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Article ; Online: Low copper-2 intake in Switzerland does not result in lower incidence of Alzheimer's disease and contradicts the Copper-2 Hypothesis.

Solioz, Marc

Experimental biology and medicine (Maywood, N.J.)

2020 Volume 245, Issue 3, Page(s) 177–179

MeSH term(s)	Alzheimer Disease/epidemiology ; Copper/metabolism ; Disease Progression ; Humans ; Incidence ; Nutrition Assessment ; Switzerland
Chemical Substances	Copper (789U1901C5)
Language	English
Publishing date	2020-01-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/1535370219899898
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Article ; Online: The copper rush of the nineties.

Solioz, Marc

Metallomics : integrated biometal science

2016 Volume 8, Issue 9, Page(s) 824–830

Abstract: The nineties witnessed the discovery of the copper ATPases, enzymes which transport copper across the cytoplasmic membranes of bacteria and eukaryotes. In the same decade, several other key components of copper homeostasis have also been discovered, like ...

Abstract	The nineties witnessed the discovery of the copper ATPases, enzymes which transport copper across the cytoplasmic membranes of bacteria and eukaryotes. In the same decade, several other key components of copper homeostasis have also been discovered, like copper chaperones and plasma membrane copper transporters. This has finally led to a molecular understanding of two inherited human diseases related to copper: Menkes disease, manifested by systemic copper deficiency, and Wilson disease, caused by defective secretion of excess copper. A historic perspective and untold stories of the events leading up to these discoveries are presented here.
Language	English
Publishing date	2016-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2474317-3
ISSN	1756-591X ; 1756-5901
ISSN (online)	1756-591X
ISSN	1756-5901
DOI	10.1039/c6mt00111d
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Article ; Online: Killing of bacteria by copper, cadmium, and silver surfaces reveals relevant physicochemical parameters.

Luo, Jiaqi / Hein, Christina / Mücklich, Frank / Solioz, Marc

Biointerphases

2017 Volume 12, Issue 2, Page(s) 20301

Abstract: The killing of bacteria on metallic copper surfaces in minutes to hours is referred to as contact killing. Why copper possesses such strong antimicrobial activity has remained enigmatic. Based on the physicochemical properties of metals, it was recently ... ...

Abstract	The killing of bacteria on metallic copper surfaces in minutes to hours is referred to as contact killing. Why copper possesses such strong antimicrobial activity has remained enigmatic. Based on the physicochemical properties of metals, it was recently predicted that cadmium should also be active in contact killing [Hans et al., Biointerphases 11, 018902 (2010)]. Here, the authors show that cadmium is indeed antimicrobial. It kills three logs of bacteria in 9 h, compared to copper which kills eight logs of bacteria. Metallic silver kills less than one log of bacteria in 9 h. These findings support the novel concept whereby oxide formation, metal ion dissolution, and a Pearson soft character are the key factors for a metal to be antibacterial. Based on these parameters, copper and cadmium are expected to be the two most antibacterial metals.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Cadmium/pharmacology ; Chemical Phenomena ; Copper/pharmacology ; Escherichia coli/drug effects ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Silver/pharmacology ; Stainless Steel/pharmacology ; Surface Properties
Chemical Substances	Anti-Bacterial Agents ; Cadmium (00BH33GNGH) ; Stainless Steel (12597-68-1) ; Silver (3M4G523W1G) ; Copper (789U1901C5)
Language	English
Publishing date	2017-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2234510-3
ISSN	1559-4106 ; 1934-8630
ISSN (online)	1559-4106
ISSN	1934-8630
DOI	10.1116/1.4980127
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Article ; Online: Desulfovibrio DA2_CueO is a novel multicopper oxidase with cuprous, ferrous and phenol oxidase activity.

Mancini, Stefano / Kumar, Ranjeet / Mishra, Veena / Solioz, Marc

Microbiology (Reading, England)

2017 Volume 163, Issue 8, Page(s) 1229–1236

Abstract: Desulfovibrio sp. A2 is a novel Gram-negative sulfate-reducing bacterium that was isolated from sediments of the Norilsk mining/smelting area in Russia. The organism possesses a monocistronic operon encoding a 71 kDa periplasmic multicopperoxidase, which ...

