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  1. Article: Nurses in China lack knowledge of inhaler devices: A cross-sectional study.

    Xie, Ning / Zheng, Zheng / Yang, Qilian / Li, Man / Ye, Xiaofen

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1152069

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1152069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prediction of papillary thyroid metastases to the central compartment: proposal of a model taking into consideration other thyroid conditions.

    Chen, Qiong / Ye, Xiaofen / Wang, Kangjian / Shen, Haolin

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1299290

    Abstract: Objective: To construct risk prediction models for cervical lymph node metastasis (CLNM) of papillary thyroid carcinoma (PTC) under different thyroid disease backgrounds and to analyze and compare risk factors among different groups.: Methods: This ... ...

    Abstract Objective: To construct risk prediction models for cervical lymph node metastasis (CLNM) of papillary thyroid carcinoma (PTC) under different thyroid disease backgrounds and to analyze and compare risk factors among different groups.
    Methods: This retrospective study included 518 patients with PTC that was pathologically confirmed post-operatively from January 2021 to November 2021. Demographic, ultrasound and pathological data were recorded. Univariate and multivariate logistic regression analyses were performed to identify factors associated with CLNM in the whole patient cohort and in patients grouped according to diagnoses of Hashimoto's thyroiditis (HT), nodular goiter (NG), and no background disease. Prediction models were constructed for each group, and their performances were compared.
    Results: Analysis of the whole PTC patient cohort identified NG as independently associated with CLNM. The independent risk factors for patients with no background disease were the maximum thyroid nodule diameter and American College of Radiology Thyroid Imaging Reporting & Data System score; those for patients with HT were the maximum thyroid nodule diameter, ACR TI-RADS score, and multifocality; and those for patients with NG were the maximum thyroid nodule diameter, ACR TI-RADS score, multifocality and gender.
    Conclusion: Background thyroid disease impacts CLNM in PTC patients, and risk factors for CLNM vary among PTC patients with different background diseases. Ultrasound is useful for diagnosing background thyroid disease, which can inform treatment planning. Different prediction models are recommended for PTC cases with different thyroid diseases.
    MeSH term(s) Humans ; Thyroid Nodule/complications ; Retrospective Studies ; Carcinoma, Papillary/pathology ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/complications ; Thyroid Cancer, Papillary/pathology ; Hashimoto Disease/complications ; Lymphatic Metastasis
    Language English
    Publishing date 2023-11-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1299290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Response to: Letter to the Editor Regarding Preemptive Intravenous Nalbuphine for the Treatment of Post-Operative Visceral Pain: A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

    Liu, Xiaofen / Hu, Jun / Zhang, Ye

    Pain and therapy

    2022  Volume 11, Issue 4, Page(s) 1497–1498

    Language English
    Publishing date 2022-08-10
    Publishing country New Zealand
    Document type Letter
    ZDB-ID 2701614-6
    ISSN 2193-651X ; 2193-8237
    ISSN (online) 2193-651X
    ISSN 2193-8237
    DOI 10.1007/s40122-022-00413-w
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  4. Article: Current status and prospect of PET-related imaging radiomics in lung cancer.

    Tang, Xin / Wu, Fan / Chen, Xiaofen / Ye, Shengli / Ding, Zhongxiang

    Frontiers in oncology

    2023  Volume 13, Page(s) 1297674

    Abstract: Lung cancer is highly aggressive, which has a high mortality rate. Major types encompass lung adenocarcinoma, lung squamous cell carcinoma, lung adenosquamous carcinoma, small cell carcinoma, and large cell carcinoma. Lung adenocarcinoma and lung ... ...

    Abstract Lung cancer is highly aggressive, which has a high mortality rate. Major types encompass lung adenocarcinoma, lung squamous cell carcinoma, lung adenosquamous carcinoma, small cell carcinoma, and large cell carcinoma. Lung adenocarcinoma and lung squamous cell carcinoma together account for more than 80% of cases. Diverse subtypes demand distinct treatment approaches. The application of precision medicine necessitates prompt and accurate evaluation of treatment effectiveness, contributing to the improvement of treatment strategies and outcomes. Medical imaging is crucial in the diagnosis and management of lung cancer, with techniques such as fluoroscopy, computed radiography (CR), digital radiography (DR), computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET)/CT, and PET/MRI being essential tools. The surge of radiomics in recent times offers fresh promise for cancer diagnosis and treatment. In particular, PET/CT and PET/MRI radiomics, extensively studied in lung cancer research, have made advancements in diagnosing the disease, evaluating metastasis, predicting molecular subtypes, and forecasting patient prognosis. While conventional imaging methods continue to play a primary role in diagnosis and assessment, PET/CT and PET/MRI radiomics simultaneously provide detailed morphological and functional information. This has significant clinical potential value, offering advantages for lung cancer diagnosis and treatment. Hence, this manuscript provides a review of the latest developments in PET-related radiomics for lung cancer.
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1297674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Helicobacter pylori

    Huang, Qiuyue / Jia, Xiaofen / Chu, Yingming / Zhang, Xuezhi / Ye, Hui

    Frontiers in medicine

    2021  Volume 8, Page(s) 713908

    Abstract: Helicobacter ... ...

