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  1. Article ; Online: Therapy-related Myeloid Neoplasms Following PARP Inhibitors-Letter.

    Batalini, Felipe / Mina, Lida A / Mina, Alain

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 29, Issue 6, Page(s) 1157

    MeSH term(s) Humans ; Female ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; DNA Damage ; DNA Repair ; Neoplasms/drug therapy ; Ovarian Neoplasms/drug therapy
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-3510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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  2. Article ; Online: How I reduce and treat posttransplant relapse of MDS.

    Mina, Alain / Greenberg, Peter L / Deeg, H Joachim

    Blood

    2024  Volume 143, Issue 14, Page(s) 1344–1354

    Abstract: Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative option for patients with high-risk myelodysplastic syndromes (MDS). Advances in conditioning regimens and supportive measures have reduced treatment- ... ...

    Abstract Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative option for patients with high-risk myelodysplastic syndromes (MDS). Advances in conditioning regimens and supportive measures have reduced treatment-related mortality and increased the role of transplantation, leading to more patients undergoing HSCT. However, posttransplant relapse of MDS remains a leading cause of morbidity and mortality for this procedure, necessitating expert management and ongoing results analysis. In this article, we review treatment options and our institutional approaches to managing MDS relapse after HSCT, using illustrative clinical cases that exemplify different clinical manifestations and management of relapse. We address areas of controversy relating to conditioning regimen intensity, chemotherapeutic bridging, and donor selection. In addition, we discuss future directions for advancing the field, including (1) the need for prospective clinical trials separating MDS from acute myeloid leukemia and focusing on posttransplant relapse, as well as (2) the validation of measurable residual disease methodologies to guide timely interventions.
    MeSH term(s) Humans ; Myelodysplastic Syndromes/therapy ; Prospective Studies ; Transplantation, Homologous ; Transplantation Conditioning/methods ; Recurrence ; Leukemia, Myeloid, Acute/therapy ; Chronic Disease ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023023005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Show issues

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  3. Article ; Online: The evolution of preclinical models for myelodysplastic neoplasms.

    Mina, Alain / Pavletic, Steven / Aplan, Peter D

    Leukemia

    2024  Volume 38, Issue 4, Page(s) 683–691

    Abstract: Myelodysplastic Neoplasms (MDS) are a group of clonal disorders characterized by ineffective hematopoiesis and morphologic dysplasia. Clinical manifestations of MDS vary widely and are dictated in large part by a range of genetic aberrations. The lack of ...

    Abstract Myelodysplastic Neoplasms (MDS) are a group of clonal disorders characterized by ineffective hematopoiesis and morphologic dysplasia. Clinical manifestations of MDS vary widely and are dictated in large part by a range of genetic aberrations. The lack of robust in vitro models for MDS has limited the ability to conduct high throughput drug screens, which in turn has hampered the development of novel therapies for MDS. There are very few well-characterized MDS cell lines, and the available cell lines expand poorly in vitro. Conventional xenograft mouse models can provide an in vivo vessel to provide growth of cancer cells, but human MDS cells engraft poorly. Three-dimensional (3D) scaffold models that form human "ossicles" represent a promising new approach and can reproduce the intricate communication between hematopoietic stem and progenitor cells and their environment. Genetically engineered mice utilize specific mutations and may not represent the entire array of human MDS; however, genetically engineered mice provided in vivo proof of principle for novel agents such as luspatercept, demonstrating the clinical utility of this approach. This review offers an overview of available preclinical MDS models and potential approaches to accelerate accurate clinical translation.
    MeSH term(s) Humans ; Animals ; Mice ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/metabolism ; Stem Cells/metabolism ; Disease Models, Animal ; Hematopoiesis ; Neoplasms
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-024-02181-2
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    Zs.A 2295: Show issues Location:
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  4. Article ; Online: Increasing megakaryopoiesis without promoting the malignant clone in myeloid malignancies.

    Mina, Alain / Platanias, Leonidas C

    Leukemia & lymphoma

    2020  Volume 61, Issue 10, Page(s) 2289–2291

    MeSH term(s) Cell Proliferation ; Clone Cells ; Humans ; Neoplasms ; Thrombopoiesis ; Thrombopoietin
    Chemical Substances Thrombopoietin (9014-42-0)
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2020.1802453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2997: Show issues Location:
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  5. Article ; Online: Use of hyperbaric oxygen in hematopoietic cell transplantation to aid post-transplant recovery.

