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  1. Article: Cannabinoid-Induced Stereoselective Inhibition of R-S-Oxazepam Glucuronidation: Cannabinoid-Oxazepam Drug Interactions.

    Bardhi, Keti / Coates, Shelby / Chen, Gang / Lazarus, Philip

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: ... by glucuronidation, with S-oxazepam metabolized primarily by UGT2B15 and R-oxazepam glucuronidation mediated ...

    Abstract Benzodiazepines (BZDs) such as oxazepam are commonly prescribed depressant drugs known for their anxiolytic, hypnotic, muscle relaxant, and anticonvulsant effects and are frequently used in conjunction with other illicit drugs including cannabis. Oxazepam is metabolized in an enantiomeric-specific manner by glucuronidation, with S-oxazepam metabolized primarily by UGT2B15 and R-oxazepam glucuronidation mediated by both UGT 1A9 and 2B7. The goal of the present study was to evaluate the potential inhibitory effects of major cannabinoids, Δ
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Fifty years of research and theory of R. S. Lazarus

    Lazarus, Richard S

    an analysis of historical and perennial issues

    1998  

    Author's details Richard S. Lazarus
    Keywords Psychology, Experimental/History
    Language English
    Size XXIII, 425 S., Ill., graph. Darst, 24 cm
    Publisher Erlbaum
    Publishing place Mahwah, NJ u.a.
    Document type Book
    Note Hier auch später erschienene, unveränderte Nachdrucke ; Literaturverz. S. 405 - 411
    ISBN 0805826572 ; 9780805826579
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  3. Book: Fifty years of research and theory by R.S. Lazarus

    Lazarus, Richard S

    an analysis of historical and perennial issues

    1998  

    Author's details Richard S. Lazarus
    MeSH term(s) Psychology, Experimental/history
    Language English
    Size xxiii, 425 p. :, ill.
    Publisher Lawerence Erlbaum Associates
    Publishing place Mahwah, N.J
    Document type Book
    ISBN 9780805826579 ; 0805826572
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article: Angstlichkeit, die S/R-Dimension und das Bewerten von Bildinhalten.

    Lazarus-Mainka, G / Bähr, M / Opitz, B

    Zeitschrift fur experimentelle und angewandte Psychologie

    1981  Volume 28, Issue 4, Page(s) 637–650

    Title translation Anxiety, the S/R dimension and the evaluation of picture contents.
    MeSH term(s) Adult ; Affect ; Anxiety/psychology ; Form Perception ; Humans ; Pattern Recognition, Visual ; Repression-Sensitization
    Language German
    Publishing date 1981
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 200129-9
    ISSN 0044-2712
    ISSN 0044-2712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1461: Show issues Location:
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  5. Article ; Online: Political homophobia and the effect on GBMSM programmes in Kenya: The significance of a community-led rapid agency assessment.

    Walimbwa, Jeffrey / Macharia, Pascal / Wambua, Solomon / Lazarus, Lisa / Lorway, Robert

    Global public health

    2023  Volume 18, Issue 1, Page(s) 2271989

    Abstract: A recent Supreme Court ruling that permitted LGBTQ + rights organisations to officially register as non-governmental organisations has led to rises in political homophobia in Kenya. Community leaders initiated and led a rapid agency assessment to examine ...

    Abstract A recent Supreme Court ruling that permitted LGBTQ + rights organisations to officially register as non-governmental organisations has led to rises in political homophobia in Kenya. Community leaders initiated and led a rapid agency assessment to examine the effects of this rising political homophobia on sexual health services access for gay, bisexual and other men who have sex with men (GBMSM). This survey assessment engaged directors and programme managers running 20 community-based organisations (CBOs) representing 19 Kenyan counties, serving the sexual health needs of more than >25,000 GBMSM. In addition to prevalent shutdowns of health services, respondents reported growing religious tensions, fears and threats of attack, withdrawal of local county government support, and rising religious tensions. At a moment when highly oppressive anti-LGBTQ + legislation has been drafted and debated in parliament, in the name of 'family protection', this commentary makes an appeal to allied health officials and global funding partners to make more explicit statements that call attention to the negative consequences of political homophobia on the grounds of public health and human rights.
    MeSH term(s) Male ; Humans ; Homosexuality, Male ; Sexual and Gender Minorities ; Kenya ; HIV Infections/prevention & control ; Homophobia
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234129-8
    ISSN 1744-1706 ; 1744-1706
    ISSN (online) 1744-1706
    ISSN 1744-1706
    DOI 10.1080/17441692.2023.2271989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Designing a nanothermometer using gel-to-liquid phase transition property of hybrid niosome.

