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Article ; Online: Self-Efficacy Improvement for Performance of Trauma-Related Skills due to a Military-Civilian Partnership.

Hall, Maj Andrew B / Englert, Maj Zachary / Hanseman, Dennis / Klein, Maj Aria

2019 Volume 84, Issue 12, Page(s) e505–e507

MeSH term(s)	Clinical Competence/standards ; Humans ; Military Medicine/education ; Military Personnel/education ; Self Efficacy ; Simulation Training ; Trauma Centers ; Traumatology/education ; United States
Language	English
Publishing date	2019-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
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Article ; Online: Objective Military Trauma Team Performance Improvement from Military-Civilian Partnerships.

Hall, Maj Andrew / Boecker, Maj Felix / Englert, Maj Zachary / Hanseman, Dennis / Fields, Maj Adrienne

The American surgeon

2019 Volume 84, Issue 12, Page(s) e555–e557

MeSH term(s)	Clinical Competence/standards ; Health Knowledge, Attitudes, Practice ; Humans ; Interprofessional Relations ; Military Medicine/education ; Military Medicine/standards ; Military Personnel/education ; Missouri ; Patient Simulation ; Trauma Centers ; Traumatology/education ; Traumatology/standards ; United States ; Wounds and Injuries
Language	English
Publishing date	2019-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Converting a Small Surgical Team into a Pandemic Response Team for an Isolated Population.

Hall, Maj Andrew / Morrow, Maj Lindsay / Monsaert, Maj Kelsey / Wilson, Col Ramey L / Dixon, Ltcol Michael

Journal of the American College of Surgeons

2020 Volume 230, Issue 6, Page(s) e27–e30

MeSH term(s)	Algorithms ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; Communicable Disease Control/organization & administration ; Humans ; Patient Care Team/organization & administration
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1181115-8
ISSN	1879-1190 ; 1072-7515
ISSN (online)	1879-1190
ISSN	1072-7515
DOI	10.1016/j.jamcollsurg.2020.04.001
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Article: Converting a Small Surgical Team into a Pandemic Response Team for an Isolated Population

Hall, Maj Andrew / Morrow, Maj Lindsay / Monsaert, Maj Kelsey / Wilson, Col Ramey L / Dixon, Ltcol Michael

J Am Coll Surg

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #47223
Database	COVID19

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Article ; Online: Variability of Value of Trauma Centers to General Surgery Combat Casualty Care Skill Sustainment.

Hall, Andrew / Qureshi, Iram / Englert, Maj Zachary / Davis, Elizabeth

Journal of surgical education

2020 Volume 78, Issue 4, Page(s) 1275–1279

Abstract: Objective: Military-civilian partnerships for the maintenance of trauma readiness skills will be required to maintain skills in preparation for future combat casualty care operations. There is little data describing relative worth of potential ... ...

Abstract	Objective: Military-civilian partnerships for the maintenance of trauma readiness skills will be required to maintain skills in preparation for future combat casualty care operations. There is little data describing relative worth of potential partnerships. This study aims to demonstrate that quantitative and qualitative differences are prevalent between trauma centers. Design: A combat casualty care relevant case (CCC-RC) was determined to be one that was open, urgent, and required a blood transfusion. Total number of urgent trauma cases and number of cases requiring transfusions between January 1, 2017 and January 1, 2019 were tallied at Saint Louis University Hospital (ACS Level 1), San Antonio Military Medical Center (ACS Level 1), Madigan Army Medical Center (Washington Level 2), and William Beaumont Army Medical Center (Texas Level 3). At the participating level 1 trauma centers, cases were segregated by surgeon. Setting: Saint Louis University Hospital (SLU), San Antonio Military Medical Center (SAMMC), Madigan Army Medical Center (MAMC), and William Beaumont Army Medical Center (WBAMC). Participants: All general surgery/trauma cases at participating hospitals between January 1, 2017 and January 1, 2019. Results: A total of 267 of 721 trauma cases performed by trauma/general surgeons at SAMMC were CCC-RCs, at SLU 213 of 342, MAMC, 5 of 13, and at WBAMC 1 of 33. While SAMMC had the most cases, SLU had the highest ratio of cases that were CCC-RC (p < 0.0001). The average number of CCC-RCs of the top 5 surgeons at each level 1 institutions were 15.7 cases/year (60.5%) at SLU and 10.3 cases/year (33.6%) at SAMMC (p < 0.0001). Conclusions: The CCC-RC definition is easily used to distinguish the value and relevancy of trauma centers to general surgeon combat casualty care readiness. The volume and proportions of relevant trauma are significantly different between trauma centers. The military trauma designated hospitals are currently inadequate to support all general surgeon readiness needs. Embedding surgeons at centers with high volumes or relevant cases is the optimum solution.
MeSH term(s)	Humans ; Military Medicine ; Military Personnel ; Texas ; Trauma Centers ; Washington ; Wounds and Injuries/surgery
Language	English
Publishing date	2020-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2277538-9
ISSN	1878-7452 ; 1931-7204
ISSN (online)	1878-7452
ISSN	1931-7204
DOI	10.1016/j.jsurg.2020.12.002
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Article ; Online: Civilian-Military Trauma Partnerships and the Visiting Surgeon Model for Maintaining Medical Readiness.

