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  1. Article: Seasonal change and correlation with environmental parameters for 2-MIB in Feng-Shen Reservoir, Taiwan.

    Tung, Shu-Chu / Lin, Tsair-Fuh / Yang, Feng-Cheng / Liu, Chia-Lin

    Environmental monitoring and assessment

    2007  Volume 145, Issue 1-3, Page(s) 407–416

    Abstract: ... with environmental conditions in Feng-Shen Reservoir (FSR), Taiwan. Long-term monitoring results, from December 2000 to July ...

    Abstract Two common drinking water earthy/musty odorants, 2-methyl-isoborneol (2-MIB) and trans-1,10-dimethyl-trans-9-decalol (geosmin), were monitored and analyzed for their correlation with environmental conditions in Feng-Shen Reservoir (FSR), Taiwan. Long-term monitoring results, from December 2000 to July 2003, indicated that 2-MIB was present in the reservoir at concentrations between 10 and 200 ng L(-1), and those of geosmin were always smaller than 10 ng L(-1). The 2-MIB concentrations followed a trend of higher concentrations during the warm seasons. After being analyzed with 10 water quality and three meteorological parameters, 2-MIB concentration was found to correlate with corresponding air and water temperatures. An analysis of air temperature history versus 2-MIB concentration in FSR suggested that 2-MIB concentration was best correlated with the mean of average daily temperature from 1 to 9 days before sampling, with R (2) = 0.90. This correlation was further employed to predict the 2-MIB concentration observed during another sampling period in FSR. A similar degree of fit was observed between predictions and experimental data, suggesting the potential applicability of the approach. In addition to the effect of temperature, heavy rainfalls that occurred before the sampling time may also reduce the 2-MIB concentration in the reservoir. A short-term continuous monitoring of the odorants for 32 h showed that both geosmin and 2-MIB concentrations in the reservoir remained almost constant, with only about a 10% difference during the sampling period. This may suggest that the odorants were uniformly distributed in the water near the sampling location in the reservoir.
    MeSH term(s) Camphanes/analysis ; Environmental Monitoring/methods ; Naphthols/analysis ; Seasons ; Taiwan ; Water Pollutants, Chemical/analysis
    Chemical Substances Camphanes ; Naphthols ; Water Pollutants, Chemical ; 2-methylisoborneol (2371-42-8) ; geosmin (MYW912WXJ4)
    Language English
    Publishing date 2007-12-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-007-0049-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5186: Show issues

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  2. Article: Seasonal change and correlation with environmental parameters for 2-MIB in Feng-Shen Reservoir, Taiwan

    Tung, Shu-Chu / Lin, Tsair-Fuh / Yang, Feng-Cheng / Liu, Chia-Lin

    Environmental monitoring and assessment. 2008 Oct., v. 145, no. 1-3

    2008  

    Abstract: ... with environmental conditions in Feng-Shen Reservoir (FSR), Taiwan. Long-term monitoring results, from December 2000 to July ...

    Abstract Two common drinking water earthy/musty odorants, 2-methyl-isoborneol (2-MIB) and trans-1,10-dimethyl-trans-9-decalol (geosmin), were monitored and analyzed for their correlation with environmental conditions in Feng-Shen Reservoir (FSR), Taiwan. Long-term monitoring results, from December 2000 to July 2003, indicated that 2-MIB was present in the reservoir at concentrations between 10 and 200 ng L⁻¹, and those of geosmin were always smaller than 10 ng L⁻¹. The 2-MIB concentrations followed a trend of higher concentrations during the warm seasons. After being analyzed with 10 water quality and three meteorological parameters, 2-MIB concentration was found to correlate with corresponding air and water temperatures. An analysis of air temperature history versus 2-MIB concentration in FSR suggested that 2-MIB concentration was best correlated with the mean of average daily temperature from 1 to 9 days before sampling, with R ² = 0.90. This correlation was further employed to predict the 2-MIB concentration observed during another sampling period in FSR. A similar degree of fit was observed between predictions and experimental data, suggesting the potential applicability of the approach. In addition to the effect of temperature, heavy rainfalls that occurred before the sampling time may also reduce the 2-MIB concentration in the reservoir. A short-term continuous monitoring of the odorants for 32 h showed that both geosmin and 2-MIB concentrations in the reservoir remained almost constant, with only about a 10% difference during the sampling period. This may suggest that the odorants were uniformly distributed in the water near the sampling location in the reservoir.
    Keywords air temperature ; drinking water ; environmental factors ; geosmin ; meteorological parameters ; monitoring ; odor compounds ; prediction ; seasonal variation ; seasons ; water quality ; water temperature ; Taiwan
    Language English
    Dates of publication 2008-10
    Size p. 407-416.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-007-0049-9
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5186: Show issues

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  3. Article ; Online: Single-Cell RNA Sequencing Reveals HIF1A as a Severity-Sensitive Immunological Scar in Circulating Monocytes of Convalescent Comorbidity-Free COVID-19 Patients.

