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  1. Book ; Online ; E-Book: Biomarkers in bipolar disorders

    Machado-Vieira, Rodrigo / Soares, Jair C.

    2022  

    Author's details edited by Rodrigo Machado-Vieira, Jair C. Soares
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxii, 505 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021221546
    ISBN 978-0-12-821399-5 ; 9780128213988 ; 0-12-821399-X ; 0128213981
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The case for reverse engineering ketamine and psychedelics: lessons from translational oncology. A Response to Miller et al. "Burning down the house: reinventing drug discovery in psychiatry for the development of targeted therapies".

    Jones, Gregory / Machado-Vieira, Rodrigo

    Molecular psychiatry

    2023  Volume 28, Issue 8, Page(s) 3164–3166

    MeSH term(s) Hallucinogens ; Ketamine/pharmacology ; Ketamine/therapeutic use ; Psychiatry ; Drug Discovery ; Proteomics
    Chemical Substances Hallucinogens ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Letter
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02102-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4812: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Corrigendum to "Lithium, Stress, and Resilience in Bipolar Disorder: Deciphering this key homeostatic synaptic plasticity regulator." [J Affect Disord. 2018;233:92-99].

    Machado-Vieira, Rodrigo

    Journal of affective disorders

    2018  Volume 253

    Language English
    Publishing date 2018-09-01
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2018.08.083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression.

    Vecera, Courtney M / C Courtes, Alan / Jones, Gregory / Soares, Jair C / Machado-Vieira, Rodrigo

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 11

    Abstract: Treatment-resistant depression (TRD) is a term used to describe a particular type of major depressive disorder (MDD). There is no consensus about what defines TRD, with various studies describing between 1 and 4 failures of antidepressant therapies, with ...

    Abstract Treatment-resistant depression (TRD) is a term used to describe a particular type of major depressive disorder (MDD). There is no consensus about what defines TRD, with various studies describing between 1 and 4 failures of antidepressant therapies, with or without electroconvulsive therapy (ECT). That is why TRD is such a growing concern among clinicians and researchers, and it explains the necessity for investigating novel therapeutic targets beyond conventional monoamine pathways. An imbalance between two primary central nervous system (CNS) neurotransmitters,
    Language English
    Publishing date 2023-11-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16111572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Explainable drug side effect prediction via biologically informed graph neural network.

    Huang, Tongtong / Lin, Ko-Hong / Machado-Vieira, Rodrigo / Soares, Jair C / Jiang, Xiaoqian / Kim, Yejin

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Early detection of potential side effects (SE) is a critical and challenging task for drug discovery and patient care. In-vitro or in-vivo approach to detect potential SEs is not scalable for many drug candidates during the preclinical stage. Recent ... ...

    Abstract Early detection of potential side effects (SE) is a critical and challenging task for drug discovery and patient care. In-vitro or in-vivo approach to detect potential SEs is not scalable for many drug candidates during the preclinical stage. Recent advances in explainable machine learning may facilitate detecting potential SEs of new drugs before market release and elucidating the critical mechanism of biological actions. Here, we leverage multi-modal interactions among molecules to develop a biologically informed graph-based SE prediction model, called HHAN-DSI. HHAN-DSI predicted frequent and even uncommon SEs of the unseen drug with higher or comparable accuracy against benchmark methods. When applying HHAN-DSI to the central nervous system, the organs with the largest number of SEs, the model revealed diverse psychiatric medications' previously unknown but probable SEs, together with the potential mechanisms of actions through a network of genes, biological functions, drugs, and SEs.
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.26.23290615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Non-canonical pathways in the pathophysiology and therapeutics of bipolar disorder.

    Machado-Vieira, Rodrigo / Courtes, Alan C / Zarate, Carlos A / Henter, Ioline D / Manji, Husseini K

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1228455

    Abstract: Bipolar disorder (BD) is characterized by extreme mood swings ranging from manic/hypomanic to depressive episodes. The severity, duration, and frequency of these episodes can vary widely between individuals, significantly impacting quality of life. ... ...