Hall, Maj Andrew / Speegle, Darrin / Glaser, Cdr Jacob

Journal of surgical education

2018 Volume 76, Issue 3, Page(s) 738–744

Abstract: Objective: The main objective of this paper is to create a model to predict the amount of trauma experience at a level 1 trauma center a visiting surgeon can expect to obtain with near certainty, in a specific amount of time, to maintain trauma skills.!# ...

Abstract	Objective: The main objective of this paper is to create a model to predict the amount of trauma experience at a level 1 trauma center a visiting surgeon can expect to obtain with near certainty, in a specific amount of time, to maintain trauma skills. Design: The trauma database of level 1 trauma center (Saint Louis University Hospital, a military civilian partnership site) was examined to identify all urgent trauma cases between 1 October 2015 and 30 September 2017. Using retrospective data, a prospective hypothesis of a mixture of various case exposures a visiting surgeon may experience was made using Monte Carlo statistical methods, various probabilities for wartime relevant specialties were examined. Setting: Saint Louis University Hospital, a level 1 trauma and tertiary referral center. Participants: Trauma patients between the dates October 1, 2015 and September 30, 2017 that underwent an operation at Saint Louis University Hospital. Results: Orthopedics and general/trauma surgery had the largest number of urgent trauma cases with an average daily amount of 1.03 and 0.49 cases, respectively. Using Monte Carlo methods, various scenarios and probabilities were tabulated. For example, a general surgeon on shift for 10days could expect to experience 4.9 (95% confidence interval 1-11) urgent cases or a visiting surgeon would require twenty-six 24-hour shifts in the summer to have a 95% certainty to experience at least 10 cases. Conclusions: Other than for orthopedics, prolonged training timelines would be required to expose a visiting surgeon to multiple operative trauma cases. Though a specific number of cases to achieve "readiness" is undefined, a visiting-surgeon model may be unacceptable if a large number of cases are required prior to military deployment. This predictive model could be extrapolated to other centers and assist in identifying adequate settings and durations of trauma training sites.
MeSH term(s)	Clinical Competence ; Humans ; Injury Severity Score ; Military Medicine/education ; Military Personnel/education ; Missouri ; Monte Carlo Method ; Prospective Studies ; Retrospective Studies ; Trauma Centers/organization & administration ; Traumatology/education ; Workload
Language	English
Publishing date	2018-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2277538-9
ISSN	1878-7452 ; 1931-7204
ISSN (online)	1878-7452
ISSN	1931-7204
DOI	10.1016/j.jsurg.2018.10.008
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Article ; Online: Declining Military Surgical Cases and the Impact on Military Surgical Graduate Medical Education.

Hall, Andrew B / Krzyzaniak, Michael / Qureshi, Iram / Cromer, Robert / Tadlock, Matthew D / Patrick, Danielle / Hatch, Quinton / Iverson, Maj Kyle / Walker, Avery / Glaser, Jacob

The American surgeon

2022 Volume 89, Issue 11, Page(s) 4316–4320

Abstract: Background: Several studies have indicated a decline in the number, types, and complexity of surgical procedures within military treatment facilities (MTFs). This study aims to determine what effect, if any, these downward trends have had on the ... ...