Abstract	Desulfovibrio sp. A2 is a novel Gram-negative sulfate-reducing bacterium that was isolated from sediments of the Norilsk mining/smelting area in Russia. The organism possesses a monocistronic operon encoding a 71 kDa periplasmic multicopperoxidase, which we call DA2_CueO. Histidine-tagged DA2_CueO expressed from a plasmid in Escherichia coli and purified by Ni-NTA affinity chromatography oxidizes Cu+ and Fe2+, and exhibits phenol oxidase activity with 2,2-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid), 2,3-dihydroxybenzoic acid and 2,6-dimethoxyphenol as substrates, using O2 as the oxidant. When expressed in an E. coli cueO knock-out strain, DA2_CueO exhibits phenol oxidase activity in vivo and enhances the copper tolerance of the strain. These findings indicate that the DA2_CueO gene of Desulfovibrio sp. A2 encodes a multicopperoxidase with a role in metal ion resistance. The enzyme displays some novel structural features, which are discussed.
MeSH term(s)	Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; Bacterial Proteins/metabolism ; Copper/metabolism ; Desulfovibrio/chemistry ; Desulfovibrio/enzymology ; Desulfovibrio/genetics ; Desulfovibrio/isolation & purification ; Ferrous Compounds/metabolism ; Geologic Sediments/microbiology ; Oxidoreductases/chemistry ; Oxidoreductases/genetics ; Oxidoreductases/isolation & purification ; Oxidoreductases/metabolism ; Phenol/metabolism
Chemical Substances	Bacterial Proteins ; Ferrous Compounds ; Phenol (339NCG44TV) ; Copper (789U1901C5) ; Oxidoreductases (EC 1.-)
Language	English
Publishing date	2017-07-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180712-x
ISSN	1465-2080 ; 1350-0872
ISSN (online)	1465-2080
ISSN	1350-0872
DOI	10.1099/mic.0.000509
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Article: Role of proteolysis in copper homoeostasis.

Solioz, M

Biochemical Society transactions

2002 Volume 30, Issue 4, Page(s) 688–691

Abstract: The cop operon of Enterococcus hirae controls cytoplasmic copper levels. It encodes two copper ATPases, a repressor, and the CopZ metallochaperone. Transcription of these genes is induced by copper. However, at higher copper concentrations, CopZ is ... ...

Abstract	The cop operon of Enterococcus hirae controls cytoplasmic copper levels. It encodes two copper ATPases, a repressor, and the CopZ metallochaperone. Transcription of these genes is induced by copper. However, at higher copper concentrations, CopZ is degraded by a copper-activated proteolytic activity. This specific proteolysis of CopZ can also be demonstrated in vitro with E. hirae extracts. Growth of the cells in copper increases the copper-inducible proteolytic activity in extracts. Zymography reveals the presence of a copper-dependent protease in crude cell lysates. Copper-stimulated proteolysis of CopZ appears to play an important role in copper homoeostasis by E. hirae.
MeSH term(s)	Bacterial Proteins/metabolism ; Copper/metabolism ; Enterococcus/metabolism ; Homeostasis ; Molecular Chaperones/metabolism ; Trans-Activators/metabolism
Chemical Substances	Bacterial Proteins ; CopZ protein, Enterococcus hirae ; Molecular Chaperones ; Trans-Activators ; Copper (789U1901C5)
Language	English
Publishing date	2002-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184237-7
ISSN	1470-8752 ; 0300-5127
ISSN (online)	1470-8752
ISSN	0300-5127
DOI	10.1042/bst0300688
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Article: Cost-effectiveness of COVID-19 vaccination in Latin America and the Caribbean: an analysis in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru.

Augustovski, Federico / Bardach, Ariel / Santoro, Adrián / Rodriguez-Cairoli, Federico / López-Osornio, Alejandro / Argento, Fernando / Havela, Maissa / Blumenfeld, Alejandro / Ballivian, Jamile / Solioz, Germán / Capula, Analía / López, Analía / Cejas, Cintia / Savedoff, William / Palacios, Alfredo / Rubinstein, Adolfo / Pichon-Riviere, Andrés

Cost effectiveness and resource allocation : C/E

2023 Volume 21, Issue 1, Page(s) 21

Abstract: Objective: Our study analyzes the cost-effectiveness of the COVID-19 vaccination campaigns in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru.: Methods: Using a previously published SVEIR model, we analyzed the impact of a ... ...

