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Article ; Online: Alcohol and Neural Network Activity: A New Link Between Alcohol in Moderation and Cardiovascular Health?

de Gaetano, Giovanni / Costanzo, Simona / Di Castelnuovo, Augusto

Journal of the American College of Cardiology

2023 Volume 81, Issue 24, Page(s) 2326–2327

MeSH term(s)	Humans ; Ethanol ; Heart ; Cardiovascular System
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2023.04.018
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Article ; Online: Response to commentaries: alcohol intake and total mortality, strengths and limitations of observational studies, waiting for clinical trials.

Di Castelnuovo, Augusto / Costanzo, Simona / de Gaetano, Giovanni / Iacoviello, Licia

Addiction (Abingdon, England)

2022 Volume 117, Issue 2, Page(s) 329–330

MeSH term(s)	Alcohol Drinking ; Humans ; Risk Factors
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1141051-6
ISSN	1360-0443 ; 0965-2140
ISSN (online)	1360-0443
ISSN	0965-2140
DOI	10.1111/add.15753
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Article ; Online: Full

Loffredo, Lorenzo / Di Castelnuovo, Augusto / Chiariello, Giovanni Alfonso / Pignatelli, Pasquale / Violi, Francesco

Haematologica

2022 Volume 107, Issue 8, Page(s) 1933–1939

MeSH term(s)	Anticoagulants/therapeutic use ; COVID-19 ; Heparin, Low-Molecular-Weight ; Humans ; Venous Thromboembolism
Chemical Substances	Anticoagulants ; Heparin, Low-Molecular-Weight
Language	English
Publishing date	2022-08-01
Publishing country	Italy
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2022.280652
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Article ; Online: Protective effect of oral anticoagulant drugs in atrial fibrillation patients admitted for COVID-19: Results from the CORIST study.

Ageno, Walter / De Candia, Erica / Iacoviello, Licia / Di Castelnuovo, Augusto

Thrombosis research

2021 Volume 203, Page(s) 138–141

MeSH term(s)	Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; COVID-19 ; Humans ; Propensity Score ; SARS-CoV-2 ; Stroke
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-05-15
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2021.05.006
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Article ; Online: High alpha-2-macroglobulin levels are a risk factor for cardiovascular disease events: A Moli-sani cohort study.

de Laat-Kremers, Romy / Costanzo, Simona / Yan, Qiuting / Di Castelnuovo, Augusto / De Curtis, Amalia / Cerletti, Chiara / de Gaetano, Giovanni / Donati, Maria Benedetta / de Laat, Bas / Iacoviello, Licia

Thrombosis research

2024 Volume 234, Page(s) 94–100

Abstract: Background: α: Methods: We determined α: Results: α: Conclusion: We show in a prospective cohort that high levels of ... ...

Abstract	Background: α Methods: We determined α Results: α Conclusion: We show in a prospective cohort that high levels of α
MeSH term(s)	Male ; Humans ; Adult ; Middle Aged ; Aged ; Female ; Cohort Studies ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/epidemiology ; Prospective Studies ; Thrombin ; Risk Factors ; Coronary Disease ; Macroglobulins
Chemical Substances	Thrombin (EC 3.4.21.5) ; Macroglobulins
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2024.01.001
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Article: Socioeconomic gradient in health: mind the gap in 'invisible' disparities.

Bonaccio, Marialaura / Di Castelnuovo, Augusto / de Gaetano, Giovanni / Iacoviello, Licia

Annals of translational medicine

2020 Volume 8, Issue 18, Page(s) 1200

Language	English
Publishing date	2020-07-23
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm.2020.04.46
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Article ; Online: Endogenous thrombin potential and time-dependent thrombin generation parameters are independent risk factors for mortality in the general population.

de Laat-Kremers, Romy / Costanzo, Simona / Roest, Mark / De Curtis, Amalia / Huskens, Dana / Di Castelnuovo, Augusto / Ninivaggi, Marisa / Cerletti, Chiara / Donati, Maria Benedetta / de Laat, Bas / Iacoviello, Licia

Journal of thrombosis and haemostasis : JTH

2024

Abstract: Background: Thrombin generation (TG) is used as a global test of coagulation and is an indicator of thrombosis and bleeding risk. Until now, data on the association of TG and mortality are inconclusive.: Objectives: We investigated the association ... ...

