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  1. Book ; Conference proceedings: New functional aspects of the suprachiasmatic nucleus of the hypothalamus

    Nakagawa, Hachiro

    1993  

    Event/congress International Symposium on New Functional Aspects of the Suprachiasmatic Nucleus of the Hypothalamus (1991, Osaka)
    Author's details International Symposium on New Functional Aspects of the Suprachiasmatic Nucleus of the Hypothalamus, Osaka, Japan, October 1991. Ed. by Hachiro Nakagawa
    Keywords Suprachiasmatic Nucleus / physiology / congresses
    Language English
    Size VIII, 264 S. : Ill., graph. Darst.
    Publisher Libbey
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT006516637
    ISBN 0-86196-329-6 ; 978-0-86196-329-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 1049 order for loan Magazin

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  2. Book: Central regulation of energy metabolism with special reference to circadian rhythm

    Nagai, Katsuya / Nakagawa, Hachiro

    1992  

    Author's details Katsuya Nagai and Hachiro Nakagawa
    Keywords Energiestoffwechsel ; Neuroendokrine Regulation ; Nervale Regulation ; Tagesrhythmus
    Subject Circadianer Rhythmus ; Zirkadianer Rhythmus ; Tagesperiodik ; Tagesrhythmik ; Circadiane Rhythmik ; Betriebsstoffwechsel ; Neurale Regulation ; Neuroregulation
    Size 194 S. : Ill., zahlr. graph. Darst.
    Publisher CRC Pr
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004390342
    ISBN 0-8493-6657-7 ; 978-0-8493-6657-4
    Database Catalogue ZB MED Medicine, Health

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    1992 A 5976 order for loan Magazin

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  3. Article ; Online: Measuring serum prothrombin in patients treated with warfarin or direct oral anticoagulants.

    Kondo, Akira / Kondo, Hirokazu / Nakagawa, Yoshihisa / Kameyama, Hideki / Ito, Hiroyuki / Shimomura, Daiki / Yamanishi, Hachiro / Hatanaka, Noriko / Yamamoto, Yoshikazu / Iwai-Kanai, Eri / Matsuo, Shuji

    Clinica chimica acta; international journal of clinical chemistry

    2021  Volume 523, Page(s) 224–230

    Abstract: Background: Warfarin therapy influences generation of γ-carboxyglutamyl (Gla) residues in prothrombin, causing reduced coagulation activity. It will leave such inactive prothrombin in serum after clot formation, resulting in serum prothrombin ... ...

    Abstract Background: Warfarin therapy influences generation of γ-carboxyglutamyl (Gla) residues in prothrombin, causing reduced coagulation activity. It will leave such inactive prothrombin in serum after clot formation, resulting in serum prothrombin constituting total inactive prothrombin in these patients.
    Methods: An ELISA was developed to measure biologically inactive prothrombin in serum, and applied to serum from warfarin therapy causing a decrease in Gla residues or direct oral anticoagulant (DOAC) therapy as its contrast.
    Results: The concentrations of serum prothrombin in both the warfarin and DOAC groups were higher than those in the healthy group (p < 0.01 and p < 0.001, respectively). When serum in the previous three groups was treated with barium carbonate to exclude prothrombin, which lost several Gla residues, the prothrombin concentration in the DOAC group decreased to the same level as that in the healthy group, indicating that prothrombin was obtained at a high level only in the warfarin group (p < 0.01).
    Conclusions: Warfarin and DOAC led to increase in serum prothrombin concentration. The reason is that DOAC decreases prothrombin recruitment during fibrin clot formation, while warfarin leads to the accumulation of inactive prothrombin, which have a decreased number of Gla residues.
    MeSH term(s) Administration, Oral ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Blood Coagulation Tests ; Humans ; Prothrombin ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI) ; Prothrombin (9001-26-7)
    Language English
    Publishing date 2021-09-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2021.09.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Coordinated regulation of circadian rhythms and homeostasis by the suprachiasmatic nucleus.

    Nakagawa, Hachiro / Okumura, Nobuaki

    Proceedings of the Japan Academy. Series B, Physical and biological sciences

    2010  Volume 86, Issue 4, Page(s) 391–409

    Abstract: We have demonstrated that in rats activities of various enzymes related to gluconeogenesis and amino acid metabolism show circadian rhythms. Based on these results, we have explored the molecular mechanisms underlying circadian oscillation and phase ... ...