    Abstract Helicobacter pylori
    Language English
    Publishing date 2021-09-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.713908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Demethylzeylasteral (T-96) Alleviates Allergic Asthma via Inhibiting MAPK/ERK and NF-κB Pathway.

    Huang, Jianan / Cai, Hui / Ye, Xiaofen / Zhang, Ge / Ye, Ling / Yang, Chunxin / Wang, Jian / Jin, Meiling

    International archives of allergy and immunology

    2024  , Page(s) 1–10

    Abstract: Introduction: Demethylzeylasteral (T-96), a new extract of Tripterygium wilfordii Hook F, exerted immunomodulatory properties in autoimmune diseases, but its effect on airway inflammatory diseases remains unclear. Our study aims to explore the ... ...

    Abstract Introduction: Demethylzeylasteral (T-96), a new extract of Tripterygium wilfordii Hook F, exerted immunomodulatory properties in autoimmune diseases, but its effect on airway inflammatory diseases remains unclear. Our study aims to explore the protective effect and underlying mechanism of T-96 in allergic asthma.
    Methods: The OVA-induced asthmatic mice were administered by gavage with T-96 (0.1 mg/10 g, 0.3 mg/10 g, or 0.6 mg/10 g) 1 h before each challenge. The airway hyperresponsiveness was assessed, pathological changes were evaluated by HE and PAS staining, and expressions of Th2 cytokines were determined by PCR and ELISA. The activation of MAPK/ERK and NF-κB pathway was assessed by western blot.
    Results: T-96 significantly relieved airway hyperresponsiveness in asthmatic mice, evidenced by reduced airway resistance (Raw) and increased lung compliance dynamic compliance (Cdyn). Also, enhanced inflammatory infiltration and mucus hypersecretion were ameliorated in lungs of asthmatic mice following increasing doses of T-96 treatment, accompanied by decreased eosinophils in bronchoalveolar lavage fluid (BALF), IgE and OVA-specific IgE levels in serum, and downregulated IL-5 and IL-13 expressions in BALF and lung tissues as well. Notably, phosphorylation levels of p38 MAPK, ERK, and p65 NF-κB were obviously increased in asthmatic mice compared with the control group, which were then abrogated upon T-96 treatment.
    Conclusion: This study first revealed that T-96 alleviated allergic airway inflammation and airway hyperresponsiveness via inhibiting MAPK/ERK and NF-κB pathway. Thus, T-96 could potentially act as a new anti-inflammatory agent in allergic asthma.
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000537837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.155: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Multi-wavelength excited triplet-triplet upconversion microcrystals based on hot-band excitation for optical information encryption.

    Gu, Xiaofen / Chen, Shuoran / Liang, Zuoqin / Ju, Xiaolei / Li, Lin / Wang, Xiaomei / Ye, Changqing

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 33, Page(s) 22103–22110

    Abstract: Multi-wavelength hot-band excitation, forbidden in the conventional Stokes fluorescence mechanism, is found to be available with cascading triplet-triplet annihilation upconversion (TTA-UC). Selective excitation of Pt(II)octaethylporphyrin (PtOEP) by ... ...

    Abstract Multi-wavelength hot-band excitation, forbidden in the conventional Stokes fluorescence mechanism, is found to be available with cascading triplet-triplet annihilation upconversion (TTA-UC). Selective excitation of Pt(II)octaethylporphyrin (PtOEP) by diode lasers with wavelengths of 532 nm, 589 nm, 635 nm, 655 nm, and 671 nm respectively can all induce 9,10-diphenylanthracene (DPA) to emit blue upconversion, with the maximum anti-Stokes shift of 0.95 eV in the microcrystals exposed to air. Whether the zero-vibrational energy level excitation or the hot-vibrational energy level excitation in the ground state, the PtOEP/DPA pair showed triplet-triplet energy transfer (TTET) efficiencies approaching ∼95%. The doped microcrystal samples without encapsulation can emit blue upconversion from green/yellow/red excitation with stability for ∼20 days under atmospheric conditions, demonstrating their potential applications in multiple information encryption.
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp02199h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The central helicase domain holds the major conformational epitopes of melanoma differentiation-associated gene 5 autoantibodies.

    Mo, Yongxin / Ye, Yan / Peng, Lisheng / Sun, Xiaobo / Zhong, Xiaofen / Wu, Rui

    Rheumatology (Oxford, England)

    2023  

    Abstract: Objectives: Autoantibodies against MDA5 serve as a biomarker for dermatomyositis (DM) and a risk factor for interstitial lung disease (ILD). MDA5 is a protein responsible for sensing RNA virus infection and activating signalling pathways against it. ... ...

