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  1. Article ; Online: Tumour mutational burden as a driver for treatment choice in resistant tumours (and beyond).

    Bersanelli, Melissa

    The Lancet. Oncology

    2020  Volume 21, Issue 10, Page(s) 1255–1257

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Biomarkers, Tumor ; Humans ; Neoplasms ; Prospective Studies
    Chemical Substances Antibodies, Monoclonal, Humanized ; Biomarkers, Tumor ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2020-09-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(20)30433-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  2. Article ; Online: COVID-19 and the newly rediscovered multidisciplinarity.

    Bersanelli, Melissa

    Immunotherapy

    2020  Volume 12, Issue 15, Page(s) 1101–1103

    MeSH term(s) Anticoagulants/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Humans ; Immunocompromised Host ; Immunologic Factors/therapeutic use ; Immunotherapy ; Interdisciplinary Research ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Chemical Substances Anticoagulants ; Immunologic Factors
    Keywords covid19
    Language English
    Publishing date 2020-09-21
    Publishing country England
    Document type Introductory Journal Article
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt-2020-0205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Controversies about COVID-19 and anticancer treatment with immune checkpoint inhibitors.

    Bersanelli, Melissa

    Immunotherapy

    2020  Volume 12, Issue 5, Page(s) 269–273

    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/etiology ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Cytokine Release Syndrome ; Disease Progression ; Humans ; Immunotherapy/adverse effects ; Neoplasms/complications ; Neoplasms/immunology ; Neoplasms/therapy ; Pandemics ; Pneumonia, Viral/etiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-03-26
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2020-0067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Reassessing Human Adipose Tissue.

    Buti, Sebastiano / Cortellini, Alessio / Bersanelli, Melissa

    The New England journal of medicine

    2022  Volume 386, Issue 22, Page(s) e61

    MeSH term(s) Adipose Tissue ; Humans
    Language English
    Publishing date 2022-05-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2204077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The latest developments in biomarkers predicting response to immunotherapy.

    Roviello, Giandomenico / Bersanelli, Melissa / Catalano, Martina

    Immunotherapy

    2022  Volume 14, Issue 14, Page(s) 1085–1088

    Abstract: Tweetable abstract Biomarkers predicting response to immune checkpoint inhibitors can facilitate the selection of patients who benefit from immunotherapy, avoiding rapid disease progression in nonresponders and needless toxicity. ...

    Abstract Tweetable abstract Biomarkers predicting response to immune checkpoint inhibitors can facilitate the selection of patients who benefit from immunotherapy, avoiding rapid disease progression in nonresponders and needless toxicity.
    MeSH term(s) Biomarkers ; Biomarkers, Tumor ; Humans ; Immunologic Factors ; Immunotherapy ; Neoplasms/therapy
    Chemical Substances Biomarkers ; Biomarkers, Tumor ; Immunologic Factors
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Editorial
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2022-0053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Avelumab Maintenance for Urothelial Carcinoma.

    Buti, Sebastiano / Bersanelli, Melissa

    The New England journal of medicine

    2020  Volume 383, Issue 25, Page(s) 2482–2483

    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Carcinoma, Transitional Cell/drug therapy ; Humans ; Urologic Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; avelumab (KXG2PJ551I)
    Language English
    Publishing date 2020-12-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2032018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Immune checkpoint inhibitors in non-conventional histologies of renal-cell carcinoma.

    Bersanelli, Melissa / Rebuzzi, Sara Elena / Roviello, Giandomenico / Catalano, Martina / Brunelli, Matteo / Rizzo, Mimma

    Human vaccines & immunotherapeutics

    2023  Volume 19, Issue 1, Page(s) 2171672

    Abstract: For years, prospective randomized clinical trials excluded patients with non-conventional histologies of renal cell carcinoma (RCC). The paucity of data has led to adopting the same treatment strategies used for clear-cell RCC (ccRCC). In the present ... ...

    Abstract For years, prospective randomized clinical trials excluded patients with non-conventional histologies of renal cell carcinoma (RCC). The paucity of data has led to adopting the same treatment strategies used for clear-cell RCC (ccRCC). In the present narrative review, we explored state of the art about use of immune checkpoint inhibitors (ICIs) in variant histologies of RCC. According to the results collected, ICIs as monotherapy showed promising antitumor activity in advanced non-clear cell (ncc)RCC. The objective response rate (ORR) was similar to that observed with single-agent anti-PD-1 in the ccRCC population, either in the first-line or the second-line setting, and responder patients experienced an early and durable benefit. Combined ICI-based strategies have shown increasing evidence in nccRCC and robust results in the sarcomatoid variants of RCC. A definitive recommendation about treating non-conventional histologies, either in adjuvant or metastatic settings, should be supported by more extensive dedicated trials.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/drug therapy ; Kidney Neoplasms/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Antineoplastic Agents/therapeutic use ; Prospective Studies
    Chemical Substances Immune Checkpoint Inhibitors ; Antineoplastic Agents
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2023.2171672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6967: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: The interplay between cholesterol (and other metabolic conditions) and immune-checkpoint immunotherapy: shifting the concept from the "inflamed tumor" to the "inflamed patient".

    Bersanelli, Melissa / Cortellini, Alessio / Buti, Sebastiano

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 7, Page(s) 1930–1934

    Abstract: The predictive ability of metabolic conditions, such as hypercholesterolemia, on the outcome of cancer patients to immune-checkpoint inhibitors (ICIs) therapy, has been recently explored. The reasons for their value in this setting are to be searched in ... ...

    Abstract The predictive ability of metabolic conditions, such as hypercholesterolemia, on the outcome of cancer patients to immune-checkpoint inhibitors (ICIs) therapy, has been recently explored. The reasons for their value in this setting are to be searched in the individual himself more than in his tumor, as the target of the immune-checkpoint blockade is the immune system. The efficacy of ICIs on the tumor may be based on two simple premises: 1) the physiological immune function has been blocked, and 2) the tumor progression (mainly) depends on this block. The metabolic syndrome may represent the epiphenomenon of an "inflamed patient," no longer able of physiological functions required to prevent chronic inflammatory events. The metabolic dysfunction could represent merely "a biomarker" of the patient who satisfies both the two premises reported above. Suggestions from preclinical and translational researches should be transferred in the clinical setting, implementing randomized clinical trials with observational endpoints such as the effect of concomitant drug medications and the impact of blood cholesterol levels and other metabolic conditions on the outcome of ICI treatment.
    MeSH term(s) Cholesterol ; Humans ; Immune Checkpoint Inhibitors ; Immunologic Factors/therapeutic use ; Immunotherapy ; Neoplasms/drug therapy
    Chemical Substances Immune Checkpoint Inhibitors ; Immunologic Factors ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2021-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2020.1852872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6967: Show issues Location:
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