    May, Lilly / Chu, Chang-Feng / Zielinski, Christina E

    Cells

    2024  Volume 13, Issue 4

    Abstract: COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is characterized by a wide range of clinical symptoms and a poorly predictable disease course. Although in-depth transcriptomic investigations of peripheral blood samples ... ...

    Abstract COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is characterized by a wide range of clinical symptoms and a poorly predictable disease course. Although in-depth transcriptomic investigations of peripheral blood samples from COVID-19 patients have been performed, the detailed molecular mechanisms underlying an asymptomatic, mild or severe disease course, particularly in patients without relevant comorbidities, remain poorly understood. While previous studies have mainly focused on the cellular and molecular dissection of ongoing COVID-19, we set out to characterize transcriptomic immune cell dysregulation at the single-cell level at different time points in patients without comorbidities after disease resolution to identify signatures of different disease severities in convalescence. With single-cell RNA sequencing, we reveal a role for hypoxia-inducible factor 1-alpha (HIF1A) as a severity-sensitive long-term immunological scar in circulating monocytes of convalescent COVID-19 patients. Additionally, we show that circulating complexes formed by monocytes with either T cells or NK cells represent a characteristic cellular marker in convalescent COVID-19 patients irrespective of their preceding symptom severity. Together, these results provide cellular and molecular correlates of recovery from COVID-19 and could help in immune monitoring and in the design of new treatment strategies.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Monocytes ; Cicatrix ; Sequence Analysis, RNA ; Hypoxia-Inducible Factor 1, alpha Subunit
    Chemical Substances HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13040300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Mi feng ch'an p'in yü chien k'ang ch'ang shou

    Ch'ü, Shou-mu / Hsü, Ching-lan

    1989  

    Title translation Bee products, health and longevity.
    Author's details Ch'ü Shou-mu, Hsü Ching-lan pien hsieh
    Keywords Bee products. ; Bee products/Therapeutic use.
    Language Chinese
    Size 2, 108 p. ;, 19 cm.
    Edition Ti 1 pan.
    Publisher Chung-kuo lin yeh ch'u pan she ; Hsin hua shu tien Pei-ching fa hsing so fa hsing
    Publishing place Pei-ching
    Document type Book
    ISBN 7503803029 ; 9787503803024
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Single-cell RNA sequencing reveals HIF1A as a severity-sensitive immunological scar in circulating monocytes of convalescent comorbidity-free COVID-19 patients

    Zielinski, Christina / May, Lilly / Chu, Chang-Feng

    bioRxiv

    Abstract: COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is characterized by a wide range of clinical symptoms and a poorly predictable disease course. Although in-depth transcriptomic investigations of peripheral blood samples ... ...

    Abstract COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is characterized by a wide range of clinical symptoms and a poorly predictable disease course. Although in-depth transcriptomic investigations of peripheral blood samples from COVID-19 patients have been performed, the detailed molecular mechanisms underlying an asymptomatic, mild or severe disease course, particularly in patients without relevant comorbidities, remain poorly understood. While previous studies have mainly focused on the cellular and molecular dissection of ongoing COVID-19, we set out to characterize transcriptomic immune cell dysregulation at the single-cell level at different time points in patients without comorbidities after disease resolution to identify signatures of different disease severities in convalescence. With single-cell RNA sequencing we reveal a role for hypoxia-inducible factor 1-alpha (HIF1A) as a severity-sensitive long-term immunological scar in circulating monocytes of convalescent COVID-19 patients. Additionally, circulating complexes formed by monocytes with either T cells or NK cells represent a characteristic cellular marker in convalescent COVID-19 patients irrespective of their preceding symptom severity. Together, these results provide cellular and molecular correlates of recovery from COVID-19 and could help in immune monitoring and in the design of new treatment strategies.
    Keywords covid19
    Language English
    Publishing date 2023-06-08
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2023.06.07.544062
    Database COVID19

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  6. Article: Examination of Fas-Induced Apoptosis of Murine Thymocytes in Thymic Tissue Slices Reveals That Fas Is Dispensable for Negative Selection.

