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Book: Spinal neurosurgery

Harrop, James S. / Maulucci, Christopher M.

(Neurosurgery by example)

2019

Author's details	edited by James S. Harrop and Christopher M. Maulucci
Series title	Neurosurgery by example
Keywords	Spine / surgery ; Spinal Diseases / surgery ; Spinal Injuries / surgery ; Neurosurgical Procedures / methods ; Spine/Surgery ; Nervous system/Surgery
Subject code	617.471059
Language	English
Size	xiii, 263 Seiten, Illustrationen, 28 cm
Publisher	Oxford University Press
Publishing place	New York
Publishing country	United States
Document type	Book
Note	Includes bibliographical references
HBZ-ID	HT020065313
ISBN	978-0-19-088777-3 ; 9780190887780 ; 0-19-088777-X ; 0190887788
Database	Catalogue ZB MED Medicine, Health

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2019 A 696	available for loan (reading room)	Lesesaal EG

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Article: Commentary on "A Prospective, Single-Blinded, Bicentric Study, and Literature Review to Assess the Need of C2-Ganglion Preservation - SAVIOUR's Criteria".

Harrop, James S

Neurospine

2021 Volume 18, Issue 1, Page(s) 96–97

Language	English
Publishing date	2021-03-31
Publishing country	Korea (South)
Document type	Editorial ; Comment
ZDB-ID	3031654-6
ISSN	2586-6591 ; 2586-6583
ISSN (online)	2586-6591
ISSN	2586-6583
DOI	10.14245/ns.2142238.119
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial.

Harrop, James S

Global spine journal

2018 Volume 8, Issue 4 Suppl, Page(s) 4S

Language	English
Publishing date	2018-12-13
Publishing country	England
Document type	Editorial
ZDB-ID	2648287-3
ISSN	2192-5690 ; 2192-5682
ISSN (online)	2192-5690
ISSN	2192-5682
DOI	10.1177/2192568218815915
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Article ; Online: Influence of Body Mass Index on Surgical and Patient Outcomes for Cervical Spine Surgery.

Naik, Anant / Moawad, Christina / Harrop, James S / Dhawan, Sanjay / Cramer, Samuel W / Arnold, Paul M

Clinical spine surgery

2023 Volume 37, Issue 2, Page(s) E73–E81

Abstract: Study design: Secondary analysis of prospectively collected registry.: Objective: We aim to investigate the effects of body mass index (BMI) on postsurgical cervical spine surgery outcomes and identify a potential substratification of obesity with ... ...

Abstract	Study design: Secondary analysis of prospectively collected registry. Objective: We aim to investigate the effects of body mass index (BMI) on postsurgical cervical spine surgery outcomes and identify a potential substratification of obesity with worse outcomes. Summary of background data: The impact of BMI on cervical spine surgery is unknown, with controversial outcomes for patients high and low BMI. Methods: The cervical spine Quality Outcomes Database was queried for a total of 10,381 patients who underwent single-stage cervical spine surgery. Patients were substratified into 6 groups based on BMI. Surgical outcomes, complications, hospitalization outcomes, and patient-reported outcomes for each cohort, including modified Japanese Orthopedic Association Score, Numeric Rating Scale arm pain, Numeric Rating Scale neck pain, Neck Disability Index, and EuroQol Health Survey, were assessed. Univariate analysis was performed for 3- and 12-month follow-up after surgical intervention. Results: Obese patients (class I, II, and III) requiring spine surgery were statistically younger than nonobese patients and had higher rates of diabetes compared with normal BMI patients. The surgical length was found to be longer for overweight and all classes of obese patients ( P < 0.01). Class III obese patients had higher odds of postoperative complications. Patients with class II and III obesity had lower odds of achieving optimal modified Japanese Orthopedic Association Score at 3 months [OR = 0.8 (0.67-0.94), P < 0.01, OR = 0.68 (0.56-0.82), P < 0.001, respectively] and 12 months [OR = 0.82 (0.68-0.98), P = 0.03, OR = 0.79 (0.64-0.98), P = 0.03, respectively]. Conclusions: This study investigates the relationship between substratified BMI and postoperative outcomes of cervical spine surgery. Class II and III obese patients have substantially greater risk factors and poor outcomes postoperatively. In addition, low BMI also presents unique challenges for patients. Further research is needed for comprehensive analysis on outcomes of cervical spine surgery after correcting BMI.
MeSH term(s)	Humans ; Body Mass Index ; Obesity/complications ; Risk Factors ; Cervical Vertebrae/surgery ; Neck Pain/complications ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2849646-2
ISSN	2380-0194 ; 2380-0186
ISSN (online)	2380-0194
ISSN	2380-0186
DOI	10.1097/BSD.0000000000001531
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Article ; Online: The Impact of Interhospital Transfer on the Extent of Neurological Recovery in Acute Traumatic Spinal Cord Injury: Analysis of a Prospective Multicenter Data Set in 970 Cases.

