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Article: Clinical studies of 5-HT function using i.v. L-tryptophan.

Price, L H / Charney, D S / Delgado, P L / Goodman, W K / Krystal, J H / Woods, S W / Heninger, G R

Progress in neuro-psychopharmacology & biological psychiatry

1990 Volume 14, Issue 4, Page(s) 459–472

Abstract: ... such clinical studies, the pharmacological challenge strategy has proven particularly useful. 2. I.v. L-TRP has ... of 5-HT function. I.v. L-TRP increases serum prolactin (PRL) in humans, probably via 5-HT mechanisms ... Under carefully standardized conditions, this PRL response to L-TRP appears to be a reasonably sensitive ...

Abstract	1. Preclinical studies reveal that long-term treatment with antidepressant drugs induces significant changes in serotonergic (5-HT) receptor sensitivity. Similarly, clinical studies suggest that brain 5-HT function is abnormal in depression. Of the available methodologies for conducting such clinical studies, the pharmacological challenge strategy has proven particularly useful. 2. I.v. L-TRP has emerged as the most frequently used challenge agent in diagnostic and neuropsychopharmacological studies of 5-HT function. I.v. L-TRP increases serum prolactin (PRL) in humans, probably via 5-HT mechanisms. Under carefully standardized conditions, this PRL response to L-TRP appears to be a reasonably sensitive and valid measure of net 5-HT function. 3. The PRL response to L-TRP is blunted in depressed patients compared with healthy controls. Blunting has not been observed in panic disorder, obsessive compulsive disorder, or schizophrenia, although preliminary findings suggest it may occur in bulimia. 4. The PRL response to L-TRP is enhanced by certain classes of thymoleptic drugs (TCAs, MAOIs, 5-HT reuptake inhibitors, lithium) in a differentially time-dependent fashion. So-called "atypical" antidepressants (trazodone, mianserin) and benzodiazepines have no effect. Such findings are generally consistent with preclinical electrophysiological findings. 5. These clinical studies of the PRL response to L-TRP, in conjunction with emerging evidence that experimentally reduced plasma TRP can reverse the therapeutic effects of some antidepressants, suggest that antidepressant drug action may be more accurately conceptualized as 5-HT dependent rather than 5-HT enhancing. The availability of more selective 5-HT-active drugs promises to further clarify 5-HT mechanisms of neuropsychiatric disease and drug action at the clinical level.
MeSH term(s)	Animals ; Humans ; Psychotropic Drugs/pharmacology ; Serotonin/pharmacology ; Serotonin/physiology ; Tryptophan/pharmacology
Chemical Substances	Psychotropic Drugs ; Serotonin (333DO1RDJY) ; Tryptophan (8DUH1N11BX)
Language	English
Publishing date	1990
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/0278-5846(90)90002-x
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Zs.A 1342: Show issues

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Article: Arsonate-specific murine T cell clones. V. Antigen presentation by L cells transfected with normal and mutant class II genes.

Norton, F L / Davis, C B / Jones, P P / Goodman, J W

Journal of immunology (Baltimore, Md. : 1950)

1989 Volume 143, Issue 2, Page(s) 446–451

Abstract: Class II-restricted murine T cell clones specific for the immunogenic determinant L-tyrosine ... p-azobenzenearsonate failed to proliferate to Ag presented by L cell lines transfected with and expressing ... for the presentation of L-tyrosine-p-azobenzenearsonate. Site-directed mutagenesis of polymorphic positions in the beta ...