    Mina, Alain / Aljitawi, Omar S

    Journal of comparative effectiveness research

    2020  Volume 9, Issue 3, Page(s) 149–153

    Language English
    Publishing date 2020-01-29
    Publishing country England
    Document type Editorial
    ISSN 2042-6313
    ISSN (online) 2042-6313
    DOI 10.2217/cer-2019-0193
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  6. Article ; Online: T time: Emerging and new therapies for peripheral T-cell lymphoma.

    Mina, Alain / Pro, Barbara

    Blood reviews

    2021  Volume 52, Page(s) 100889

    Abstract: Peripheral T-cell Lymphomas (PTCL) are a heterogenous group of aggressive non-Hodgkin lymphomas that are far less sensitive to chemotherapy than their B-cell counterparts. Despite their poor prognosis, they are treated similarly to most aggressive B-cell ...

    Abstract Peripheral T-cell Lymphomas (PTCL) are a heterogenous group of aggressive non-Hodgkin lymphomas that are far less sensitive to chemotherapy than their B-cell counterparts. Despite their poor prognosis, they are treated similarly to most aggressive B-cell lymphomas, heavily relying on CHOP or CHOP-like combination chemotherapy irrespective of their different subtypes or biology. The last decade has seen the emergence of many targeted therapies that include histone deacetylase inhibitors, hypomethylating agents, monoclonal antibodies and PIK3 inhibitors, among others. However, prognosis remains poor especially in the relapsed/refractory setting. Using an extensive pubmed search, the authors will be summarizing the different trials that led to these approved targeted agents as well as novel combination strategies. The fundamental recognition that different subtypes of PTCL have specific biological features that drive not only proliferation, but also responses to different treatment approaches, should be informing the design of future clinical trials.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Histone Deacetylase Inhibitors/therapeutic use ; Humans ; Lymphoma, T-Cell, Peripheral/diagnosis ; Lymphoma, T-Cell, Peripheral/drug therapy ; Prognosis
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents ; Histone Deacetylase Inhibitors
    Language English
    Publishing date 2021-09-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2021.100889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2207: Show issues Location:
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  7. Article ; Online: Convalescent hyperimmune plasma in patients with hematologic malignancies and severe COVID-19 infections.

    Mina, Alain / Small, Sara / Platanias, Leonidas C

    Leukemia & lymphoma

    2021  Volume 62, Issue 6, Page(s) 1284–1286

    MeSH term(s) COVID-19 ; Hematologic Neoplasms/therapy ; Humans ; Immunologic Deficiency Syndromes ; Immunotherapy ; SARS-CoV-2
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1897808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2997: Show issues Location:
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  8. Article ; Online: Next-Generation Sequencing in Myeloproliferative Neoplasms: Is This Indicated in All Patients?

    Mina, Alain Antoine / Stein, Brady

    Current hematologic malignancy reports

    2019  Volume 14, Issue 3, Page(s) 137–144

    Abstract: Purpose of review: To discuss the impact that next-generation sequencing has had on myeloproliferative neoplasm prognosis and treatment response.: Recent findings: Extended genetic testing has led to a more comprehensive understanding of the ... ...

    Abstract Purpose of review: To discuss the impact that next-generation sequencing has had on myeloproliferative neoplasm prognosis and treatment response.
    Recent findings: Extended genetic testing has led to a more comprehensive understanding of the mutational landscape in the myeloproliferative neoplasms. More refined prognostic models that predict disease course have therefore been developed. In myelofibrosis, this has led to a more nuanced prognostic assessment which is a necessary tool for the identification of potential transplant patients. The extended molecular profile may also help set expectations for ruxolitinib response duration. In essential thrombocythemia and polycythemia vera, elucidation of the molecular landscape beyond driving mutations may identify patients at risk for more rapid progression. However, results from testing are less likely to lead to action, at least in the current era. Use of next-generation sequencing has become routine in myelofibrosis, as a means of identifying patients at highest risk for progression, who may be eligible for transplantation. Extended genetic sequencing is still investigational in essential thrombocytosis and polycythemia vera, and not recommended by guidelines.
    MeSH term(s) High-Throughput Nucleotide Sequencing/methods ; Humans ; Mutation ; Myeloproliferative Disorders/genetics
    Language English
    Publishing date 2019-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2229765-0
    ISSN 1558-822X ; 1558-8211
    ISSN (online) 1558-822X
    ISSN 1558-8211
    DOI 10.1007/s11899-019-00514-y
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    Zs.A 6332: Show issues Location:
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  9. Article ; Online: Epidemiology of pathogens causing acute diarrhea in patients presenting to the emergency departments in 4 hospitals in Lebanon.