Abstract	Background: Thrombin generation (TG) is used as a global test of coagulation and is an indicator of thrombosis and bleeding risk. Until now, data on the association of TG and mortality are inconclusive. Objectives: We investigated the association between TG and mortality in the prospective Moli-sani cohort (n = 21 920). Methods: TG was measured using calibrated automated thrombinography using PPP-Reagent Low. Lag time (LT), endogenous thrombin potential (ETP), peak height, time-to-peak (TTP), and velocity index were quantified. The association of TG and mortality was studied by Cox regression and adjusted for sex, age, body mass index, smoking, contraceptives, and medical history (cardiovascular diseases, hypertension, hypercholesterolemia, diabetes, and cancer). Results: LT and TTP were 4.1 ± 1.0 minutes and 6.6 ± 1.5 minutes, on average. The peak height was 364 ± 88 nM, velocity index was 163 ± 63 nM/min, and ETP was 1721 ± 411 nM·min. ETP was negatively associated with all-cause mortality (hazard ratio [HR], 0.86; 95% CI, 0.81-0.92; P < .001). Subjects in the lowest quintile of the ETP (ETP Conclusion: Low ETP and TTP/LT ratios are independent risk factors for all-cause mortality in the general population.
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1016/j.jtha.2024.02.005
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Zs.MO 295: Show issues

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Article ; Online: Diet Quality and Risk of SARS-CoV-2 Infection or COVID-19: A Systematic Review of Observational Studies.

Sharma, Sukshma / Di Castelnuovo, Augusto / Cerletti, Chiara / Donati, Maria Benedetta / de Gaetano, Giovanni / Iacoviello, Licia / Bonaccio, Marialaura

Advances in nutrition (Bethesda, Md.)

2023 Volume 14, Issue 6, Page(s) 1596–1616

Abstract: The COVID-19 pandemic highlighted the importance of healthy diets in the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19. Evidence suggests the influence of diet and dietary patterns during post-COVID-19, ...

Abstract	The COVID-19 pandemic highlighted the importance of healthy diets in the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19. Evidence suggests the influence of diet and dietary patterns during post-COVID-19, and the impact of the COVID-19 pandemic on dietary habits and quality. However, limited evidence lies on the association between a healthy diet, and risk of SARS-CoV-2 infection or COVID-19. This study aimed to conduct a systematic review of observational studies to examine the association between diet quality, and the risk of SARS-CoV-2 infection or COVID-19 among adult populations. 6158 research articles from Scopus, EMBASE, PubMed, and MEDLINE databases were identified for eligibility. Only observational studies were included. Study quality was assessed using the National Institutes of Health Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Thirteen studies were included (4 with SARS-CoV-2 infection and 9 with COVID-19 as the outcome); 3 were case-control, 3 were cross-sectional, and 7 were prospective studies. Adherence to Mediterranean diet was examined as exposure in 7 studies, and was associated with decreased risk of SARS-CoV-2 infection in 2 studies, with estimates varying from 12% to 22%, while COVID-19 risk or severity was found to be reduced in 3 studies with odds ratios (ORs) ranging from 36% to 77%. The Dietary Approaches to Stop Hypertension diet was inversely associated with COVID-19 hospitalization (OR: 0.19; 95% CI: 0.07, 0.55), whereas a healthy plant-based diet had an inverse association with both COVID-19 infection (hazard ratio [HR]: 0.91; 95% CI: 0.88, 0.94) and severity (HR: 0.59; 95% CI: 0.47, 0.74). Studies examining individual food groups generally found lower risk of infection or COVID-19 in association with larger dietary intakes of fruits, vegetables, and fiber. The overall findings of the observational studies in this review support the concept that nutritious diets might lower the risk of SARS-CoV-2 infection or COVID-19. This study was registered at PROSPERO as CRD42023397371.
MeSH term(s)	United States ; Adult ; Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Pandemics ; Prospective Studies ; Diet, Healthy ; Observational Studies as Topic
Language	English
Publishing date	2023-09-23
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2583634-1
ISSN	2156-5376 ; 2156-5376
ISSN (online)	2156-5376
ISSN	2156-5376
DOI	10.1016/j.advnut.2023.09.006
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Article ; Online: Dietary indices underpinning front-of-pack nutrition labels and health outcomes: a systematic review and meta-analysis of prospective cohort studies.

Montericcio, Alberto / Bonaccio, Marialaura / Ghulam, Anwal / Di Castelnuovo, Augusto / Gianfagna, Francesco / de Gaetano, Giovanni / Iacoviello, Licia

The American journal of clinical nutrition

2023 Volume 119, Issue 3, Page(s) 756–768

Abstract: ... review. The meta-analysis comprised 8 studies analyzing the FSAm-NPS dietary index (DI) as exposure ... The pooled HRs associated with a 2-unit increase in the FSAm-NPS DI of all-cause mortality, CVD, and ...