Abstract	Class II-restricted murine T cell clones specific for the immunogenic determinant L-tyrosine-p-azobenzenearsonate failed to proliferate to Ag presented by L cell lines transfected with and expressing the appropriate class II genes, but are activated to kill the APC in an Ag-dependent, MHC-restricted manner. Inhibition of APC proliferation was used as an assay to determine the relative contributions of polymorphic sites on the class II alpha- and beta-chains to MHC-restricted activation of I-A beta k-restricted cloned T cells. Transfectants expressing A beta k in conjunction with the alpha chain of k, u, or d were equally effective APCs, whereas transfectants expressing A beta u were completely ineffective, implicating the beta-chain as more critical for the presentation of L-tyrosine-p-azobenzenearsonate. Site-directed mutagenesis of polymorphic positions in the beta chain revealed a remarkable stringency for the k haplotype, in contrast to the relaxed alpha-chain requirement. These results, in conjunction with others, indicate that the relative contribution of polymorphic sites on class II alpha- and beta-chains to T cell Ag recognition can differ markedly, and, furthermore, may vary as a function of the Ag.
MeSH term(s)	Animals ; Antigen-Presenting Cells/immunology ; Azo Compounds/immunology ; Clone Cells/classification ; Clone Cells/immunology ; Cytotoxicity, Immunologic ; Epitopes/immunology ; Genes, MHC Class II ; Histocompatibility Antigens Class II/genetics ; L Cells (Cell Line)/immunology ; L Cells (Cell Line)/metabolism ; Mice ; Mice, Inbred A ; Mutation ; Protein Conformation ; T-Lymphocytes, Cytotoxic/classification ; T-Lymphocytes, Cytotoxic/immunology ; Transfection ; Tyrosine/analogs & derivatives ; Tyrosine/immunology ; p-Azobenzenearsonate/analogs & derivatives ; p-Azobenzenearsonate/immunology
Chemical Substances	Azo Compounds ; Epitopes ; Histocompatibility Antigens Class II ; tyrosine-4-azobenzenearsonate (33650-94-1) ; Tyrosine (42HK56048U) ; p-Azobenzenearsonate (7334-23-8)
Language	English
Publishing date	1989-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Imaging in the investigation and management of Staphylococcus aureus bacteraemia: a role for advanced imaging techniques.

Goodman, A L / Cook, G J / Goh, V

The Journal of hospital infection

2020 Volume 105, Issue 2, Page(s) 234–241

Abstract: Staphylococcus aureus bacteraemia (SAB) continues to affect ∼25,000 patients in the UK per year with a high crude mortality of 30% at 90 days. Prompt source control improves outcomes in sepsis and SAB and is included in sepsis guidelines. A recent ... ...

Abstract	Staphylococcus aureus bacteraemia (SAB) continues to affect ∼25,000 patients in the UK per year with a high crude mortality of 30% at 90 days. Prompt source control improves outcomes in sepsis and SAB and is included in sepsis guidelines. A recent clinical trial of adjunctive antibiotic treatment in SAB found that the majority of recurrences of SAB were associated with a failure of source management. In this condition, the ability to control the source of infection may be limited by the ability to detect a focus of infection. Echocardiogram is now a routinely used tool to detect such unknown foci in the form of unexpected infectious vegetations. We review the literature to explore the utility of advanced imaging techniques, such as [18F]fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and magnetic resonance imaging (including whole-body MRI), to detect foci which may otherwise be missed. As unknown foci are associated with increased mortality, we propose that increasing the detection of foci could enable improved source control and result in improved outcomes in SAB.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Bacteremia/diagnostic imaging ; Diagnostic Imaging/methods ; Disease Management ; Echocardiography ; Humans ; Positron Emission Tomography Computed Tomography ; Standard of Care ; Staphylococcal Infections/diagnostic imaging ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/prevention & control ; United Kingdom
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-01-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	779366-2
ISSN	1532-2939 ; 0195-6701
ISSN (online)	1532-2939
ISSN	0195-6701
DOI	10.1016/j.jhin.2020.01.007
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Zs.A 1586: Show issues

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Article ; Online: Progress and Pitfalls in the Provision of Quality Care for Adults With Attention Deficit Hyperactivity Disorder in Primary Care.

