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  1. Article: The Antidiabetic Activity of Combining the Aqueous Extracts of Vernonia amygdalina Leaves and Tamarindus indica Fruit Pulp in Streptozotocin-Induced Wistar Rats.

    Tekou, Florian Amel / Woumbo, Cerile Ypolyte / Kemtsop, Michel Pegui / Dzoyem, Jean Paul / Kuate, Dieudonné / Todem, David

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46807

    Abstract: Background Many plants are used to reduce the side effects of diabetes mellitus. These plants ( ... ...

    Abstract Background Many plants are used to reduce the side effects of diabetes mellitus. These plants (including
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antioxidant and antidiabetic activities of a polyphenol rich extract obtained from

    Woumbo, Cerile Ypolyte / Kuate, Dieudonné / Metue Tamo, Danielle Gaelle / Womeni, Hilaire Macaire

    Frontiers in nutrition

    2022  Volume 9, Page(s) 1030385

    Abstract: Functional foods have gained popularity in recent decades. They are exploited for their bioactive compounds like polyphenols, which are highly demanded in cosmetic, pharmaceutical and nutraceutical industries. However, extractive techniques and ... ...

    Abstract Functional foods have gained popularity in recent decades. They are exploited for their bioactive compounds like polyphenols, which are highly demanded in cosmetic, pharmaceutical and nutraceutical industries. However, extractive techniques and conditions used up to recently are almost obsolete and must be optimized for higher efficiency. The current study aimed to evaluate the antidiabetic potential of an optimized extract of
    Language English
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.1030385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Valorization of Glycine max (Soybean) Seed Waste

    Cerile Ypolyte Woumbo / Dieudonné Kuate / Mathilde Julie Klang / Hilaire Macaire Womeni

    Journal of Chemistry, Vol

    Optimization of the Microwave-Assisted Extraction (MAE) and Characterization of Polyphenols from Soybean Meal Using Response Surface Methodology (RSM)

    2021  Volume 2021

    Abstract: The present study aimed at determining the optimal conditions for extraction of total phenolic compounds from soybean (Glycine max) meal, a by-product of the soybean seeds industry, using a green protocol with microwave-assisted extraction (MAE). A face- ... ...

    Abstract The present study aimed at determining the optimal conditions for extraction of total phenolic compounds from soybean (Glycine max) meal, a by-product of the soybean seeds industry, using a green protocol with microwave-assisted extraction (MAE). A face-centered composite design (FCCD) was used for optimization. Based on a screening aimed to determine the factors that significantly influenced the responses, a 50% hydro-ethanolic solution was used with solvent/dry matter ratio (60/1–110/1), power (120–270 W), and time (0–10 min) as factors, while the responses studied were total phenolic and flavonoid contents. FTIR, TLC, DPPH, and FRAP anti-oxidants tests were used to characterize the extracts obtained with optimum conditions. The factors that significantly influenced both responses were the individual effect of all factors, the interaction between solvent/dry matter ratio and extraction time, the quadratic effect of solvent/dry matter ratio, and power for total phenolic content, while only the quadratic effect of power significantly influenced the flavonoid content. The highest contents of phenols (13.09 mg GAE/g) and flavonoid (7.39 mg CE/g) were obtained at 120 W for 0.16 min with a solvent/dry matter ratio of 60/1. ATR-FTIR spectra indicated the presence of polyphenolic compounds in the extract, namely flavonoids. TLC indicated the presence of at least nine compounds in the extract, among which catechin and quercetin were identified with respective Rf of 0.98 and 0.93. DPPH assay showed the anti-oxidant capacity for the extract with an IC50 of 194.98 µg/ml. RSM permitted us to develop a green protocol for maximum extraction of polyphenols from soybean seeds waste using less solvent, low power, and a reduced time in MAE.
    Keywords Chemistry ; QD1-999
    Subject code 660
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cooking methods affect phytochemical composition and anti-obesity potential of soybean (Glycine max) seeds in Wistar rats

    Cerile Ypolyte Woumbo / Dieudonné Kuate / Hilaire Macaire Womeni

    Heliyon, Vol 3, Iss

    2017  Volume 8

    Abstract: This work aimed at investigating the effects of three domestic cooking methods (roasting, sprouting and boiling) on phytochemical contents (phenolic content, flavonoid, fibre), and anti-obesity (weight loss, hypoglycemic effect, serum lipids) potential ... ...

