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  1. Article ; Online: Emergency retransplant for primary non-function of liver allograft.

    Halle-Smith, James M / Hall, Lewis A / Hann, Angus / Isaac, John L / Murphy, Nick / Roberts, Keith J / Rajoriya, Neil / Perera, M Thamara P R

    The British journal of surgery

    2023  Volume 110, Issue 10, Page(s) 1267–1270

    MeSH term(s) Humans ; Liver ; Transplantation, Homologous ; Allografts ; Reoperation ; Graft Survival ; Retrospective Studies ; Graft Rejection
    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad110
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    Uk I Zs.66: Show issues Location:
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  2. Article: Low C-reactive Protein and Urea Distinguish Primary Nonfunction From Early Allograft Dysfunction Within 48 Hours of Liver Transplantation.

    Halle-Smith, James M / Hall, Lewis / Hann, Angus / Arshad, Asif / Armstrong, Matthew J / Bangash, Mansoor N / Murphy, Nick / Cuell, James / Isaac, John L / Ferguson, James / Roberts, Keith J / Mirza, Darius F / Perera, M Thamara P R

    Transplantation direct

    2023  Volume 9, Issue 6, Page(s) e1484

    Abstract: Primary nonfunction (PNF) is a life-threatening complication of liver transplantation (LT), but in the early postoperative period, it can be difficult to differentiate from early allograft dysfunction (EAD). The aim of this study was to determine if ... ...

    Abstract Primary nonfunction (PNF) is a life-threatening complication of liver transplantation (LT), but in the early postoperative period, it can be difficult to differentiate from early allograft dysfunction (EAD). The aim of this study was to determine if serum biomarkers can distinguish PNF from EAD in the initial 48 h following LT.
    Materials and methods: A retrospective study of adult patients that underwent LT between January 2010 and April 2020 was performed. Clinical parameters, absolute values and trends of C-reactive protein (CRP), blood urea, creatinine, liver function tests, platelets, and international normalized ratio in the initial 48 h after LT were compared between the EAD and PNF groups.
    Results: There were 1937 eligible LTs, with PNF and EAD occurring in 38 (2%) and 503 (26%) patients, respectively. A low serum CRP and urea were associated with PNF. CRP was able to differentiate between the PNF and EAD on postoperative day (POD)1 (20 versus 43 mg/L;
    Discussion: The biochemical profile immediately following LT can distinguish PNF from EAD; CRP, urea, and aspartate transaminase are more effective than ALT and bilirubin in distinguishing PNF from EAD in the initial postoperative 48 h. Clinicians should consider the values of these markers when making treatment decisions.
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001484
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  3. Article ; Online: Assessment of Deceased Brain Dead Donor Liver Grafts via Normothermic Machine Perfusion: Lactate Clearance Time Threshold Can Be Safely Extended to 6 Hours.

    Hann, Angus / Lembach, Hanns / Nutu, Anisa / Mergental, Hynek / Isaac, John L / Isaac, John R / Oo, Ye H / Armstrong, Matthew J / Rajoriya, Neil / Afford, Simon / Bartlett, David / Mirza, Darius F / Hartog, Hermien / Perera, M Thamara P R

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2021  Volume 28, Issue 3, Page(s) 493–496

    MeSH term(s) Brain Death ; Humans ; Lactic Acid ; Liver/surgery ; Liver Transplantation/adverse effects ; Living Donors ; Organ Preservation ; Perfusion/adverse effects
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.26317
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    Zs.A 4702: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Management of Ascites Following Deceased Donor Liver Transplantation: A Case Series.

    Al-Zoubi, Mohammad / Alarabiyat, Moath / Hann, Angus / Mehrzhad, Homoyon / Karkhanis, Salil / Muiesan, Paolo / Abradelo, Manuel / Hartog, Hermien / Roberts, Keith / Mirza, Darius F / Isaac, John R / Dasari, Bobby V M

    Transplantation direct

    2022  Volume 8, Issue 8, Page(s) e1350

    Abstract: Background: Persistent ascites after orthotropic liver transplantation has numerous causes and can be challenging to manage. This study aimed to determine the outcomes associated with conservative and endovascular intervention of posttransplant ascites ... ...

