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Book ; Online ; E-Book: Digital Mental Health

Passos, Ives Cavalcante / Rabelo-da-Ponte, Francisco Diego / Kapczinski, Flávio

A Practitioner's Guide

2023

Abstract: This innovative book focuses on potential, limitations, and recommendations for the digital mental health landscape. Authors synthesize existing literature on the validity of digital health technologies, including smartphones apps, sensors, chatbots and ... ...

Author's details	edited by Ives Cavalcante Passos, Francisco Diego Rabelo-da-Ponte, Flavio Kapczinski
Abstract	This innovative book focuses on potential, limitations, and recommendations for the digital mental health landscape. Authors synthesize existing literature on the validity of digital health technologies, including smartphones apps, sensors, chatbots and telepsychiatry for mental health disorders. They also note that collecting real-time biological information is usually better than just collect filled-in forms, and that will also mitigate problems related to recall bias in clinical appointments. Limitations such as confidentiality, engagement and retention rates are moreover discussed. Presented in fifteen chapters, the work addresses the following questions: may smartphones and sensors provide more accurate information about patients’ symptoms between clinical appointments, which in turn avoid recall bias? Is there evidence that digital phenotyping could help in clinical decisions in mental health? Is there scientific evidence to support the use of mobile interventions in mental health? Digital Mental Health will help clinicians and researchers, especially psychiatrics and psychologists, to define measures and to determine how to test apps or usefulness, feasibility and efficacy in order to develop a consensus about reliability. These professionals will be armed with the latest evidence as well as prepared to a new age of mental health.
Keywords	Psychiatry ; Medicine ; Mental health ; Clinical Medicine ; Mental Health ; Salut mental ; Tecnologia mèdica
Subject code	780
Language	English
Size	1 online resource (263 pages)
Edition	1st ed. 2023.
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-031-10698-9 ; 9783031106972 ; 978-3-031-10698-9 ; 3031106970
DOI	10.1007/978-3-031-10698-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Heterogeneity in gender dysphoria in a Brazilian sample awaiting gender-affirming surgery: a data-driven analysis.

Silva, Dhiordan Cardoso / Rabelo-da-Ponte, Francisco Diego / Salati, Leonardo Romeira / Lobato, Maria Inês Rodrigues

BMC psychiatry

2022 Volume 22, Issue 1, Page(s) 79

Abstract: Background: Population heterogeneity and the lack of clinical and sociodemographic information in transgender individuals with gender dysphoria (GD) remains a challenge for specialized services in mental health and surgical procedures. It aimed to ... ...

Abstract	Background: Population heterogeneity and the lack of clinical and sociodemographic information in transgender individuals with gender dysphoria (GD) remains a challenge for specialized services in mental health and surgical procedures. It aimed to identify and describe profiles in a sample waiting for gender-affirming surgery. Methods: A sample of 100 outpatients with GD was assessed through a structured interview, Emotion Regulation Difficulty Scale (DERS), Ruminative Response Scale (RRS), Depression, Anxiety and Stress Scale (DASS-21) and Life Satisfaction scale (SWLS). Cluster analysis was used to identify different profile categories. Results: Two subgroups with different profiles were identified: with less clinical severity (LCS) and with high clinical severity (HCS) on emotional dysregulation, acute symptoms of depression, anxiety, stress and association with mental rumination. The HCS cluster had greater vulnerability in terms of psychiatric history, use of psychotropic drugs, HIV positive, child abuse and suicidal behavior. Conclusion: Different profiles were found regarding the vulnerability to mental health in a sample of transgender people with GD who seek a public hospital service for the same clinical-surgical objective. Longitudinal studies are essential to monitor the impact of these contrasts and to target personalized therapeutic approaches in the prevention of psychiatric disorders.
MeSH term(s)	Brazil ; Child ; Gender Dysphoria/psychology ; Gender Dysphoria/surgery ; Humans ; Mental Health ; Suicidal Ideation ; Transgender Persons/psychology
Language	English
Publishing date	2022-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-022-03727-3
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Article ; Online: A network analysis of early trauma and impulsive behavior in individuals with mono- and poly-dependence of alcohol and crack cocaine.

Volpatto, Vanessa Loss / Schuch, Jaqueline Bohrer / Rabelo-da-Ponte, Francisco Diego / Borgonhi, Ellen Mello / de Freitas, Júlia Corrêa / Ornell, Felipe / Proença, Ramon Agostini / Pio, Rodrigo Pereira / von Diemen, Lisia / Kessler, Felix Henrique Paim

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

2024

Abstract: Objective: To investigate the relationship between impulsivity and early trauma through a network analysis in individuals diagnosed with different substance use disorders (SUD).: Methods: This cross-sectional study includes a sample of 556 men with ... ...

