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Article ; Online: Greenness assessment of microextraction techniques in therapeutic drug monitoring.

Pour, Parastoo Hosseini / Suzaei, Foad Mashayekhi / Daryanavard, Seyed Mosayeb

Bioanalysis

2024

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ISSN	1757-6199
ISSN (online)	1757-6199
DOI	10.4155/bio-2023-0266
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In Situ

Sorouri, Farzaneh / Hosseini, Parastoo / Sharifzadeh, Mohammad / Kiani, Sahar / Khoobi, Mehdi

ACS applied materials & interfaces

2023 Volume 15, Issue 36, Page(s) 42251–42270

Abstract: Dysfunctional clinical outcomes following spinal cord injury (SCI) result from glial scar formation, leading to the inhibition of new axon growth and impaired regeneration. Nevertheless, nerve regeneration after SCI is possible, provided that the state ... ...

Abstract	Dysfunctional clinical outcomes following spinal cord injury (SCI) result from glial scar formation, leading to the inhibition of new axon growth and impaired regeneration. Nevertheless, nerve regeneration after SCI is possible, provided that the state of neuron development in the injured environment is improved. Hence, biomaterial-based therapy would be a promising strategy to endow a desirable environment for tissue repair. Herein, we designed a novel multifunctional injectable hydrogel with antioxidant, neuroprotective, and neuroregenerative effects. Bucladesine-encapsulated chitosan nanoparticles (BCS NPs) were first prepared and embedded in a matrix of thiol-functionalized hyaluronic acid modified with ferulic acid (HASH-FA). The target hydrogel (HSP-F/BCS) was then created through Michael-type addition between HASH-FA containing BCS NPs and four-arm polyethylene glycol-maleimide (4-Arm-PEG-Mal). The obtained hydrogel with shear thinning behavior showed viscoelastic and mechanical properties similar to the normal nerve tissue. FA conjugation significantly improved the antioxidant activity of HA, and suppressed intracellular ROS formation.
MeSH term(s)	Animals ; Rats ; Bucladesine ; Axons ; Gliosis ; Spinal Cord Injuries/drug therapy ; Spinal Cord Regeneration ; Antioxidants/pharmacology ; Hydrogels/pharmacology
Chemical Substances	ferulic acid (AVM951ZWST) ; Bucladesine (63X7MBT2LQ) ; Antioxidants ; Hydrogels
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c08366
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Article ; Online: Role of hemagglutinin esterase in replication of SARS-CoV-2.

Zandi, Milad / Soltani, Saber / Hosseini, Parastoo

Expert opinion on therapeutic targets

2021 Volume 25, Issue 10, Page(s) 909

MeSH term(s)	COVID-19 ; Hemagglutinins, Viral ; Humans ; SARS-CoV-2 ; Viral Fusion Proteins
Chemical Substances	Hemagglutinins, Viral ; Viral Fusion Proteins ; hemagglutinin esterase
Language	English
Publishing date	2021-11-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2055208-7
ISSN	1744-7631 ; 1472-8222
ISSN (online)	1744-7631
ISSN	1472-8222
DOI	10.1080/14728222.2021.1999417
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Article: Molecular characterization of the neuraminidase gene of

Kaveh, Kimia / Tazarghi, Abbas / Hosseini, Parastoo / Fotouhi, Fatemeh / Ajorloo, Mehdi / Rabiei Roodsari, Mehdi / Razavi Nikoo, Hadi

Virusdisease

2023 Volume 34, Issue 1, Page(s) 21–28

Abstract: Neuraminidase inhibitors are the only FDA-approved class of antiviral agents ... ...

Abstract	Neuraminidase inhibitors are the only FDA-approved class of antiviral agents against
Language	English
Publishing date	2023-02-14
Publishing country	India
Document type	Journal Article
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-022-00806-7
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Article: Investigating the effect of

Hosseini, Parastoo / Rahimi Foroushani, Abbas / Marjani, Arezoo / Tavakoli, Mahnaz / Amiri, Abdollah / Hosseini, Amin / Bahavar, Atefeh / Mozhgani, Sayed-Hamidreza / Norouzi, Mehdi

Iranian journal of microbiology

2023 Volume 15, Issue 3, Page(s) 475–481

Abstract: Background and objectives: HTLV-1 is responsible for two important diseases, HAM/TSP and ATLL. Approximately 10 to 20 million people are infected with HTLV-1 worldwide. Identifying altered genes in different cancers is crucial for finding potential ... ...

Abstract	Background and objectives: HTLV-1 is responsible for two important diseases, HAM/TSP and ATLL. Approximately 10 to 20 million people are infected with HTLV-1 worldwide. Identifying altered genes in different cancers is crucial for finding potential treatment strategies. One of the proteins of the RAS/MAPK signaling pathway is MEK1, which is made from the Materials and methods: Ten ATLL and 10 healthy control individuals were investigated in this study. We used ELISA test to screen anti-HTLV-I antibodies and PCR for confirmation of infection. Then, we extracted total RNA from fresh whole blood, and cDNA was synthesized. The expression levels of the Results: MAP2K1 Conclusion: These results could be a perspective in the prevention, prognosis, and targeted treatment of diseases in which the
Language	English
Publishing date	2023-06-28
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652849-6
ISSN	2008-4447 ; 2008-3289
ISSN (online)	2008-4447
ISSN	2008-3289
DOI	10.18502/ijm.v15i3.12910
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Article ; Online: Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice.