    Helou, Mariana / Nasr, Janane / Hajjar, Micheline / Bourji, Alaa / Feghaly, Rita / Jabbour, Elsy / Abboud, Edmond / Abboud, Emma / Mahdi, Ahmad / Mina, Jonathan / Asmar, Alain / Husni, Rola

    Medicine

    2024  Volume 103, Issue 9, Page(s) e37316

    Abstract: Acute diarrhea is a prevalent disease worldwide and a cause of mortality in low and middle-income countries. In previous studies, the causative enteropathogen is found in 38% to 58% of patients, leaving a considerable diagnostic gap. In this study, we ... ...

    Abstract Acute diarrhea is a prevalent disease worldwide and a cause of mortality in low and middle-income countries. In previous studies, the causative enteropathogen is found in 38% to 58% of patients, leaving a considerable diagnostic gap. In this study, we intend to determine the pathogenic agents responsible for acute diarrhea in patients presenting to the Emergency Departments of several Lebanese hospitals. A total of 100 stool samples were collected between June 2022 and June 2023 from patients presenting with acute diarrhea to the Emergency Departments. Pathogens were detected by multiplex polymerase chain reaction. The average age for the patients was 53 years old. All patients presented with diarrhea, 15 of them had fever associated. In total, 46 patients were admitted to the hospital (70%), among them 80% received Intravenous antibiotics. Campylobacter was the most common agent detected in 36%, followed by Rotavirus 19%, and Noroviruses 15%. The rest was detected at lower percentages. Bacteria accounted for 49% of cases, viruses for 39%, and parasitic infection 6%. Acute diarrhea epidemiology is understudied in Lebanon. This study is the first Lebanese data about acute diarrhea pathogens. Avoiding overuse of antibiotics in bacterial versus viral infections can be achieved while prevention campaigns can raise awareness about food and water safety at the community level.
    MeSH term(s) Humans ; Infant ; Middle Aged ; Lebanon/epidemiology ; Diarrhea/etiology ; Rotavirus ; Bacteria ; Anti-Bacterial Agents/therapeutic use ; Hospitals ; Emergency Service, Hospital ; Feces/microbiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hematological manifestations of COVID-19.

    Mina, Alain / van Besien, Koen / Platanias, Leonidas C

    Leukemia & lymphoma

    2020  Volume 61, Issue 12, Page(s) 2790–2798

    Abstract: The emergence of the Coronavirus Disease -19 (COVID-19) pandemic, has had a tremendous global impact, resulting in substantial morbidity and mortality worldwide and especially in the United States, where nearly one third of the cases are located. ... ...

    Abstract The emergence of the Coronavirus Disease -19 (COVID-19) pandemic, has had a tremendous global impact, resulting in substantial morbidity and mortality worldwide and especially in the United States, where nearly one third of the cases are located. Although involvement of the lower respiratory track accounts for most of the morbidity and mortality seen, the virus involves several organ systems and the syndrome exhibits clinical diversity with a wide range of symptoms and manifestations. The involvement of elements of the hematopoietic system is prominent in severe cases and associated with poor outcomes and mortality. Lymphopenia, leukopenia, thrombocytopenia, disseminated intravascular coagulation, and a prothrombotic state are common manifestations of COVID-19 and have important treatment and prognostic implications. Better understanding of the mechanisms of the pathophysiology of COVID-19-induced hematological abnormalities may ultimately result in better ways to treat them and decrease the associated morbidity and mortality.
    MeSH term(s) COVID-19/blood ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Disseminated Intravascular Coagulation/diagnosis ; Disseminated Intravascular Coagulation/mortality ; Disseminated Intravascular Coagulation/virology ; Hematopoietic System/virology ; Humans ; Lymphopenia/diagnosis ; Lymphopenia/mortality ; Lymphopenia/virology ; Pandemics ; Prognosis ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Thrombocytopenia/diagnosis ; Thrombocytopenia/mortality ; Thrombocytopenia/virology
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2020.1788017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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