    Abstract Objectives: Autoantibodies against MDA5 serve as a biomarker for dermatomyositis (DM) and a risk factor for interstitial lung disease (ILD). MDA5 is a protein responsible for sensing RNA virus infection and activating signalling pathways against it. However, little is known about antigen epitopes on MDA5 autoantibodies. We aimed to determine the interaction of the MDA5 autoantibody-antigen epitope.
    Methods: Cell-based assays (CBAs), immunoprecipitation-immunoblot assays, and various immunoblotting techniques were used in the study.
    Results: We demonstrate that DM patient autoantibodies recognize MDA5 epitopes in a native conformation-dependent manner. Furthermore, we identified the central helicase domain formed by Hel1, Hel2i, Hel2, and pincer (3Hel) as the major epitopes. As proof of principle, the purified 3Hel efficiently absorbed MDA5 autoantibodies from patient sera through immunoprecipitation-immunoblot assay.
    Conclusion: Our study uncovers the nature of antigen epitopes on MDA5 and provides guidance for diagnosis and targeted therapeutic approach development.
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead397
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
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    Zs.MO 497: Show issues

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  9. Article ; Online: Altered trends of local brain function in classical trigeminal neuralgia patients after a single trigger pain.

    Yan, Juncheng / Wang, Luoyu / Pan, Lei / Ye, Haiqi / Zhu, Xiaofen / Feng, Qi / Wang, Haibin / Ding, Zhongxiang / Ge, Xiuhong

    BMC medical imaging

    2024  Volume 24, Issue 1, Page(s) 66

    Abstract: Objective: To investigate the altered trends of regional homogeneity (ReHo) based on time and frequency, and clarify the time-frequency characteristics of ReHo in 48 classical trigeminal neuralgia (CTN) patients after a single pain stimulate.: Methods! ...

    Abstract Objective: To investigate the altered trends of regional homogeneity (ReHo) based on time and frequency, and clarify the time-frequency characteristics of ReHo in 48 classical trigeminal neuralgia (CTN) patients after a single pain stimulate.
    Methods: All patients underwent three times resting-state functional MRI (before stimulation (baseline), after stimulation within 5 s (triggering-5 s), and in the 30th min of stimulation (triggering-30 min)). The spontaneous brain activity was investigated by static ReHo (sReHo) in five different frequency bands and dynamic ReHo (dReHo) methods.
    Results: In the five frequency bands, the number of brain regions which the sReHo value changed in classical frequency band were most, followed by slow 4 frequency band. The left superior occipital gyrus was only found in slow 2 frequency band and the left superior parietal gyrus was only found in slow 3 frequency band. The dReHo values were changed in midbrain, left thalamus, right putamen, and anterior cingulate cortex, which were all different from the brain regions that the sReHo value altered. There were four altered trends of the sReHo and dReHo, which dominated by decreased at triggering-5 s and increased at triggering-30 min.
    Conclusions: The duration of brain function changed was more than 30 min after a single pain stimulate, although the pain of CTN was transient. The localized functional homogeneity has time-frequency characteristic in CTN patients after a single pain stimulate, and the changed brain regions of the sReHo in five frequency bands and dReHo complemented to each other. Which provided a certain theoretical basis for exploring the pathophysiology of CTN.
    MeSH term(s) Humans ; Brain Mapping ; Trigeminal Neuralgia/diagnostic imaging ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Pain
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2061975-3
    ISSN 1471-2342 ; 1471-2342
    ISSN (online) 1471-2342
    ISSN 1471-2342
    DOI 10.1186/s12880-024-01239-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Enhanced functional connectome of cerebellum in chronic insomnia patients.

    Lin, Shiqi / Ye, Xi / Yang, Yuping / Yang, Jingyi / Xu, Guang / Wang, Xinzhi / Ma, Xiaofen

    Brain and behavior

    2023  Volume 13, Issue 7, Page(s) e3103

    Abstract: Background: Functional abnormalities of the cerebellum have been found to be closely associated with chronic insomnia (CI). However, whether there are abnormalities in the topology of the functional connectome of the cerebellum in these patients is ... ...

    Abstract Background: Functional abnormalities of the cerebellum have been found to be closely associated with chronic insomnia (CI). However, whether there are abnormalities in the topology of the functional connectome of the cerebellum in these patients is still unknown. This study aimed to investigate topological abnormalities of the cerebellar functional connectome in individuals with CI.
    Materials and methods: We used resting-state functional magnetic resonance imaging (rs-fMRI) and graph-theoretic analysis to construct a functional connectivity matrix and extract topological property features of the cerebellar functional connectome in patients with CI. We examined global and nodal topological property changes in the cerebellar functional connectome in 102 patients with CI (CI group) and 101 healthy participants without insomnia symptoms (HC group) to determine the differences between groups. Correlations between the topological properties of the cerebellar functional connectome and clinical assessments were calculated to confirm the differences between groups.
    Results: The cerebellar functional connectome of both CI and HC patients exhibited small-world properties. The CI group showed higher standardized clustering coefficients at the global properties and higher betweenness centrality in the cerebellar Crus II vermis region at the nodal properties compared with participants in the HC group. However, the topological properties of cerebellar functional connectome abnormalities in the CI group were not significantly different from those in clinical assessments.
    Conclusion: Our findings suggest that the abnormal global and nodal topological properties of the cerebellar functional connectome are associated with CI and could serve as an important biomarker for CI.
    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/diagnostic imaging ; Brain ; Connectome/methods ; Magnetic Resonance Imaging/methods ; Cerebellum/diagnostic imaging
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.3103
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