Bak, Alex B / Moghaddamjou, Ali / Harrop, James S / Aarabi, Bizhan / Fehlings, Michael G

Neurosurgery

2023 Volume 94, Issue 1, Page(s) 90–98

Abstract: Background and objectives: Interhospital transfer from community hospitals to centers specialized in managing traumatically injured individuals can strain patients, healthcare systems, and delay appropriate care. The purpose was to compare long-term ... ...

Abstract	Background and objectives: Interhospital transfer from community hospitals to centers specialized in managing traumatically injured individuals can strain patients, healthcare systems, and delay appropriate care. The purpose was to compare long-term neurological outcomes in transferred or directly admitted patients with traumatic spinal cord injury (SCI). Methods: An ambispective cohort study was conducted using prospectively collected data (between 2005 and 2018) from 11 specialized level 1 trauma centers across the United States and Canada. All patients who underwent surgical management for SCI were included and placed into 2 comparison cohorts: (1) direct admission and (2) transfer from intermediate hospital. Outcomes were change in American Spinal Injury Association Impairment Scale grade and its components: upper-extremity motor, lower-extremity motor, pinprick, and light touch scores from baseline (assessed ≤72 hours after injury) to follow-up (12-52 weeks). Nearest-neighbor 1:1 propensity score matching between the transferred and directly admitted cohorts was performed. Paired analysis using McNemar's test and paired Student's t -test was used to determine the extent of the difference in neurological outcomes. Results: Nine hundred seventy patients (55.5% male, 55.2 ± 18.9 years) with traumatic SCI were directly admitted to a specialized trauma center (N = 474, 48.9%) or transferred from an intermediate hospital (N = 496, 51.1%). After propensity score matching, 283 pairs were matched. Compared with a matched cohort of transferred patients, American Spinal Injury Association Impairment Scale grade improved more in directly admitted patients (56.2% vs 46.3%, P = .024), as did upper-extremity motor score (13.7 ± 12.8 vs 10.4 ± 11.5, P = .018) and light touch score (22.0 ± 29.7 vs 16.9 ± 26.6, P = .034). Conclusion: Patients with SCI directly admitted to specialized trauma centers have greater neurological recovery compared with patients transferred from an intermediate hospital. Feasibility of direct admission to a center specialized in the management of acute SCI through implementation of a standardized code program must be further investigated. Level of evidence: Therapeutic level II.
MeSH term(s)	Humans ; Male ; Female ; Cohort Studies ; Prospective Studies ; Spinal Cord Injuries/surgery ; Spinal Injuries ; Hospitalization ; Recovery of Function
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/neu.0000000000002642
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Article ; Online: Association Between Postoperative Fever and Readmission Rates in Lumbar Fusion Patients.

Stricsek, Geoffrey P / Montenegro, Thiago S / Gonzalez, Glenn A / Singh, Akash / Harrop, Catriona / Harrop, James

Clinical spine surgery

2021 Volume 34, Issue 6, Page(s) E349–E353

Abstract: Study design: This is a retrospective observational study.: Objective: This study evaluates the impact of postoperative fever on the rate of readmission among lumbar fusion patients.: Summary of background data: Postoperative fever is a common ... ...

Abstract	Study design: This is a retrospective observational study. Objective: This study evaluates the impact of postoperative fever on the rate of readmission among lumbar fusion patients. Summary of background data: Postoperative fever is a common event across surgical specialties that often triggers an extensive work-up that can significantly increase hospital costs and length of stay, although the results are usually negative for infection. There is a paucity of literature studying postoperative fever in lumbar fusion patients. Materials and methods: A retrospective chart review of all the patients who underwent elective posterior lumbar spinal fusion from January, 2018 to November, 2018 was conducted. Fever was defined as a temperature >100.4ºF. Patients were categorized into 4 groups based on their highest recorded temperature postoperatively. The association between demographic variables, tests ordered per patient, length of stay, and readmission rates per group were analyzed using a t test, and 1-way analysis of variance for continuous outcomes, and the Fisher exact test for categorical variables. Results: Of 107 patients, 58% had no fever recorded, 17.75% had temperatures between 100.5 and 100.90ºF, 18.69% temperatures between 101 and 101.90ºF, and 4.67% of patients temperatures equal or higher than 102.0ºF. The number of tests per patient increase with the range of temperatures analyzed (P<0.01), but the rate of readmission of all the 4 groups are not significantly different (0.107). There is no significant difference in the number of febrile episodes per day between patients who were and who were not readmitted (0.209). Conclusions: A diagnostic testing policy guided by clinician assessment of symptoms and physical exam may limit unnecessary testing and reduce hospital length of stay and cost without sacrificing patient safety.
MeSH term(s)	Humans ; Length of Stay ; Lumbar Vertebrae/surgery ; Patient Readmission ; Postoperative Complications/etiology ; Retrospective Studies ; Spinal Fusion/adverse effects
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2849646-2
ISSN	2380-0194 ; 2380-0186
ISSN (online)	2380-0194
ISSN	2380-0186
DOI	10.1097/BSD.0000000000001131
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Article ; Online: Spinal cord injury: debating the efficacy of methylprednisolone.