    Abstract Bipolar disorder (BD) is characterized by extreme mood swings ranging from manic/hypomanic to depressive episodes. The severity, duration, and frequency of these episodes can vary widely between individuals, significantly impacting quality of life. Individuals with BD spend almost half their lives experiencing mood symptoms, especially depression, as well as associated clinical dimensions such as anhedonia, fatigue, suicidality, anxiety, and neurovegetative symptoms. Persistent mood symptoms have been associated with premature mortality, accelerated aging, and elevated prevalence of treatment-resistant depression. Recent efforts have expanded our understanding of the neurobiology of BD and the downstream targets that may help track clinical outcomes and drug development. However, as a polygenic disorder, the neurobiology of BD is complex and involves biological changes in several organelles and downstream targets (pre-, post-, and extra-synaptic), including mitochondrial dysfunction, oxidative stress, altered monoaminergic and glutamatergic systems, lower neurotrophic factor levels, and changes in immune-inflammatory systems. The field has thus moved toward identifying more precise neurobiological targets that, in turn, may help develop personalized approaches and more reliable biomarkers for treatment prediction. Diverse pharmacological and non-pharmacological approaches targeting neurobiological pathways other than neurotransmission have also been tested in mood disorders. This article reviews different neurobiological targets and pathophysiological findings in non-canonical pathways in BD that may offer opportunities to support drug development and identify new, clinically relevant biological mechanisms. These include: neuroinflammation; mitochondrial function; calcium channels; oxidative stress; the glycogen synthase kinase-3 (GSK3) pathway; protein kinase C (PKC); brain-derived neurotrophic factor (BDNF); histone deacetylase (HDAC); and the purinergic signaling pathway.
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1228455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Lithium, Stress, and Resilience in Bipolar Disorder: Deciphering this key homeostatic synaptic plasticity regulator.

    Machado-Vieira, Rodrigo

    Journal of affective disorders

    2017  Volume 233, Page(s) 92–99

    Abstract: Background: Lithium is the lightest metal and the only mood stabilizer that has been used for over half a century for the treatment of bipolar disorder (BD). As a small ion, lithium is omnipresent, and consequently, its molecular mechanisms and targets ... ...

    Abstract Background: Lithium is the lightest metal and the only mood stabilizer that has been used for over half a century for the treatment of bipolar disorder (BD). As a small ion, lithium is omnipresent, and consequently, its molecular mechanisms and targets are widespread. Currently, lithium is a crucial pharmacotherapy for the treatment of acute mood episodes, prophylactic therapy, and suicide prevention in BD. Besides, lithium blood level is the most widely used biomarker in clinical psychiatry. The concept of stress in BD characterizes short- and long-term deleterious effects at multiple levels (from genes to behaviors) and the ability to establish homeostatic regulatory mechanisms to either prevent or reverse these effects. Within this concept, lithium has consistently shown anti-stress effects, by normalizing components across several levels associated with BD-induced impairments in cellular resilience and plasticity.
    Methods: A literature search for biomarkers associated with lithium effects at multiple targets, with a particular focus on those related to clinical outcomes was performed. An extensive search of the published literature using PubMed, Medline and Google Scholar was performed. Example search terms included lithium, plasticity, stress, efficacy, and neuroimaging. Articles determined by the author to focus on lithium's impact on neural plasticity markers (central and periphery) and clinical outcomes were examined in greater depth. Relevant papers were evaluated, selected and included in this review.
    Results: Lithium induces neurotrophic and neuroprotective effects in a wide range of preclinical and translational models. Lithium's neurotrophic effects are related to the enhancement of cellular proliferation, differentiation, growth, and regeneration, whereas its neuroprotective effects limit the progression of neuronal atrophy or cell death following the onset of BD. Lithium's neurotrophic and neuroprotective effects seem most pronounced in the presence of pathology, which again supports its pivotal role as an active homeostatic regulator.
    Limitations: Few studies associated with clinical outcomes. Due to space limitations, the author was unable to detail all findings, in special those originated from preclinical studies.
    Conclusions: These results support a potential role for biomarkers involved in neuroprotection and activation of plasticity pathways in lithium's clinical response. Evidence supporting this model comes from results evaluating macroscopic and microscopic brain structure as well neurochemical findings in vivo from cellular to sub-synaptic (molecules and intracellular signaling) compartments using central and peripheral biomarkers. Challenges to precisely decipher lithium's biological mechanisms involved in its therapeutic profile include the complex nature of the illness and clinical subtypes, family history and comorbid conditions. In the context of personalized medicine, it is necessary to validate predictive biomarkers of response to lithium by designing longitudinal clinical studies during mood episodes and associated clinical dimensions in BD.
    MeSH term(s) Antidepressive Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Bipolar Disorder/physiopathology ; Brain/pathology ; Homeostasis ; Humans ; Lithium Compounds/therapeutic use ; Neuronal Plasticity/drug effects ; Neuronal Plasticity/physiology ; Neurons/metabolism ; Signal Transduction/drug effects ; Stress, Psychological/physiopathology
    Chemical Substances Antidepressive Agents ; Lithium Compounds
    Language English
    Publishing date 2017-12-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2017.12.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1485: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: Convergent evidence for the antiviral effects of several FDA-approved phenothiazine antipsychotics against SARS-CoV-2 and other coronaviruses.

