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  1. Article ; Online: Acetylcholinesterase enzyme among cancer patients a potential diagnostic and prognostic indicator a multicenter case-control study.

    Ahmed, Gasmelseed Y / Osman, Ahmed A / Mukhtar, Ahlam

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5127

    Abstract: Acetylcholinesterase enzyme (AChE) activity is impaired by a variety of inhibitors including organophosphorus pesticides, leading to the accumulation of acetylcholine. In this study, we aimed to determine the association between cancer and the blood ... ...

    Abstract Acetylcholinesterase enzyme (AChE) activity is impaired by a variety of inhibitors including organophosphorus pesticides, leading to the accumulation of acetylcholine. In this study, we aimed to determine the association between cancer and the blood level of the (AChE). This is a multicenter hospital-based case-control study conducted in the Radiation and Isotopes Center Khartoum, and Institute of Nuclear Medicine and Molecular Biology and Oncology Gezira. One hundred and fifty participants, half of them cancer patients and half cancer free were recruited. All participants were screened for demographic, environmental, occupational, and clinical characteristics. Blood for the (AChE) activity test was drawn from participants in the two groups. The mean age of the participants was 40.6 ± 14.8 years. Geographical distribution showed the Central Region of Sudan had the highest rate of cancer, followed by North State, Khartoum State, West State, and East State. The most common tumor subtype was breast cancer, followed by leukemia, colon, esophageal, and prostate cancer. Inferential analysis revealed significantly impaired (AChE) activity among cancer patients compared to controls (53.4 ± 20.3% vs. 93.8 ± 8.8, p-value 0.001). There was a significant statistical association between impaired (AChE) activity and cancer. (AChE) activity might be applied in the future as a diagnostic biomarker and therapeutic target. Further large sample and molecular studies are recommended.
    MeSH term(s) Male ; Humans ; Adult ; Middle Aged ; Acetylcholinesterase ; Prognosis ; Case-Control Studies ; Organophosphorus Compounds ; Pesticides ; Breast Neoplasms ; Cholinesterase Inhibitors
    Chemical Substances Acetylcholinesterase (EC 3.1.1.7) ; Organophosphorus Compounds ; Pesticides ; Cholinesterase Inhibitors
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55604-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Journal ; Article ; Online: Controlling the spread of COVID-19 in Sudan with limited resources

    Gasmelseed Ahmed / Yassir Mohamed / Razi Adulhameed / Majdi Ishag / Ahamed Elzubair

    a unique community-engaged approach

    2020  

    Abstract: ... 636 ... ...

    Abstract 636

    637
    Keywords Coronavirus Disease (COVID-19) ; COVID-19 ; Health Resources ; Community-Based Participatory Research ; Disease Outbreaks ; Betacoronavirus ; Volunteers ; prevention and control ; epidemiology
    Language English
    Publisher World Health Organization. Regional Office for the Eastern Mediterranean
    Document type Journal ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Controlling the spread of COVID-19 in Sudan with limited resources: a unique community-engaged approach.

    Ahmed, Gasmelseed / Mohamed, Yassir / Adulhameed, Razi / Ishag, Majdi / Elzubair, Ahamed

    Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

    2020  Volume 26, Issue 6, Page(s) 636–637

    MeSH term(s) Betacoronavirus ; COVID-19 ; Communicable Disease Control/organization & administration ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Sudan/epidemiology ; Volunteers
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1291071-5
    ISSN 1687-1634 ; 1020-3397
    ISSN (online) 1687-1634
    ISSN 1020-3397
    DOI 10.26719/emhj.20.072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Controlling the spread of COVID-19 in Sudan with limited resources: a unique community-engaged approach

    Ahmed, Gasmelseed / Mohamed, Yassir / Adulhameed, Razi / Ishag, Majdi / Elzubair, Ahamed

    East Mediterr Health J

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #632837
    Database COVID19

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  5. Article ; Online: Correction to: Attitudes and Practice of Health Care Providers Toward Cancer Screening: A Cross-sectional Multicenter Study, Saudi Arabia.

    Ahmed, Gasmelseed Y / Al Mutair, Abbas / Bashir, Shahinaz / Acunin, Rommel / Al Aljabr, Nora / Alnumari, Rasha / Alarab, Ghina / Hussein, Siddig Mohamed / Saha, Chandni / Al-Jamea, Lamiaa H / Woodman, Alexander / Almusalami, Eman

    Journal of epidemiology and global health

    2022  Volume 12, Issue 4, Page(s) 574

    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2645324-1
    ISSN 2210-6014 ; 2210-6014
    ISSN (online) 2210-6014
    ISSN 2210-6014
    DOI 10.1007/s44197-022-00074-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Quality of Nursing Work Life among Nurses in Saudi Arabia: A Descriptive Cross-Sectional Study.