Abstract	Objective: To investigate the relationship between impulsivity and early trauma through a network analysis in individuals diagnosed with different substance use disorders (SUD). Methods: This cross-sectional study includes a sample of 556 men with SUD (195 with alcohol use, 157 with crack cocaine use and 214 with multiple substance use). The Childhood Trauma Questionnaire was applied to investigate early trauma and the Barratt Impulsiveness Scale to assess impulsive behavior. The connection between trauma and impulsivity was assessed using network analysis through Fused Graphical Lasso algorithm. Results: No connection was observed between impulsivity and trauma networks in individuals with alcohol use. In cocaine users, networks were linked through the motor domain and sexual abuse nodes. Inversely connections were observed between emotional neglect node and perseverance and not planning nodes. In poly-use, the connection between impulsivity and trauma networks was weak, with cognitive complexity being the node that connects to the trauma network through physical abuse. There were inversely proportional connections between motor domain and emotional neglect nodes, and cognitive instability and physical neglect. Conclusions: Our results suggest that the relationship between the type of early (childhood) trauma and the expression of impulsivity could lead to a different substance use profile.
Language	English
Publishing date	2024-03-06
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2024119-7
ISSN	1809-452X ; 1809-452X
ISSN (online)	1809-452X
ISSN	1809-452X
DOI	10.47626/1516-4446-2023-3265
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Article ; Online: Precision Psychiatry: The Future Is Now.

Passos, Ives Cavalcante / Ballester, Pedro / Rabelo-da-Ponte, Francisco Diego / Kapczinski, Flavio

Canadian journal of psychiatry. Revue canadienne de psychiatrie

2021 Volume 67, Issue 1, Page(s) 21–25

MeSH term(s)	Humans ; Mental Health Services ; Psychiatry ; Telemedicine
Language	English
Publishing date	2021-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	304227-3
ISSN	1497-0015 ; 0008-4824 ; 0706-7437
ISSN (online)	1497-0015
ISSN	0008-4824 ; 0706-7437
DOI	10.1177/0706743721998044
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Article ; Online: Stigmatizing attitudes toward psychiatric disorders: A cross-sectional population-based survey.

Blum, Gabriela Brendel / Bins, Rafael Bittencourt / Rabelo-da-Ponte, Francisco Diego / Passos, Ives Cavalcante

Journal of psychiatric research

2021 Volume 139, Page(s) 179–184

Abstract: Background: Stigmatizing attitudes against individuals diagnosed with mental illness could increase the severity of psychiatric symptoms, lead to delay in getting medical support, and decrease adherence to treatments. Identifying the groups most ... ...

Abstract	Background: Stigmatizing attitudes against individuals diagnosed with mental illness could increase the severity of psychiatric symptoms, lead to delay in getting medical support, and decrease adherence to treatments. Identifying the groups most associated with stigmatization could orientate actions to reduce this prejudice and improve patients' prognosis. Objective: To investigate variables associated with stigmatization toward psychiatric disorders in Brazil. Methods: A Web-based survey was sent out to assess the sociodemographic characteristics of the respondents and their perception of mental illness. Included participants were composed of Brazilians aged 18 years or over, with access to the internet and social networks. The questionnaire was available from June to August 2018 on Facebook. Results: A total of 2414 respondents were included. The majority were female, white, aged between 18 and 29 years, and had more than 10 years of study. The variables associated with stigma were male sex, fewer years of education, lower household income, the presence of a psychiatric disorder in a first-degree relative, and internalized stigma. Conclusions: The present study identified variables associated with the stigma against psychiatric disorders. Future studies should propose intervention strategies, such as to foster education about mental illness and to promote the importance of seeking help from a mental health professional, to address this problem in Brazil.
MeSH term(s)	Adolescent ; Adult ; Attitude ; Brazil ; Cross-Sectional Studies ; Female ; Humans ; Male ; Mental Disorders/epidemiology ; Social Stigma ; Stereotyping ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2021.05.033
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Article ; Online: Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review.

Thawley, Alexandra Jade / Veneziani, Luciana Peixoto / Rabelo-da-Ponte, Francisco Diego / Riederer, Ingo / Mendes-da-Cruz, Daniella Areas / Bambini-Junior, Victorio

Frontiers in immunology

2022 Volume 13, Page(s) 874064

Abstract: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-17A (IL-17A ... ...

