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  1. Book: Establishing a Hematopoietic Stem Cell Transplantation Unit

    Gluckman, Éliane / Aljurf, Mahmoud / Niederwieser, Dietger

    A Practical Guide

    2018  

    Abstract: This text aims to provide simplified practical guidelines to start a hematopoietic stem cell transplantation unit which could be implemented in most centers and countries worldwide. The book also provides guidelines for existing transplantation units to ... ...

    Author's details Éliane Gluckman, MD Eurocord Hôpital Saint Louis, Paris, France Dietger Niederwieser, MD University of Leipzig, Department of Hematology and Medical Oncology, Germany Mahmoud Aljurf, MD King Faisal Specialist Hospital and Research Centre, Oncology Centre, Riyadh, Kingdom of Saudi Arabia
    Abstract This text aims to provide simplified practical guidelines to start a hematopoietic stem cell transplantation unit which could be implemented in most centers and countries worldwide. The book also provides guidelines for existing transplantation units to upgrade their practice and implement new policies and procedures, in addition to developing therapies according to latest international standards and regulations. -- The book covers a wide range of practical implementation tools including HSCT...
    Keywords MHMC045 ; MHMC020 ; ABO blood typing ; blood marrow ; donor safety ; Multiple Myeloma ; Myeloproliferative Disorders ; sickle cell disease ; multiple myeloma ; myeloproliferative disorders
    Language English
    Size 320 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_19
    Format 160 x 241 x 22
    ISBN 9783319593562 ; 3319593560
    Database PDA

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  2. Book ; Online ; E-Book: Congenital and acquired bone marrow failure

    Aljurf, Mahmoud / Gluckman, Eliane / Dufour, C.

    2017  

    Author's details edited by M.D. Aljurf, E. Gluckman, C. Dufour
    Keywords Bone Marrow Diseases
    Language English
    Size 1 Online-Ressource (xii, 276 Seiten), Illustrationen
    Publisher Elsevier AP
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019343794
    ISBN 978-0-12-804175-8 ; 9780128041529 ; 0-12-804175-7 ; 0128041528
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article ; Online: Role of HLA Matching in Single Umbilical Cord Blood Transplantation Outcomes.

    Gluckman, Eliane

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2019  Volume 26, Issue 3, Page(s) e53–e54

    MeSH term(s) Adult ; Cord Blood Stem Cell Transplantation ; Haplotypes ; Hematopoietic Stem Cell Transplantation ; Histocompatibility Testing ; Humans
    Language English
    Publishing date 2019-12-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2019.12.014
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  4. Article: La greffe de cellules souches hématopoïétiques hier et aujourd'hui.

    Gluckman, Éliane / Rafii, Hanadi

    Soins; la revue de reference infirmiere

    2021  Volume 66, Issue 854, Page(s) 26–31

    Abstract: Bone marrow transplant, more recently called hematopoietic stem cell transplant (HSC), is a complex medical procedure in which a patient with or without malignant hematologic disease receives a combination of chemoradiation followed by an injection of ... ...

    Title translation Hematopoietic stem cell transplant yesterday and today.
    Abstract Bone marrow transplant, more recently called hematopoietic stem cell transplant (HSC), is a complex medical procedure in which a patient with or without malignant hematologic disease receives a combination of chemoradiation followed by an injection of HSC, either from the same patient (autologous transplant) or from a healthy donor (allogeneic transplant).
    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Neoplasms ; Tissue Donors ; Transplantation, Homologous
    Language French
    Publishing date 2021-05-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 604655-1
    ISSN 0038-0814
    ISSN 0038-0814
    DOI 10.1016/S0038-0814(21)00096-7
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  5. Article ; Online: Umbilical cord blood transfusions in low-income countries.

    Gluckman, Eliane

    The Lancet. Haematology

    2015  Volume 2, Issue 3, Page(s) e85–6

    MeSH term(s) Blood Transfusion ; Fetal Blood ; Humans ; Platelet Transfusion ; Poverty ; Umbilical Cord
    Language English
    Publishing date 2015-03
    Publishing country England
    Document type Comment ; Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(15)00019-8
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  6. Article ; Online: Improving survival for Fanconi anemia patients.