    Abstract This work aimed at investigating the effects of three domestic cooking methods (roasting, sprouting and boiling) on phytochemical contents (phenolic content, flavonoid, fibre), and anti-obesity (weight loss, hypoglycemic effect, serum lipids) potential of soybean seeds in obese male rats. Ten different forms were implemented, combining hulled/unhulled and raw/cooked soybean seeds using a basal and a hypercaloric diet as controls. Unhulled Roasted Soybean (URS) exhibited the highest phenolic content and a greater antioxidant activity by the FRAP assay than BHT at certain concentrations. Hulled boiled Soybean (HBS) showed the highest flavonoid content while Hulled Germinated Soybean (HGS) presented the lowest fibre content (P < 0.05). Unhulled Boiled Soybean (UBS) induced the best reduction in food intake while Unhulled Soybean Extract (USE) exhibited the greatest slimming effect. HBS exhibited the best cholesterol lowering ability; URS and Unhulled germinated Soybean (UGS) respectively induced the highest increase in HDL cholesterol levels and reduction in triglyceride levels. UBS demonstrated the highest ability to lower LDL cholesterol. UGS exhibited the highest ability to lower the postprandial blood glucose. Culinary treatments affect phytochemical content and anti-obesity potential of soybean seeds.
    Keywords Food science ; Nutrition ; Food analysis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 630
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Cooking methods affect phytochemical composition and anti-obesity potential of soybean (

    Woumbo, Cerile Ypolyte / Kuate, Dieudonné / Womeni, Hilaire Macaire

    Heliyon

    2017  Volume 3, Issue 8, Page(s) e00382

    Abstract: This work aimed at investigating the effects of three domestic cooking methods (roasting, sprouting and boiling) on phytochemical contents (phenolic content, flavonoid, fibre), and anti-obesity (weight loss, hypoglycemic effect, serum lipids) potential ... ...

    Abstract This work aimed at investigating the effects of three domestic cooking methods (roasting, sprouting and boiling) on phytochemical contents (phenolic content, flavonoid, fibre), and anti-obesity (weight loss, hypoglycemic effect, serum lipids) potential of soybean seeds in obese male rats. Ten different forms were implemented, combining hulled/unhulled and raw/cooked soybean seeds using a basal and a hypercaloric diet as controls. Unhulled Roasted Soybean (URS) exhibited the highest phenolic content and a greater antioxidant activity by the FRAP assay than BHT at certain concentrations. Hulled boiled Soybean (HBS) showed the highest flavonoid content while Hulled Germinated Soybean (HGS) presented the lowest fibre content (P < 0.05). Unhulled Boiled Soybean (UBS) induced the best reduction in food intake while Unhulled Soybean Extract (USE) exhibited the greatest slimming effect. HBS exhibited the best cholesterol lowering ability; URS and Unhulled germinated Soybean (UGS) respectively induced the highest increase in HDL cholesterol levels and reduction in triglyceride levels. UBS demonstrated the highest ability to lower LDL cholesterol. UGS exhibited the highest ability to lower the postprandial blood glucose. Culinary treatments affect phytochemical content and anti-obesity potential of soybean seeds.
    Language English
    Publishing date 2017-08-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2017.e00382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effect of cooking treatments on the phytochemical composition and antidiabetic potential of

    Tekou, Florian Amel / Kuate, Dieudonne / Nguekouo, Philippe Tekem / Woumbo, Cerile Ypolyte / Oben, Julius Enyong

    Food science & nutrition

    2018  Volume 6, Issue 6, Page(s) 1684–1691

    Abstract: The present study aimed at evaluating the effects of domestic culinary treatment on phytochemical contents (phenolic content and dietary fiber), and the antidiabetic potential ... ...

    Abstract The present study aimed at evaluating the effects of domestic culinary treatment on phytochemical contents (phenolic content and dietary fiber), and the antidiabetic potential of
    Language English
    Publishing date 2018-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cooking methods affect phytochemical composition and anti-obesity potential of soybean (Glycine max) seeds in Wistar rats

    Woumbo, Cerile Ypolyte / Kuate, Dieudonné / Womeni, Hilaire Macaire

    Heliyon. 2017 Aug., v. 3, no. 8

    2017  

    Abstract: This work aimed at investigating the effects of three domestic cooking methods (roasting, sprouting and boiling) on phytochemical contents (phenolic content, flavonoid, fibre), and anti-obesity (weight loss, hypoglycemic effect, serum lipids) potential ... ...