    Abstract We have demonstrated that in rats activities of various enzymes related to gluconeogenesis and amino acid metabolism show circadian rhythms. Based on these results, we have explored the molecular mechanisms underlying circadian oscillation and phase response to light of the master clock located in the dorsomedial subdivision of the suprachiasmatic nucleus (SCN) and found various proteins closely related to phase response such as BIT/SHPS-1 and those of circadian oscillation, some of which are involved in protein-tyrosine phosphorylation.On the other hand, we have presented several lines of evidence that the ventrolateral subdivision of the SCN includes not only the control center of energy supply to the brain, but also that of homeostasis such as blood glucose, blood pressure, water balance, and body temperature. We have also shown that besides these functions, the latter subdivision is involved in the regulations of hormone secretions such as insulin, glucagon, corticosterone and vasopressin. It has been also shown by electrophysiological means that light exposure to rat eye enhances sympathetic nerve activity, whereas it depresses parasympathetic nerve activity. Thus, environmental light is implicated not only in the phase-shift through the retinohypthalamic tract (RHT), but also control of autonomic nerve activities through the RHT, It is also discussed in this review how the two divisions are interconnected and how environmental light is involved in this interconnection.
    MeSH term(s) Animals ; Autonomic Nervous System/physiology ; Autonomic Nervous System/radiation effects ; Circadian Rhythm/drug effects ; Circadian Rhythm/genetics ; Circadian Rhythm/physiology ; Eating/physiology ; Eating/radiation effects ; Homeostasis/physiology ; Homeostasis/radiation effects ; Humans ; Light ; Suprachiasmatic Nucleus/metabolism ; Suprachiasmatic Nucleus/physiology ; Suprachiasmatic Nucleus/radiation effects
    Language English
    Publishing date 2010-04-09
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 161781-3
    ISSN 1349-2896 ; 0386-2208
    ISSN (online) 1349-2896
    ISSN 0386-2208
    DOI 10.2183/pjab.86.391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Erythema multiforme-like generalized contact dermatitis to l-menthol contained in anti-inflammatory medical compresses as an ingredient.

    Nakagawa, Satoshi / Tagami, Hachiro / Aiba, Setsuya

    Contact dermatitis

    2009  Volume 61, Issue 3, Page(s) 178–179

    MeSH term(s) Administration, Cutaneous ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Erythema Multiforme/chemically induced ; Female ; Humans ; Menthol/administration & dosage ; Menthol/adverse effects ; Menthol/analysis ; Patch Tests
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Menthol (1490-04-6)
    Language English
    Publishing date 2009-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/j.1600-0536.2009.01585.x
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    Zs.A 1116: Show issues Location:
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  6. Article: Rapidly growing cobblestone-like nodules as a manifestation of myeloid sarcoma.

    Nakagawa, Satoshi / Tagami, Hachiro / Ichinohasama, Ryo / Aiba, Setsuya

    Acta dermato-venereologica

    2008  Volume 88, Issue 6, Page(s) 633–634

    MeSH term(s) Aged, 80 and over ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Male ; Neoplasms, Multiple Primary/diagnosis ; Sarcoma, Myeloid/diagnosis ; Skin Neoplasms/diagnosis
    Language English
    Publishing date 2008
    Publishing country Sweden
    Document type Case Reports ; Letter
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-0521
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    Ui VI Zs.101: Show issues Location:
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  7. Article: Effective control of rush progression of CD8+ mycosis fungoides with pegylated interferon.