Abstract	Background: Several studies have indicated a decline in the number, types, and complexity of surgical procedures within military treatment facilities (MTFs). This study aims to determine what effect, if any, these downward trends have had on the relationship between the military health system (MHS) and surgical graduate medical education. Methods: Graduating chief resident final ACGME case logs from 4 of thirteen military general surgery programs were evaluated from 2015 to 2020. The proportion of total cases performed by residents at military institutions were compared on a year over year basis. Results: The proportion of cases performed within the military hospitals declined 3.27% each year between 2015 and 2020 ( Conclusions: There has been a statistically significant decline over time in the proportion of cases logged by residents within the studied military treatment facilities. Investment into military hospitals to increase case numbers, case diversity, and complexity and/or acceptance of this gradual decline with greater shifting of educational workload onto civilian hospitals is required.
MeSH term(s)	Humans ; Internship and Residency ; Retrospective Studies ; Clinical Competence ; Education, Medical, Graduate ; Workload ; General Surgery/education
Language	English
Publishing date	2022-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348221109451
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Article ; Online: Risk of ischemic heart disease in women after radiotherapy for breast cancer.

Darby, Sarah C / Ewertz, Marianne / McGale, Paul / Bennet, Anna M / Blom-Goldman, Ulla / Brønnum, Dorthe / Correa, Candace / Cutter, David / Gagliardi, Giovanna / Gigante, Bruna / Jensen, Maj-Britt / Nisbet, Andrew / Peto, Richard / Rahimi, Kazem / Taylor, Carolyn / Hall, Per

The New England journal of medicine

2013 Volume 368, Issue 11, Page(s) 987–998

Abstract: Background: Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of ischemic heart disease is uncertain.: Methods: We conducted a population- ... ...

Abstract	Background: Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of ischemic heart disease is uncertain. Methods: We conducted a population-based case-control study of major coronary events (i.e., myocardial infarction, coronary revascularization, or death from ischemic heart disease) in 2168 women who underwent radiotherapy for breast cancer between 1958 and 2001 in Sweden and Denmark; the study included 963 women with major coronary events and 1205 controls. Individual patient information was obtained from hospital records. For each woman, the mean radiation doses to the whole heart and to the left anterior descending coronary artery were estimated from her radiotherapy chart. Results: The overall average of the mean doses to the whole heart was 4.9 Gy (range, 0.03 to 27.72). Rates of major coronary events increased linearly with the mean dose to the heart by 7.4% per gray (95% confidence interval, 2.9 to 14.5; P<0.001), with no apparent threshold. The increase started within the first 5 years after radiotherapy and continued into the third decade after radiotherapy. The proportional increase in the rate of major coronary events per gray was similar in women with and women without cardiac risk factors at the time of radiotherapy. Conclusions: Exposure of the heart to ionizing radiation during radiotherapy for breast cancer increases the subsequent rate of ischemic heart disease. The increase is proportional to the mean dose to the heart, begins within a few years after exposure, and continues for at least 20 years. Women with preexisting cardiac risk factors have greater absolute increases in risk from radiotherapy than other women. (Funded by Cancer Research UK and others.).
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/complications ; Breast Neoplasms/drug therapy ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Case-Control Studies ; Chemotherapy, Adjuvant ; Female ; Heart/radiation effects ; Humans ; Mastectomy ; Middle Aged ; Myocardial Ischemia/etiology ; Myocardial Ischemia/mortality ; Radiation Injuries/etiology ; Radiation Injuries/mortality ; Radiotherapy Dosage ; Radiotherapy, Adjuvant/adverse effects ; Risk ; Risk Factors
Language	English
Publishing date	2013-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMoa1209825
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Article ; Online: Cardiac dose estimates from Danish and Swedish breast cancer radiotherapy during 1977-2001.

Taylor, Carolyn W / Brønnum, Dorthe / Darby, Sarah C / Gagliardi, Giovanna / Hall, Per / Jensen, Maj-Britt / McGale, Paul / Nisbet, Andrew / Ewertz, Marianne

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2011 Volume 100, Issue 2, Page(s) 176–183

Abstract: Background and purpose: To estimate target and cardiac doses from breast cancer radiotherapy in Denmark and in the Stockholm and Umeå areas of Sweden during 1977-2001.: Methods: Representative samples of irradiated women were identified from the ... ...

