabolism ; Hypertension/metabolism ; Kidney Cortex/metabolism ; Kidney Medulla/metabolism ; Oxidative Stress/physiology ; Oxygen/metabolism ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2006-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2228557-X
    ISSN 1745-8331 ; 1745-8323
    ISSN (online) 1745-8331
    ISSN 1745-8323
    DOI 10.1038/ncpneph0083
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  7. Article ; Online: Microvascular effects of aldosterone and angiotensin type 2 receptors.

    Pallone, Thomas L

    Hypertension (Dallas, Tex. : 1979)

    2005  Volume 45, Issue 5, Page(s) 845–846

    MeSH term(s) Aldosterone/physiology ; Animals ; Humans ; Microcirculation/physiology ; Receptor, Angiotensin, Type 2/physiology
    Chemical Substances Receptor, Angiotensin, Type 2 ; Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2005-05
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/01.HYP.0000161868.75872.e6
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  8. Article: Microdissected perfused vessels.

    Pallone, Thomas L

    Methods in molecular medicine

    2003  Volume 86, Page(s) 443–456

    MeSH term(s) Animals ; Arterioles/anatomy & histology ; Arterioles/physiology ; Biological Transport, Active ; Capillary Permeability ; Dissection/methods ; Fluorescent Dyes ; In Vitro Techniques ; Kidney/blood supply ; Microscopy, Video ; Perfusion/instrumentation ; Perfusion/methods ; Vasoconstriction ; Water/metabolism
    Chemical Substances Fluorescent Dyes ; Water (059QF0KO0R)
    Language English
    Publishing date 2003
    Publishing country United States
    Document type Journal Article
    ISSN 1543-1894
    ISSN 1543-1894
    DOI 10.1385/1-59259-392-5:443
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  9. Article ; Online: Descending Vasa Recta Endothelial Membrane Potential Response Requires Pericyte Communication.

    Zhong Zhang / Kristie Payne / Thomas L Pallone

    PLoS ONE, Vol 11, Iss 5, p e

    2016  Volume 0154948

    Abstract: Using dual-cell electrophysiological recording, we examined the routes for equilibration of membrane potential between the pericytes and endothelia that comprise the descending vasa recta (DVR) wall. We measured equilibration between pericytes in intact ... ...

    Abstract Using dual-cell electrophysiological recording, we examined the routes for equilibration of membrane potential between the pericytes and endothelia that comprise the descending vasa recta (DVR) wall. We measured equilibration between pericytes in intact vessels, between pericytes and endothelium in intact vessels and between pericytes physically separated from the endothelium. Dual pericyte recording on the abluminal surface of DVR showed that both resting potential and subsequent time-dependent voltage fluctuations after vasoconstrictor stimulation remained closely equilibrated, regardless of the agonist employed (angiotensin II, vasopressin or endothelin 1). When pericytes where removed from the vessel wall but retained physical contact with one another, membrane potential responses were also highly coordinated. In contrast, responses of pericytes varied independently when they were isolated from both the endothelium and from contact with one another. When pericytes and endothelium were in contact, their resting potentials were similar and their temporal responses to stimulation were highly coordinated. After completely isolating pericytes from the endothelium, their mean resting potentials became discordant. Finally, complete endothelial isolation eliminated all membrane potential responses to angiotensin II. We conclude that cell-to-cell transmission through the endothelium is not needed for pericytes to equilibrate their membrane potentials. AngII dependent responses of DVR endothelia may originate from gap junction coupling to pericytes rather than via receptor dependent signaling in the endothelium, per se.
    Keywords Medicine ; R ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Syncytial communication in descending vasa recta includes myoendothelial coupling.

    Zhang, Zhong / Payne, Kristie / Pallone, Thomas L

    American journal of physiology. Renal physiology

    2014  Volume 307, Issue 1, Page(s) F41–52

    Abstract: Using dual cell patch-clamp recording, we examined pericyte, endothelial, and myoendothelial cell-to-cell communication in descending vasa recta. Graded current injections into pericytes or endothelia yielded input resistances of 220 ± 21 and 128 ± 20 MΩ, ...

    Abstract Using dual cell patch-clamp recording, we examined pericyte, endothelial, and myoendothelial cell-to-cell communication in descending vasa recta. Graded current injections into pericytes or endothelia yielded input resistances of 220 ± 21 and 128 ± 20 MΩ, respectively (P < 0.05). Injection of positive or negative current into an endothelial cell depolarized and hyperpolarized adjacent endothelial cells, respectively. Similarly, current injection into a pericyte depolarized and hyperpolarized adjacent pericytes. During myoendothelial studies, current injection into a pericyte or an endothelial cell yielded small, variable, but significant change of membrane potential in heterologous cells. Membrane potentials of paired pericytes or paired endothelia were highly correlated and identical. Paired measurements of resting potentials in heterologous cells were also correlated, but with slight hyperpolarization of the endothelium relative to the pericyte, -55.2 ± 1.8 vs. -52.9 ± 2.2 mV (P < 0.05). During dual recordings, angiotensin II or bradykinin stimulated temporally identical variations of pericyte and endothelial membrane potential. Similarly, voltage clamp depolarization of pericytes or endothelial cells induced parallel changes of membrane potential in the heterologous cell type. We conclude that the descending vasa recta endothelial syncytium is of lower resistance than the pericyte syncytium and that high-resistance myoendothelial coupling also exists. The myoendothelial communication between pericytes and endothelium maintains near identity of membrane potentials at rest and during agonist stimulation. Finally, endothelia membrane potential lies slightly below pericyte membrane potential, suggesting a tonic role for the former to hyperpolarize the latter and provide a brake on vasoconstriction.
    MeSH term(s) Angiotensin II/pharmacology ; Animals ; Bradykinin/pharmacology ; Cell Communication/drug effects ; Cell Communication/physiology ; Endothelial Cells/drug effects ; Endothelial Cells/physiology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiology ; Kidney Medulla/drug effects ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Patch-Clamp Techniques ; Pericytes ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Angiotensin II (11128-99-7) ; Bradykinin (S8TIM42R2W)
    Language English
    Publishing date 2014-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00178.2014
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