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  1. Article ; Online: Addressing Knowledge Gaps in the Primary Prevention of Atherosclerotic Heart Disease.

    Gidding, Samuel S

    Journal of the American Heart Association

    2024  Volume 13, Issue 6, Page(s) e033991

    MeSH term(s) Humans ; Coronary Artery Disease/prevention & control ; Hypercholesterolemia ; Primary Prevention ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.033991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Childhood Screening for Familial Hypercholesterolemia: JACC Review Topic of the Week.

    Gidding, Samuel S

    Journal of the American College of Cardiology

    2023  Volume 82, Issue 15, Page(s) 1558–1563

    Abstract: Screening for familial hypercholesterolemia (FH) in childhood remains controversial. Existing guidelines offer practitioners conflicting advice despite generally agreeing on the evidence and areas in which evidence is lacking, including a lack of long- ... ...

    Abstract Screening for familial hypercholesterolemia (FH) in childhood remains controversial. Existing guidelines offer practitioners conflicting advice despite generally agreeing on the evidence and areas in which evidence is lacking, including a lack of long-term clinical trials demonstrating coronary event reduction as a result of screening and long-term data on statin side effects. A limitation of existing evidence-based frameworks is reliance on 1 evidence grading system to determine recommendations. However, rigorous evidence evaluation alternatives relevant to FH exist. FH is considered a tier 1 genetic condition, meaning that identification and treatment will improve health outcomes among those affected. Elevated low-density lipoprotein cholesterol, the primary consequence of FH, can be considered causal for atherosclerosis and coronary heart disease. Incorporating these concepts into existing evidence pathways allows the inclusion of surrogate clinical trial outcomes (low-density lipoprotein cholesterol reduction and atherosclerosis regression) and observational data on medication safety, strengthening the evidence for pediatric screening for FH.
    MeSH term(s) Child ; Humans ; Atherosclerosis/diagnosis ; Atherosclerosis/prevention & control ; Cholesterol ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/genetics ; Hyperlipoproteinemia Type II/drug therapy
    Chemical Substances Cholesterol (97C5T2UQ7J) ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.07.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Familial Hypercholesterolemia: The Atlantic Divide.

    Gidding, Samuel S

    The Journal of pediatrics

    2022  Volume 256, Page(s) 1–2

    MeSH term(s) Humans ; Hyperlipoproteinemia Type II/diagnosis
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.09.021
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  4. Article ; Online: 50 Years Ago in TheJournalofPediatrics: If We Know That Cardiovascular Risk Factors Measured in Childhood Predict Atherosclerosis, Why Don't We Measure Them?

    Gidding, Samuel S

    The Journal of pediatrics

    2022  Volume 244, Page(s) 48

    MeSH term(s) Atherosclerosis ; Cardiovascular Diseases ; Heart Disease Risk Factors ; Humans ; Risk Factors
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.01.026
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  5. Article ; Online: Pubertal-stage adjustment decreases prevalence of obesity.

    Gidding, Samuel S

    The Journal of pediatrics

    2021  Volume 236, Page(s) 325–328

    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2021.06.057
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  6. Article ; Online: Finding Familial Hypercholesterolemia.

    Gidding, Samuel S

    Clinical chemistry

    2021  Volume 67, Issue 5, Page(s) 710–712

    MeSH term(s) Humans ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/genetics
    Language English
    Publishing date 2021-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvaa316
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  7. Article ; Online: Diagnosing Hypertension in Childhood, New Considerations.

    Gidding, Samuel S

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 78, Issue 1, Page(s) 38–39

    MeSH term(s) Blood Pressure/physiology ; Blood Pressure Determination/methods ; Child ; Humans ; Hypertension/diagnosis ; Hypertension/physiopathology ; Hypertension/prevention & control
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.121.17488
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    Zs.A 1488: Show issues Location:
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  8. Article ; Online: 50 Years Ago in TheJournalofPediatrics: Inflammation and Vasculitis: Changing Paradigms.

    Gidding, Samuel S

    The Journal of pediatrics

    2021  Volume 233, Page(s) 205

    MeSH term(s) History, 20th Century ; Humans ; Mucocutaneous Lymph Node Syndrome/history ; Pediatrics/history ; Periodicals as Topic/history ; Polyarteritis Nodosa/history
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2021.02.049
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  9. Article: Overcoming the real and imagined barriers to cholesterol screening in pediatrics.

    Schubert, Tyler J / Gidding, Samuel S / Jones, Laney K

    Journal of clinical lipidology

    2024  

    Abstract: Recent guidance by the United States Preventive Services Task Force has renewed the debate surrounding the benefits of pediatric lipid screening. This commentary reviews the evolution of the pediatric lipid screening recommendations in the United States, ...

    Abstract Recent guidance by the United States Preventive Services Task Force has renewed the debate surrounding the benefits of pediatric lipid screening. This commentary reviews the evolution of the pediatric lipid screening recommendations in the United States, followed by an exploration of real and imagined challenges that prevent optimal cholesterol screening rates in children. Real challenges substantively prevent the uptake of these guidelines into practice; imagined challenges, such as identifying the best age to screen, are often context-dependent and can also be surmounted. Experiences from other countries identify potential facilitators to improving screening and additional barriers. Implementation science provides guidance on overcoming the real barriers, translating evidence-based recommendations into clinical practice, and informing the next wave of solutions to overcome these challenges.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 2365061-8
    ISSN 1876-4789 ; 1933-2874
    ISSN (online) 1876-4789
    ISSN 1933-2874
    DOI 10.1016/j.jacl.2024.02.008
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  10. Article ; Online: Improving Children's Diets Needs a Public Health Strategy.

    Gidding, Samuel S

    Hypertension (Dallas, Tex. : 1979)

    2020  Volume 76, Issue 5, Page(s) 1418–1419

    MeSH term(s) Adult ; Blood Pressure ; Child ; Diet ; Humans ; Infant ; Public Health ; Risk Factors ; Young Adult
    Language English
    Publishing date 2020-10-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.120.15912
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