Callen, Elisabeth F / Clay, Tarin L / Alai, Jillian / Goodman, David W / Adler, Lenard A / Shields, Joel / Faraone, Stephen V

Journal of attention disorders

2023 Volume 27, Issue 6, Page(s) 575–582

Abstract: Objective: Quality care for attention deficit hyperactivity disorder (ADHD) in adults has lagged behind other psychiatric disorders. We sought to assess how the achievement of quality measures (QMs) for diagnosing and treating ADHD in adults has changed ...

Abstract	Objective: Quality care for attention deficit hyperactivity disorder (ADHD) in adults has lagged behind other psychiatric disorders. We sought to assess how the achievement of quality measures (QMs) for diagnosing and treating ADHD in adults has changed over time. Method: We assessed 10 QMs in electronic health records (EHRs) from primary care and behavioral health clinics from 2010 to 2020 for 71,310 patients diagnosed with ADHD. Results: The achievement of QMs increased over time ( Conclusion: Increase in quality care from 2010 to 2020 along with clear evidence that more efforts are needed to improve quality of care for adults with ADHD seen in primary care.
MeSH term(s)	Humans ; Adult ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/therapy ; Quality of Health Care ; Primary Health Care
Language	English
Publishing date	2023-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/10870547231155875
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Zs.A 5196: Show issues

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Article ; Online: Participant Acceptability of Questionnaires Impacts Sexual Victimization Prevalence Rates.

Anderson, RaeAnn E / Goodman, Erica L / Carstens Namie, Emily M

Journal of child sexual abuse

2023 Volume 32, Issue 6, Page(s) 771–789

Abstract: ... Refusal Sexual Persistence Scales-Victimization (PRSPS-V). Participants then answered questions ... about each measure's perceived difficulty and their preference between the two. Participants found the PRSPS-V easier ... who preferred the PRSPS-V reported more instances of sexual victimization on the PRSPS-V by 9.8%. Our results ...

Abstract	Obtaining accurate prevalence rates of sexual violence is made difficult by discrepancies in self-report questionnaires. Thus, the current study sought to explore participants' perceptions of acceptability (i.e., perceived difficulty and preference) as a potential mechanism of discrepancy between different questionnaires. Participants were 673 college students who completed two frequently used sexual victimization questionnaires, the Sexual Experiences Survey-Short Form Victimization (SES-SFV) and the Post-Refusal Sexual Persistence Scales-Victimization (PRSPS-V). Participants then answered questions about each measure's perceived difficulty and their preference between the two. Participants found the PRSPS-V easier to understand and preferred it 2.5 to 1 over the SES-SFV. Preference was related to reporting; participants who preferred the PRSPS-V reported more instances of sexual victimization on the PRSPS-V by 9.8%. Our results indicate that acceptability impacts reported prevalence rates and is one mechanism of discrepancy between questionnaires. Thus, researchers may wish to consider acceptability when choosing sexual victimization questionnaires.
MeSH term(s)	Humans ; Child ; Prevalence ; Universities ; Child Abuse, Sexual ; Sex Offenses ; Crime Victims ; Surveys and Questionnaires ; Rape
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1158969-3
ISSN	1547-0679 ; 1053-8712
ISSN (online)	1547-0679
ISSN	1053-8712
DOI	10.1080/10538712.2023.2240778
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Zs.A 3736: Show issues

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Article ; Online: Adult hypertension referral pathway and therapeutic management: British and Irish Hypertension Society position statement.

Lewis, Philip / George, Jacob / Kapil, Vikas / Poulter, Neil R / Partridge, Sarah / Goodman, James / Faconti, Luca / McCormack, Terry / Wilkinson, Ian B

Journal of human hypertension

2024 Volume 38, Issue 1, Page(s) 3–7

Abstract: In the UK, most adults with hypertension are managed in Primary Care. Referrals to Secondary Care Hypertension Specialists are targeted to patients in whom further investigations are likely to change management decisions. In this position statement the ... ...