    Lazarus, Ronak / Kothari, Rupal / Kaja, Sravani / Venuganti, Venkata Vamsi Krishna / Nag, Amit

    The Analyst

    2023  Volume 148, Issue 14, Page(s) 3169–3173

    Abstract: The gel-to-liquid phase transition property of a hybrid niosome, which is made with a non-ionic surfactant, span 60 (S60), and triblock copolymer L64, is effectively utilized to design a nanothermometer for temperature sensing in the physiological range ( ...

    Abstract The gel-to-liquid phase transition property of a hybrid niosome, which is made with a non-ionic surfactant, span 60 (S60), and triblock copolymer L64, is effectively utilized to design a nanothermometer for temperature sensing in the physiological range (20 °C to 50 °C). The fluorescence signal of a polarity-sensitive probe, Coumarin 153, loaded into the niosome, is used as an indicator for temperature sensing. Due to its excellent temperature sensitivity and resolution, the sensor is capable of sensing temperature inside FaDu cells.
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d3an00557g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2423: Show issues Location:
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  7. Article ; Online: One Year On: Poland's Public Health Initiatives and National Response to Millions of Refugees from Ukraine.

    Jankowski, Mateusz / Lazarus, Jeffrey V / Kuchyn, Iurii / Zemskov, Sergii / Gałązkowski, Robert / Gujski, Mariusz

    Medical science monitor : international medical journal of experimental and clinical research

    2023  Volume 29, Page(s) e940223

    Abstract: The Russian military invasion of Ukraine on February 24, 2022, resulted in the largest refugee crisis in Europe since World War II. As a neighboring country to Ukraine, Poland was the main country to initially receive refugees. Between February 24, 2022, ...

    Abstract The Russian military invasion of Ukraine on February 24, 2022, resulted in the largest refugee crisis in Europe since World War II. As a neighboring country to Ukraine, Poland was the main country to initially receive refugees. Between February 24, 2022, and February 24, 2023, 10.056 million refugees from Ukraine, mainly women and children, crossed the Polish-Ukrainian border. Up to 2 million of these refugees from Ukraine found shelter in private homes throughout Poland. More than 90% of the resident refugees in Poland were women and children, and approximately 900 000 refugees from Ukraine have sought employment, mainly in the services sector. Since February 2022, there has been rapid development of a national legal framework to ensure access to healthcare, including providing refugees who are healthcare workers with job opportunities. Epidemiological surveillance and prevention programs for infectious diseases and mental health support systems have been implemented. These initiatives have required the use of language translators to ensure that there are no barriers to understanding and implementing public health measures. Hopefully, the lessons learned from Poland and neighboring countries that have hosted millions of Ukrainian refugees can help future preparedness for supporting refugees. This review aims to summarize the lessons learned by the Polish public health services during the past year and outlines the public health initiatives that have been implemented and are still ongoing.
    MeSH term(s) Child ; Female ; Humans ; Male ; Ukraine ; Poland ; Public Health ; Refugees ; Europe
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/MSM.940223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4924: Show issues Location:
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  8. Article ; Online: A person-centred approach to enhance the long-term health and wellbeing of people living with HIV in Europe.

    Lazarus, Jeffrey V / Cascio, Mario / Anderson, Jane / Pasanen, Sini / Harding, Richard

    Journal of the International AIDS Society

    2023  Volume 26 Suppl 1, Page(s) e26117

    MeSH term(s) Humans ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Europe/epidemiology ; Quality of Life
    Language English
    Publishing date 2023-06-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.26117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Multifaceted Quality Improvement Interventions to Prevent Hemodialysis Catheter-Related Bloodstream Infections: A Systematic Review.

    Lazarus, Benjamin / Bongetti, Elisa / Ling, Jonathan / Gallagher, Martin / Kotwal, Sradha / Polkinghorne, Kevan R

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2023  Volume 82, Issue 4, Page(s) 429–442.e1

    Abstract: Rationale & objective: Central venous catheters (CVCs) are widely used for hemodialysis but are prone to burdensome and costly bloodstream infections. We determined whether multifaceted quality improvement interventions in hemodialysis units can prevent ...