Harrop, James S

Neurosurgery

2014 Volume 61 Suppl 1, Page(s) 30–31

MeSH term(s)	Humans ; Methylprednisolone/therapeutic use ; Neuroprotective Agents/therapeutic use ; Spinal Cord Injuries/drug therapy
Chemical Substances	Neuroprotective Agents ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2014-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/NEU.0000000000000391
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Article ; Online: An Introduction to the North American Clinical Trials Network for Spinal Cord Injury Special Edition: Reflections on Accomplishments and a Look to the Future.

Fehlings, Michael G / Neal, Chris J / Hejrati, Nader / Harrop, James S / Toups, Elizabeth G / Guest, James D

Journal of neurotrauma

2023 Volume 40, Issue 17-18, Page(s) 1811–1816

Abstract: The North American Clinical Trials Network (NACTN) has been established as a network of translational clinical research centers focused on traumatic spinal cord injury (SCI) with the goals of facilitating clinical translational research, promotion of ... ...

Abstract	The North American Clinical Trials Network (NACTN) has been established as a network of translational clinical research centers focused on traumatic spinal cord injury (SCI) with the goals of facilitating clinical translational research, promotion of enhanced clinical care protocols including the principle of early surgery for SCI, and improving outcomes for individuals with acute SCI. Since its foundation in 2004 by Dr. Robert Grossman, NACTN has evolved into a powerful multi-stakeholder consortium of eight neurosurgical department faculties at university-affiliated institutions in the United States and Canada, a data management center, and a pharmacological center. To date, high-quality data from more than 1000 patients have been prospectively collected, providing us with a strong body of evidence surrounding SCI epidemiology, the natural history, and complications of acute and subacute SCI management. Key accomplishments of NACTN are summarized in this Focus issue. They include the launch, in collaboration with AO Spine, of the international, multi-center, placebo-controlled, Phase III Riluzole in Acute Spinal Cord Injury Study (RISCIS) that recruited 192 patients. While the primary analyses did not achieve the predetermined endpoint of efficacy for Riluzole, likely related to insufficient power, pre-planned secondary analyses demonstrated that all subgroups of cervical SCI subjects (AIS grades A, B and C) treated with Riluzole showed significant gains in functional recovery. The Focus Issue also includes a detailed analysis of the pharmacokinetics and pharmacodynamics of riluzole in the setting of acute SCI (RISCIS-PK study). Additional achievements include key contributions to the evidence supporting the role of early surgery in acute SCI, and a better understanding of the impact of complications on the outcomes of SCI. Future directions of NACTN will build on past accomplishments and focus on enhanced collaborations with other SCI networks, advanced analytics to examine large datasets, and a greater focus on chronic SCI.
MeSH term(s)	Humans ; Canada ; Recovery of Function ; Riluzole ; Spinal Cord Injuries/therapy ; Clinical Trials as Topic
Chemical Substances	Riluzole (7LJ087RS6F)
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2022.0402
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Article ; Online: Past, Present, and Future of Cervical Disc Arthroplasty: Insights From Presidents of the Cervical Spine Research Society.

Du, Jerry Y / Gonzalez, Glenn A / Albert, Todd J / Rhee, John M / Riew, K Daniel / Vaccaro, Alexander R / Harrop, James S

Clinical spine surgery

2023 Volume 36, Issue 9, Page(s) 331–334

MeSH term(s)	Humans ; Arthroplasty ; Neck ; Cervical Vertebrae/surgery ; Intervertebral Disc/surgery ; Diskectomy ; Treatment Outcome ; Intervertebral Disc Degeneration/surgery ; Spinal Fusion
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2849646-2
ISSN	2380-0194 ; 2380-0186
ISSN (online)	2380-0194
ISSN	2380-0186
DOI	10.1097/BSD.0000000000001536
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Article ; Online: Type II odontoid fractures: what to do?

Harrop, James S

World neurosurgery

2013 Volume 80, Issue 3-4, Page(s) 313–314

MeSH term(s)	Atlanto-Axial Joint/abnormalities ; Atlanto-Axial Joint/pathology ; Atlanto-Axial Joint/surgery ; Congenital Abnormalities/pathology ; Congenital Abnormalities/surgery ; Female ; Fracture Fixation, Internal/methods ; Humans ; Minimally Invasive Surgical Procedures/methods ; Neurosurgical Procedures/methods
Language	English
Publishing date	2013-09
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2012.04.011
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