    Machado-Vieira, Rodrigo / Quevedo, João / Shahani, Lokesh / Soares, Jair C

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2021  Volume 43, Issue 5, Page(s) 462–464

    MeSH term(s) Antipsychotic Agents ; Antiviral Agents/therapeutic use ; COVID-19 ; Humans ; Phenothiazines ; SARS-CoV-2
    Chemical Substances Antipsychotic Agents ; Antiviral Agents ; Phenothiazines
    Language English
    Publishing date 2021-05-19
    Publishing country Brazil
    Document type Editorial
    ISSN 1809-452X
    ISSN (online) 1809-452X
    DOI 10.1590/1516-4446-2020-0024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Role of the Gut Microbiome in Bipolar Disorder and its Common Medical Comorbidities.

    Jones, Gregory H / Pinjari, Omar F / Vecera, Courtney M / Smith, Kacy / Barrera, Anita / Machado-Vieira, Rodrigo

    Frontiers in neuroendocrinology

    2023  Volume 70, Page(s) 101078

    Abstract: Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with significant psychosocial and medical disease burden. Much difficulty has been encountered in developing novel therapeutics and objective biomarkers for clinical use in this ... ...

    Abstract Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with significant psychosocial and medical disease burden. Much difficulty has been encountered in developing novel therapeutics and objective biomarkers for clinical use in this population. In that regard, gut-microbial homeostasis appears to modulate several key pathways relevant to a variety of psychiatric, metabolic, and inflammatory disorders. Microbial impact on immune, endocrine, endocannabinoid, kynurenine, and other pathways are discussed throughout this review. Emphasis is placed on this system's relevance to current pharmacology, diet, and comorbid illness in bipolar disorder. Despite the high level of optimism promoted in many reviews on this topic, substantial obstacles exist before any microbiome-related findings can provide meaningful clinical utility. Beyond a comprehensive overview of pathophysiology, this review hopes to highlight several key areas where progress is needed. As well, novel microbiome-associated suggestions are presented for future research.
    MeSH term(s) Humans ; Bipolar Disorder ; Gastrointestinal Microbiome/physiology ; Microbiota
    Language English
    Publishing date 2023-05-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390985-2
    ISSN 1095-6808 ; 0532-7466 ; 0091-3022
    ISSN (online) 1095-6808
    ISSN 0532-7466 ; 0091-3022
    DOI 10.1016/j.yfrne.2023.101078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The next generation of clinical studies with antidepressants in bipolar disorder.

    Machado-Vieira, Rodrigo

    Frontiers in psychiatry

    2014  Volume 5, Page(s) 27

    Language English
    Publishing date 2014-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2014.00027
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