    Fujimura, Taku / Okuyama, Ryuhei / Hashimoto, Akira / Watanabe, Hiroshi / Nakagawa, Satoshi / Tagami, Hachiro / Aiba, Setsuya

    Acta dermato-venereologica

    2006  Volume 86, Issue 2, Page(s) 161–162

    MeSH term(s) Aged ; Antineoplastic Agents/therapeutic use ; CD8-Positive T-Lymphocytes/pathology ; Female ; Humans ; Interferon-alpha/therapeutic use ; Mycosis Fungoides/immunology ; Mycosis Fungoides/therapy ; Neoplasm Recurrence, Local/drug therapy ; Polyethylene Glycols/therapeutic use ; Radiotherapy, High-Energy ; Recombinant Proteins ; Skin Neoplasms/immunology ; Skin Neoplasms/therapy
    Chemical Substances Antineoplastic Agents ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (30IQX730WE) ; interferon alfa-2a (47RRR83SK7) ; peginterferon alfa-2a (Q46947FE7K)
    Language English
    Publishing date 2006
    Publishing country Sweden
    Document type Case Reports ; Letter
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-0017
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  8. Article: Degeneration of retinal neuronal processes and pigment epithelium in the early stage of the streptozotocin-diabetic rats.

    Aizu, Yoshinori / Oyanagi, Kiyomitsu / Hu, Jianguo / Nakagawa, Hachiro

    Neuropathology : official journal of the Japanese Society of Neuropathology

    2002  Volume 22, Issue 3, Page(s) 161–170

    Abstract: Early pathological and electro-physiological changes of the retina in the streptozotocin (STZ)-diabetic rats were investigated through optical and electron microscopy in two strains and electro-retinography in one strain. In Sprague-Dawley (SD) rats I ... ...

    Abstract Early pathological and electro-physiological changes of the retina in the streptozotocin (STZ)-diabetic rats were investigated through optical and electron microscopy in two strains and electro-retinography in one strain. In Sprague-Dawley (SD) rats I month after the onset of diabetes, the thickness of the inner plexiform layer (IPL) and photoreceptor segment layer (PSL) was significantly reduced by 9.9% and 18.9%, respectively (P < 0.01, P < 0.05). In Brown-Norway (BN) rats STZ-diabetic for 1 month, the thickness of the IPL was also significantly reduced by 15.7% (P < 0.05). Cytochemical study using peanut agglutinin (PNA), a lectin binding selectively to the cone photoreceptor-associated domains of the inter-photoreceptor matrix, revealed a marked reduction in intensity, number and length of the PNA-binding cone photoreceptors. Electron microscopy showed deepened hollows in the basal infoldings of the retinal pigment epithelium (RPE) of STZ-rats diabetic for 1 month and large concavities into the cytoplasm in STZ-rats diabetic for 6 months. Blood vessels in the retina and choroid were unremarkable. Single-flash electro-retinogram revealed a reduction in the amplitudes of alpha- and beta-waves of electro-retinogram (ERG) of 1 month STZ BN rats (P < 0.05). These findings indicate that the degeneration of rods/cones in the PSL and RPE are the most prominent pathological alteration sites in the early stage of diabetic rats.
    MeSH term(s) Animals ; Choroid/metabolism ; Choroid/pathology ; Choroid/physiopathology ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Experimental/physiopathology ; Electroretinography ; Glial Fibrillary Acidic Protein/metabolism ; Immunohistochemistry ; Male ; Microscopy, Electron ; Nerve Degeneration/pathology ; Peanut Agglutinin/metabolism ; Pigment Epithelium of Eye/metabolism ; Pigment Epithelium of Eye/pathology ; Pigment Epithelium of Eye/physiopathology ; Rats ; Rats, Sprague-Dawley ; Retina/metabolism ; Retina/physiopathology ; Retina/ultrastructure ; Time Factors
    Chemical Substances Glial Fibrillary Acidic Protein ; Peanut Agglutinin
    Language English
    Publishing date 2002-11-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1483794-8
    ISSN 1440-1789 ; 0919-6544
    ISSN (online) 1440-1789
    ISSN 0919-6544
    DOI 10.1046/j.1440-1789.2002.00439.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5086: Show issues Location:
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  9. Article: The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide.

    Oba, Ryutaro / Igarashi, Akira / Kamata, Makiko / Nagata, Kinya / Takano, Syoichi / Nakagawa, Hachiro

    The European journal of neuroscience

    2005  Volume 21, Issue 3, Page(s) 733–740

    Abstract: We reported recently that angiotensin-converting enzyme (ACE) significantly degraded amyloid beta-peptide (A beta) to inhibit aggregation and cytotoxicity of A beta in PC12h cells in vitro. On the other hand, others reported that ACE had two domains with ...