    Abstract Background: Persistent ascites after orthotropic liver transplantation has numerous causes and can be challenging to manage. This study aimed to determine the outcomes associated with conservative and endovascular intervention of posttransplant ascites after deceased donor liver transplantation.
    Methods: Adult (≥18 y) liver transplant recipients (between 2006 and 2019) who underwent hepatic venous pressure studies to investigate posttransplant ascites were included in this retrospective study. Comparisons were made between those who were managed with conservative therapy versus endovascular intervention and were also based on hepatic venous wedge pressure gradient (normal [≤10 mm Hg] versus elevated [>10 mm Hg]).
    Results: A total of 30 patients underwent hepatic venography to investigate ascites during the study period. The median time from transplant to venography was 70 d. At least 1 endovascular intervention was performed in 18 of 30 patients (62%), and 12 of 30 patients (38%) were managed conservatively. Endovascular interventions included angioplasty (n = 4), hepatic vein stenting (n = 9), or a transjugular intrahepatic portosystemic shunt (n = 7). The mean (range) hepatic venous wedge pressure gradient for the conservative and endovascular intervention groups was 12 mm Hg (3-23) and14 mm Hg (2-35), respectively. At a 6-mo follow-up, ascites resolved in 6 of 12 patients (50%) and 11 of 18 patients (61%) in the medical management and endovascular groups, respectively. The graft survival rates at 6 and 12 mo were (7/12 [58%] versus 17/18 [94%],
    Conclusions: Despite medical or endovascular intervention, resolution of ascites is achieved in <60% of patients with persistent ascites. Biopsy findings and venographic pressure studies should be carefully integrated into the management of posttransplant ascites.
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Controversies regarding shielding and susceptibility to COVID-19 disease in liver transplant recipients in the United Kingdom.

    John Hann, Angus / Lembach, Hanns / McKay, Siobhan C / Perrin, Moira / Isaac, John / Oo, Ye H / Mutimer, David / Mirza, Darius F / Hartog, Hermien / Perera, Thamara

    Transplant infectious disease : an official journal of the Transplantation Society

    2020  Volume 22, Issue 5, Page(s) e13352

    MeSH term(s) COVID-19 ; Cross Infection ; Humans ; Liver Transplantation ; Middle East Respiratory Syndrome Coronavirus ; Risk Factors ; SARS-CoV-2 ; Transplant Recipients ; United Kingdom
    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country Denmark
    Document type Letter ; Comment
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13352
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    Zs.A 5100: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Liver graft outcomes from donors with vaccine induced thrombosis and thrombocytopenia (VITT): United Kingdom multicenter experience.

    Hann, Angus / Hartog, Hermien / Nutu, Anisa / Quist, Katherine / Sanabria-Mateos, Rebecca / Greenhall, George H B / Ushiro-Lumb, Ines / Nicolson, Phillip L R / Cain, Owen / Oo, Ye H / Chauhan, Abhishek / Lester, Will / Pollok, Joerg-Matthias / Prachalias, Andreas / Isaac, John R / Thorburn, Douglas / Forsythe, John / Sharif, Khalid / Neil, Desley A H /
    Mirza, Darius F / Perera, M Thamara P R

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2021  Volume 22, Issue 3, Page(s) 996–998

    MeSH term(s) Graft Survival ; Humans ; Liver ; Thrombocytopenia/chemically induced ; Thrombosis/etiology ; Tissue Donors ; Tissue and Organ Procurement ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Letter ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.16869
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    Zs.A 5542: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Biliary Strictures Are Associated With Both Early and Late Hepatic Artery Stenosis.

    Hann, Angus / Seth, Rashmi / Mergental, Hynek / Hartog, Hermien / Alzoubi, Mohammad / Stangou, Arie / El-Sherif, Omar / Ferguson, James / Roberts, Keith / Muiesan, Paolo / Oo, Ye / Issac, John R / Mirza, Darius / Perera, M Thamara P R

    Transplantation direct

    2020  Volume 7, Issue 1, Page(s) e643

    Abstract: Background: Hepatic artery stenosis (HAS) following liver transplantation results in hypoperfusion and ischemic damage to the biliary tree. This study aimed to investigate how vascular intervention, liver function test derangement, and time point of HAS ...