Abstract	Background and purpose: To estimate target and cardiac doses from breast cancer radiotherapy in Denmark and in the Stockholm and Umeå areas of Sweden during 1977-2001. Methods: Representative samples of irradiated women were identified from the databases of the Danish Breast Cancer Cooperative Group and the Swedish Nationwide Cancer Registry. Virtual simulation, computed tomography planning and manual planning were used to reconstruct radiotherapy regimens on a typical woman. Estimates of target dose and various measures of cardiac dose were derived from individual radiotherapy charts. Results: Doses were estimated in 681 Danish and 130 Swedish women. Mean heart dose for individual women varied from 1.6 to 14.9 Gray in Denmark and from 1.2 to 22.1 Gray in Sweden. In Denmark, mean target doses averaged across women increased from 40.6 to 53.8 Gray during 1977-2001 but, despite this, mean heart dose averaged across women remained around 6 Gy for left-sided and 2-3 Gray for right-sided radiotherapy. In Sweden mean target dose averaged across women increased from 38.7 to 46.6 Gray during 1977-2001, while mean heart dose averaged across women decreased from 12.0 to 7.3 Gray for left-sided and from 3.6 to 3.2 Gray for right-sided radiotherapy. Temporal trends for mean biologically effective dose [BED] to the heart, mean dose to the left anterior descending coronary artery, the right coronary artery and the circumflex coronary artery were broadly similar. Conclusions: Cardiac doses in Denmark were low relative to those in Sweden. In both countries, target dose increased during 1977-2001. Despite this, cardiac doses remained constant in Denmark and decreased in Sweden.
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/radiotherapy ; Coronary Vessels/radiation effects ; Denmark ; Female ; Heart/radiation effects ; Humans ; Middle Aged ; Radiation Dosage ; Sweden ; Time Factors
Language	English
Publishing date	2011-03-04
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2011.01.020
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Article ; Online: Novel GFM2 variants associated with early-onset neurological presentations of mitochondrial disease and impaired expression of OXPHOS subunits.

Glasgow, Ruth I C / Thompson, Kyle / Barbosa, Inês A / He, Langping / Alston, Charlotte L / Deshpande, Charu / Simpson, Michael A / Morris, Andrew A M / Neu, Axel / Löbel, Ulrike / Hall, Julie / Prokisch, Holger / Haack, Tobias B / Hempel, Maja / McFarland, Robert / Taylor, Robert W

Neurogenetics

2017 Volume 18, Issue 4, Page(s) 227–235

Abstract: Mitochondrial diseases are characterised by clinical, molecular and functional heterogeneity, reflecting their bi-genomic control. The nuclear gene GFM2 encodes mtEFG2, a protein with an essential role during the termination stage of mitochondrial ... ...

Abstract	Mitochondrial diseases are characterised by clinical, molecular and functional heterogeneity, reflecting their bi-genomic control. The nuclear gene GFM2 encodes mtEFG2, a protein with an essential role during the termination stage of mitochondrial translation. We present here two unrelated patients harbouring different and previously unreported compound heterozygous (c.569G>A, p.(Arg190Gln); c.636delA, p.(Glu213Argfs*3)) and homozygous (c.275A>C, p.(Tyr92Ser)) recessive variants in GFM2 identified by whole exome sequencing (WES) together with histochemical and biochemical findings to support the diagnoses of pathological GFM2 variants in each case. Both patients presented similarly in early childhood with global developmental delay, raised CSF lactate and abnormalities on cranial MRI. Sanger sequencing of familial samples confirmed the segregation of bi-allelic GFM2 variants with disease, while investigations into steady-state mitochondrial protein levels revealed respiratory chain subunit defects and loss of mtEFG2 protein in muscle. These data demonstrate the effects of defective mtEFG2 function, caused by previously unreported variants, confirming pathogenicity and expanding the clinical phenotypes associated with GFM2 variants.
MeSH term(s)	Child ; Exome/genetics ; Female ; Homozygote ; Humans ; Male ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Diseases/genetics ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Mutation/genetics ; Pedigree ; Peptide Elongation Factor G/genetics ; Phenotype
Chemical Substances	GFM2 protein, human ; Mitochondrial Proteins ; Peptide Elongation Factor G
Language	English
Publishing date	2017-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339887-8
ISSN	1364-6753 ; 1364-6745
ISSN (online)	1364-6753
ISSN	1364-6745
DOI	10.1007/s10048-017-0526-4
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