    Gluckman, Eliane

    Blood

    2015  Volume 125, Issue 24, Page(s) 3676

    Abstract: In this issue of Blood, MacMillan et al give the results of sequential modifications of the conditioning regimen to improve the outcome of unrelated bone marrow transplantation in Fanconi anemia (FA). Over a period of 10 years, they show that transplant ... ...

    Abstract In this issue of Blood, MacMillan et al give the results of sequential modifications of the conditioning regimen to improve the outcome of unrelated bone marrow transplantation in Fanconi anemia (FA). Over a period of 10 years, they show that transplant toxicity has decreased and engraftment has improved, resulting in a 5-year overall survival probability of 94%. The major change was the use of fludarabine in the conditioning, with decreased doses of irradiation and cyclophosphamide. They attribute their success to progressive modifications of the conditioning regimen; nevertheless, the improvement may also have been due to better patient selection, use of high-resolution HLA typing for donor selection, and improved supportive care treatment.
    MeSH term(s) Fanconi Anemia/therapy ; Female ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male
    Language English
    Publishing date 2015-06-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-04-639476
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  7. Article ; Online: Relationship between soft tissue dimensions and tomographic radial root position classification system for immediate implant installation.

    Rodrigues, Diogo Moreira / Gluckman, Howard / Pontes, Carla Cruvinel / Januário, Alessandro Lourenço / Petersen, Rodrigo Lima / de Moraes, José Rodrigo / Barboza, Eliane Porto

    Odontology

    2024  

    Abstract: The aim of this study was to evaluate the relationship between soft tissue dimensions and radial root position (RRP) classification for immediate implant placement on maxillary anterior teeth. Maxillary anterior teeth (n = 420) were analyzed in the ... ...

    Abstract The aim of this study was to evaluate the relationship between soft tissue dimensions and radial root position (RRP) classification for immediate implant placement on maxillary anterior teeth. Maxillary anterior teeth (n = 420) were analyzed in the radial plane of cone beam computed tomography (CBCT) scans. Each tooth was classified according to its RRP: class I, (IA, IB); class II (IIA, IIB) class III; class IV, and class V. Soft tissue thickness at different landmarks, supracrestal soft tissue height, and crestal bone thickness were measured in CBCT. Keratinized tissue width was clinically measured. Gingival phenotype (thick or thin) was evaluated by transparency of the periodontal probe and at the landmark 2 mm from the gingival margin in CBCT. Class I tooth position accounted for 31.7%, class II for 45%, class III for 13.3%, class IV for 0.5%, and class V for 9.5%. The gingival phenotype was associated with RRP (χ
    Language English
    Publishing date 2024-02-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2092085-4
    ISSN 1618-1255 ; 1618-1247
    ISSN (online) 1618-1255
    ISSN 1618-1247
    DOI 10.1007/s10266-023-00897-8
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  8. Article ; Online: OBITUARY- Riccardo Saccardi (20th April 1956-19th February 2024).

    Bacigalupo, Andrea / Bonifazi, Francesca / Ciceri, Fabio / Gluckman, Eliane / Greco, Raffaella / Nozzoli, Chiara / Lombardini, Letizia / Martino, Massimo / Rambaldi, Alessandro / Rocha, Vanderson / Ruggeri, Annalisa / Snowden, John / Sureda, Anna

    Bone marrow transplantation

    2024  

    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Editorial
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-024-02296-1
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    Zs.A 2168: Show issues Location:
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  9. Article ; Online: Allogeneic transplantation strategies including haploidentical transplantation in sickle cell disease.

    Gluckman, Eliane

    Hematology. American Society of Hematology. Education Program

    2013  Volume 2013, Page(s) 370–376

    Abstract: Sickle cell disease (SCD) is the most common inherited hemoglobinopathy. Despite antenatal counseling and neonatal screening programs implemented in higher income countries, SCD is still associated with multiple morbidities and early mortality. To date, ... ...