    Abstract This work aimed at investigating the effects of three domestic cooking methods (roasting, sprouting and boiling) on phytochemical contents (phenolic content, flavonoid, fibre), and anti-obesity (weight loss, hypoglycemic effect, serum lipids) potential of soybean seeds in obese male rats. Ten different forms were implemented, combining hulled/unhulled and raw/cooked soybean seeds using a basal and a hypercaloric diet as controls. Unhulled Roasted Soybean (URS) exhibited the highest phenolic content and a greater antioxidant activity by the FRAP assay than BHT at certain concentrations. Hulled boiled Soybean (HBS) showed the highest flavonoid content while Hulled Germinated Soybean (HGS) presented the lowest fibre content (P < 0.05). Unhulled Boiled Soybean (UBS) induced the best reduction in food intake while Unhulled Soybean Extract (USE) exhibited the greatest slimming effect. HBS exhibited the best cholesterol lowering ability; URS and Unhulled germinated Soybean (UGS) respectively induced the highest increase in HDL cholesterol levels and reduction in triglyceride levels. UBS demonstrated the highest ability to lower LDL cholesterol. UGS exhibited the highest ability to lower the postprandial blood glucose. Culinary treatments affect phytochemical content and anti-obesity potential of soybean seeds.
    Keywords Glycine max ; antioxidant activity ; blood glucose ; blood serum ; chemical constituents of plants ; fiber content ; flavonoids ; food intake ; glycemic effect ; high density lipoprotein cholesterol ; high energy diet ; low density lipoprotein cholesterol ; males ; soybeans ; triacylglycerols ; weight loss
    Language English
    Dates of publication 2017-08
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2017.e00382
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Effect of boiling and roasting on the antidiabetic activity of Abelmoschus esculentus (Okra) fruits and seeds in type 2 diabetic rats

    Nguekouo, Phylippe Tekem / Anne Pascale Nouemsi Kengne / Cerile Ypolyte Woumbo / Dieudonné Kuate / Florian Amel Tekou / Julius Enyong Oben

    Journal of food biochemistry. 2018 Dec., v. 42, no. 6

    2018  

    Abstract: The present investigation aimed to study the effect of two culinary treatments (boiling and roasting) on the antidiabetic potential of Abelmoschus esculentus fruits and seeds in type 2 diabetic rats. Crude fiber, total phenolic content, and in vitro free ...

    Abstract The present investigation aimed to study the effect of two culinary treatments (boiling and roasting) on the antidiabetic potential of Abelmoschus esculentus fruits and seeds in type 2 diabetic rats. Crude fiber, total phenolic content, and in vitro free radical scavenging capacity of the various culinary forms of the fruits and seeds were assessed. Streptozotoccin and high‐fat diet‐induced type 2 diabetes Wistar rats were randomly assigned to six groups of 10 rats each, and treated for 28 days with either metformin or suspensions of one of the following: untreated fruits (UTF), boiled fruits, untreated seeds, and roasted seeds. Controls were made up of untreated nondiabetic (T−) and diabetic (T+) animals. Fasting blood glucose was measured on a weekly basis. The lipid profile and markers of the hepatic and kidney toxicity were measured at the end of the experimentation. Boiling and roasting did not affect the fiber content of the Abelmoschus esculentus fruits and seeds, but significantly (p < 0.05) lowered the total phenolic content as well as their free radical scavenging capacity. Daily administration of processed and UTF and seed suspensions significantly decreased (p < 0.05) the blood glucose level of rats. A significant decrease (p < 0.05) in the serum level of triglycerides, total cholesterol, LDL cholesterol, transaminases (alanine aminotransferase and aspartate aminotransferase), creatinine, and urea was observed along with a significant increase (p < 0.05) in the serum level of total protein. Boiling and roasting do not significantly influence the antidiabetic potential of A. esculentus fruits and seeds. PRACTICAL APPLICATIONS: A. esculentus commonly called Okra, a fiber‐rich fruit, has already demonstrated hypoglycemic and hypolipidemic activities, which makes this plant an interesting alternative for the management of diabetes. The fruit is popularly used in food preparations in different parts of the world. During thermal processing operations, the fiber and phenolic content may be altered in their functionality and could result in either the decrease or increase of antioxidant and antidiabetic activities of this fruit. Hence, appropriate processing methods or culinary form should be established in order to increase the health‐promoting properties of this plant food.
    Keywords Abelmoschus esculentus ; alanine transaminase ; animal disease models ; aspartate transaminase ; blood glucose ; blood serum ; boiling ; creatinine ; crude fiber ; free radical scavengers ; fruits ; glycemic effect ; health promotion ; high fat diet ; laboratory animals ; lipid composition ; low density lipoprotein cholesterol ; metformin ; nephrotoxicity ; noninsulin-dependent diabetes mellitus ; okra ; protein content ; rats ; roasting ; seeds ; triacylglycerols ; urea
    Language English
    Dates of publication 2018-12
    Size p. e12669.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.12669
    Database NAL-Catalogue (AGRICOLA)

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