    Abstract We reported recently that angiotensin-converting enzyme (ACE) significantly degraded amyloid beta-peptide (A beta) to inhibit aggregation and cytotoxicity of A beta in PC12h cells in vitro. On the other hand, others reported that ACE had two domains with highly homologous active centres, the N-domain and C-domain, but that they differed in their characteristics such as optimum chloride ion concentration, inhibition kinetics for various ACE inhibitors and rate of hydrolysis for many substrates. The aim of this study was to determine the specific ACE domain primarily responsible for degradation of A beta. For this purpose, a series of ACE recombinant proteins, each containing only one intact domain, was constructed and expressed in COS7. Our results showed that all ACE recombinant proteins obtained were enzymatically active in terms of angiotensin I cleavage. However, inhibition of A beta aggregation and cytotoxicity of the N-domain were higher than those of the C-domain. Reverse-phase high-performance liquid chromatography analyses confirmed that the N domain degraded A beta. Our results indicate that the N domain of ACE is primarily responsible for the degradation of A beta.
    MeSH term(s) Alzheimer Disease/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Binding Sites/drug effects ; COS Cells ; Cercopithecus aethiops ; Humans ; PC12 Cells ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Peptidyl-Dipeptidase A/metabolism ; Peptidyl-Dipeptidase A/pharmacology ; Rats
    Chemical Substances Amyloid beta-Peptides ; Angiotensin-Converting Enzyme Inhibitors ; Peptide Fragments ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2005-02
    Publishing country France
    Document type Comparative Study ; Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/j.1460-9568.2005.03912.x
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    Zs.A 2548: Show issues Location:
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  10. Article: Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin-induced diabetic rats.

    Aizu, Yoshinori / Katayama, Hiroyuki / Takahama, Sachiko / Hu, Jianguo / Nakagawa, Hachiro / Oyanagi, Kiyomitsu

    Neuroreport

    2003  Volume 14, Issue 16, Page(s) 2067–2071

    Abstract: Intraocular injections of ciliary neurotrophic factor (CNTF) or intraocular adenovirus-mediated CNTF gene transfer have been reported to inhibit retinal alterations in inherited retinal degeneration in mice strains. To investigate whether or not CNTF ... ...

    Abstract Intraocular injections of ciliary neurotrophic factor (CNTF) or intraocular adenovirus-mediated CNTF gene transfer have been reported to inhibit retinal alterations in inherited retinal degeneration in mice strains. To investigate whether or not CNTF administered by eye drops prevents retinal degeneration in streptozotocin (STZ)-induced diabetic rats, recombinant CNTF was administered to eyes of diabetic rats (n=20) twice daily for 1 month after the onset of diabetes. The b-wave amplitude of electroretinogram in CNTF-administered diabetic rats was significantly larger than that of diabetic rats, and approached that of the controls. Atrophy of the inner plexiform layer, and cavity formation in the pigment epithelium, which were observed in diabetic rats, were prevented in CNTF-administered diabetic rats. These results indicate that CNTF administration by eye drops prevents retinal degeneration in STZ-induced diabetic rats.
    MeSH term(s) Animals ; Atrophy/drug therapy ; Atrophy/physiopathology ; Atrophy/prevention & control ; Blood Glucose ; Cell Death/drug effects ; Cell Death/physiology ; Ciliary Neurotrophic Factor/administration & dosage ; Ciliary Neurotrophic Factor/therapeutic use ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/complications ; Electroretinography/drug effects ; Instillation, Drug ; Male ; Nerve Degeneration/etiology ; Nerve Degeneration/physiopathology ; Nerve Degeneration/prevention & control ; Neurons/drug effects ; Neurons/pathology ; Pigment Epithelium of Eye/drug effects ; Pigment Epithelium of Eye/pathology ; Pigment Epithelium of Eye/physiopathology ; Rats ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/therapeutic use ; Retinal Degeneration/etiology ; Retinal Degeneration/physiopathology ; Retinal Degeneration/prevention & control ; Treatment Outcome
    Chemical Substances Blood Glucose ; Ciliary Neurotrophic Factor ; Recombinant Proteins
    Language English
    Publishing date 2003-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/00001756-200311140-00012
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