    Al Mutair, Abbas / Al Bazroun, Mohammed I / Almusalami, Eman M / Aljarameez, Faiza / Alhasawi, Amal I / Alahmed, Fatimah / Saha, Chandni / Alharbi, Hanan F / Ahmed, Gasmelseed Y

    Nursing reports (Pavia, Italy)

    2022  Volume 12, Issue 4, Page(s) 1014–1022

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-12-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2039-4403
    ISSN (online) 2039-4403
    DOI 10.3390/nursrep12040097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Acceptance, Advocacy, and Perception of Health Care Providers on COVID-19 Vaccine: Comparing Early Stage of COVID-19 Vaccination with Latter Stage in the Eastern Region of Saudi Arabia.

    Almusalami, Eman M / Al-Bazroun, Mohammed I / Alhasawi, Amal I / Alahmed, Fatimah S / Al-Muslim, Zahra M / Al-Bazroun, Lubana I / Muslim, Maryam / Saha, Chandni / Kay, Elbert / Alzahrani, Zeyad A / Ahmed, Gasmelseed Y / Al Mutair, Abbas

    Vaccines

    2023  Volume 11, Issue 2

    Abstract: Vaccination of healthcare providers has recently gained focused attention of public health officials. As HCPs have direct contact with the population, and HCPs significantly influence the population, this study aimed to compare the acceptance rate, ... ...

    Abstract Vaccination of healthcare providers has recently gained focused attention of public health officials. As HCPs have direct contact with the population, and HCPs significantly influence the population, this study aimed to compare the acceptance rate, advocacy rate, and beliefs about the COVID-19 vaccine among HCPs in two time periods. In this repeated cross-sectional study, different HCPs were assessed in two periods ten months apart, i.e., November to December 2020 and September to October 2021, which were before and after COVID-19 vaccine approval by authorities. The study was conducted in Qatif Central Hospital, Eastern Region of Saudi Arabia. There were 609 respondents: 236 participants in the first period and 373 participants in the second period. Only 13 participants did not get the COVID-19 vaccine. There was around a 40% difference in the acceptance rate between the two study periods; the latter period was higher at 94.7%. Furthermore, 24.1% was the difference between the willingness to advocate the COVID-19 vaccine for others; the first period had a lower percentage (60.1%). Overall, results of the study showed that vaccine hesitancy, as well as the willingness to advocate for the vaccine, were improved between the pre-vaccine approval period and post-vaccine approval period, showing that the efforts made by the government improved COVID-19 acceptance and advocacy among HCPs. However, vaccine hesitancy is not a new issue, and for a better understanding of HCPs' beliefs, a qualitative study is needed.
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11020488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Admission levels of Soluble Urokinase Plasminogen Activator Receptor (suPAR) are Associated with the Development of Severe Complications in Hospitalised COVID-19 Patients: A Prospective Cohort Study.

    Oulhaj, Abderrahim / Alsuwaidi, Ahmed R / Suliman, Abubaker / Gasmelseed, Huda / Khan, Shaima / Alawi, Shamma / Hukan, Yaman / George, Junu / Alshamsi, Fayez / Sheikh, Farrukh / Babiker, Zahir Osman Eltahir / Prattes, Juergen / Sourij, Harald

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 107, Page(s) 188–194

    Abstract: Objective: To examine the association between plasma levels of the soluble urokinase plasminogen activator receptor (suPAR) and the incidence of severe complications of COVID-19.: Methods: 403 RT-PCR-confirmed COVID-19 patients were recruited and ... ...

    Abstract Objective: To examine the association between plasma levels of the soluble urokinase plasminogen activator receptor (suPAR) and the incidence of severe complications of COVID-19.
    Methods: 403 RT-PCR-confirmed COVID-19 patients were recruited and prospectively followed-up at a major hospital in the United Arab Emirates. The primary endpoint was time from admission until the development of a composite outcome, including acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, or death from any cause. Patients discharged alive were considered as competing events to the primary outcome. Competing risk regression was used to quantify the association between suPAR and the incidence of the primary outcome.
    Results: 6.2% of patients experienced ARDS or ICU admission, but none died. Taking into account competing risk, the incidence of the primary outcome was 11.5% (95% confidence interval [CI], 6.7-16.3) in patients with suPAR levels >3.91 ng/mL compared to 2.9% (95% CI, 0.4-5.5) in those with suPAR ≤3.91 ng/mL. Also, an increase by 1 ng/mL in baseline suPAR resulted in a 58% rise in the hazard of developing the primary outcome (hazard ratio 1.6, 95% CI, 1.2-2.1, p = 0.003).
    Conclusion: suPAR has an excellent prognostic utility in predicting severe complications in hospitalised COVID-19 patients.
    MeSH term(s) Adult ; Aged ; COVID-19/blood ; COVID-19/complications ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Patient Admission ; Prospective Studies ; Receptors, Urokinase Plasminogen Activator/blood ; SARS-CoV-2
    Chemical Substances Receptors, Urokinase Plasminogen Activator
    Language English
    Publishing date 2021-04-20
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.04.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Healthcare Provider Attitudes toward the Newly Developed COVID-19 Vaccine: Cross-Sectional Study.