Abstract	In the UK, most adults with hypertension are managed in Primary Care. Referrals to Secondary Care Hypertension Specialists are targeted to patients in whom further investigations are likely to change management decisions. In this position statement the British and Irish Hypertension Society provide clinicians with a framework for referring patients to Hypertension Specialists. Additional therapeutic advice is provided to optimise patient management whilst awaiting specialist review. Our aim is to ensure that referral criteria to Hypertension Specialists are consistent across the UK and Ireland to ensure equitable access for all patients.
MeSH term(s)	Adult ; Humans ; Hypertension/diagnosis ; Hypertension/therapy ; Ireland ; Referral and Consultation ; White People ; United Kingdom
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/s41371-023-00882-2
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Zs.A 2380: Show issues

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Article ; Online: Determinants of gestational surrogates' satisfaction in relation to the characteristics of surrogacy cases.

Yee, Samantha / Goodman, Carly V / Librach, Clifford L

Reproductive biomedicine online

2019 Volume 39, Issue 2, Page(s) 249–261

Abstract: Research question: The study undertook an evaluation of the retrospective experiences of gestational surrogates within a Canadian context.: Design: Data were collected using an anonymous online survey from June 2016 to February 2017 with participants ...

Abstract	Research question: The study undertook an evaluation of the retrospective experiences of gestational surrogates within a Canadian context. Design: Data were collected using an anonymous online survey from June 2016 to February 2017 with participants recruited from the Canadian surrogacy community and the internet. The characteristics of surrogacy arrangements carried out by the participants, factors influencing their surrogacy satisfaction, the impact of surrogacy on their family functioning, and their attitudes towards carrying a pregnancy for different types of intended parents were analysed. Results: A total of 184 gestational surrogates (mean age at surrogacy 32 years, range 21-48 years) who were involved in 287 arrangements completed a study-specific survey. More than three-quarters of these cases involved an agency (225 cases, 78.4%). Most of the intended parents were heterosexual couples (158, 55.1%), followed by same-sex male couples (113, 39.4%). More than one-third of these cases were for non-residents from 15 different countries (n = 108, 37.6%). The two main determinants of surrogates' satisfaction were being a surrogate for domestic intended parents (P < 0.05) and having a viable pregnancy outcome (P < 0.005). Nine out of ten participants were comfortable with carrying a pregnancy for same-sex male couples (93.4%) and cancer survivors (89.6%), yet less than one-third (30.7%) were comfortable with being a surrogate for heterosexual couples at advanced ages of over 50 years. Conclusions: The findings suggest that many intended parents, including same-sex male couples and non-residents, used Canadian surrogacy services to build their families. A better understanding of the fundamentals contributing to positive experiences would help clinicians develop better practice models to care for the well-being of surrogates.
MeSH term(s)	Adult ; Canada ; Female ; Humans ; Internet ; Male ; Middle Aged ; Oocyte Donation ; Personal Satisfaction ; Pregnancy ; Pregnancy Outcome ; Reproductive Techniques, Assisted ; Retrospective Studies ; Sexual and Gender Minorities ; Surrogate Mothers/psychology ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2019-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2019.04.001
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Zs.A 5792: Show issues

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Article ; Online: Publisher Correction: Advancing T cell-based cancer therapy with single-cell technologies.

Bucktrout, Samantha L / Banovich, Nicholas E / Butterfield, Lisa H / Cimen-Bozkus, Cansu / Giles, Josephine R / Good, Zinaida / Goodman, Daniel / Jonsson, Vanessa D / Lareau, Caleb / Marson, Alexander / Maurer, Deena M / Munson, Paul V / Stubbington, Mike / Taylor, Sarah / Cutchin, Abbey

Nature medicine

2024

Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-024-02841-x
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Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: "They just looked at me like I was human": The experiences of parenting women and providers with substance use disorder treatment.