Shaban, Parastoo / Honari, Niloofar / Erfanian, Nafiseh / Hosseini, Mehran / Safarpour, Hossein / Nasseri, Saeed

Iranian journal of allergy, asthma, and immunology

2023 Volume 22, Issue 3, Page(s) 281–289

Abstract: Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J ... ...

Abstract	Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were randomly assigned to receive intraperitoneal treatments of saline, dexamethasone (2 mg/kg), and 100 and 200 mg/kg of Z.J extracts, respectively. 24 h after intratracheal administration of LPS, bronchoalveolar lavage fluid and lung tissues were harvested and assessed for inflammatory cell influx, tumor necrosis factor-α (TNF-α) levels, and histological assessments. Treatment with Z.J extracts (100 and 200 mg/kg) and dexamethasone effectively reduced LPS-induced neutrophil and other inflammatory cell influx into the lung tissue compared to the untreated group. additionally, both doses of Z.J extracts (100 and 200 mg/kg) significantly ameliorated the lung wet-to-dry ratio and histopathological damage. Furthermore, compared to the untreated ALI mice, Z.J extract at the highest dose could significantly reduce the TNF-α level. The present findings indicated that Z.J could effectively ameliorate LPS-induced ALI inflammatory responses and might be considered a promising alternative therapy for the ALI phenotype.
MeSH term(s)	Mice ; Male ; Animals ; Lipopolysaccharides/pharmacology ; Ziziphus ; Tumor Necrosis Factor-alpha ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/pathology ; Lung/pathology ; Bronchoalveolar Lavage Fluid ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Dexamethasone/adverse effects ; Mice, Inbred BALB C ; NF-kappa B
Chemical Substances	Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents ; Dexamethasone (7S5I7G3JQL) ; NF-kappa B
Language	English
Publishing date	2023-06-16
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2488724-9
ISSN	1735-5249 ; 1735-1502
ISSN (online)	1735-5249
ISSN	1735-1502
DOI	10.18502/ijaai.v22i3.13056
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Article ; Online: Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice

Parastoo Shaban / Niloofar Honari / Nafiseh Erfanian / Mehran Hosseini / Hossein Safarpour / Saeed Nasseri

Iranian Journal of Allergy, Asthma and Immunology, Vol 22, Iss

2023 Volume 3

Abstract	Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were randomly assigned to receive intraperitoneal treatments of saline, dexamethasone (2 mg/kg), and 100 and 200 mg/kg of Z.J extracts, respectively. 24 h after intratracheal administration of LPS, bronchoalveolar lavage fluid and lung tissues were harvested and assessed for inflammatory cell influx, tumor necrosis factor-α (TNF-α) levels, and histological assessments. Treatment with Z.J extracts (100 and 200 mg/kg) and dexamethasone effectively reduced LPS-induced neutrophil and other inflammatory cell influx into the lung tissue compared to the untreated group. additionally, both doses of Z.J extracts (100 and 200 mg/kg) significantly ameliorated the lung wet-to-dry ratio and histopathological damage. Furthermore, compared to the untreated ALI mice, Z.J extract at the highest dose could significantly reduce the TNF-α level. The present findings indicated that Z.J could effectively ameliorate LPS-induced ALI inflammatory responses and might be considered a promising alternative therapy for the ALI phenotype.
Keywords	Acute lung injury ; Inflammation ; Lipopolysaccharides ; Ziziphus ; Medicine ; R
Subject code	630
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The role of single-domain antibodies (or nanobodies) in SARS-CoV-2 neutralization

Zebardast, Arghavan / Hosseini, Parastoo / Hasanzadeh, Ali / latifi, Tayebeh

Molecular biology reports. 2022 Jan., v. 49, no. 1

2022

Abstract: The severe acute respiratory syndrome (SARS-CoV-2), a newly emerging of coronavirus, continues to infect humans in the absence of a viable treatment. Neutralizing antibodies that disrupt the interaction of RBD and ACE2 has been under the spotlight as a ... ...