    Chu, Chang-Feng / Feng, Hsing-Kai / Sun, Kuang-Hui / Hsu, Chia-Lin / Dzhagalov, Ivan L

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 586807

    Abstract: The death receptor Fas can induce cell death through the extrinsic pathway of apoptosis in a variety of cells, including developing thymocytes. Although Fas-induced cell death has been researched and modeled extensively, most of the studies have been ... ...

    Abstract The death receptor Fas can induce cell death through the extrinsic pathway of apoptosis in a variety of cells, including developing thymocytes. Although Fas-induced cell death has been researched and modeled extensively, most of the studies have been done
    Language English
    Publishing date 2020-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.586807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Symptom-correlated MiRNA signature as a potential biomarker for Kawasaki disease.

    Chen, Chia-Chun / Chu, Hsueh-Yao / Chang, Ian Yi-Feng / Chang, Yu-Sun / Weng, Ken-Pen / Chang, Ling-Sai / Liu, Shih-Feng / Kuo, Ho-Chang

    Biomedical journal

    2023  , Page(s) 100684

    Language English
    Publishing date 2023-12-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.100684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: In Situ Observation of Solvent-Mediated Cyclic Intermediates during the Alkene Epoxidation/Hydration over a Ti-Beta/H

    Wang, Chang / Chu, Yueying / Lei, Qifeng / Hu, Min / Deng, Feng / Xu, Jun / Dai, Weili

    Angewandte Chemie (International ed. in English)

    2024  , Page(s) e202404633

    Abstract: Solvent effects in catalytic reactions have received widespread attention as they can promote reaction rates and product selectivities by orders of magnitude. It is well accepted that the stable five-membered cyclic intermediates formed between the ... ...

    Abstract Solvent effects in catalytic reactions have received widespread attention as they can promote reaction rates and product selectivities by orders of magnitude. It is well accepted that the stable five-membered cyclic intermediates formed between the solvent molecules and Ti species are crucial to the alkene epoxidation in a heterogeneous Ti(IV)-H
    Language English
    Publishing date 2024-03-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202404633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Examination of Fas-Induced Apoptosis of Murine Thymocytes in Thymic Tissue Slices Reveals That Fas Is Dispensable for Negative Selection

    Chang-Feng Chu / Hsing-Kai Feng / Kuang-Hui Sun / Chia-Lin Hsu / Ivan L. Dzhagalov

    Frontiers in Cell and Developmental Biology, Vol

    2020  Volume 8

    Abstract: ... significant variation in the entry into the cell death pathway. This model also allowed us to revisit the role ...

    Abstract The death receptor Fas can induce cell death through the extrinsic pathway of apoptosis in a variety of cells, including developing thymocytes. Although Fas-induced cell death has been researched and modeled extensively, most of the studies have been done in vitro because of the lethality of Fas triggering in vivo. Thus, little is known about the time line of this type of cell death in vivo, specifically, how does the presence of macrophages and pro-survival cytokines affect apoptosis progression. In addition, although the sequence and timing of events during intrinsic pathway activation in thymocytes in situ have been described, no corresponding data for the extrinsic pathway are available. To address this gap in our knowledge, we established a novel system to study Fas-induced thymocyte cell death using tissue explants. We found that within 1 h of Fas ligation, caspase 3 was activated, within 2 h phosphatidylserine was externalized to serve as an “eat-me” signal, and at the same time, we observed signs of cell loss, likely due to efferocytosis. Both caspase 3 activation and phosphatidylserine exposure were critical for cell loss. Although Fas ligand (FasL) was delivered simultaneously to all cells, we observed significant variation in the entry into the cell death pathway. This model also allowed us to revisit the role of Fas in negative selection, and we ruled out an essential part for it in the deletion of autoreactive thymocytes. Our work provides a timeline for the apoptosis-associated events following Fas triggering in situ and confirms the lack of involvement of Fas in the negative selection of thymocytes.
    Keywords Fas ; thymocytes ; apoptosis ; negative selection ; FasL ; caspase 3 ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential.

    de Almeida, Gustavo P / Lichtner, Peter / Eckstein, Gertrud / Brinkschmidt, Tonio / Chu, Chang-Feng / Sun, Shan / Reinhard, Julian / Mädler, Sophia C / Kloeppel, Markus / Verbeek, Mareike / Zielinski, Christina E

    Science immunology

    2022  Volume 7, Issue 67, Page(s) eabe2634

    Abstract: Tissue-resident memory T cells ( ... ...

    Abstract Tissue-resident memory T cells (T
    MeSH term(s) Female ; Graft vs Host Disease/immunology ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Skin/immunology ; T-Lymphocytes/immunology ; Transplantation Conditioning
    Language English
    Publishing date 2022-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abe2634
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