Abstract	Objective: Our study analyzes the cost-effectiveness of the COVID-19 vaccination campaigns in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru. Methods: Using a previously published SVEIR model, we analyzed the impact of a vaccination campaign (2021) from a national healthcare perspective. The primary outcomes were quality adjusted life years (QALYs) lost and total costs. Other outcomes included COVID-19 cases, hospitalizations, deaths, and life years. We applied a discount rate of 3% for health outcomes. We modeled a realistic vaccination campaign in each country (the realistic country-specific campaign). Additionally, we assessed a standard campaign (similar, "typical" for all countries), and an optimized campaign (similar in all countries with higher but plausible population coverage). One-way deterministic sensitivity analyses were performed. Findings: Vaccination was health improving as well as cost-saving in almost all countries and scenarios. Our analysis shows that vaccination in this group of countries prevented 573,141 deaths (508,826 standard; 685,442 optimized) and gained 5.07 million QALYs (4.53 standard; 6.03 optimized). Despite the incremental costs of vaccination campaigns, they had a total net cost saving to the health system of US$16.29 billion (US$16.47 standard; US$18.58 optimized). The realistic (base case) vaccination campaign in Chile was the only scenario, which was not cost saving, but it was still highly cost-effective with an ICER of US$22 per QALY gained. Main findings were robust in the sensitivity analyses. Interpretation: The COVID-19 vaccination campaign in seven Latin American and Caribbean countries -that comprise nearly 80% of the region- was beneficial for population health and was also cost-saving or highly cost-effective.
Language	English
Publishing date	2023-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2119372-1
ISSN	1478-7547
ISSN	1478-7547
DOI	10.1186/s12962-023-00430-2
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Article: Publisher Correction: cost-effectiveness of COVID-19 vaccination in Latin America and the Caribbean: an analysis in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru.

Cost effectiveness and resource allocation : C/E

2023 Volume 21, Issue 1, Page(s) 56

Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	2119372-1
ISSN	1478-7547
ISSN	1478-7547
DOI	10.1186/s12962-023-00466-4
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Article ; Online: Physicochemical properties of copper important for its antibacterial activity and development of a unified model.

Hans, Michael / Mathews, Salima / Mücklich, Frank / Solioz, Marc

Biointerphases

2015 Volume 11, Issue 1, Page(s) 18902

Abstract: Contact killing is a novel term describing the killing of bacteria when they come in contact with metallic copper or copper-containing alloys. In recent years, the mechanism of contact killing has received much attention and many mechanistic details are ... ...

Abstract	Contact killing is a novel term describing the killing of bacteria when they come in contact with metallic copper or copper-containing alloys. In recent years, the mechanism of contact killing has received much attention and many mechanistic details are available. The authors here review some of these mechanistic aspects with a focus on the critical physicochemical properties of copper which make it antibacterial. Known mechanisms of contact killing are set in context to ionic, corrosive, and physical properties of copper. The analysis reveals that the oxidation behavior of copper, paired with the solubility properties of copper oxides, are the key factors which make metallic copper antibacterial. The concept advanced here explains the unique position of copper as an antibacterial metal. Based on our model, novel design criteria for metallic antibacterial materials may be derived.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Chemical Phenomena ; Copper/chemistry ; Copper/pharmacology ; Microbial Viability/drug effects ; Models, Biological ; Oxidation-Reduction ; Pharmacological Phenomena
Chemical Substances	Anti-Bacterial Agents ; Copper (789U1901C5)
Language	English
Publishing date	2015-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2234510-3
ISSN	1559-4106 ; 1934-8630
ISSN (online)	1559-4106
ISSN	1934-8630
DOI	10.1116/1.4935853
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Article ; Online: Copper Reduction and Contact Killing of Bacteria by Iron Surfaces.

Mathews, Salima / Kumar, Ranjeet / Solioz, Marc

Applied and environmental microbiology

2015 Volume 81, Issue 18, Page(s) 6399–6403

Abstract: The well-established killing of bacteria by copper surfaces, also called contact killing, is currently believed to be a combined effect of bacterial contact with the copper surface and the dissolution of copper, resulting in lethal bacterial damage. Iron ...