Abstract	Background: Nutrient profiling systems are increasingly used to characterize the healthfulness of foods for front-of-package (FOP) labeling, which have been proposed as an effective public health strategy to help people make healthier food choices. Objective: This study aimed to review available evidence from cohort studies that evaluated the association of dietary indices underpinning FOP nutrition labels with all-cause mortality and incidence of cardiovascular diseases (CVDs) or cancer. Methods: PubMed, Web of Science, and Scopus were systematically searched up to October 2023. We included articles if they were prospective cohort studies, if the exposure was any dietary index underpinning FOP nutrition labels [e.g., the modified Food Standard Agency-Nutrient Profiling System (FSAm-NPS) and the Health Star Rating System], and if outcomes were all-cause mortality or incidence of or mortality due to CVD and cancer. Random-effects models were used to calculate the pooled hazard ratios (HRs) and 95% CIs. Results: We identified 11 records (7 unique prospective studies), which were included in the systematic review. The meta-analysis comprised 8 studies analyzing the FSAm-NPS dietary index (DI) as exposure. The pooled HRs associated with a 2-unit increase in the FSAm-NPS DI of all-cause mortality, CVD, and cancer risk were 1.06 (95% confidence interval [CI]: 0.99, 1.13; I Conclusions: DIs underpinning most common FOP nutrition labels and reflecting nutrient-poor diets show a tendency toward an increased incidence of CVD and cancer, but the observed effects are quite modest in magnitude. Further studies at the population level are needed to support the widely shared hypothesis that FOP labels, possibly in conjunction with other interventions, may contribute to reduce noncommunicable disease risk. This meta-analysis was registered at PROSPERO as CRD42021292625.
MeSH term(s)	Humans ; Cardiovascular Diseases/prevention & control ; Consumer Behavior ; Diet ; Food Labeling ; Food Preferences ; Neoplasms/prevention & control ; Neoplasms/epidemiology ; Nutritive Value
Language	English
Publishing date	2023-12-23
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.1016/j.ajcnut.2023.12.017
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Article ; Online: Breakfast quality and its sociodemographic and psychosocial correlates among Italian children, adolescents, and adults from the Italian Nutrition & HEalth Survey (INHES) study.

Martinez, Claudia Francisca / Ruggiero, Emilia / Di Castelnuovo, Augusto / Esposito, Simona / Costanzo, Simona / Cerletti, Chiara / Donati, Maria Benedetta / de Gaetano, Giovanni / Iacoviello, Licia / Bonaccio, Marialaura

Nutrition journal

2024 Volume 23, Issue 1, Page(s) 20

Abstract: Background: Breakfast quality, together with regularity of breakfast, has been suggested to be associated with cardiometabolic health advantages. We aimed to evaluate the quality of breakfast and its socioeconomic and psychosocial correlates in a large ... ...

Abstract	Background: Breakfast quality, together with regularity of breakfast, has been suggested to be associated with cardiometabolic health advantages. We aimed to evaluate the quality of breakfast and its socioeconomic and psychosocial correlates in a large sample of the Italian population. Methods: Cross-sectional analyses on 7,673 adult and 505 children/adolescent regular breakfast eaters from the Italian Nutrition & Health Survey (INHES; 2010-2013). Dietary data were collected through a single 24-h dietary recall. Breakfast quality was assessed through the Breakfast Quality Index (BQI) combining intake of ten food groups, energy, and nutrients of public health concern, and potentially ranging from 0 to 10. The association of sociodemographic and psychosocial factors with BQI were analyzed by multivariable-adjusted linear regression models. Results: The average BQI was 4.65 (SD ± 1.13) and 4.97 (SD ± 1.00) in adults and children/adolescents, respectively. Amongst adults, older age (β = 0.19; 95%CI 0.06 to 0.31 for > 65 vs. 20-40 years) and having a high educational level (β = 0.13; 0.03 to 0.23; for postsecondary vs. up to elementary) were independent predictors of better breakfast quality, while men reported lower BQI (β = -0.08; -0.14 to -0.02 vs. women). Perceived stress levels at home and work and financial stress were inversely associated with BQI. Children/adolescents living in Central and Southern Italian regions had lower BQI compared to residents in Northern Italy (β = -0.55; -0.91 to -0.19 and β = -0.24; -0.47 to -0.01, respectively). Conclusions: In adults, breakfast quality was associated with age, sex, and educational level. Perceived stress levels were inversely associated with the quality of breakfast. In children/adolescents, a north-south gradient in breakfast quality was observed.
MeSH term(s)	Male ; Adult ; Child ; Humans ; Adolescent ; Female ; Breakfast ; Cross-Sectional Studies ; Diet ; Health Surveys ; Italy ; Feeding Behavior
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2091602-4
ISSN	1475-2891 ; 1475-2891
ISSN (online)	1475-2891
ISSN	1475-2891
DOI	10.1186/s12937-024-00924-6
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