    Abstract Sickle cell disease (SCD) is the most common inherited hemoglobinopathy. Despite antenatal counseling and neonatal screening programs implemented in higher income countries, SCD is still associated with multiple morbidities and early mortality. To date, the only curative approach to SCD is hematopoietic stem cell transplantation, but this therapy is not yet established worldwide. The registries of the European Blood and Marrow Transplant (EBMT) and the Centre for International Blood and Marrow Transplant Research (CIBMTR) account, respectively, for 611 and 627 patients receiving transplantations for SCD. Most of these patients were transplanted with grafts from an HLA-identical sibling donor. The main obstacles to increasing the number of transplantations are a lack of awareness on the part of physicians and families, the absence of reliable prognostic factors for severity, and the perceived risk that transplantation complications may outweigh the benefits of early transplantation. Results show that more than 90% of patients having undergone an HLA-identical sibling transplantation after myeloablative conditioning are cured, with very limited complications. Major improvement is expected from the use of new reduced-toxicity conditioning regimens and the use of alternative donors, including unrelated cord blood transplantations and related haploidentical bone marrow or peripheral blood stem cell transplantations.
    MeSH term(s) Allografts ; Anemia, Sickle Cell/pathology ; Anemia, Sickle Cell/physiopathology ; Anemia, Sickle Cell/therapy ; Cord Blood Stem Cell Transplantation ; European Union ; Hematopoietic Stem Cell Transplantation ; Histocompatibility Testing ; Humans ; Peripheral Blood Stem Cell Transplantation ; Registries ; Siblings ; Transplantation Conditioning/methods
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1520-4383
    ISSN (online) 1520-4383
    DOI 10.1182/asheducation-2013.1.370
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  10. Article ; Online: Impact of donor NKG2D and MICA gene polymorphism on clinical outcomes of adult and paediatric allogeneic cord blood transplantation for malignant diseases.

    Cox, Steven T / Patterson, Warren / Duggleby, Richard / Jones, Owen J R / Madrigal, J Alejandro / Querol, Sergi / Salvador, Francesc Rudilla / Mata, Maria Jose Herrero / Volt, Fernanda / Gluckman, Éliane / Szydlo, Richard / Danby, Robert D / Hernandez, Diana

    European journal of haematology

    2024  

    Abstract: Objectives: NKG2D is an activating receptor expressed by natural killer (NK) and CD8+ T cells and activation intensity varies by NKG2D expression level or nature of its ligand. An NKG2D gene polymorphism determines high (HNK1) or low (LNK1) expression. ... ...

    Abstract Objectives: NKG2D is an activating receptor expressed by natural killer (NK) and CD8+ T cells and activation intensity varies by NKG2D expression level or nature of its ligand. An NKG2D gene polymorphism determines high (HNK1) or low (LNK1) expression. MICA is the most polymorphic NKG2D ligand and stronger effector cell activation associates with methionine rather than valine at residue 129. We investigated correlation between cord blood (CB) NKG2D and MICA genotypes and haematopoietic stem cell (HSC) transplant outcome.
    Methods: We retrospectively studied 267 CB HSC recipients (178 adult and 87 paediatric) who underwent transplant for malignant disease between 2007 and 2018, analysing CB graft DNA for NKG2D and MICA polymorphisms using Sanger sequencing. Multivariate analysis was used to correlate these results with transplant outcomes.
    Results: In adult patients, LNK1 homozygous CB significantly improved 60-day neutrophil engraftment (hazard ratio (HR) 0.6; 95% confidence interval (CI) 0.4-0.9; p = .003). In paediatrics, HNK1 homozygous CB improved 60-day engraftment (HR 0.4; 95% CI 0.2-0.7; p = .003), as did MICA-129 methionine+ CB grafts (HR 1.7 95% CI 1.1-2.6; p = .02).
    Conclusion: CB NKG2D and MICA genotypes potentially improve CB HSC engraftment. However, results contrast between adult and paediatric recipients and may reflect transplant procedure disparities between cohorts.
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.14202
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    Zs.A 323: Show issues Location:
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