Bosak, J / Messersmith, L / Bryer, C / Drainoni, M / Goodman, D / Adams, M / Barry, T / Flanagan, C / Flanagan, V / Wolff, K / Declercq, E

Journal of substance use and addiction treatment

2023 Volume 157, Page(s) 209240

Abstract: Background: The current US addiction treatment system does not effectively meet the needs of pregnant and parenting women with substance use disorder (SUD). The aim of this research was to identify barriers and facilitators to engagement and retention ... ...

Abstract	Background: The current US addiction treatment system does not effectively meet the needs of pregnant and parenting women with substance use disorder (SUD). The aim of this research was to identify barriers and facilitators to engagement and retention in SUD residential treatment for pregnant and parenting women. This research was part of a co-design process to collaboratively create a more patient-centered long-term residential program. Design and methods: The study conducted semi-structured individual interviews with both parenting women with lived experience (WWLE) in residential SUD treatment and SUD treatment providers. Interviews aimed to elicit participants' experiences either receiving or providing care. The study team analyzed data in NVivo-12 using a deductive codebook based on the six principles of trauma informed care (TIC). Results: We conducted a total of 32 interviews (WWLE =13, SUD providers =19). The study identified four major themes: 1) peer relationships provide inspiration and diminish shame; 2) providing individuals safe space to stumble in recovery creates opportunities for growth and builds self-efficacy; 3) reasonable, clear boundaries create a structured, protective environment for early recovery; 4) nonjudgmental connections facilitate engagement and build trust. We identified small pivotal moments along the continuum of care that showed how the elements in the four themes enhanced engagement and retention in treatment. These interactions, along the care continuum, are either structural (workflow process) or relational (interpersonal). Conclusion: This research increases understanding of the interplay of the structural and relational barriers and facilitators to engagement and retention in treatment. These seemingly minor positive or negative interactions along the care continuum are pivotal to fully operationalizing TIC and optimizing women's engagement in treatment. Improvement strategies that integrate the voices of WWLE and collaboratively co-design a more patient-centered system are critical steps to improving engagement in SUD treatment and more equitable SUD treatment services.
MeSH term(s)	Pregnancy ; Humans ; Female ; Parenting ; Continuity of Patient Care ; Substance-Related Disorders/therapy ; Behavior, Addictive ; Trust
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ISSN	2949-8759
ISSN (online)	2949-8759
DOI	10.1016/j.josat.2023.209240
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Article ; Online: Pre-pandemic Executive Function Protects Against Pandemic Anxiety in Children with and Without Autism Spectrum Disorder.

Romero, Celia / Kupis, Lauren / Goodman, Zachary T / Dirks, Bryce / Baez, Adriana / Beaumont, Amy L / Cardona, Sandra M / Parlade, Meaghan V / Alessandri, Michael / Nomi, Jason S / Perry, Lynn K / Uddin, Lucina Q

Journal of autism and developmental disorders

2023

Abstract: The COVID-19 pandemic may have exacerbated depression, anxiety, and executive function (EF) difficulties in children with autism spectrum disorder (ASD). EF skills have been positively associated with mental health outcomes. Here, we probed the ... ...

Abstract	The COVID-19 pandemic may have exacerbated depression, anxiety, and executive function (EF) difficulties in children with autism spectrum disorder (ASD). EF skills have been positively associated with mental health outcomes. Here, we probed the psychosocial impacts of pandemic responses in children with and without ASD by relating pre-pandemic EF assessments with anxiety and depression symptoms several months into the pandemic. We found that pre-pandemic inhibition and shifting difficulties, measured by the Behavior Rating Inventory of Executive Function, predicted higher risk of anxiety symptoms. These findings are critical for promoting community recovery and maximizing clinical preparedness to support children at increased risk for adverse psychosocial outcomes.
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-023-06175-4
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Zs.A 765: Show issues

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