    Ahmed, Gasmelseed / Almoosa, Zainab / Mohamed, Dalia / Rapal, Janepple / Minguez, Ofelia / Abu Khurma, Issam / Alnems, Ayman / Al Mutair, Abbas

    Nursing reports (Pavia, Italy)

    2021  Volume 11, Issue 1, Page(s) 187–194

    Abstract: Background: During the long wait and the global anxiety for a vaccine against COVID-19, impressively high-safety and effective vaccines were invented by multiple pharmaceutical companies.: Aim: We aimed to assess the attitudes of healthcare providers ...

    Abstract Background: During the long wait and the global anxiety for a vaccine against COVID-19, impressively high-safety and effective vaccines were invented by multiple pharmaceutical companies.
    Aim: We aimed to assess the attitudes of healthcare providers and evaluate their intention to advocate for the vaccine.
    Methods: This was a cross-sectional study conducted in a tertiary private hospital where an electronic survey was distributed among healthcare providers (HCPs). The survey contained two sections: socio-demographic characteristics and Likert-scale perception, with 72% internal consistency.
    Results: The response rate to the email survey was 37% (n = 236). In addition, 169 (71.6%) of respondents were women, with more than half (134, 56.8%) aged ≤35 years. A total of 110 (46.6%) had over 10 years of experience, and most of them were nurses (146, 62%). Univariate analysis revealed that older participants significantly accepted and advocated for the new vaccine more than the younger ones. In the multivariate analysis, men were significantly more likely than women to accept and advocate for the new vaccine, as were those with chronic illnesses. Participants with allergy were significantly less likely to accept the vaccine than others. odds ratio (OR) and
    Conclusion: The acceptance rate for the newly-developed COVID-19 vaccines was average among HCPs. Sex, age, presence of chronic illnesses, and allergy were significant predictors of accepting the vaccine.
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2039-4403
    ISSN (online) 2039-4403
    DOI 10.3390/nursrep11010018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Depression, Stress and Anxiety in Patients Recovering from COVID -19 Pneumonia after Hospitalization

    Safwat Eldaabossi / Sherif Osman / Amgad Awad / Saber Abo Elhassan / Abdallah . Elatrash / Gasmelseed Y. Ahmed / Abbas Al Mutair / Hatem Elkenany / Waheed Mahdi

    International Journal of Medical Arts, Vol 4, Iss 3, Pp 2243-

    Experience at Almoosa Specialist Hospital

    2022  Volume 2251

    Abstract: Background: The coronavirus disease 2019 [COVID-19] pandemic has created an environment in which many determinants of mental health are affected. Our objective was to determine the prevalence of depression, stress, and anxiety symptoms in adult patients ... ...

    Abstract Background: The coronavirus disease 2019 [COVID-19] pandemic has created an environment in which many determinants of mental health are affected. Our objective was to determine the prevalence of depression, stress, and anxiety symptoms in adult patients discharged and recovering after hospitalization for COVID -19 pneumonia, at Almoosa Hospital. Materials and Methods: In a cross-sectional study, the Depression Anxiety Stress Scale 21 [DASS21] assessment instrument was used to measure distress along the three axes of depression, anxiety, and stress and distributed one month after discharge and recovery. Medical records were reviewed to collect information on medical details.Results: Of the 466 respondents, 53.2% were female, with an average age of 54.20 years. Mental health problems were noted in 130 [27.9%] patients with anxiety symptoms, 79 [17%] with stress symptoms, and 63 [13.5%] with depression symptoms. Patients with mental health problems [depression, anxiety, and stress symptoms] were found to have significantly higher D-dimer levels than patients without these symptoms. The severity of depressive symptoms was found to be significantly associated with decreased oxygen saturation and increased length of stay in the intensive care unit [ICU]. Conclusion: Patients recovering from COVID-19 pneumonia have high rates of mental health problems. Significantly higher D-dimer levels were found in patients with mental health problems. The severity of depressive symptoms was associated with decreased oxygen saturation and increased ICU length of stay. Early recognition and appropriate management of mental health problems are needed.
    Keywords anxiety ; stress ; covid-19 ; emotional wellbeing ; depression ; saudi arabia ; mental health ; Medicine (General) ; R5-920
    Subject code 150
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Al-Azhar University, Faculty of Medicine (Damietta)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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