Abstract	Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-17A (IL-17A or IL-17), have been implicated as part of immune alterations that may contribute to this outcome. In this context, rodent models have helped elucidate the role of T-cell activation and IL-17 secretion in the pathogenesis of ASD. Regarding the preclinical findings, the data available is contradictory in offspring but not in the pregnant dams, pointing to IL-17 as one of the main drivers of altered behaviour in some models ASD, whilst there are no alterations described in IL-17 levels in others. To address this gap in the literature, a systematic review of altered IL-17 levels in rodent models of ASD was conducted. In total, 28 studies that explored IL-17 levels were included and observed that this cytokine was generally increased among the different models of ASD. The data compiled in this review can help the choice of animal models to study the role of cytokines in the development of ASD, seeking a parallel with immune alterations observed in individuals with this condition. Systematic review registration: PROSPERO, identifier CRD42022306558.
MeSH term(s)	Animals ; Autism Spectrum Disorder ; Cytokines ; Female ; Interleukin-17 ; Pregnancy ; Rodentia
Chemical Substances	Cytokines ; Interleukin-17
Language	English
Publishing date	2022-06-10
Publishing country	Switzerland
Document type	Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.874064
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Article ; Online: Perinatal factors as risk factors of bipolar disorder onset in young adulthood: a 22-year birth cohort.

Gnielka, Vanessa / Montezano, Bruno Braga / Baldez, Daniel Prates / Shintani, Augusto Ossamu / Rabelo-da-Ponte, Francisco Diego / Menezes, Ana Maria Baptista / Wehrmeister, Fernando C / Gonçalves, Helen / Kunz, Maurício / Kauer-Sant'Anna, Márcia / Watts, Devon / Kapczinski, Flávio / Passos, Ives Cavalcante

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

2024

Abstract: Background: Bipolar disorder (BD) is a leading cause of disability-adjusted life years in young adults. Complications during prenatal periods have been associated with BD previously. The study aims to examine the association between perinatal factors ... ...

Abstract	Background: Bipolar disorder (BD) is a leading cause of disability-adjusted life years in young adults. Complications during prenatal periods have been associated with BD previously. The study aims to examine the association between perinatal factors and BD in order to prevent the risk of developing BD. Methods: 3,794 subjects from the 1993 Pelotas population-based birth cohort study were included. We assessed 27 initial variables at birth and modelled BD onset at 18 and 22 years. We performed bivariate analysis, using binomial logistic regression models. The variables with p-value smaller than 0.05 were included into a multiple regression with confounding variables. Results: Maternal smoking was associated with a 1.42-fold increased risk of BD at 18 or 22 years old (95% CI: 1.091-1.841), and maternal passive exposure to tobacco with a 1.43-fold increased risk (95% CI: 1.086-1.875). No association was found between other perinatal factors and BD after controlling for confounding factors. Conclusion: The results of this cohort corroborate with previous findings in the literature that already indicate the negative outcomes of maternal smoking during pregnancy. They may now be linked to other studies to target these factors for preventing the development of BD.
Language	English
Publishing date	2024-02-12
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2024119-7
ISSN	1809-452X ; 1809-452X
ISSN (online)	1809-452X
ISSN	1809-452X
DOI	10.47626/1516-4446-2023-3338
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Article ; Online: Convalescent Plasma Therapy in Patients With Severe or Life-Threatening COVID-19: A Metadata Analysis.

Rabelo-da-Ponte, Francisco Diego / Silvello, Daiane / Scherer, Juliana Nichterwitz / Ayala, Alejandro Raul / Klamt, Fábio

The Journal of infectious diseases

2020 Volume 222, Issue 9, Page(s) 1575–1578

MeSH term(s)	Betacoronavirus ; C-Reactive Protein/metabolism ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/therapy ; Humans ; Immunization, Passive ; Metadata ; Pandemics ; Patient Acuity ; Pneumonia, Viral/blood ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Severity of Illness Index ; Viral Load
Chemical Substances	C-Reactive Protein (9007-41-4)
Keywords	covid19
Language	English
Publishing date	2020-07-07
Publishing country	United States
Document type	Letter ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiaa509
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Article ; Online: Depression in mothers at childhood: Direct and indirect association with problematic gaming in late adolescence/young adulthood.

Roza, Thiago Henrique / Rabelo-da-Ponte, Francisco Diego / Spritzer, Daniel Tornaim / Hoffmann, Maurício Scopel / Massuda, Raffael / Salum, Giovanni Abrahão / Miguel, Euripedes Constantino / Rohde, Luis Augusto / Pan, Pedro Mario / Kessler, Felix Henrique Paim / Gadelha, Ary / Passos, Ives Cavalcante

Journal of psychiatric research

2023 Volume 159, Page(s) 14–21

Abstract: Objectives: Little is known about the relationship between depression in mothers and problematic gaming in their children. Therefore, we aimed to investigate the potential role of mothers' depression in childhood as a risk factor for problematic gaming ... ...