    Abstract Background: Hepatic artery stenosis (HAS) following liver transplantation results in hypoperfusion and ischemic damage to the biliary tree. This study aimed to investigate how vascular intervention, liver function test derangement, and time point of HAS onset influence biliary complications.
    Methods: A single-center retrospective study of adult patients that underwent primary liver transplantation. Patients were grouped according to the presence or absence of HAS and then into early (≤90 d) or late (>90 d) subgroups. Biliary complications comprised anastomotic (AS) or non ASs (NASs).
    Results: Computed tomography angiography confirmed HAS was present in 39 of 1232 patients (3.2%). This occurred at ≤90 and >90 days in 20 (1.6%) and 19 (1.5%), respectively. The incidence of biliary strictures (BSs) in the group with HAS was higher than the group without (13/39; 33% versus 85/1193; 7.1%,
    Conclusions: BS occurs at a significantly higher rate in the presence of HAS. Onset of HAS at ≤90 or ≥90 days can both be associated with morbidity. Significant liver function test derangement at HAS diagnosis indicates a higher likelihood of biliary intervention for strictures.
    Language English
    Publishing date 2020-12-15
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001092
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  8. Article ; Online: Health-related quality of life, uncertainty and coping strategies in solid organ transplant recipients during shielding for the COVID-19 pandemic.

    McKay, Siobhan C / Lembach, Hanns / Hann, Angus / Okoth, Kelvin / Anderton, Joy / Nirantharakumar, Krishnarajah / Magill, Laura / Torlinska, Barbara / Armstrong, Matthew / Mascaro, Jorge / Inston, Nicholas / Pinkney, Thomas / Ranasinghe, Aaron / Borrows, Richard / Ferguson, James / Isaac, John / Calvert, Melanie / Perera, M Thamara P R / Hartog, Hermien

    Transplant international : official journal of the European Society for Organ Transplantation

    2021  Volume 34, Issue 11, Page(s) 2122–2137

    Abstract: Strict isolation of vulnerable individuals has been a strategy implemented by authorities to protect people from COVID-19. Our objective was to investigate health-related quality of life (HRQoL), uncertainty and coping behaviours in solid organ ... ...

    Abstract Strict isolation of vulnerable individuals has been a strategy implemented by authorities to protect people from COVID-19. Our objective was to investigate health-related quality of life (HRQoL), uncertainty and coping behaviours in solid organ transplant (SOT) recipients during the COVID-19 pandemic. A cross-sectional survey of adult SOT recipients undergoing follow-up at our institution was performed. Perceived health status, uncertainty and coping strategies were assessed using the EQ-5D-5L, Short-form Mishel Uncertainty in Illness Scale (SF-MUIS) and Brief Cope, respectively. Interactions with COVID-19 risk perception, access to health care, demographic and clinical variables were assessed. The survey was completed by 826 of 3839 (21.5%) invited participants. Overall, low levels of uncertainty in illness were reported, and acceptance was the major coping strategy (92%). Coping by acceptance, feeling protected, self-perceived susceptibility to COVID-19 were associated with lower levels of uncertainty. Health status index scores were significantly lower for those with mental health illness, compromised access to health care, a perceived high risk of severe COVID-19 infection and higher levels of uncertainty. A history of mental health illness, risk perceptions, restricted healthcare access, uncertainty and coping strategies was associated with poorer HRQoL in SOT recipients during strict isolation. These findings may allow identification of strategies to improve HRQoL in SOT recipients during the pandemic.
    MeSH term(s) Adaptation, Psychological ; Adult ; COVID-19 ; Cross-Sectional Studies ; Humans ; Organ Transplantation ; Pandemics ; Quality of Life ; SARS-CoV-2 ; Transplant Recipients ; Uncertainty
    Language English
    Publishing date 2021-09-16
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.14010
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    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Controversies regarding shielding and susceptibility to COVID-19 disease in liver transplant recipients in the United Kingdom

    John Hann, Angus / Lembach, Hanns / McKay, Siobhan C / Perrin, Moira / Isaac, John / Oo, Ye H / Mutimer, David / Mirza, Darius F / Hartog, Hermien / Perera, Thamara

    Transpl Infect Dis

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32500939
    Database COVID19

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  10. Article ; Online: Controversies regarding shielding and susceptibility to COVID‐19 disease in liver transplant recipients in the United Kingdom

    John Hann, Angus / Lembach, Hanns / McKay, Siobhan C. / Perrin, Moira / Isaac, John / Oo, Ye H. / Mutimer, David / Mirza, Darius F. / Hartog, Hermien / Perera, Thamara

    Transplant Infectious Disease ; ISSN 1398-2273 1399-3062

    2020  

    Keywords Transplantation ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/tid.13352
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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