Abstract	The well-established killing of bacteria by copper surfaces, also called contact killing, is currently believed to be a combined effect of bacterial contact with the copper surface and the dissolution of copper, resulting in lethal bacterial damage. Iron can similarly be released in ionic form from iron surfaces and would thus be expected to also exhibit contact killing, although essentially no contact killing is observed by iron surfaces. However, we show here that the exposure of bacteria to iron surfaces in the presence of copper ions results in efficient contact killing. The process involves reduction of Cu(2+) to Cu(+) by iron; Cu(+) has been shown to be considerably more toxic to cells than Cu(2+). The specific Cu(+) chelator, bicinchoninic acid, suppresses contact killing by chelating the Cu(+) ions. These findings underline the importance of Cu(+) ions in the contact killing process and infer that iron-based alloys containing copper could provide novel antimicrobial materials.
MeSH term(s)	Alloys ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/isolation & purification ; Cell Membrane/drug effects ; Cell Membrane/physiology ; Copper/chemistry ; Copper Sulfate/pharmacology ; Enterococcus/drug effects ; Enterococcus/physiology ; Escherichia coli ; Iron/chemistry ; Microbial Viability ; Oxidation-Reduction ; Quinolines/pharmacology ; Surface Properties
Chemical Substances	Alloys ; Anti-Infective Agents ; Quinolines ; Copper (789U1901C5) ; bicinchoninic acid (CX56TX9Y1I) ; Iron (E1UOL152H7) ; Copper Sulfate (LRX7AJ16DT)
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/AEM.01725-15
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Article ; Online: Xenon-inhibition of the MscL mechano-sensitive channel and the CopB copper ATPase under different conditions suggests direct effects on these proteins.

Petrov, Evgeny / Menon, Gopalakrishnan / Rohde, Paul R / Battle, Andrew R / Martinac, Boris / Solioz, Marc

PloS one

2018 Volume 13, Issue 6, Page(s) e0198110

Abstract: Xenon is frequently used as a general anesthetic in humans, but the mechanism remains an issue of debate. While for some membrane proteins, a direct interaction of xenon with the protein has been shown to be the inhibitory mechanism, other membrane ... ...

Abstract	Xenon is frequently used as a general anesthetic in humans, but the mechanism remains an issue of debate. While for some membrane proteins, a direct interaction of xenon with the protein has been shown to be the inhibitory mechanism, other membrane protein functions could be affected by changes of membrane properties due to partitioning of the gas into the lipid bilayer. Here, the effect of xenon on a mechanosensitive ion channel and a copper ion-translocating ATPase was compared under different conditions. Xenon inhibited spontaneous gating of the Escherichia coli mechano-sensitive mutant channel MscL-G22E, as shown by patch-clamp recording techniques. Under high hydrostatic pressure, MscL-inhibition was reversed. Similarly, the activity of the Enterococcus hirae CopB copper ATPase, reconstituted into proteoliposomes, was inhibited by xenon. However, the CopB ATPase activity was also inhibited by xenon when CopB was in a solubilized state. These findings suggest that xenon acts by directly interacting with these proteins, rather than via indirect effects by altering membrane properties. Also, inhibition of copper transport may be a novel effect of xenon that contributes to anesthesia.
MeSH term(s)	Adenosine Triphosphatases/antagonists & inhibitors ; Cation Transport Proteins/antagonists & inhibitors ; Escherichia coli Proteins/antagonists & inhibitors ; Ion Channel Gating/drug effects ; Ion Channels/antagonists & inhibitors ; Ion Channels/drug effects ; Ion Channels/metabolism ; Mechanotransduction, Cellular/drug effects ; Patch-Clamp Techniques ; Xenon/pharmacology
Chemical Substances	Cation Transport Proteins ; Escherichia coli Proteins ; Ion Channels ; MscL protein, E coli ; Xenon (3H3U766W84) ; Adenosine Triphosphatases (EC 3.6.1.-) ; CopB ATPase, Enterococcus hirae (EC 3.6.1.-)
Language	English
Publishing date	2018-06-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0198110
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