Abstract	Objectives: Little is known about the relationship between depression in mothers and problematic gaming in their children. Therefore, we aimed to investigate the potential role of mothers' depression in childhood as a risk factor for problematic gaming in their offspring in late adolescence/young adulthood. Methods: We assessed data from 1557 participants on three waves (T0 collected in 2010/2011, T1 in 2013/2014, and T2 in 2018/2019) of a large Brazilian school-based cohort. Mother's depression at T0 was tested as a predictor of problematic gaming at T2 in a logistic regression model. In mediation analyses, we individually assessed internalizing or externalizing disorders at T1 as mediators in this association, with participants' sex being tested as a moderator in both models. Inverse probability weights were used to account for sample attrition at T2. All models were adjusted for maternal and participant-related covariates. Results: Mother's depression at T0 was significantly associated with problematic gaming at T2 (OR = 2.09, p < 0.001) even after adjusting for multiple confounding factors. The presence of any internalizing disorder at T1 was a partial mediator of this relationship, accounting for 8.18% (p = 0.032) of the total effect, while the presence of any externalizing disorder at T1 was not a significant mediator. Participants' sex was not a significant moderator in mediation models. Conclusions: These findings suggest mother's depression in childhood as a risk factor for problematic gaming in later developmental stages, which may be partially mediated by internalizing psychopathology.
MeSH term(s)	Female ; Child ; Humans ; Adolescent ; Young Adult ; Adult ; Mothers ; Depression ; Psychopathology ; Logistic Models ; Video Games
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2023.01.022
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Article ; Online: Assessment of cognitive functioning using the Mini Mental State Examination in men with Alcohol and Crack Cocaine Use Disorder.

Schuch, Jaqueline B / Becker, Natália / Rabelo-da-Ponte, Francisco Diego / Ornell, Felipe / Freitas, Hellen J M / Rebelatto, Fernando P / Sordi, Anne O / Pechansky, Flavio / von Diemen, Lisia / Kessler, Felix H P

Trends in psychiatry and psychotherapy

2023 Volume 45, Page(s) e20220567

Abstract: Introduction: Consumption of substances has been associated with cognitive impairment. The Mini Mental State Examination (MMSE) is an easy-to-apply screening tool used to assess cognitive functions.: Objectives: To evaluate the cognitive performance ... ...

Abstract	Introduction: Consumption of substances has been associated with cognitive impairment. The Mini Mental State Examination (MMSE) is an easy-to-apply screening tool used to assess cognitive functions. Objectives: To evaluate the cognitive performance of individuals with alcohol (AUD) and/or crack cocaine use disorder (CUD) and polysubstance use using the MMSE and to investigate the impact of substance use profile and the moderation effect of educational level on MMSE performance. Methods: Cross-sectional study with 508 adult male inpatients diagnosed with substance use disorders (245 with AUD, 85 with CUD, and 178 with polysubstance use). Cognitive performance was assessed using the MMSE scale (total and composite scores). Results: Individuals with AUD had worse total MMSE scores and scored worse for all three MMSE components compared to individuals with polysubstance use (p < 0.001, oral/written language comprehension, p < 0.001, attention/memory, and p = 0.007, motor functions). MMSE scores were positively correlated with educational level (p < 0.017), but were not associated with age, recent drug use, or years of drug use. Educational level moderated the impact of substance use on MMSE performance, especially total score and composite language comprehension score. Individuals with a low educational level (≤ 8 years) had worse performance than those with a high educational level (≥ 9 years), mainly in individuals with AUD (p < 0.001). Discussion: Individuals with a low educational level and alcohol use are more prone to present cognitive impairment than crack cocaine users, especially involving language aspects. Better-preserved cognitive function could impact treatment adherence and might guide the decision of therapeutic strategies.
MeSH term(s)	Adult ; Humans ; Male ; Crack Cocaine ; Cross-Sectional Studies ; Cognition ; Mental Status and Dementia Tests ; Substance-Related Disorders ; Ethanol
Chemical Substances	Crack Cocaine ; Ethanol (3K9958V90M)
Language	English
Publishing date	2023-03-08
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2708374-3
ISSN	2238-0019 ; 2238-0019
ISSN (online)	2238-0019
ISSN	2238-0019
DOI	10.47626/2237-6089-2022-0567
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