Abstract	The severe acute respiratory syndrome (SARS-CoV-2), a newly emerging of coronavirus, continues to infect humans in the absence of a viable treatment. Neutralizing antibodies that disrupt the interaction of RBD and ACE2 has been under the spotlight as a way of developing the COVID-19 treatment. Some animals, such as llamas, manufacture heavy-chain antibodies that have a single variable domain (VHH) instead of two variable domains (VH/VL) as opposed to typical antibodies. Nanobodies are antigen-specific, single-domain, changeable segments of camelid heavy chain-only antibodies that are recombinantly produced. These types of antibodies exhibit a wide range of strong physical and chemical properties, like high solubility, and stability. The VHH's high-affinity attachment to the receptor-binding domain (RBD) allowed the neutralization of SARS-CoV-2. To tackle COVID-19, some nanobodies are being developed against SARS-CoV-2, some of which have been recently included in clinical trials. Nanobody therapy may be useful in managing the COVID-19 pandemic as a potent and low-cost treatment. This paper describes the application of nanobodies as a new class of recombinant antibodies in COVID-19 treatment.
Keywords	COVID-19 infection ; Camelidae ; Severe acute respiratory syndrome coronavirus 2 ; manufacturing ; molecular biology ; neutralization ; solubility ; therapeutics
Language	English
Dates of publication	2022-01
Size	p. 647-656.
Publishing place	Springer Netherlands
Document type	Article
Note	Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06819-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ethanolic extract of

Honari, Niloofar / Shaban, Parastoo / Nasseri, Saeed / Hosseini, Mehran

Journal of complementary & integrative medicine

2021 Volume 19, Issue 2, Page(s) 261–267

Abstract: Objectives: Acute lung injury (ALI) is a life-threatening pulmonary dysfunction associated with severe inflammation. There are still no effective pharmacological therapies for the treatment of ALI. In this concern, several anti-inflammatory agents could ...

Abstract	Objectives: Acute lung injury (ALI) is a life-threatening pulmonary dysfunction associated with severe inflammation. There are still no effective pharmacological therapies for the treatment of ALI. In this concern, several anti-inflammatory agents could be used as add-on therapy to inhibit inflammation. Methods: The ALI model was established via the intra-tracheal (i.t.) administration of LPS (2 mg/kg) to male BALB/c mice. The ALI mice were divided into four groups (n=8 each) which intra-peritoneally (i.p.) treated with repeated doses of saline (model), dexamethasone (2 mg/kg), and AW (150-300 mg/kg) 1, 11 and 23 h post LPS administration. Twenty-four hours after the LPS challenge, bronchoalveolar lavage fluid (BALF) and lung tissue were evaluated for inflammatory cell influx, level of tumor necrosis factor-α (TNF-α) and histopathological changes. Results: The AW (150-300 mg/kg) treated mice showed lower inflammatory cells infiltration in BALF and TNF-α level when compared to the model group. In addition, LPS induced several pathological alterations such as edema, alveolar hemorrhage and inflammatory cell infiltration into the interstitium and alveolar spaces. Treatment with AW significantly reduced LPS-induced pathological injury. Conclusions: Taken together, the data here indicated that AW may be considered as a promising add-on therapy for ALI.
MeSH term(s)	Achillea ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/pathology ; Animals ; Anti-Inflammatory Agents/adverse effects ; Inflammation/drug therapy ; Iran ; Lipopolysaccharides/adverse effects ; Lung/pathology ; Mice ; Mice, Inbred BALB C ; Plant Extracts/adverse effects ; Tumor Necrosis Factor-alpha
Chemical Substances	Anti-Inflammatory Agents ; Lipopolysaccharides ; Plant Extracts ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2021-05-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2197618-1
ISSN	1553-3840 ; 2194-6329
ISSN (online)	1553-3840
ISSN	2194-6329
DOI	10.1515/jcim-2021-0045
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of single-domain antibodies (or nanobodies) in SARS-CoV-2 neutralization.

Zebardast, Arghavan / Hosseini, Parastoo / Hasanzadeh, Ali / Latifi, Tayebeh

Molecular biology reports

2021 Volume 49, Issue 1, Page(s) 647–656

Abstract	The severe acute respiratory syndrome (SARS-CoV-2), a newly emerging of coronavirus, continues to infect humans in the absence of a viable treatment. Neutralizing antibodies that disrupt the interaction of RBD and ACE2 has been under the spotlight as a way of developing the COVID-19 treatment. Some animals, such as llamas, manufacture heavy-chain antibodies that have a single variable domain (VHH) instead of two variable domains (VH/VL) as opposed to typical antibodies. Nanobodies are antigen-specific, single-domain, changeable segments of camelid heavy chain-only antibodies that are recombinantly produced. These types of antibodies exhibit a wide range of strong physical and chemical properties, like high solubility, and stability. The VHH's high-affinity attachment to the receptor-binding domain (RBD) allowed the neutralization of SARS-CoV-2. To tackle COVID-19, some nanobodies are being developed against SARS-CoV-2, some of which have been recently included in clinical trials. Nanobody therapy may be useful in managing the COVID-19 pandemic as a potent and low-cost treatment. This paper describes the application of nanobodies as a new class of recombinant antibodies in COVID-19 treatment.
MeSH term(s)	Animals ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/pharmacology ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Antibodies, Viral/pharmacology ; COVID-19/immunology ; COVID-19/therapy ; Humans ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; Single-Domain Antibodies/chemistry ; Single-Domain Antibodies/immunology ; Single-Domain Antibodies/pharmacology ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Drug Treatment
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Single-Domain Antibodies ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-10-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06819-7
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