    Abstract Rationale & objective: Central venous catheters (CVCs) are widely used for hemodialysis but are prone to burdensome and costly bloodstream infections. We determined whether multifaceted quality improvement interventions in hemodialysis units can prevent hemodialysis catheter-related bloodstream infections (HDCRBSI).
    Study design: Systematic review.
    Setting & study populations: PubMed, EMBASE, and CENTRAL were searched from inception to April 23, 2022, to identify randomized trials, time-series analyses, and before-after studies that examined the effect of multifaceted quality improvement interventions on the incidence of HDCRBSI or access-related bloodstream infections (ARBSI) among people receiving hemodialysis outside of the intensive care unit (ICU).
    Data extraction: Two people independently extracted data and assessed the risk of bias and quality of evidence using validated tools.
    Analytical approach: Intervention effects, validity, and characteristics of studies with the same design were compared. Differences between study designs were described.
    Results: We included 21 studies from 8,824 identified by our search. Among 15 studies that measured HDCRBSI, 2 methodologically heterogenous cluster randomized trials reported discordant intervention effects, 2 interrupted time-series analyses reported favorable interventions with discordant patterns of effect, and 11 before-after studies reported favorable interventions with a very high risk of bias. Among 6 studies that only measured ARBSI, 1 time-series analysis and 1 before-after study did not find a favorable intervention effect, and 4 before-after studies reported a favorable effect with a very high risk of bias. The overall quality of evidence was low for HDCRBSI and very low for ARBSI.
    Limitations: Nine definitions of HDCRBSI were used. Ten studies included hospital-based and satellite facilities but did not report separate intervention effects for each type of facility.
    Conclusions: Multifaceted quality improvement interventions may prevent HDCRBSI outside the ICU. However, evidence supporting them is of low quality, and further carefully conducted studies are warranted.
    Registration: Registered at PROSPERO with registration number CRD42021252290.
    Plain-language summary: People with kidney failure rely on central venous catheters to facilitate life-sustaining hemodialysis treatments. Unfortunately, hemodialysis catheters are a common source of problematic bloodstream infections. Quality improvement programs have effectively prevented catheter-related infections in intensive care units, but it is unclear whether they can be adapted to patients using hemodialysis catheters in the community. In a systematic review that included 21 studies, we found that most quality improvement programs were reported to be successful. However, the findings were mixed among higher-quality studies, and overall the quality of evidence was low. Ongoing quality improvement programs should be complemented by more high-quality research.
    MeSH term(s) Humans ; Quality Improvement ; Central Venous Catheters/adverse effects ; Intensive Care Units ; Sepsis ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/prevention & control
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2023.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1669: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 468: Show issues

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  10. Article ; Online: Management of proximal humerus bone loss with allograft prosthetic composite technique in shoulder arthroplasty.

    Cox, Ryan M / Mandava, Nikhil / Lazarus, Mark D / Williams, Gerald R / Namdari, Surena

    Journal of shoulder and elbow surgery

    2023  

    Abstract: Background: Proximal humerus bone loss in shoulder arthroplasty is a difficult problem with limited treatment options. It most commonly occurs in the setting of a previously failed shoulder arthroplasty; however, it is occasionally encountered in cases ... ...

    Abstract Background: Proximal humerus bone loss in shoulder arthroplasty is a difficult problem with limited treatment options. It most commonly occurs in the setting of a previously failed shoulder arthroplasty; however, it is occasionally encountered in cases of primary shoulder arthroplasty. Reconstruction of the proximal humerus is essential for soft tissue tension for implant stability and maximizing function. The purpose of this study was to analyze the clinical and functional outcomes of the allograft prosthetic composite (APC) technique for the management of proximal humeral bone loss in shoulder arthroplasty.
    Methods: A retrospective review was performed of all patients who underwent primary or revision shoulder arthroplasty using an APC technique with a reverse shoulder arthroplasty prosthesis for the management of proximal humerus bone loss. Data collected included demographic variables, previous shoulder surgeries, indication for APC, type of allograft utilized, fixation technique, and reoperation and revision rates. Patients were contacted by phone and/or email survey to obtain the latest patient-reported functional outcome scores.
    Results: We identified 14 patients who underwent shoulder arthroplasty using the APC technique with a reverse shoulder arthroplasty prosthesis. One (7.1%) was performed as a primary arthroplasty, and 13 (92.9%) were performed as revision arthroplasties. The indications for APC were instability (21.4%), periprosthetic fracture (21.4%), periprosthetic joint infection (14.3%), humeral component loosening (14.3%), rotator cuff failure (14.3%), fracture sequelae (7.1%), and failed hemiarthroplasty (7.1%). In terms of allograft type, 10 (71.4%) were performed with proximal femur allograft and 4 (28.6%) with proximal humerus allograft. There were 6 patients (42.9%) who sustained postoperative complications, 5 patients (35.7%) had instability, and 1 (7.1%) patient had postoperative wound drainage. All patients with a complication required a revision arthroplasty.
    Conclusion: The APC technique used to address proximal humerus bone loss in shoulder arthroplasty has a high complication rate with fair patient-reported functional outcome scores. Most of the postoperative complications and reoperations are related to implant instability.
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1170782-3
    ISSN 1532-6500 ; 1058-2746
    ISSN (online) 1532-6500
    ISSN 1058-2746
    DOI 10.1016/j.jse.2023.09.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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